AChE
AChE, also know as acetylcholinesterase, is a hydrolase that hydrolyzes the neurotransmitter acetylcholine.
Products for AChE
- Cat.No. Product Name Information
- GN10155 (+)- Corydaline
- GN10654 (+)-Corynoline
- GC34947 (-)-Corynoxidine (-)-Corynoxidine is an acetylcholinesterase inhibitor with an IC50 value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa.
- GC14400 (-)-Huperzine A AChE inhibitor
- GC48551 (-)-Physostigmine (salicylate) An alkaloid and cholinergic agent
- GC34993 (R)-Rivastigmine D6 tartrate
- GC11965 (±)-Huperzine A A neuroprotective AChE inhibitor
- GC41774 1,2,3-Trimyristoyl-rac-glycerol 1,2,3-Trimyristoyl-rac-glycerol, an active molluscicidal component ofMyristica fragransHoutt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue ofLymnaea acuminata.
- GC38698 1-Naphthyl acetate 1-Naphthyl acetate is an attractive chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity.
- GC11606 4-Methylbenzylidene camphor ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities.
- GC15203 Acephate Anticholinesterase insecticide
- GC35236 Acetylshikonin Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity.
- GC62827 Acotiamide D6
- GC38732 Acotiamide monohydrochloride trihydrate Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC50 of 1.79 μM.
- GC35272 Ajmalicine A terpenoid indole alkaloid
- GC35279 Aldicarb sulfone Aldicarb sulfone(Temik sulfone) is a carbamate insecticide; is a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse.
- GC16974 Ambenonium dichloride Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity.
- GC15438 Asoxime (chloride) Asoxime (chloride) (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR.
- GC31193 Benactyzine hydrochloride Benactyzine hydrochloride is a butyrylcholinesterase (BChE) inhibitor with a Ki of 0.010 mM.
- GC15628 bis(7)-Tacrine bis(7)-Tacrine is a dimeric AChE inhibitor derived from tacrine.
- GC35564 BuChE-IN-TM-10 BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM.
-
GC60108
Chlorpyrifos
Chlorpyrifos, as a broad-spectrum organophosphorothioate insecticide, has a principal mechanism of toxicity by inactivation of acetylcholinesterase at nerve junctions.
- GC39836 Coumaran Coumaran (2,3-Dihydrobenzofuran) is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L.
- GC43336 Cyanidin 3-O-β-D-Galactopyranoside (chloride) Cyanidin 3-O-β-D-Galactopyranoside (chloride) (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g.
- GC38625 Dehydronuciferine Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL.
- GC31190 Demecarium Bromide (BC-48) Demecarium Bromide (BC-48) (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM.
- GC60774 Dihydro Donepezil Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil.
- GC63620 Dihydrowithaferin A Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE).
- GC30810 Donepezil (E2020) Donepezil (E2020) (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively.
- GC14490 Donepezil HCl Donepezil HCl (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity.
- GC63334 Donepezil-d7 hydrochloride
- GC30908 Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) is a potent competitive inhibitor of BChE, and the ki values of Drofenine is calculated to be 3 uM.
- GC17705 Edrophonium (chloride) acetylcholinesterase (AChE) inhibitor
- GN10716 Epiberberine
- GC35996 Epiberberine chloride Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively.
- GC60164 Fenitrothion Fenitrothion, one of the most widely used organophosphorus pesticides, is a cholinesterase inhibiting insecticide/acaricid.
- GC16573 Galanthamine An alkaloid with AChE inhibitory and nAChR potentiating activities
- GC36103 Galanthamine hydrobromide
- GC36104 Galanthaminone Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
-
GC13474
Garcinol
Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity
- GC15832 GSK 264220A endothelial lipase and lipoprotein lipase inhibitor
- GC64193 Hemicholinium 3 Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM.
- GC38793 Huperzine B Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor.
- GC60913 Huperzine C Huperzine C is an alkaloid isolated from Huperzia serrate.
- GC15604 Hydroxytacrine (maleate) anticholinesterase activity
- GN10437 Imperatorin
- GC36334 Isoeugenol acetate Isoeugenol acetate (Acetyl isoeugenol), an essential oil constituent of nutmeg, clove, and cinnamon, shows excellent inhibitory effects against some metabolic enzymes such as acetylcholinesterase (AChE) enzymes (IC50=77 nM; Ki=16 nM), α-glycosidase (IC50=19.25 nM; Ki=21 nM), and α-amylase (IC50=411.5 nM).
