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Alzheimer

Alzheimer

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress.

Products for  Alzheimer

  1. Cat.No. Product Name Information
  2. GC11965 (±)-Huperzine A A neuroprotective AChE inhibitor (±)-Huperzine A  Chemical Structure
  3. GC46451 16F16 A PDI inhibitor 16F16  Chemical Structure
  4. GC18817 3β-hydroxy-5-Cholestenoic Acid 3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1. 3β-hydroxy-5-Cholestenoic Acid  Chemical Structure
  5. GC40053 5α,6α-epoxy Cholestanol An oxysterol and a metabolite of cholesterol produced by oxidation 5α,6α-epoxy Cholestanol  Chemical Structure
  6. GC52172 5-hydroxy Indole-3-acetic Acid-d6 5-hydroxy Indole-3-acetic Acid-d6  Chemical Structure
  7. GC46720 6,9-Dichloro-1,2,3,4-tetrahydroacridine A synthetic intermediate in the synthesis of AChE inhibitors 6,9-Dichloro-1,2,3,4-tetrahydroacridine  Chemical Structure
  8. GC42584 6-O-desmethyl Donepezil 6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil. 6-O-desmethyl Donepezil  Chemical Structure
  9. GC40587 8,12-iso-iPF2α-VI 8,12-iso-iPF2α-VI is an isoprostane produced by non-enzymatic, free radical-induced peroxidative damage to membrane lipids. 8,12-iso-iPF2α-VI  Chemical Structure
  10. GC45378 Alaproclate (hydrochloride)   Alaproclate (hydrochloride)  Chemical Structure
  11. GC40024 Altenusin

    Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.

    Altenusin  Chemical Structure
  12. GC42796 Amylin (human) (trifluoroacetate salt) Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. Amylin (human) (trifluoroacetate salt)  Chemical Structure
  13. GP10099 amyloid A protein fragment [Homo sapiens] Apolipoproteins related to HDL in plasma amyloid A protein fragment [Homo sapiens]  Chemical Structure
  14. GP10118 Amyloid Beta-Peptide (1-40) (human)

    Amyloid β-Peptide (1-40) (human), (C194H295N53O58S1), a peptide with the sequence H2N-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OH, MW= 4329.8. Amyloid beta (Aβ or Abeta) is a peptide of 36–43 amino acids that is processed from the Amyloid precursor protein.

    Amyloid Beta-Peptide (1-40) (human)  Chemical Structure
  15. GP10049 Amyloid Beta-Peptide (12-28) (human) Amyloid Beta-Peptide (12-28) (human)  Chemical Structure
  16. GP10082 Amyloid Beta-peptide (25-35) (human)

    Amyloid beta-peptide (25-35) (human) is an fragment of Alzheimer's Amyloid beta peptide which has neurotoxic effects.

    Amyloid Beta-peptide (25-35) (human)  Chemical Structure
  17. GP10046 Amyloid Precursor C-Terminal Peptide

    For beta amyloid generation

    Amyloid Precursor C-Terminal Peptide  Chemical Structure
  18. GP10057 Amyloid β-Peptide (10-20) (human) Amyloid β-Peptide (10-20) (human)  Chemical Structure
  19. GP10094 Amyloid β-peptide (10-35), amide Amyloid β-peptide (10-35), amide  Chemical Structure
  20. GP10097 Amyloid β-Protein (1-15) Amyloid β-Protein (1-15)  Chemical Structure
  21. GC46851 Amyloid-β (1-42) Peptide (trifluoroacetate salt) A 42-amino acid protein fragment of amyloid-β Amyloid-β (1-42) Peptide (trifluoroacetate salt)  Chemical Structure
  22. GC42801 Amyloid-β (1-8) Peptide Amyloid-β (1-8) is a wild-type control for the mutation-containing amyloid-β (1-8, A2V) peptide . Amyloid-β (1-8) Peptide  Chemical Structure
  23. GC42802 Amyloid-β (1-8, A2V) Peptide Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor protein (APP) numbering convention (APP A673V). Amyloid-β (1-8, A2V) Peptide  Chemical Structure
  24. GC42803 Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt) Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)  Chemical Structure
  25. GP10083 Beta-Amyloid (1-11) Beta-Amyloid (1-11)  Chemical Structure
  26. GP10101 Beta-Sheet Breaker Peptide iAβ5 Beta-Sheet Breaker Peptide iAβ5  Chemical Structure
  27. GC42937 Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt) Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand. Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)  Chemical Structure
  28. GC46997 C22 Galactosylceramide (d18:1/22:0) A sphingolipid C22 Galactosylceramide (d18:1/22:0)  Chemical Structure
  29. GC43274 Citromycetin Citromycetin is a fungal metabolite originally isolated from P. Citromycetin  Chemical Structure
  30. GP10010 COG 133 COG 133  Chemical Structure
  31. GC43322 CRANAD 28 CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively. CRANAD 28  Chemical Structure
  32. GC49557 Cu-GTSM A copper-containing compound with diverse biological activities Cu-GTSM  Chemical Structure
  33. GC12942 DAPT (GSI-IX)

