TNF-α
Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.
Products for TNF-α
- Cat.No. Product Name Information
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GC10350
TIC10 isomer
Potent Akt/ERK inhibitor
- GC48292 α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities.
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GC69795
(Rac)-BIO8898
(Rac)-BIO8898 is a CD40-CD154 co-stimulatory interaction inhibitor. (Rac)-BIO8898 inhibits the binding of CD154 to CD40-Ig, with an IC50 of 25 μM.
- GC63972 5,7-Dimethoxyflavanone 5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S.
- GC45772 6(5H)-Phenanthridinone An inhibitor of PARP1 and 2
- GC35184 7,3',4'-Tri-O-methylluteolin 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines.
- GC45960 9c(i472) 9c(i472) is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM.
- GC34214 Adalimumab (Anti-Human TNF-alpha, Human Antibody) Adalimumab (Anti-Human TNF-alpha, Human Antibody) is a human monoclonal IgG1 antibody targeting tumour necrosis factorα (TNF-α).
- GC46862 Apigenin-d5 An internal standard for the quantification of apigenin
- GC35377 Apratastat An inhibitor of ADAM17 and MMPs
- GC10420 Apremilast (CC-10004) An orally available PDE4 inhibitor
- GN10415 Astilbin
- GC42880 Avenanthramide-C methyl ester Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM).
- GC35440 AX-024 AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM.
- GC19046 AX-024 hydrochloride AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.
- GC68369 Belantamab
- GC65031 Belimumab Belimumab (LymphoStat B) is a human IgG1λ monoclonal antibody that inhibits B-cell activating factor (BAFF).
- GC62451 Benpyrine Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM.
- GC42925 Berteroin Berteroin is a sulforaphane analog found in cruciferous vegetables including Chinese cabbage, rucola salad leaves, and mustard oil.
- GC67680 BIO8898
- GC35523 Bioymifi A DR5 agonist
- GC42953 BMS 345541 (trifluoroacetate salt) BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM).
- GC68288 Brentuximab
- GC33826 C 87 C 87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.
- GC34513 C25-140 C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13.
- GC43110 C8 Galactosylceramide (d18:1/8:0) C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids.
- GC43176 CAY10575 CAY10575 (Compound 8) is an IKK2 inhibitor with an IC50 of 0.075 μM.
- GC43189 CAY10681 Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer.
- GC43190 CAY10682 (±)-Nutlin-3 blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo.
- GC40650 CAY10706 CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells.
- GC33337 CDC801 CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC50 of 1.1 μM and 2.5 μM, respectively.
- GC15083 Celastrol A triterpenoid antioxidant
- GC18392 Cellocidin Cellocidin is an antibiotic originally isolated from S.
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GC65487
Certolizumab pegol
Certolizumab pegol (Certolizumab) is a recombinant, polyethylene glycolylated, antigen-binding fragment of a humanized monoclonal antibody that selectively targets and neutralizes tumour necrosis factor-α (TNF-α).
- GC14500 CPI-1189 necrosis factor (TNF) alpha inhibitor
- GC33330 Cynaropicrin A sesquiterpene lactone
- GC43368 D,L-1′-Acetoxychavicol Acetate D,L-1′-Acetoxychavicol acetate is a natural compound first isolated from the rhizomes of ginger-like plants.
- GC60796 D-Trimannuronic acid D-Trimannuronic acid, an alginate oligomer is extracted from seaweed.
- GC68305 Dacetuzumab
- GC33934 DCVC DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) is a bioactive metabolite of trichloroethylene (TCE).
- GC64864 EJMC-1 EJMC-1 is a moderately potent TNF-α inhibitor with an IC50 value of 42 μM.
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GC34579
Etanercept
Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor.
- GC30910 Eucalyptol (1,8-Cineole) A bicyclic monoterpene with diverse biological activities
- GN10030 Fisetin
- GC48827 Flufenamic Acid-d4 An internal standard for the quantification of flufenamic acid
- GN10727 Forsythoside B
- GC36106 Gamma-glutamylcysteine (TFA) Gamma-glutamylcysteine (γ-Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx).
- GN10151 Geraniin
- GN10254 Ginsenoside Rc
- GN10538 Ginsenoside Rh1
- GC66345 Golimumab Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research.
