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Neuroscience

Neuroscience

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Targets for  Neuroscience

Products for  Neuroscience

  1. Cat.No. Product Name Information
  2. GC12432 (+)-Anabasine hydrochloride neuronal nicotinic ACh receptor partial agonist (+)-Anabasine hydrochloride  Chemical Structure
  3. GN10745 (+)-Bicuculline

    (+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor.

    (+)-Bicuculline  Chemical Structure
  4. GC34954 (+)-Borneol (+)-Borneol  Chemical Structure
  5. GN10605 (+)-Catechin hydrate (+)-Catechin hydrate  Chemical Structure
  6. GC34957 (+)-Cevimeline hydrochloride hemihydrate (+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011), a potent muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. (+)-Cevimeline hydrochloride hemihydrate  Chemical Structure
  7. GN10654 (+)-Corynoline (+)-Corynoline  Chemical Structure
  8. GC45263 (+)-D-threo-PDMP (hydrochloride) (+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP. (+)-D-threo-PDMP (hydrochloride)  Chemical Structure
  9. GC30933 (+)-Kavain

    An Analytical Reference Standard

    (+)-Kavain  Chemical Structure
  10. GC10736 (+)-Muscarine iodide

    Muscarinic acetylcholine receptor agonist

    (+)-Muscarine iodide  Chemical Structure
  11. GC68210 (+)-Norfenfluramine (+)-Norfenfluramine  Chemical Structure
  12. GC30848 (+)-PD 128907 hydrochloride

