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Neuroscience

Neuroscience

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

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Products for  Neuroscience

  1. Cat.No. Product Name Information
  2. GC18022 (S)-Flurbiprofen inhibitors of COX-1 and COX-2 (S)-Flurbiprofen  Chemical Structure
  3. GC10739 (S)-HexylHIBO Group I mGlu receptor antagonist (S)-HexylHIBO  Chemical Structure
  4. GC15977 (S)-Ketoprofen COX-1 and COX-2 inhibitor (S)-Ketoprofen  Chemical Structure
  5. GC41389 (S)-Ketorolac (S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC50s = 0.1 and 2.7 μM for COX-1 and COX-2, respectively). (S)-Ketorolac  Chemical Structure
  6. GC41738 (S)-KT109 (S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109. (S)-KT109  Chemical Structure
  7. GC40145 (S)-Laudanosine (S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium. (S)-Laudanosine  Chemical Structure
  8. GC16349 (S)-MCPG mGluR antagonist (S)-MCPG  Chemical Structure
  9. GC67989 (S)-Mirtazapine (S)-Mirtazapine  Chemical Structure
  10. GC68410 (S)-Mirtazapine-d3 (S)-Mirtazapine-d3  Chemical Structure
  11. GC14820 (S)-Naproxen (S)-Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. (S)-Naproxen  Chemical Structure
  12. GC49179 (S)-O-Desmethyl Naproxen A metabolite of (S)-naproxen (S)-O-Desmethyl Naproxen  Chemical Structure
  13. GC46355 (S)-Pramipexole-d5 (hydrochloride) An internal standard for the quantification of (S)-pramipexole (S)-Pramipexole-d5 (hydrochloride)  Chemical Structure
  14. GC33686 (S)-Rasagiline (TVP1022) (S)-Rasagiline (TVP1022) (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. (S)-Rasagiline (TVP1022)  Chemical Structure
  15. GC35006 (S)-Rasagiline mesylate (S)-Rasagiline (TVP1022) mesylate is the relatively inactive S-enantiomer form of Rasagiline mesylate. (S)-Rasagiline mesylate  Chemical Structure
  16. GC69941 (S)-Renzapride

    (S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. It also acts as an antagonist for the 5HT2b and 5HT3 receptors. Renzapride can be used in research on constipation-predominant irritable bowel syndrome (C-IBS).

    (S)-Renzapride  Chemical Structure
  17. GC15464 (S)-SNAP 5114 GABA uptake inhibitor (S)-SNAP 5114  Chemical Structure
  18. GC60424 (S)-Venlafaxine (S)-Venlafaxine is the (S)-configuration of Venlafaxine. Venlafaxine is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant agent. (S)-Venlafaxine  Chemical Structure
  19. GC69979 (S)-VQW-765

    (S)-VQW-765 ((S)-AQW-051) is a partial agonist of the α7 nicotinic acetylcholine receptor (nAChR) with oral activity, selectivity and efficacy. It has potential applications in cognitive impairments associated with neurological diseases such as Alzheimer's disease or schizophrenia.

    (S)-VQW-765  Chemical Structure
  20. GC14805 (S)-WAY 100135 dihydrochloride 5-HT1A receptor antagonist,potent and selective (S)-WAY 100135 dihydrochloride  Chemical Structure
  21. GC30212 (S)-Willardiine ((-)-Willardiine) (S)-Willardiine ((-)-Willardiine) is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM. (S)-Willardiine ((-)-Willardiine)  Chemical Structure
  22. GC35011 (Z)-Thiothixene (Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1. (Z)-Thiothixene  Chemical Structure
  23. GC18596 (±)-2-propyl-4-Pentenoic Acid

    (±)-2-propyl-4-Pentenoic acid (4-ene VPA) is a major metabolite of valproic acid .