- GC15573 GSK481 RIP1(Receptor Interacting Protein Kinase 1) inhibitor
- GC18796 Herbicidin A Herbicidin A is an adenine nucleoside antibiotic originally isolated from S.
- GC31739 Hispidol ((Z)-Hispidol) Hispidol ((Z)-Hispidol) ((Z)-Hispidol ((Z)-Hispidol)) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.
- GC31692 Homoplantaginin A flavonoid glycoside with antioxidant and anti-inflammatory activities
- GC13074 HU 211 NMDA antagonist, novel and non-competitive
- GN10217 Hypaconitine
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GC43894
IKK2 Inhibitor VI
Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling.
- GC19533 Infliximab Infliximab is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α.
- GC64767 ISIS 104838 ISIS?104838?is an antisense oligonucleotide drug that reduces the production of tumor necrosis factor (TNF-alpha),?a substance that contributes to joint pain and swelling in rheumatoid arthritis.
- GC46015 KY 05009 A TNIK inhibitor
- GC47544 Lauric Acid-13C An internal standard for the quantification of lauric acid
- GC62400 LEESGGGLVQPGGSMK acetate LEESGGGLVQPGGSMK acetate, a proteolysis peptide, is a component of Infliximab.
- GC14976 Lenalidomide (CC-5013) An analog of thalidomide
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GC13473
Lenalidomide hemihydrate
TNF-α secretion inhibitor
- GC14015 Lenalidomide hydrochloride An analog of thalidomide
- GC60225 Licarin A Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells.
- GC66382 Lucatumumab Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research.
- GC12045 LY 303511 An inhibitor of cell proliferation
- GC44097 LY303511 (hydrochloride) LY303511 is a close structural analog of LY294002, a selective phosphatidylinositol 3-kinase (PI3K) inhibitor.
- GC17632 Maslinic Acid inhibitor of NO, H2O2 , IL-6 and TNF-α
- GN10335 Mesaconitine
- GC48907 Metaxalone-d6 An internal standard for the quantification of metaxalone
- GC16007 Methylthiouracil antithyroid preparation
- GN10055 Mulberroside A
- GC16673 N-Formyl-Met-Leu-Phe formyl peptide receptor 1 (FPR1) agonist
- GC11167 Necrostatin 2 A potent inhibitor of necroptosis
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GC11008
Necrostatin-1
A RIP1 kinase inhibitor
- GC39070 Negletein Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells.
- GN10429 Neochlorogenic acid
- GC44388 NF-κB Control NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.
- GC11697 Pomalidomide (CC-4047) An inhibitor of cereblon
- GC11751 QNZ (EVP4593) An inhibitor of NF-κB activation
- GC11659 R-7050 R-7050 is a novel cell-permeable triazoloquinoxaline compound that selectively inhibited TNF-α induced cellular signaling.
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GC69801
Ragifilimab
Ragifilimab (INCAGN-1876) is a monoclonal antibody that targets glucocorticoid-induced TNFR-related protein (GITR), which is an agonist. Ragifilimab can be used in the research of advanced or metastatic solid tumors.
- GC45798 Rhein-13C4 An internal standard for the quantification of rhein
- GC37555 Roquinimex Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.
- GC39815 Semapimod tetrahydrochloride Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6.
- GN10216 Shikonin
- GC50196 Simvastatin - d6 Deuterated simvastatin
- GN10280 Sinensetin
- GC33133 SPD304 A smallmolecule inhibitor of TNFα activity
- GC68470 SPD304 dihydrochloride
- GC44943 sPLA2 Inhibitor sPLA2 Inhibitor, a D-tyrosine derivative, is an orally active, potent secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 29 nM for human nonpancreatic secretory PLA2 isoform IIa (hnpsPLA2-IIa).
- GC48098 SR 12343 An IKKβ NBD mimetic
- GC48099 SR 12460 An IKKβ NBD mimetic
- GC33825 Taurochenodeoxycholic acid (12-Deoxycholyltaurine) Taurochenodeoxycholic acid (12-Deoxycholyltaurine) (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.
- GC41342 Terrecyclic Acid Terrecyclic acid is a sesquiterpene originally isolated from A.
- GC17054 Thalidomide An immunomodulatory compound with diverse biological activities
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GC70039
TNF-α (46-65), human TFA
TNF-α (46-65), human (TFA) is a peptide fragment of human TNF-α.