    Inhibitor of γ-secretase

    DAPT (GSI-IX)  Chemical Structure
  34. GC49913 Davunetide (acetate) A neuroprotective ADNP-derived peptide Davunetide (acetate)  Chemical Structure
  35. GC45765 Deferiprone-d3 An internal standard for the quantification of deferiprone Deferiprone-d3  Chemical Structure
  36. GC47186 Deoxy Donepezil (hydrochloride) A potential impurity found in bulk preparations of donepezil Deoxy Donepezil (hydrochloride)  Chemical Structure
  37. GC43494 DL-threo-PDMP (hydrochloride) DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-threo (1R,2R) and L-threo (1S,2S) PDMP. DL-threo-PDMP (hydrochloride)  Chemical Structure
  38. GC47263 Donecopride (fumarate hydrate) A 5-HT4 receptor partial agonist and AChE inhibitor Donecopride (fumarate hydrate)  Chemical Structure
  39. GC40018 Donepezil N-oxide Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil. Donepezil N-oxide  Chemical Structure
  40. GC47264 Donepezil-d4 (hydrochloride) An internal standard for the quantification of donepezil Donepezil-d4 (hydrochloride)  Chemical Structure
  41. GC43700 FSB FSB is a fluorescent probe that has been used for the detection of amyloid plaques in human postmortem brain from patients with Alzheimer's disease and of curli amyloid fibers in E. FSB  Chemical Structure
  42. GC43708 Fulvic Acid Fulvic acid is a phenolic acid and fungal metabolite originally isolated from Penicillium. Fulvic Acid  Chemical Structure
  43. GC52047 Fustin Fustin  Chemical Structure
  44. GC52078 Galantamine (hydrobromide) An alkaloid with AChE inhibitory and nAChR potentiating activities Galantamine (hydrobromide)  Chemical Structure
  45. GC47389 Galantamine-d3 (hydrobromide) An internal standard for the quantification of galantamine Galantamine-d3 (hydrobromide)  Chemical Structure
  46. GC49273 Glycerophosphorylethanolamine (sodium salt) An active metabolite of phosphatidylethanolamine Glycerophosphorylethanolamine (sodium salt)  Chemical Structure
  47. GC49493 IRL 1620 (trifluoroacetate salt) A peptide ETB receptor agonist IRL 1620 (trifluoroacetate salt)  Chemical Structure
  48. GC52027 Isolariciresinol A lignan with diverse biological activities Isolariciresinol  Chemical Structure
  49. GC49306 Isopimaric Acid A diterpenoid resin acid Isopimaric Acid  Chemical Structure
  50. GC18568 JNJ-40418677 A modulator of γ-secretase JNJ-40418677  Chemical Structure
  51. GC49436 L-3-n-Butylphthalide A phthalide with antiplatelet and neuroprotective activities L-3-n-Butylphthalide  Chemical Structure
  52. GC47563 L-Glutamic Acid (ammonium salt) An excitatory neurotransmitter L-Glutamic Acid (ammonium salt)  Chemical Structure
  53. GC49417 L-Serine-13C3 An internal standard for the quantification of L-serine L-Serine-13C3  Chemical Structure
  54. GC49461 L-Serine-d7 An internal standard for the quantification of L-serine L-Serine-d7  Chemical Structure
  55. GC45917 Leucettine L41 An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3 Leucettine L41  Chemical Structure
  56. GC19221 Leucomethylene blue Mesylate Leucomethylene blue (Mesylate) is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes. Leucomethylene blue Mesylate  Chemical Structure
  57. GC40078 Memantine-d6 (hydrochloride) Memantine-d6 is intended for use as an internal standard for the quantification of memantine by GC- or LC-MS. Memantine-d6 (hydrochloride)  Chemical Structure
  58. GC44225 ML-345

    Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling.