- GN10352 Isoimperatorin
- GC36336 Isomerazin Isomerazin is a coumarin isolated from Poncirus trifoliate Raf.
- GC36340 Isorosmanol Isorosmanol is an abietane-type diterpene isolated from the leaves of sage, with antioxidant, neuroprotective and neurotrophic effects.
- GC15895 Itopride hydrochloride AChE inhibitor
- GC38433 Jatrorrhizine Jatrorrhizine is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities.
- GC43926 Jatrorrhizine (chloride) Jatrorrhizine is an alkaloid that has been found in the Chinese herb C.
- GC60957 Jatrorrhizine hydroxide Jatrorrhizine?hydroxide is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities.
- GC17304 JW 642 monoacylglycerol lipase (MAGL) inhibitor
-
GC17385
KML 29
KML 29 is reported to display IC50 values of 43, 15, and 5.9 nM toward rat, mouse, and human monoacylglycerol lipase (MAGL), respectively.
- GC39052 Leptomerine Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl.
- GC61017 Lycoramine hydrobromide Lycoramine hydrobromide, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate.
-
GC18891
Malathion
An organophosphate insecticide
- GC32194 Metrifonate (Trichlorfon)
- GC30446 MHP 133 MHP 133 is a drug with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.
- GC36770 N-p-trans-Coumaroyltyramine N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM.
- GC40847 Neoeriocitrin Neoeriocitrin is a flavonoid that has been found in C.
- GC30290 Neostigmine methyl sulfate A reversible acetylcholinesterase inhibitor
- GC61848 O-Desmethyl Galanthamine O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid.
- GC63305 Obidoxime dichloride Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning.
- GC63134 P11149 P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE.
- GC14163 PE 154 human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitor
- GC61453 Penconazole Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew.
- GC13783 Phenserine acetylcholinesterase inhibitor
-
GC17391
Physostigmine hemisulfate
cholinesterase inhibitor
- GC38411 Picfeltarraenin IA
- GC36915 Picfeltarraenin IB Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.
- GC36916 Picfeltarraenin IV Picfeltarraenin IV, a triterpenoid obtained from Picriafel-terrae Lour (P.
- GC60291 Pirimiphos-methyl Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms.
- GC18207 Pitofenone (hydrochloride) Pitofenone is an antispasmodic agent and an inhibitor of acetylcholinesterase (AChE; Kis = 36 and 45 μM for bovine erythrocyte and electric eel enzyme, respectively).
- GN10578 Polygalacic acid
- GC33684 Pralidoxime chloride (2-PAM chloride) Pralidoxime chloride (2-PAM chloride) is a potent reactivator of acetylcholinesterase (AChE).
- GC39656 Pralidoxime iodide Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE).
-
GC11617
Pristimerin
monoacylglycerol lipase (MGL) inhibitor
- GC61206 Profenofos Profenofos is an insecticida used on field crops, vegetables, and fruit crops.
- GC30856 Protriptyline hydrochloride Protriptyline hydrochloride is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD.
- GC39141 Pseudocoptisine acetate Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber.
- GC61566 Pseudocoptisine chloride Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber.
- GC15348 Pyridostigmine Bromide Reversible cholinesterase inhibitor
- GC34288 Pyridostigmine D6 bromide
- GN10145 Rhodionin
- GC37528 Rhodiosin Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM.
- GC10267 Rivastigmine A cholinesterase inhibitor
- GC64285 Rivastigmine carbamate impurity Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine.
- GC12994 Rivastigmine Tartrate AChR inhibitor
- GC31699 Scopoletin (Gelseminic acid) Scopoletin (Gelseminic acid) is an inhibitor of acetylcholinesterase (AChE).
-
GC12123
sn-Glycero-3-phosphocholine
Nootropic phospholipid
- GC33067 Sophoflavescenol Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 ?M, 0.17 ?M, 17.89 ?g/mL, 10.98 ?M, 8.37 ?M and 8.21 ?M, respectively.
- GC12937 STF 083010 IRE1α endonuclease inhibitor
- GC38982 Swertianolin Swertianolin, a xanthone isolated from Gentianella Acuta, inhibits acetylcholinesterase (AChE).
- GC31044 T 82 T 82 is a potent 5-HT3 antagonist and acetylcholinesterase (AChE) inhibitor, used for treatment of Alzheimer's Disease.
-
GC12813
Tacrine hydrochloride
cholinesterase inhibitor
- GC37718 Tacrine hydrochloride hydrate Tacrine hydrochloride hydrate is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.
- GN10616 Timosaponin A3