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Home >> Signaling Pathways >> Cardiovascular

Cardiovascular

Cardiovascular

Cardiovascular

The cardiovascular system consists of the heart, blood and blood vessels. These organs form the 3 major closed circulation systems in the body, i.e., the pulmonary, coronary and systemic circulations. Cardiovascular disease includes heart disease, vascular diseases of the brain and kidney, and peripheral arterial diseases. Cardiovascular disease is the leading cause of death globally. Studies on cardiovascular regulation are important to provide a better understanding of this group of diseases and to help improve the corresponding treatment.

Targets for  Cardiovascular

Products for  Cardiovascular

  1. Cat.No. Product Name Information
  2. GC45208 α-hydroxy Metoprolol α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol. α-hydroxy Metoprolol Chemical Structure
  3. GC48283 α-Linolenic Acid-d14 An internal standard for the quantification of αLinolenic acid α-Linolenic Acid-d14 Chemical Structure
  4. GC45602 α-Linolenic Acid-d5 MaxSpec• Standard   α-Linolenic Acid-d5 MaxSpec• Standard Chemical Structure
  5. GC49467 β-Aescin A triterpenoid saponin with diverse biological activities β-Aescin Chemical Structure
  6. GC49890 β-Glycerophosphate-d5 (sodium salt hydrate) An internal standard for the quantification of β-glycerophosphate β-Glycerophosphate-d5 (sodium salt hydrate) Chemical Structure
  7. GC40105 βARK1 Inhibitor βARK1 Inhibitor (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a GRK2 (β-ARK1) inhibitor. βARK1 Inhibitor Chemical Structure
  8. GC52400 γ-Glu-Ala (trifluoroacetate salt) A dipeptide γ-Glu-Ala (trifluoroacetate salt) Chemical Structure
  9. GC52404 γ-Glu-Phe (trifluoroacetate salt) A dipeptide with metabolism-altering activity γ-Glu-Phe (trifluoroacetate salt) Chemical Structure
  10. GC41393 ω-3 Arachidonic Acid methyl ester ω-3 Fatty acids, represented primarily by docosahexaenoic acid, eicosapentaenoic acid, and α-linoleate, are essential dietary nutrients required for normal growth and development. ω-3 Arachidonic Acid methyl ester Chemical Structure
  11. GC41661 (±)-4-hydroxy Propranolol β-D-Glucuronide (±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol. (±)-4-hydroxy Propranolol β-D-Glucuronide Chemical Structure
  12. GC46273 (±)-Atenolol-d7 An internal standard for the quantification of (±)-atenolol (±)-Atenolol-d7 Chemical Structure
  13. GC46289 (±)-Felodipine-d5 An internal standard for the quantification of (±)-felodipine (±)-Felodipine-d5 Chemical Structure
  14. GC46307 (±)-Propranolol-d7 An internal standard for the quantification of propranolol (±)-Propranolol-d7 Chemical Structure
  15. GC40229 (±)-Warfarin-d5 (±)-Warfarin-d5 is intended for use as an internal standard for the quantification of warfarin by GC- or LC-MS. (±)-Warfarin-d5 Chemical Structure
  16. GC40386 (±)11(12)-EpETE Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms. (±)11(12)-EpETE Chemical Structure
  17. GC40467 (±)11-HETE (±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. (±)11-HETE Chemical Structure
  18. GC41649 (±)13-HODE cholesteryl ester (±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL. (±)13-HODE cholesteryl ester Chemical Structure
  19. GC40430 (±)14(15)-EET

    (±)14(15)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450.

