CaMK
The Ca2+/calmodulin-dependent kinase (CaMK) family has been recognized as a key mediator in living organisms and various biological processes.
Calcium/calmodulin kinase II (CaMK II) is a multifunctional cytoplasmic calcium and calmodulin-dependent protein kinase that phosphorylates and alters the function of a variety of substrates. The CaMK II pathway has been found to regulate the RANKL-induced osteoclast formation via the cAMP-response element binding protein (CREB) pathway.
Among many signaling pathways of proliferation, intracellular calciumol/L has been extensively demonstrated to be very important. In cytoplasm, calciumol/L binds to calmodulin, and then activates the Ca2+/calmodulin (CaM) dependent kinases (CaMKs) which are a family of structurally related serine/threonine protein kinases including CaMKI-IV. CaMKII, a multi functional protein kinase, is ubiquitously involved in many physiological processes including control of cell cycle, apoptosis, gene expression, and neurotransmission.
Targets for CaMK
Products for CaMK
- Cat.No. Product Name Information
- GC12739 A 484954 A eukaryotic elongation factor-2 (eEF-2) kinase inhibitor
- GC60037 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases.
- GC33683 Autocamtide 2 (Autocamtide II) Autocamtide 2 (Autocamtide II) is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII).
- GC34390 Autocamtide 2, amide Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays.
- GC35432 Autocamtide-2-related inhibitory peptide (TFA)
- GC50305 Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide
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GC14326
Calmidazolium chloride
Calmodulin antagonist
- GC31170 Calmodulin-Dependent Protein Kinase II 290-309 Calmodulin-Dependent Protein Kinase II 290-309 is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.
- GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.
- GC35601 CaMKII-IN-1 CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.
- GC35820 DDD107498 succinate DDD107498 succinate (DDD-498 succinate) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P.
- GC11362 K 252a A protein kinase inhibitor
- GC14202 KN-62 Inhibitor of Ca2+/calmodulin-dependent kinase type II
- GC14132 KN-92 An inactive control compound for a CaMKII inhibitor
- GC15988 KN-92 hydrochloride An inactive control compound for a CaMKII inhibitor
- GC16981 KN-92 phosphate
- GC10629 KN-93 Selective inhibitor of Ca2+/calmodulin-dependent kinase type II
- GC12501 KN-93 hydrochloride CaMK II inhibitor
- GC12804 KN-93 Phosphate CaM kinase II inhibitor, water soluble and cell permeable
- GC30356 Metofenazate (Methophenazine) Metofenazate (Methophenazine) is a selective calmodulin inhibitor.
- GC49440 ML-9 A PKB/Akt inhibitor
- GC17329 MLCK inhibitor peptide 18 Selective competitive inhibitor of myosin light chain kinase
- GC13793 NH125 Selective eEF-2 kinase inhibitor
- GC33775 Rimacalib (SMP 114) Rimacalib (SMP 114) (SMP 114) is a Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC50s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ.
- GC37694 STO-609 A CaMKK inhibitor
- GC33732 Syntide 2 A protein kinase substrate
- GC37710 Syntide 2 (TFA)
- GC62146 XST-14 XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects.