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Home >> Signaling Pathways >> Neuroscience >> 5-HT Receptor

5-HT Receptor

5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.

Products for  5-HT Receptor

  1. Cat.No. Product Name Information
  2. GC64563 α-Methylserotonin α-Methylserotonin Chemical Structure
  3. GC11577 α-Methyl-5-hydroxytryptamine maleate 5-HT2B receptor agonist α-Methyl-5-hydroxytryptamine maleate Chemical Structure
  4. GC16735 (±)-McN 5652

    5-HT uptake inhibitor

     (±)-McN 5652 Chemical Structure
  5. GC68210 (+)-Norfenfluramine (+)-Norfenfluramine Chemical Structure
  6. GC32644 (4E)-SUN9221 (4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities. (4E)-SUN9221 Chemical Structure
  7. GC17333 (R)-(+)-8-Hydroxy-DPAT hydrobromide 5-HT1A serotonin receptor agonist (R)-(+)-8-Hydroxy-DPAT hydrobromide Chemical Structure
  8. GC50258 (R)-Citalopram oxalate Enantiomer of escitalopram oxalate (R)-Citalopram oxalate Chemical Structure
  9. GC67937 (R)-Mirtazapine (R)-Mirtazapine Chemical Structure
  10. GC34995 (R,R)-Palonosetron Hydrochloride (R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron. (R,R)-Palonosetron Hydrochloride Chemical Structure
  11. GC63632 (Rac)-Lorcaserin (Rac)-Lorcaserin Chemical Structure
  12. GC63382 (Rac)-Lorcaserin hydrochloride (Rac)-Lorcaserin hydrochloride Chemical Structure
  13. GC67989 (S)-Mirtazapine (S)-Mirtazapine Chemical Structure
  14. GC68410 (S)-Mirtazapine-d3 (S)-Mirtazapine-d3 Chemical Structure
  15. GC69941 (S)-Renzapride

    (S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. It also acts as an antagonist for the 5HT2b and 5HT3 receptors. Renzapride can be used in research on constipation-predominant irritable bowel syndrome (C-IBS).

     (S)-Renzapride Chemical Structure
  16. GC14805 (S)-WAY 100135 dihydrochloride 5-HT1A receptor antagonist,potent and selective (S)-WAY 100135 dihydrochloride Chemical Structure
  17. GC35011 (Z)-Thiothixene (Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1. (Z)-Thiothixene Chemical Structure
  18. GC12587 1-(1-Naphthyl) piperazine (hydrochloride) ligand for 5-HT receptors 1-(1-Naphthyl) piperazine (hydrochloride) Chemical Structure
  19. GC16031 1-(3-Chlorophenyl)piperazine (hydrochloride)

    5-HT2C/2B receptor agonist/partial agonist

     1-(3-Chlorophenyl)piperazine (hydrochloride) Chemical Structure
  20. GC14607 1-Methylpsilocin 5-HT2C agonist,potent and selective 1-Methylpsilocin Chemical Structure
  21. GC16876 1-Phenylbiguanide hydrochloride 5-HT3 receptor agonist 1-Phenylbiguanide hydrochloride Chemical Structure
  22. GC60017 2'-O-Methylisoliquiritigenin 2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a very significant effect on ne NE pathway. 2'-O-Methylisoliquiritigenin Chemical Structure
  23. GC38108 2-Methyl-5-HT 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT Chemical Structure
  24. GC11176 2-Methyl-5-hydroxytryptamine hydrochloride 2-Methyl-5-hydroxytryptamine hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-hydroxytryptamine hydrochloride Chemical Structure
  25. GC14959 2-[1-(4-Piperonyl)piperazinyl]benzothiazole 5-HT4 receptor 2-[1-(4-Piperonyl)piperazinyl]benzothiazole Chemical Structure
  26. GC14343 3,4-dihydro Naratriptan selective serotonin 5-HT1B agonist 3,4-dihydro Naratriptan Chemical Structure
  27. GC15569 3-AQC 5-HT3 antagonist 3-AQC Chemical Structure
  28. GC60499 3-Hydroxy agomelatine 3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine Chemical Structure
  29. GC68328 3-Hydroxy agomelatine-d3 3-Hydroxy agomelatine-d3 Chemical Structure
  30. GC62799 4,4-Diphenylbutylamine hydrochloride 4,4-Diphenylbutylamine shows affinity for the 5-HT2A and H1 receptors with Kis of 2589 and 1670 nM, respectively. 4,4-Diphenylbutylamine hydrochloride Chemical Structure
  31. GC16040 4F 4PP oxalate 5-HT2A antagonist 4F 4PP oxalate Chemical Structure
  32. GC14814 5-Carboxamidotryptamine maleate 5-HT1 agonist 5-Carboxamidotryptamine maleate Chemical Structure
  33. GC31234 5-HT1A modulator 1 5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively. 5-HT1A modulator 1 Chemical Structure
  34. GC60028 5-HT1A modulator 2 hydrochloride 5-HT1A modulator 2 hydrochloride, a derivative of 8-OH-DPAT, is a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding. 5-HT1A modulator 2 hydrochloride Chemical Structure
  35. GC32655 5-HT2 antagonist 1 5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity. 5-HT2 antagonist 1 Chemical Structure
  36. GC32664 5-HT2A antagonist 1 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. 5-HT2A antagonist 1 Chemical Structure
  37. GC65568 5-HT2B antagonist-1 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 Chemical Structure
  38. GC31263 5-HT3 antagonist 1 5-HT3 antagonist 1 is a potent and selective antagonist of serotonin 3 (5-HT3) receptor. 5-HT3 antagonist 1 Chemical Structure
  39. GC31247 5-HT3 antagonist 2 5-HT3 antagonist 2 is a 5-HT3 receptor antagonist. 5-HT3 antagonist 2 Chemical Structure
  40. GC65983 5-HT3 antagonist 5 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice. 5-HT3 antagonist 5 Chemical Structure
  41. GC31227 5-HT3-In-1 5-HT3-In-1 is extracted from patent EP0748807A1, compound example 8. 5-HT3-In-1 Chemical Structure
  42. GC30314 5-HT4 antagonist 1 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. 5-HT4 antagonist 1 Chemical Structure
  43. GC31144 5-HT7 agonist 1 5-HT7 agonist 1 is a selective 5-HT7 receptor agonist, with an IC50 of 222.93 nM, can be used for the 5-HT7 receptor related disease, such as CNS disorders. 5-HT7 agonist 1 Chemical Structure
  44. GC14940 5-Methoxytryptamine 5-Methoxytryptamine Chemical Structure
  45. GC64182 5-Methoxytryptamine hydrochloride 5-Methoxytryptamine hydrochloride Chemical Structure
  46. GC17477 5-Nonyloxytryptamine oxalate 5-HT1B agonist 5-Nonyloxytryptamine oxalate Chemical Structure
  47. GC31296 5HT6-ligand-1 5HT6-ligand-1 is a potent 5-HT6 receptor ligand with a Ki of 1.43 nM. 5HT6-ligand-1 Chemical Structure
  48. GC14000 6-fluoro-DL-Tryptophan 6-fluoro-DL-Tryptophan is a potent, competitive inhibitor of tryptophan hydroxylase. 6-fluoro-DL-Tryptophan Chemical Structure
  49. GC14966 8-Hydroxy-DPAT hydrobromide 5-HT1A agonist 8-Hydroxy-DPAT hydrobromide Chemical Structure
  50. GC12427 8-Hydroxy-PIPAT oxalate 5-HT1A receptor agonist 8-Hydroxy-PIPAT oxalate Chemical Structure
  51. GC30888 8-OH-DPAT (8-Hydroxy-DPAT) 8-OH-DPAT (8-Hydroxy-DPAT) is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT (8-Hydroxy-DPAT) weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5). 8-OH-DPAT (8-Hydroxy-DPAT) Chemical Structure
  52. GC31055 Abaperidone Abaperidone is a potent antagonist of 5-HT2A?receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM. Abaperidone Chemical Structure
  53. GC35252 Adoprazine Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine Chemical Structure
  54. GC17981 Agomelatine MT1/MT2 / 5-HT2C agonist Agomelatine Chemical Structure
  55. GC35269 Agomelatine hydrochloride Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine hydrochloride Chemical Structure
  56. GC35270 Agomelatine L(+)-Tartaric acid Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine L(+)-Tartaric acid Chemical Structure
  57. GC11556 AL 34662 potent 5-HT2 receptor agonist AL 34662 Chemical Structure
  58. GC15153 Almotriptan Malate 5-HT1B/1D-receptor agonist Almotriptan Malate Chemical Structure
  59. GC31054 Alniditan (Alnitidan) Alniditan (Alnitidan) (Alnitidan) is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan (Alnitidan) Chemical Structure
  60. GC62417 Alniditan dihydrochloride Alniditan (Alnitidan) dihydrochloride is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK?293 cells, respectively. Alniditan dihydrochloride Chemical Structure
  61. GC13654 Alosetron A 5-HT3 receptor antagonist Alosetron Chemical Structure
  62. GC35301 Alosetron ((Z)-2-butenedioate) Alosetron (GR 68755) (Z)-2-butenedioate is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron ((Z)-2-butenedioate) Chemical Structure
  63. GC35302 Alosetron (Hydrochloride(1:X)) Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron (Hydrochloride(1:X)) Chemical Structure
  64. GC35303 Alosetron D3 Hydrochloride Alosetron D3 Hydrochloride (GR-68755C D3) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist. Alosetron D3 Hydrochloride Chemical Structure
  65. GC11166 Alosetron Hydrochloride A 5-HT3 receptor antagonist Alosetron Hydrochloride Chemical Structure
  66. GC64265 Alosetron-13C,d3 Alosetron-13C,d3 Chemical Structure
  67. GC32905 Alprenolol ((RS)-Alprenolol) Alprenolol ((RS)-Alprenolol) ((RS)-Alprenolol ((RS)-Alprenolol); dl-Alprenolol ((RS)-Alprenolol)) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol ((RS)-Alprenolol) is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent. Alprenolol ((RS)-Alprenolol) Chemical Structure
  68. GC14105 Alprenolol hydrochloride β-adrenoceptor and 5-HT1A receptor antagonist. Alprenolol hydrochloride Chemical Structure
  69. GC14030 Altanserin hydrochloride 5-HT2A receptor antagonist Altanserin hydrochloride Chemical Structure
  70. GC10891 Alverine Citrate Drug used for functional gastrointestinal disorders Alverine Citrate Chemical Structure
  71. GC13723 Amitriptyline HCl Amitriptyline HCl is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline HCl Chemical Structure
  72. GC14008 Anpirtoline hydrochloride 5-HT1B receptor agonist Anpirtoline hydrochloride Chemical Structure
  73. GC31207 Ansofaxine hydrochloride (LY03005) Ansofaxine hydrochloride (LY03005) (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively. Ansofaxine hydrochloride (LY03005) Chemical Structure
  74. GC31134 AP521 AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM. AP521 Chemical Structure
  75. GC31291 AR-A 2 (AR-A 000002) AR-A 2 (AR-A 000002) is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 (AR-A 000002) can be used in the research of depression and anxiety. AR-A 2 (AR-A 000002) Chemical Structure
  76. GC10117 Aripiprazole 5-HT receptor partial agonist Aripiprazole Chemical Structure
  77. GC35386 Aripiprazole D8 Aripiprazole D8 Chemical Structure
  78. GC68687 Aripiprazole-d8