     (±)14(15)-EET Chemical Structure
  20. GC41651 (±)14(15)-EET-SI Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. (±)14(15)-EET-SI Chemical Structure
  21. GC40434 (±)16-HETE Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE Chemical Structure
  22. GC41288 (±)17(18)-EpETE-Ethanolamide (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. (±)17(18)-EpETE-Ethanolamide Chemical Structure
  23. GC40362 (±)18-HEPE (±)18-HEPE is produced by non-enzymatic oxidation of EPA. (±)18-HEPE Chemical Structure
  24. GC40436 (±)18-HETE (±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. (±)18-HETE Chemical Structure
  25. GC41655 (±)19(20)-EDP Ethanolamide (±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). (±)19(20)-EDP Ethanolamide Chemical Structure
  26. GC40437 (±)5(6)-DiHET lactone 5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET. (±)5(6)-DiHET lactone Chemical Structure
  27. GC40438 (±)5(6)-EET 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. (±)5(6)-EET Chemical Structure
  28. GC40421 (±)8(9)-EE-14(Z)-E (±)14(15)-EE-8(Z)-E is a potent vasodilator in bovine coronary arteries. (±)8(9)-EE-14(Z)-E Chemical Structure
  29. GC40443 (±)9-HETE (±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. (±)9-HETE Chemical Structure
  30. GC40541 (±)9-HODE

    (±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid.

     (±)9-HODE Chemical Structure
  31. GC41666 (±)9-HODE cholesteryl ester (±)9-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL. (±)9-HODE cholesteryl ester Chemical Structure
  32. GC40356 (±)9-HpODE (±)9-HpODE is a racemic mixture of the fatty acid hydroperoxide product (9(S)-HpODE) formed from lipoxygenase action on linoleic acid. (±)9-HpODE Chemical Structure
  33. GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin (3R,5R)-Rosuvastatin (calcium salt) Chemical Structure
  34. GC41694 (3S)-hydroxy Quinidine (3S)-hydroxy Quinidine is an active quinidine metabolite. (3S)-hydroxy Quinidine Chemical Structure
  35. GC48508 (4-Carboxybutyl-d4)triphenylphosphonium (bromide) An internal standard for the quantification of (4-carboxybutyl)triphenylphosphonium (4-Carboxybutyl-d4)triphenylphosphonium (bromide) Chemical Structure
  36. GC40444 (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic Acid (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE, a major arachidonic acid metabolite from the 15-lipoxygenase pathway. (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic Acid Chemical Structure
  37. GC49003 (E)-Ajoene A disulfide with diverse biological activities (E)-Ajoene Chemical Structure
  38. GC46336 (E)-Guggulsterone A farnesoid X receptor antagonist (E)-Guggulsterone Chemical Structure
  39. GC40552 (R)-Acenocoumarol Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. (R)-Acenocoumarol Chemical Structure
  40. GC41722 (R,S)-Carvedilol Glucuronide (R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide. (R,S)-Carvedilol Glucuronide Chemical Structure
  41. GC40553 (S)-Acenocoumarol Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. (S)-Acenocoumarol Chemical Structure
  42. GC48719 (S)-Canadine (S)-Canadine is an alkaloid and intermediate in the biosynthesis of berberine with insecticidal activity. (S)-Canadine Chemical Structure
  43. GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog 1(R)-(Trifluoromethyl)oleyl alcohol Chemical Structure
  44. GC41837 1,3,7-Trimethyluric Acid

    1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes.

     1,3,7-Trimethyluric Acid Chemical Structure
  45. GC46387 1,3,7-Trimethyluric Acid-d9 An internal standard for the quantification of 1,3,7-trimethyluric acid 1,3,7-Trimethyluric Acid-d9 Chemical Structure
  46. GC41846 1,3-Dioctanoyl-2-Oleoyl-rac-glycerol 1,3-Dioctanoyl-2-oleoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1 and sn-3 positions and oleic acid at the sn-2 position. 1,3-Dioctanoyl-2-Oleoyl-rac-glycerol Chemical Structure
  47. GC49346 1-(3-Chlorophenyl)biguanide (hydrochloride) A 5-HT3 receptor agonist 1-(3-Chlorophenyl)biguanide (hydrochloride) Chemical Structure
  48. GC18235 1-O-Hexadecyl-sn-glycerol

    1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether.