    (±)-2-propyl-4-Pentenoic Acid  Chemical Structure
  24. GC12774 (±)-Anatoxin A fumarate

    nicotinic agonist

    (±)-Anatoxin A fumarate  Chemical Structure
  25. GC12927 (±)-Baclofen A GABAB agonist (±)-Baclofen  Chemical Structure
  26. GC11965 (±)-Huperzine A A neuroprotective AChE inhibitor (±)-Huperzine A  Chemical Structure
  27. GC13786 (±)-Salsolinol (hydrochloride) depolarize dopamineric neurons (±)-Salsolinol (hydrochloride)  Chemical Structure
  28. GC14252 (–)-Stepholidine A dopamine receptor antagonist and 5-HT1A partial agonist (–)-Stepholidine  Chemical Structure
  29. GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog 1(R)-(Trifluoromethyl)oleyl alcohol  Chemical Structure
  30. GC46366 1,2,3,4-Tetrahydro-β-carboline A serotonin reuptake inhibitor and metabolite of tryptamine 1,2,3,4-Tetrahydro-β-carboline  Chemical Structure
  31. GC45698 1,2,3-Triheptanoyl-rac-glycerol 1,2,3-Triheptanoyl-rac-glycerol (Propane-1,2,3-triyl triheptanoate) is a synthetic medium-chain triglyceride (MCT) consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. 1,2,3-Triheptanoyl-rac-glycerol  Chemical Structure
  32. GC41774 1,2,3-Trimyristoyl-rac-glycerol 1,2,3-Trimyristoyl-rac-glycerol, an active molluscicidal component ofMyristica fragransHoutt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue ofLymnaea acuminata. 1,2,3-Trimyristoyl-rac-glycerol  Chemical Structure
  33. GC46009 1,2,3-Trioctanoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2,3-trioctanoyl glycerol-13C3 1,2,3-Trioctanoyl-rac-glycerol-13C3  Chemical Structure
  34. GC18334 1,2-Dierucoyl-sn-glycero-3-PC 1,2-Dierucoyl-sn-glycero-3-PC (DEPC) is the composition of liposome membrane. 1,2-Dierucoyl-sn-glycero-3-PC  Chemical Structure
  35. GC42050 1-β-D-Glucosylsphingadienine (d18:2 (4E,8E)) 1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides. 1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))  Chemical Structure
  36. GC42051 1-β-D-Glucosylsphingosine (d18:1) 1-β-D-Glucosylsphingosine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucocerebrosides. 1-β-D-Glucosylsphingosine (d18:1)  Chemical Structure
  37. GC12587 1-(1-Naphthyl) piperazine (hydrochloride) ligand for 5-HT receptors 1-(1-Naphthyl) piperazine (hydrochloride)  Chemical Structure
  38. GC41751 1-(3,5-Dimethylphenyl)piperazine 1-(3,5-Dimethylphenyl)piperazine is a piperidine compound that is inactive at dopamine and serotonin receptors. 1-(3,5-Dimethylphenyl)piperazine  Chemical Structure
  39. GC49346 1-(3-Chlorophenyl)biguanide (hydrochloride) A 5-HT3 receptor agonist 1-(3-Chlorophenyl)biguanide (hydrochloride)  Chemical Structure
  40. GC16031 1-(3-Chlorophenyl)piperazine (hydrochloride)

