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Home >> Signaling Pathways >> Neuroscience >> BACE

BACE

BACE (β-Secretase) is an aspartic-acid protease that cleaves the amyloid precursor protein (APP) and takes part in the generation of Amyloid β.

Products for  BACE

  1. Cat.No. Product Name Information
  2. GC14130 AZD3839 AZD3839 is a potent and selective orally active, brain-permeable BACE1 inhibitor (Ki=26 nM). AZD3839 shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. AZD3839 exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 can be used for the research of Alzheimer's disease. AZD3839 Chemical Structure
  3. GC15715 AZD3839 BACE1 inhibitor,potent and selective AZD3839 Chemical Structure
  4. GC17227 LY2886721 BACE inhibitor LY2886721 Chemical Structure
  5. GC11098 Verubecestat (MK-8931) Verubecestat (MK-8931) (MK-8931) is an orally active, high-affinity BACE1 and BACE2 inhibitor with Ki values of 2.2 nM and 0.38 nM. Verubecestat (MK-8931) Chemical Structure
  6. GC26035 Verubecestat (MK-8931) Trifluoroacetate Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat (MK-8931) Trifluoroacetate Chemical Structure

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