    ML-345  Chemical Structure
  59. GP10006 Myelin Basic Protein (68-82), guinea pig Myelin Basic Protein (68-82), guinea pig  Chemical Structure
  60. GP10130 Myelin Basic Protein (87-99)

    An encephalitogenic peptide

    Myelin Basic Protein (87-99)  Chemical Structure
  61. GC44416 N-methyl Mesoporphyrin IX A ferrochelatase inhibitor and turn-on biosensor for DNA N-methyl Mesoporphyrin IX  Chemical Structure
  62. GC47746 NAP 226-90 A metabolite of rivastigmine NAP 226-90  Chemical Structure
  63. GC44399 NIAD-4 NIAD-4 is a fluorescent probe that crosses the blood-brain barrier to bind with high affinity to amyloid-β (Aβ) plaques (Ki = 10 nM). NIAD-4  Chemical Structure
  64. GC52214 Nicotinamide riboside-d4 (triflate)

    An internal standard for the quantification of nicotinamide riboside

    Nicotinamide riboside-d4 (triflate)  Chemical Structure
  65. GC49090 Nilvadipine-d4 An internal standard for the quantification of nilvadipine Nilvadipine-d4  Chemical Structure
  66. GC49815 Oleuropein aglycone A polyphenol with diverse biological activities Oleuropein aglycone  Chemical Structure
  67. GC49024 Palmitic Acid MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Palmitic Acid MaxSpec® Standard  Chemical Structure
  68. GC49023 Palmitic Acid-d9 MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Palmitic Acid-d9 MaxSpec® Standard  Chemical Structure
  69. GC47955 Phloroglucinol A phenol with diverse biological activities Phloroglucinol  Chemical Structure
  70. GC49192 Piracetam-d6 An internal standard for the quantification of piracetam Piracetam-d6  Chemical Structure
  71. GC48362 PMX-205 (trifluoroacetate salt) A potent antagonist of C5aR PMX-205 (trifluoroacetate salt)  Chemical Structure
  72. GC44674 Pramlintide (acetate hydrate) Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. Pramlintide (acetate hydrate)  Chemical Structure
  73. GC46208 Propentofylline A xanthine derivative and neuroprotective agent Propentofylline  Chemical Structure
  74. GC49108 Racecadotril-d5 An internal standard for the quantification of racecadotril Racecadotril-d5  Chemical Structure
  75. GC48028 Rasagiline-13C3 (mesylate) An internal standard for the quantification of rasagiline Rasagiline-13C3 (mesylate)  Chemical Structure
  76. GC18483 RU-505 RU-505 is an inhibitor of the interaction between amyloid-β (Aβ) and fibrinogen, with a higher efficacy for inhibiting monomeric forms of Aβ bound to fibrinogen over oligomeric forms. RU-505  Chemical Structure
  77. GC12096 Semagacestat (LY450139) A pan γ-secretase inhibitor Semagacestat (LY450139)  Chemical Structure
  78. GC40068 Setosusin Setosusin is a meroterpenoid fungal metabolite originally isolated from C. Setosusin  Chemical Structure
  79. GC45831 SRI-011381 A TGF-β signaling activator SRI-011381  Chemical Structure
  80. GC52496 Sulfatide (bovine) (sodium salt) A mixture of isolated bovine sulfatides Sulfatide (bovine) (sodium salt)  Chemical Structure
  81. GC44968 Sulfatides (bovine) (sodium salt) Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. Sulfatides (bovine) (sodium salt)  Chemical Structure
  82. GC44987 TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt) TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide. TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)  Chemical Structure
  83. GC45137 Valproic Acid Acyl-D-Glucuronide Valproic acid acyl-D-glucuronide is the major urinary metabolite of valproic acid. Valproic Acid Acyl-D-Glucuronide  Chemical Structure
  84. GC48969 Withanone A phytochemical with diverse biological activities Withanone  Chemical Structure

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