    5-HT2C/2B receptor agonist/partial agonist

    1-(3-Chlorophenyl)piperazine (hydrochloride)  Chemical Structure
  41. GC49294 1-(4-Chlorobenzhydryl)piperazine An inactive metabolite of meclizine and chlorcyclizine 1-(4-Chlorobenzhydryl)piperazine  Chemical Structure
  42. GC41761 1-(6-Methoxy-2-naphthyl)ethanol 1-(6-Methoxy-2-naphthyl)ethanol is a potential impurity in commercial preparations of naproxen. 1-(6-Methoxy-2-naphthyl)ethanol  Chemical Structure
  43. GC18009 1-Acetyl-4-methylpiperazine hydrochloride nAChR agonist 1-Acetyl-4-methylpiperazine hydrochloride  Chemical Structure
  44. GC12863 1-BCP potentiator of AMPA-mediated responses 1-BCP  Chemical Structure
  45. GC49861 1-Carboxycyclohexaneacetic Acid A potential impurity in commercial preparations of gabapentin 1-Carboxycyclohexaneacetic Acid  Chemical Structure
  46. GC46050 1-Deoxysphingosine (m18:1(4E)) An atypical sphingolipid 1-Deoxysphingosine (m18:1(4E))  Chemical Structure
  47. GC60447 1-Hydroxy-ibuprofen 1-Hydroxy Ibuprofen is a metabolite of Ibuprofen in P. 1-Hydroxy-ibuprofen  Chemical Structure
  48. GC14607 1-Methylpsilocin 5-HT2C agonist,potent and selective 1-Methylpsilocin  Chemical Structure
  49. GC38698 1-Naphthyl acetate 1-Naphthyl acetate is an attractive chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity. 1-Naphthyl acetate  Chemical Structure
  50. GC49818 1-Octen-3-ol 1-Octen-3-ol, a fatty acid fragrant, is a self-stimulating oxylipin messenger. 1-Octen-3-ol  Chemical Structure
  51. GC40910 1-Oleoyl-2-hydroxy-sn-glycero-3-PE 1-Oleoyl-2-hydroxy-sn-glycero-3-PE is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine. 1-Oleoyl-2-hydroxy-sn-glycero-3-PE  Chemical Structure
  52. GC45979 1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol A triacylglycerol 1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol  Chemical Structure
  53. GC16876 1-Phenylbiguanide hydrochloride 5-HT3 receptor agonist 1-Phenylbiguanide hydrochloride  Chemical Structure
  54. GC49366 1-Salicylate Glucuronide A metabolite of salicylic acid and aspirin 1-Salicylate Glucuronide  Chemical Structure
  55. GC49088 1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE A phospholipid 1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE  Chemical Structure
  56. GC42045 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC is a phospholipid containing stearic acid and docosahexaenoic acid at the sn-1 and sn-2 positions, respectively. 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC  Chemical Structure
  57. GC40176 1-Stearoyl-rac-glycerol 1-Stearoyl-rac-glycerol is a monoacylglycerol that contains stearic acid at the sn-1 position. 1-Stearoyl-rac-glycerol  Chemical Structure
  58. GC49820 10,11-dihydro-10,11-dihydroxy Carbamazepine A metabolite of carbamazepine and oxcarbazepine 10,11-dihydro-10,11-dihydroxy Carbamazepine  Chemical Structure
  59. GC13863 10Panx A peptide inhibitor of PANX1 10Panx  Chemical Structure
  60. GC46412 11β-Prostaglandin F2α-d4 An internal standard for the quantification of 11β-PGF F 11β-Prostaglandin F2α-d4  Chemical Structure
  61. GC18798 11-cis Retinal

    11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin.

    11-cis Retinal  Chemical Structure
  62. GC48821 11-cis Retinol An isomer of vitamin A 11-cis Retinol  Chemical Structure
  63. GC18637 11β-Prostaglandin F2α

    11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.