    A potent D3 receptor agonist

    (+)-PD 128907 hydrochloride  Chemical Structure
  13. GC34959 (+)-Sparteine (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine  Chemical Structure
  14. GC11062 (+)-Tubocurarine chloride nicotinic acetylcholine receptor antagonist (+)-Tubocurarine chloride  Chemical Structure
  15. GC12870 (+)-UH 232 maleate D2 antagonist (+)-UH 232 maleate  Chemical Structure
  16. GC11049 (+/-)-Sulfinpyrazone platelet COX inhibitor (+/-)-Sulfinpyrazone  Chemical Structure
  17. GC38677 (-)-α-Pinene (-)-α-Pinene is a monoterpene and shows sleep enhancing property through a direct binding to GABAA-benzodiazepine (BZD) receptors by acting as a partial modulator at the BZD binding site. (-)-α-Pinene  Chemical Structure
  18. GC45244 (-)-(α)-Kainic Acid (hydrate) A potent central nervous system stimulant for induction of seizures (-)-(α)-Kainic Acid (hydrate)  Chemical Structure
  19. GC31084 (-)-(S)-B-973B (-)-(S)-B-973B  Chemical Structure
  20. GC10065 (-)-Bicuculline methiodide GABAA receptor antagonist (-)-Bicuculline methiodide  Chemical Structure
  21. GC16857 (-)-Bicuculline methobromide (-)-Bicuculline methobromide  Chemical Structure
  22. GC15636 (-)-Bicuculline methochloride (-)-Bicuculline methochloride  Chemical Structure
  23. GC40842 (-)-Catechin (-)-Catechin  Chemical Structure
  24. GC32957 (-)-Catechin gallate ((-)-Catechin 3-gallate) (-)-Catechin gallate ((-)-Catechin 3-gallate) is a minor constituent in green tea catechins. (-)-Catechin gallate ((-)-Catechin 3-gallate) inhibits the activity of COX-1 and COX-2 enzymes. (-)-Catechin gallate ((-)-Catechin 3-gallate)  Chemical Structure
  25. GC34947 (-)-Corynoxidine (-)-Corynoxidine is an acetylcholinesterase inhibitor with an IC50 value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa. (-)-Corynoxidine  Chemical Structure
  26. GC17470 (-)-Cotinine α3/α6β2 nAChR activator (-)-Cotinine  Chemical Structure
  27. GC18343 (-)-CP 55,940 (-)-CP 55,940 is a potent and non-selective cannabinoid (CB) receptor agonist with Ki values of 0.5 to 5 and 0.69 to 2.8 nM for CB1 and CB2 receptors, respectively. (-)-CP 55,940  Chemical Structure
  28. GC10603 (-)-epicatechin gallate major catechin in green tea (-)-epicatechin gallate  Chemical Structure
  29. GC14400 (-)-Huperzine A AChE inhibitor (-)-Huperzine A  Chemical Structure
  30. GC34949 (-)-Isocorypalmine An isoquinoline alkaloid and metabolite of L-THP with diverse biological activities (-)-Isocorypalmine  Chemical Structure
  31. GC45250 (-)-L-threo-PDMP (hydrochloride) (-)-L-threo-PDMP is an enhancer of ganglioside biosynthesis. (-)-L-threo-PDMP (hydrochloride)  Chemical Structure
  32. GC14157 (-)-Lobeline hydrochloride nicotinic receptor partial agonist (-)-Lobeline hydrochloride  Chemical Structure
  33. GC48551 (-)-Physostigmine (salicylate) An alkaloid and cholinergic agent (-)-Physostigmine (salicylate)  Chemical Structure
  34. GC17877 (-)-Quinpirole hydrochloride dopamine D2 receptor agonist (-)-Quinpirole hydrochloride  Chemical Structure
  35. GC46248 (-)-Ropivacaine-d7 (hydrochloride) An internal standard for the quantification of (–)-ropivacaine (-)-Ropivacaine-d7 (hydrochloride)  Chemical Structure
  36. GC30889 (-)-Securinine An alkaloid (-)-Securinine  Chemical Structure
  37. GC38489 (1α,1'S,4β)-Lanabecestat (1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. (1α,1'S,4β)-Lanabecestat  Chemical Structure
  38. GC16207 (1S,3R)-ACPD group I and II mGlu receptor agonist (1S,3R)-ACPD  Chemical Structure
  39. GC18622 (2'S)-Nicotine-1-oxide (2'S)-Nicotine-1-oxide is a metabolite of nicotine . (2'S)-Nicotine-1-oxide  Chemical Structure
  40. GC11379 (2R,4R)-APDC group II metabotropic glutamate receptor agonist (2R,4R)-APDC  Chemical Structure
  41. GC60000 (2S)-6-Prenylnaringenin (2S)-6-Prenylnaringenin is the most efficient compound in forebrain. (2S)-6-Prenylnaringenin  Chemical Structure
  42. GC32644 (4E)-SUN9221 (4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities. (4E)-SUN9221  Chemical Structure
  43. GC52100 (Arg)9 (trifluoroacetate salt) A cationic cell-penetrating peptide (Arg)9 (trifluoroacetate salt)  Chemical Structure
  44. GC66255 (E)-3,4,5-Trimethoxycinnamic acid (E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy. (E)-3,4,5-Trimethoxycinnamic acid  Chemical Structure
  45. GC49003 (E)-Ajoene A disulfide with diverse biological activities (E)-Ajoene  Chemical Structure
  46. GC40286 (E,Z)-2-propyl-2-Pentenoic Acid (E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity. (E,Z)-2-propyl-2-Pentenoic Acid  Chemical Structure
  47. GC17333 (R)-(+)-8-Hydroxy-DPAT hydrobromide 5-HT1A serotonin receptor agonist (R)-(+)-8-Hydroxy-DPAT hydrobromide  Chemical Structure
  48. GC69834 (R)-(+)-Dimethindene maleate

    (R)-(+)-Dimethindene maleate is an orally active H1-receptor blocker with anti-histamine properties in pigs.

