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Dopamine Transporter

Dopamine Transporter (DAT) is an integral membrane protein that removes dopamine from the synaptic cleft and deposits it into surrounding cells, thus terminating the signal of the neurotransmitter. Dopamine transporter (DAT) controls the spatial and temporal dynamics of dopamine (DA) neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons. Many diseases such as depression, bipolar disorder, Parkinson’s disease, and attention deficit hyperactivity disorder are associated with abnormal DA levels, implicating DAT as a factor in their etiology. Medications used to treat these disorders and many addictive drugs target DAT and enhance dopaminergic signaling by suppressing transmitter reuptake. DAT is regulated by multiple signaling systems, with PKC and ERK being two of the most well-characterized.

Targets for  Dopamine Transporter

Products for  Dopamine Transporter

  1. Cat.No. Product Name Information
  2. GC60527 5,7-Dimethoxyluteolin 5,7-Dimethoxyluteolin, a 5,7-dimethylluteolin derivative, is a dopamine transporter (DAT) activator with an EC50 of 3.417 μM. 5,7-Dimethoxyluteolin  Chemical Structure
  3. GC30981 Amitifadine hydrochloride (DOV-21947 hydrochloride) Amitifadine hydrochloride (DOV-21947 hydrochloride) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively. Amitifadine hydrochloride (DOV-21947 hydrochloride)  Chemical Structure
  4. GC31283 Centanafadine (EB-1020) Centanafadine (EB-1020) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. Centanafadine (EB-1020)  Chemical Structure
  5. GC31175 Centanafadine hydrochloride (EB-1020 (hydrochloride)) Centanafadine (hydrochloride) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. Centanafadine hydrochloride (EB-1020 (hydrochloride))  Chemical Structure
  6. GC19117 Dasotraline

    Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.

    Dasotraline  Chemical Structure
  7. GC19118 Dasotraline hydrochloride Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. Dasotraline hydrochloride  Chemical Structure
  8. GC10126 Desipramine hydrochloride noradrenalin transporters inhibitor Desipramine hydrochloride  Chemical Structure
  9. GC18187 Diclofensine (hydrochloride) Diclofensine is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. Diclofensine (hydrochloride)  Chemical Structure
  10. GC33711 Diclofensine (Ro 8-4650) Diclofensine (Ro 8-4650)(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. Diclofensine (Ro 8-4650)  Chemical Structure
  11. GC34559 DOV-216,303 Free Base DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 Free Base  Chemical Structure
  12. GC30780 Fipexide Fipexide, a parachloro-phenossiacetic acid derivative, is a nootropic drug. Fipexide  Chemical Structure
  13. GC36126 GBR 12935 GBR 12935 is a potent, and selective dopamine reuptake inhibitor. GBR 12935  Chemical Structure
  14. GC13853 GBR 12935 dihydrochloride dopamine reuptake inhibitor GBR 12935 dihydrochloride  Chemical Structure
  15. GC33713 Levophacetoperane hydrochloride Levophacetoperane hydrochloride  Chemical Structure
  16. GC31020 SPD-473 citrate SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior. SPD-473 citrate  Chemical Structure
  17. GC13322 Vanoxerine potent and selective DRI (Dopamine reuptake inhibitor) Vanoxerine  Chemical Structure
  18. GC17741 Vanoxerine dihydrochloride potent and selective DRI (Dopamine reuptake inhibitor) Vanoxerine dihydrochloride  Chemical Structure

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