    11β-Prostaglandin F2α  Chemical Structure
  64. GC49808 12-methyl Tridecanoic Acid A methylated fatty acid 12-methyl Tridecanoic Acid  Chemical Structure
  65. GC18783 13,14-dihydro-15-keto Prostaglandin E1 13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity. 13,14-dihydro-15-keto Prostaglandin E1  Chemical Structure
  66. GC41910 13-Docosenamide 13-Docosenamide is the amide of docosenoic acid. 13-Docosenamide  Chemical Structure
  67. GC41907 13C C16 Sphingomyelin (d18:1/16:0) 13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. 13C C16 Sphingomyelin (d18:1/16:0)  Chemical Structure
  68. GC41908 13C6 Glucosylsphingosine (d18:1) 13C6 Glucosylsphingosine (d18:1) is an isotopically enriched form of 1-β-D-glucosylsphingosine (d18:1) that is intended for use as an internal standard for the quantification of 1-β-D-glucosylsphingosine by GC- or LC-MS. 13C6 Glucosylsphingosine (d18:1)  Chemical Structure
  69. GC46437 14-dehydro Zymostenol A cholesterol precursor 14-dehydro Zymostenol  Chemical Structure
  70. GC40988 15(R)-17-phenyl trinor Prostaglandin F2α 17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide. 15(R)-17-phenyl trinor Prostaglandin F2α  Chemical Structure
  71. GC41922 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester  Chemical Structure
  72. GC41093 15(S)-Latanoprost 15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. 15(S)-Latanoprost  Chemical Structure
  73. GC49036 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α A nitric oxide-donating derivative of 17-phenyl trinor prostaglandin F 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α  Chemical Structure
  74. GC41934 15-keto Latanoprost Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. 15-keto Latanoprost  Chemical Structure
  75. GC40989 15-keto Latanoprost (free acid) 15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost (free acid)  Chemical Structure
  76. GC41936 15-keto-17-phenyl trinor Prostaglandin F2α Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. 15-keto-17-phenyl trinor Prostaglandin F2α  Chemical Structure
  77. GC41937 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug. 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide  Chemical Structure
  78. GC41947 16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide The actions of many clinical F-series prostaglandins (PGs), including those used for estrous synchronization and for reduction of intraocular pressure (IOP), are mediated through the PGF2α (FP) receptor. 16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide  Chemical Structure
  79. GC41948 16-phenoxy tetranor Prostaglandin F2α isopropyl ester Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. 16-phenoxy tetranor Prostaglandin F2α isopropyl ester  Chemical Structure
  80. GC40961 16-phenoxy tetranor Prostaglandin F2α methyl ester Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. 16-phenoxy tetranor Prostaglandin F2α methyl ester  Chemical Structure
  81. GC46451 16F16 A PDI inhibitor 16F16  Chemical Structure
  82. GC41207 17(R)-HDHA Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals. 17(R)-HDHA  Chemical Structure
  83. GC41208 17(S)-HDHA 17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain. 17(S)-HDHA  Chemical Structure
  84. GC17223 17-PA GABAA receptor antagonist 17-PA  Chemical Structure
  85. GC41960 17-phenoxy trinor Prostaglandin F2α ethyl amide Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-phenoxy trinor Prostaglandin F2α ethyl amide  Chemical Structure
  86. GC40990 17-phenyl trinor Prostaglandin F2α 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor. 17-phenyl trinor Prostaglandin F2α  Chemical Structure
  87. GC41967 17-phenyl trinor Prostaglandin F2α amide 17-phenyl trinor Prostaglandin F2α amide is a N-desethyl metabolite of Bimatoprost. 17-phenyl trinor Prostaglandin F2α amide  Chemical Structure
  88. GC41969 17-phenyl trinor Prostaglandin F2α cyclopropyl amide 17-phenyl trinor Prostaglandin F2α cyclopropyl amide (17-phenyl trinor PGF2α cyclopropyl amide) is a novel analog of 17-phenyl trinor PGF2α ethyl amide. 17-phenyl trinor Prostaglandin F2α cyclopropyl amide  Chemical Structure
  89. GC41970 17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide  Chemical Structure
  90. GC41971 17-phenyl trinor Prostaglandin F2α diethyl amide 17-phenyl trinor Prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl amide. 17-phenyl trinor Prostaglandin F2α diethyl amide  Chemical Structure
  91. GC46458 17-phenyl trinor Prostaglandin F2α dimethyl amide An isomer of 17-phenyl trinor prostaglandin F ethyl amide 17-phenyl trinor Prostaglandin F2α dimethyl amide  Chemical Structure
  92. GC41972 17-phenyl trinor Prostaglandin F2α isopropyl ester 17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. 17-phenyl trinor Prostaglandin F2α isopropyl ester  Chemical Structure
  93. GC41973 17-phenyl trinor Prostaglandin F2α methyl amide 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2α. 17-phenyl trinor Prostaglandin F2α methyl amide  Chemical Structure
  94. GC40392 17-phenyl trinor Prostaglandin F2α methyl ester 17-phenyl trinor Prostaglandin F2α methyl ester is a prodrug of Bimatoprost. 17-phenyl trinor Prostaglandin F2α methyl ester  Chemical Structure
  95. GC46463 17-phenyl trinor Prostaglandin F2α-d4 An internal standard for the quantification of bimatoprost (free acid) 17-phenyl trinor Prostaglandin F2α-d4  Chemical Structure
  96. GC41975 17-trifluoromethylphenyl trinor Prostaglandin F2α A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. 17-trifluoromethylphenyl trinor Prostaglandin F2α  Chemical Structure
  97. GC41976 17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide  Chemical Structure
  98. GC41978 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester  Chemical Structure
  99. GC46466 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α A prostaglandin F derivative similar to latanoprost free acid 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α  Chemical Structure
  100. GC49823 2′-C-β-Methylguanosine An active nucleoside metabolite of BMS-986094 2′-C-β-Methylguanosine  Chemical Structure
  101. GC60017 2'-O-Methylisoliquiritigenin 2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a very significant effect on ne NE pathway. 2'-O-Methylisoliquiritigenin  Chemical Structure

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