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CaMK

The Ca2+/calmodulin-dependent kinase (CaMK) family has been recognized as a key mediator in living organisms and various biological processes.

Calcium/calmodulin kinase II (CaMK II) is a multifunctional cytoplasmic calcium and calmodulin-dependent protein kinase that phosphorylates and alters the function of a variety of substrates. The CaMK II pathway has been found to regulate the RANKL-induced osteoclast formation via the cAMP-response element binding protein (CREB) pathway.

Among many signaling pathways of proliferation, intracellular calciumol/L has been extensively demonstrated to be very important. In cytoplasm, calciumol/L binds to calmodulin, and then activates the Ca2+/calmodulin (CaM) dependent kinases (CaMKs) which are a family of structurally related serine/threonine protein kinases including CaMKI-IV. CaMKII, a multi functional protein kinase, is ubiquitously involved in many physiological processes including control of cell cycle, apoptosis, gene expression, and neurotransmission.

Targets for  CaMK

Products for  CaMK

  1. Cat.No. Product Name Information
  2. GC12739 A 484954 A eukaryotic elongation factor-2 (eEF-2) kinase inhibitor A 484954  Chemical Structure
  3. GC60037 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride  Chemical Structure
  4. GC33683 Autocamtide 2 (Autocamtide II) Autocamtide 2 (Autocamtide II) is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 (Autocamtide II)  Chemical Structure
  5. GC34390 Autocamtide 2, amide Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays. Autocamtide 2, amide  Chemical Structure
  6. GC35432 Autocamtide-2-related inhibitory peptide (TFA) Autocamtide-2-related inhibitory peptide (TFA)  Chemical Structure
  7. GC50305 Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide Autocamtide-2-related inhibitory peptide, myristoylated  Chemical Structure
  8. GC14326 Calmidazolium chloride

    Calmodulin antagonist

    Calmidazolium chloride  Chemical Structure
  9. GC31170 Calmodulin-Dependent Protein Kinase II 290-309 Calmodulin-Dependent Protein Kinase II 290-309 is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Calmodulin-Dependent Protein Kinase II 290-309  Chemical Structure
  10. GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Calmodulin-Dependent Protein Kinase II(290-309) acetate  Chemical Structure
  11. GC35601 CaMKII-IN-1 CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC. CaMKII-IN-1  Chemical Structure
  12. GC35820 DDD107498 succinate DDD107498 succinate (DDD-498 succinate) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. DDD107498 succinate  Chemical Structure
  13. GC11362 K 252a A protein kinase inhibitor K 252a  Chemical Structure
  14. GC14202 KN-62 Inhibitor of Ca2+/calmodulin-dependent kinase type II KN-62  Chemical Structure
  15. GC14132 KN-92 An inactive control compound for a CaMKII inhibitor KN-92  Chemical Structure
  16. GC15988 KN-92 hydrochloride An inactive control compound for a CaMKII inhibitor KN-92 hydrochloride  Chemical Structure
  17. GC16981 KN-92 phosphate KN-92 phosphate  Chemical Structure
  18. GC10629 KN-93 Selective inhibitor of Ca2+/calmodulin-dependent kinase type II KN-93  Chemical Structure
  19. GC12501 KN-93 hydrochloride CaMK II inhibitor KN-93 hydrochloride  Chemical Structure
  20. GC12804 KN-93 Phosphate CaM kinase II inhibitor, water soluble and cell permeable KN-93 Phosphate  Chemical Structure
  21. GC30356 Metofenazate (Methophenazine) Metofenazate (Methophenazine) is a selective calmodulin inhibitor. Metofenazate (Methophenazine)  Chemical Structure
  22. GC49440 ML-9 A PKB/Akt inhibitor ML-9  Chemical Structure
  23. GC17329 MLCK inhibitor peptide 18 Selective competitive inhibitor of myosin light chain kinase MLCK inhibitor peptide 18  Chemical Structure
  24. GC13793 NH125 Selective eEF-2 kinase inhibitor NH125  Chemical Structure
  25. GC33775 Rimacalib (SMP 114) Rimacalib (SMP 114) (SMP 114) is a Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC50s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ. Rimacalib (SMP 114)  Chemical Structure
  26. GC37694 STO-609 A CaMKK inhibitor STO-609  Chemical Structure
  27. GC33732 Syntide 2 A protein kinase substrate Syntide 2  Chemical Structure
  28. GC37710 Syntide 2 (TFA) Syntide 2 (TFA)  Chemical Structure
  29. GC62146 XST-14 XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects. XST-14  Chemical Structure

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