     1-O-Hexadecyl-sn-glycerol Chemical Structure
  49. GC42008 1-Octadecyl Lysophosphatidic Acid 1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. 1-Octadecyl Lysophosphatidic Acid Chemical Structure
  50. GC49071 1-Palmitoyl-d9 Lysophosphatidic Acid An internal standard for the quantification of 1-palmitoyl lysophosphatidic acid 1-Palmitoyl-d9 Lysophosphatidic Acid Chemical Structure
  51. GC46496 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-PC An internal standard for the quantification of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-PC Chemical Structure
  52. GC49733 1-Stearoyl-2-eicosapentaenoyl-sn-glycero-3-PC A phospholipid 1-Stearoyl-2-eicosapentaenoyl-sn-glycero-3-PC Chemical Structure
  53. GC49118 10-hydroxy Warfarin A metabolite of (R)-warfarin 10-hydroxy Warfarin Chemical Structure
  54. GC46408 11-dehydro Thromboxane B2-d4 An internal standard for the quantification of 11dehydro thromboxane B2 11-dehydro Thromboxane B2-d4 Chemical Structure
  55. GC18634 11-deoxy Prostaglandin E1 11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1. 11-deoxy Prostaglandin E1 Chemical Structure
  56. GC41401 11-deoxy Prostaglandin F1α 11-deoxy PGF1α is a synthetic analog of PGF1α. 11-deoxy Prostaglandin F1α Chemical Structure
  57. GC41402 11-deoxy Prostaglandin F1β 11-deoxy PGF1β is a synthetic analog of PGF1β. 11-deoxy Prostaglandin F1β Chemical Structure
  58. GC18637 11β-Prostaglandin F2α

    11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.