    (R)-(+)-Dimethindene maleate  Chemical Structure
  49. GC41709 (R)-(+)-Docosahexaenyl-1'-Hydroxy-2'-Propylamide N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. (R)-(+)-Docosahexaenyl-1'-Hydroxy-2'-Propylamide  Chemical Structure
  50. GC41711 (R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide N-Acyl ethanolamines have diverse biological actions that are strongly affected by the associated acyl group. (R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide  Chemical Structure
  51. GC11219 (R)-(+)-Tolterodine (R)-(+)-Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. (R)-(+)-Tolterodine  Chemical Structure
  52. GC11809 (R)-(-)-α-Methylhistamine dihydrobromide (R)-(-)-α-Methylhistamine dihydrobromide is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a Kd of 50.3 nM. (R)-(-)-α-Methylhistamine dihydrobromide  Chemical Structure
  53. GC17722 (R)-3,4-DCPG AMPA receptor antagonist with weak activity at NMDA receptors and little activity at kainate receptors (R)-3,4-DCPG  Chemical Structure
  54. GC14124 (R)-3-Carboxy-4-hydroxyphenylglycine NMDA and AMPA/kainate receptor antagonist (R)-3-Carboxy-4-hydroxyphenylglycine  Chemical Structure
  55. GC40594 (R)-AM1241 (R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241  Chemical Structure
  56. GC14111 (R)-baclofen GABA receptor agonist (R)-baclofen  Chemical Structure
  57. GC34986 (R)-Baclofen hydrochloride (R)-Baclofen hydrochloride (Arbaclofen hydrochloride) is a selective GABAB receptor agonist. (R)-Baclofen hydrochloride  Chemical Structure
  58. GC69805 (R)-Casopitant

    (R)-Casopitant ((R)-GW679769) is an isomer of Casopitant. Casopitant is an NK(1) receptor antagonist that can be used in the research of chemotherapy-induced nausea and vomiting.

    (R)-Casopitant  Chemical Structure
  59. GC41715 (R)-Cetirizine (hydrochloride) A selective histamine H1 receptor antagonist (R)-Cetirizine (hydrochloride)  Chemical Structure
  60. GC50258 (R)-Citalopram oxalate Enantiomer of escitalopram oxalate (R)-Citalopram oxalate  Chemical Structure
  61. GC41718 (R)-KT109 (R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109. (R)-KT109  Chemical Structure
  62. GC67937 (R)-Mirtazapine (R)-Mirtazapine  Chemical Structure
  63. GC68383 (R)-Preclamol (R)-Preclamol  Chemical Structure
  64. GC34993 (R)-Rivastigmine D6 tartrate (R)-Rivastigmine D6 tartrate  Chemical Structure
  65. GC18238 (R)-γ-Valerolactone (R)-γ-Valerolactone ((R)-GVL) is an isomer of GVL, a prodrug to γ-hydroxyvaleric acid (GHV). (R)-γ-Valerolactone  Chemical Structure
  66. GC34995 (R,R)-Palonosetron Hydrochloride (R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron. (R,R)-Palonosetron Hydrochloride  Chemical Structure
  67. GC16032 (R,S)-Anatabine Aβ inhibitor (R,S)-Anatabine  Chemical Structure
  68. GC16139 (R,S)-Anatabine (tartrate) Aβ inhibitor (R,S)-Anatabine (tartrate)  Chemical Structure
  69. GC52185 (R,S)-Anatabine-d4 (R,S)-Anatabine-d4  Chemical Structure
  70. GC63632 (Rac)-Lorcaserin (Rac)-Lorcaserin  Chemical Structure
  71. GC63382 (Rac)-Lorcaserin hydrochloride (Rac)-Lorcaserin hydrochloride  Chemical Structure
  72. GC62745 (Rac)-PF-06256142 (Rac)-PF-06256142 is the less effective enantiomer of PF-06256142. (Rac)-PF-06256142  Chemical Structure
  73. GC60004 (rel)-Tranylcypromine D5 hydrochloride Tranylcypromine-d5 (SKF 385-d5) hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride. (rel)-Tranylcypromine D5 hydrochloride  Chemical Structure
  74. GC10349 (RS)-(±)-Sulpiride (RS)-(±)-Sulpiride is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class, used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression. (RS)-(±)-Sulpiride  Chemical Structure
  75. GC16542 (RS)-3,4-DCPG antagonist of AMPA receptors and agonist of mGluR8 (RS)-3,4-DCPG  Chemical Structure
  76. GC15342 (RS)-3,5-DHPG

    DHPG ((RS)-3,5-DHPG) is an amino acid that is a selective potent agonist for group I mGluR (mGluR 1 and mGluR 5) and has no effect on Group II and III mGluR.