    Aripiprazole-d8 is the deuterated form of Aripiprazole.

     Aripiprazole-d8 Chemical Structure
  79. GC17525 AS 19 Potent 5-HT7 agonist AS 19 Chemical Structure
  80. GC11824 Asenapine Inhibits adrenergic receptor/5-HT receptor Asenapine Chemical Structure
  81. GC14518 Asenapine hydrochloride Asenapine hydrochloride Chemical Structure
  82. GC63819 Asenapine maleate Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic. Asenapine maleate Chemical Structure
  83. GC16807 AT 1015 Long-acting 5-HT2A antagonist AT 1015 Chemical Structure
  84. GC30907 AVN-492 AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM). AVN-492 Chemical Structure
  85. GC15687 Azasetron HCl Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron HCl Chemical Structure
  86. GC14491 B-HT 920 A potent agonist of D2 receptors B-HT 920 Chemical Structure
  87. GC31113 Befiradol (NLX-112) Befiradol (NLX-112) (NLX-112) is a selective 5-HT1A receptor agonist. Befiradol (NLX-112) Chemical Structure
  88. GC60630 Befiradol hydrochloride Befiradol hydrochloride (NLX-112 hydrochloride) is a selective 5-HT1A receptor agonist. Befiradol hydrochloride Chemical Structure
  89. GC34304 Befiradol hydrochloride (NLX-112 (hydrochloride)) Befiradol hydrochloride (NLX-112 (hydrochloride)) Chemical Structure
  90. GC15092 BGC 20-761 5-HT6 antagonist,selective and high affinity BGC 20-761 Chemical Structure
  91. GC12541 Bilobalide A neuroprotective natural product Bilobalide Chemical Structure
  92. GC14925 BIMU 8 5-HT4 agonist BIMU 8 Chemical Structure
  93. GC14160 Blonanserin Atypical antipsychotic Blonanserin Chemical Structure
  94. GC10848 BMY 7378 5-HT1A partial agonist and α1D adrenoceptor antagonist BMY 7378 Chemical Structure
  95. GC15311 BP 554 maleate Selective 5-HT1A agonist BP 554 maleate Chemical Structure
  96. GC11186 Brexpiprazole 5-HT2A, α1B-, and α2C-adrenergic receptors antagonist Brexpiprazole Chemical Structure
  97. GC60662 Brexpiprazole S-oxide

    Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4).

     Brexpiprazole S-oxide Chemical Structure
  98. GC16226 BRL-15572 dihydrochloride BRL-15572 is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 dihydrochloride Chemical Structure
  99. GC17130 BRL-54443 5-HT1E/1F receptor agonist,potent and selective BRL-54443 Chemical Structure
  100. GC30989 Bromperidol (R-11333) Bromperidol (R-11333) (R-11333) possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol (R-11333) Chemical Structure
  101. GC11384 BTS 54-505 hydrochloride Potent SNRI,sibutramine metabolite BTS 54-505 hydrochloride Chemical Structure

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