     11β-Prostaglandin F2α Chemical Structure
  59. GC41882 12(S)-HETrE 12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA). 12(S)-HETrE Chemical Structure
  60. GC41893 13(R)-HODE cholesteryl ester 13(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. 13(R)-HODE cholesteryl ester Chemical Structure
  61. GC41895 13(S)-HODE cholesteryl ester 13(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. 13(S)-HODE cholesteryl ester Chemical Structure
  62. GC41897 13(S)-HOTrE 13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid. 13(S)-HOTrE Chemical Structure
  63. GC40745 13,14-dehydro-15-cyclohexyl Carbaprostacyclin 13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2. 13,14-dehydro-15-cyclohexyl Carbaprostacyclin Chemical Structure
  64. GC41433 13,14-dihydro Prostaglandin E1 13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. 13,14-dihydro Prostaglandin E1 Chemical Structure
  65. GC40424 14,15-EE-5(Z)-E Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E Chemical Structure
  66. GC40425 14,15-EE-8(Z)-E Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-8(Z)-E Chemical Structure
  67. GC46438 14S(15R)-EET A cytochrome P450 metabolite of arachidonic acid 14S(15R)-EET Chemical Structure
  68. GC41173 15(R)-Pinane Thromboxane A2 15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2. 15(R)-Pinane Thromboxane A2 Chemical Structure
  69. GC41166 15(S)-15-methyl Prostaglandin D2 15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. 15(S)-15-methyl Prostaglandin D2 Chemical Structure
  70. GC41103 15-keto Prostaglandin A1 Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. 15-keto Prostaglandin A1 Chemical Structure
  71. GC41935 15-keto Treprostinil (sodium salt) 15-keto Treprostinil is an impurity found in treprostinil, which is a stable analog of prostaglandin I2 with a longer plasma half-life. 15-keto Treprostinil (sodium salt) Chemical Structure
  72. GC40973 16(R)-Iloprost Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. 16(R)-Iloprost Chemical Structure
  73. GC40974 16(S)-Iloprost Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. 16(S)-Iloprost Chemical Structure
  74. GC41159 16,16-dimethyl Prostaglandin D2 16,16-dimethyl PGD2 is a metabolically stable synthetic analog of PGD2. 16,16-dimethyl Prostaglandin D2 Chemical Structure
  75. GC18777 16,16-dimethyl Prostaglandin E1 16,16-dimethyl PGE1 is a metabolically stable synthetic analog of PGE1. 16,16-dimethyl Prostaglandin E1 Chemical Structure
  76. GC46464 17R(18S)-EpETE An EPA metabolite and activator of BKCa channels 17R(18S)-EpETE Chemical Structure
  77. GC46474 18-Deoxyherboxidiene A bacterial metabolite with antiangiogenic activity 18-Deoxyherboxidiene Chemical Structure
  78. GC18635 18-hydroxy-11-deoxy Corticosterone 18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. 18-hydroxy-11-deoxy Corticosterone Chemical Structure
  79. GC40457 19(R)-HETE 19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. 19(R)-HETE Chemical Structure
  80. GC40417 19-hydroxy Cholesterol 19-hydroxy Cholesterol is formed during metabolic oxidation of cholesterol. 19-hydroxy Cholesterol Chemical Structure
  81. GC46475 19R(20S)-EpDPA A DHA metabolite 19R(20S)-EpDPA Chemical Structure
  82. GC18748 1a,1b-dihomo Prostaglandin E1 Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology. 1a,1b-dihomo Prostaglandin E1 Chemical Structure
  83. GC52122 2’-Deoxyadenosine-5’-diphosphate (sodium salt) A nucleotide diphosphate 2’-Deoxyadenosine-5’-diphosphate (sodium salt) Chemical Structure
  84. GC42065 2,3-dinor Thromboxane B1 Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. 2,3-dinor Thromboxane B1 Chemical Structure
  85. GC49671 2,3-Oxidosqualene An intermediate in the biosynthesis of sterols 2,3-Oxidosqualene Chemical Structure
  86. GC19560 2-(2-Phenylethyl)chromone 2-(2-Phenylethyl)chromone (Flidersiachromone) is one of 2-(2-phenylethyl)chromones that can be found in Chinese eaglewood from Aquilaria sinensis. 2-(2-Phenylethyl)chromone Chemical Structure
  87. GC42135 2-chloro Palmitic Acid 2-chloro Palmitic Acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-chloro Palmitic Acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-chloro Palmitic Acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3. 2-chloro Palmitic Acid Chemical Structure
  88. GC40503 2-HOBA 2-HOBA (2-HOBA) a selective dicarbonyl scavenger, is an antioxidant and scavanger of free radicals and isolevuglandins (IsoLGs). 2-HOBA Chemical Structure
  89. GC42189 2-oxo Clopidogrel 2-oxo Clopidogrel is an intermediary metabolite of clopidogrel. 2-oxo Clopidogrel Chemical Structure
  90. GC41104 20-carboxy Arachidonic Acid 20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. 20-carboxy Arachidonic Acid Chemical Structure
  91. GC41614 24-dehydro Cholesterol 24-dehydro Cholesterol is a molecule similar to cholesterol. 24-dehydro Cholesterol Chemical Structure
  92. GC46243 24-dehydro Cholesterol-d6 An internal standard for the quantification of 24-dehydro cholesterol 24-dehydro Cholesterol-d6 Chemical Structure
  93. GC46528 25-hydroxy Cholesterol-d6 An internal standard for the quantification of 25hydroxy cholesterol 25-hydroxy Cholesterol-d6 Chemical Structure
  94. GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate A metabolite of certain phenols and glycosides 3-(3-Hydroxyphenyl)propionic Acid sulfate Chemical Structure
  95. GC40799 3-hydroxy-3-Methylglutaric anhydride The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase mediates the rate-limiting step in cholesterol synthesis, converting HMG-CoA to mevalonate. 3-hydroxy-3-Methylglutaric anhydride Chemical Structure
  96. GC52048 3-hydroxy-4-Methoxyphenethylamine (hydrochloride) 3-hydroxy-4-Methoxyphenethylamine (hydrochloride) is a catecholamine compound that has an inhibitory effect on dihydropteridine reductase. 3-hydroxy-4-Methoxyphenethylamine (hydrochloride) Chemical Structure
  97. GC52149 306-O12B

    An ionizable cationic lipidoid

     306-O12B Chemical Structure
  98. GC42338 4-Aminobenzoic Acid hydrazide 4-Aminobenzoic Acid hydrazide is an irreversible MPO myeloperoxidase inhibitor with an IC50 of 0.3 μM. 4-Aminobenzoic Acid hydrazide Chemical Structure
  99. GC42405 4-hydroxy Atorvastatin (calcium salt) 4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. 4-hydroxy Atorvastatin (calcium salt) Chemical Structure
  100. GC18425 4-hydroxy Atorvastatin lactone

    4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.

     4-hydroxy Atorvastatin lactone Chemical Structure
  101. GC42411 4-hydroxy Nonenal Alkyne

    4-hydroxy Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid.

     4-hydroxy Nonenal Alkyne Chemical Structure

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