    (RS)-3,5-DHPG  Chemical Structure
  77. GC12985 (RS)-3-Hydroxyphenylglycine PI-linked metabotropic glutamate receptors agonist (RS)-3-Hydroxyphenylglycine  Chemical Structure
  78. GC13288 (RS)-4-Carboxy-3-hydroxyphenylglycine broad spectrum EAA agonist/antagonist (RS)-4-Carboxy-3-hydroxyphenylglycine  Chemical Structure
  79. GC13773 (RS)-4-Carboxyphenylglycine broad spectrum EAA ligand (RS)-4-Carboxyphenylglycine  Chemical Structure
  80. GC11771 (RS)-APICA group II metabotropic glutamate receptor antagonist (RS)-APICA  Chemical Structure
  81. GC12279 (RS)-MCPG mGluR antagonist (RS)-MCPG  Chemical Structure
  82. GC11997 (RS)-MCPG disodium salt group I/group II metabotropic glutamate receptor antagonist (RS)-MCPG disodium salt  Chemical Structure
  83. GC11433 (RS)-PPG group III metabotropic glutamate receptor agonist (RS)-PPG  Chemical Structure
  84. GC10704 (S)-(+)-α-Methylhistamine dihydrobromide H3 histamine receptor agonist (S)-(+)-α-Methylhistamine dihydrobromide  Chemical Structure
  85. GC41727 (S)-(+)-3-Quinuclidinol

    (S)-(+)-Quinuclidinol is a precursor in the synthesis of solifenacin.

    (S)-(+)-3-Quinuclidinol  Chemical Structure
  86. GC14479 (S)-(+)-Dimethindene maleate

    M2 muscarinic receptor antagonist

    (S)-(+)-Dimethindene maleate  Chemical Structure
  87. GC13114 (S)-(+)-Ibuprofen COX inhibitor (S)-(+)-Ibuprofen  Chemical Structure
  88. GC64804 (S)-(+)-Ibuprofen D3 (S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen D3  Chemical Structure
  89. GC11889 (S)-(-)-5-Fluorowillardiine AMPA receptor agonist (S)-(-)-5-Fluorowillardiine  Chemical Structure
  90. GC34998 (S)-(-)-5-Fluorowillardiine hydrochloride (S)-(-)-5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist. (S)-(-)-5-Fluorowillardiine hydrochloride  Chemical Structure
  91. GC64735 (S)-(-)-Levamisole (S)-(-)-Levamisole (Levamisole), an anthelmintic agent with immunomodulatory properties. (S)-(-)-Levamisole  Chemical Structure
  92. GC14639 (S)-3,4-DCPG mGlu8a agonist (S)-3,4-DCPG  Chemical Structure
  93. GC16858 (S)-3,5-DHPG group I mGlu receptor agonist (S)-3,5-DHPG  Chemical Structure
  94. GC11536 (S)-3-Carboxy-4-hydroxyphenylglycine group I metabotropic glutamate receptor antagonist and group II mGlu agonist (S)-3-Carboxy-4-hydroxyphenylglycine  Chemical Structure
  95. GC16234 (S)-3-Hydroxyphenylglycine group I metabotropic glutamate receptors agonist (S)-3-Hydroxyphenylglycine  Chemical Structure
  96. GC45964 (S)-3-N-Cbz-amino-succinimide An anticonvulsant (S)-3-N-Cbz-amino-succinimide  Chemical Structure
  97. GC12012 (S)-4-Carboxy-3-hydroxyphenylglycine group I mGlu1a/1a receptor antagonist and mGluR2 agonist (S)-4-Carboxy-3-hydroxyphenylglycine  Chemical Structure
  98. GC14176 (S)-4-Carboxyphenylglycine group I metabotropic glutamate receptor antagonist (S)-4-Carboxyphenylglycine  Chemical Structure
  99. GC40595 (S)-AM1241 (S)-AM1241 binds to cannabinoid (CB) receptors and is selective for the CB2 over the CB1 receptor (Kis = 658 and >10,000 nM, respectively, in a membrane assay using human receptors). (S)-AM1241  Chemical Structure
  100. GC63655 (S)-Amisulpride (S)-Amisulpride (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride  Chemical Structure
  101. GC46352 (S)-DO271 An inactive control for DO264 (S)-DO271  Chemical Structure

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