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Home >> Signaling Pathways >> Neuroscience >> Monoamine Oxidase

Monoamine Oxidase

Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Targets for  Monoamine Oxidase

Products for  Monoamine Oxidase

  1. Cat.No. Product Name Information
  2. GC62726 (±)-Amiflamine (±)-Amiflamine (FLA 336) is a potent monoamine oxidase-A (MAO-A) inhibitor with a pIC50 of 5.57. (±)-Amiflamine Chemical Structure
  3. GC60004 (rel)-Tranylcypromine D5 hydrochloride Tranylcypromine-d5 (SKF 385-d5) hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride. (rel)-Tranylcypromine D5 hydrochloride Chemical Structure
  4. GC33686 (S)-Rasagiline (TVP1022) (S)-Rasagiline (TVP1022) (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. (S)-Rasagiline (TVP1022) Chemical Structure
  5. GC35006 (S)-Rasagiline mesylate (S)-Rasagiline (TVP1022) mesylate is the relatively inactive S-enantiomer form of Rasagiline mesylate. (S)-Rasagiline mesylate Chemical Structure
  6. GC31021 2614W94 2614W94 is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and IC50 of 5 nM and Ki of 1.6 nM with serotonin as substrate. 2614W94 Chemical Structure
  7. GC60519 4-Hydroxyderricin 4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is a potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC50 of 3.43 μM. 4-Hydroxyderricin Chemical Structure
  8. GC35192 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone 7-?Hydroxy-?3,?4-?dihydro-?2(1H)?-?quinolinone (3,4-Dihydro-7-hydroxy-2(1H)-quinolinone) is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B. 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone Chemical Structure
  9. GC33983 Amitraz (BTS-27419) Amitraz (BTS-27419) is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis. Amitraz (BTS-27419) Chemical Structure
  10. GC39187 Azure B Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B Chemical Structure
  11. GC33718 Brofaromine (CGP 11305A) Brofaromine (CGP 11305A) (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC50 of 0.2μM for MAO-A. Brofaromine (CGP 11305A) Chemical Structure
  12. GC14122 Clorgyline (hydrochloride) MAO-A inhibitor Clorgyline (hydrochloride) Chemical Structure
  13. GC62706 Contezolid Contezolid (MRX-I), a new and orally active oxazolidinone, is an antibiotic in study for complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. Contezolid Chemical Structure
  14. GC31094 CR4056 CR4056 Chemical Structure
  15. GC31155 CX-157 CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3?ng/mL. CX-157 Chemical Structure
  16. GC30392 Desmethoxyyangonin (Demethoxyyangonin) Desmethoxyyangonin (Demethoxyyangonin) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B. Desmethoxyyangonin (Demethoxyyangonin) Chemical Structure
  17. GC30963 Eprobemide (LIS 630) Eprobemide (LIS 630) is a non-competitive reversible inhibitor of monoamine oxidase A. Eprobemide (LIS 630) Chemical Structure
  18. GC65609 Glicoricone Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone Chemical Structure
  19. GC32764 GSK-LSD1 Dihydrochloride An LSD1 inhibitor GSK-LSD1 Dihydrochloride Chemical Structure
  20. GC15384 Harmane endogenous ligand for imidazoline binding sites Harmane Chemical Structure
  21. GC60917 Hydroxyamine hydrochloride Hydroxyamine hydrochloride is a selective monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxyamine hydrochloride Chemical Structure
  22. GC60939 Iproniazid Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid Chemical Structure
  23. GC33677 Iproniazid phosphate Iproniazid phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid phosphate Chemical Structure
  24. GC12962 Isatin endogenous monoamine oxidase inhibitor Isatin Chemical Structure
  25. GC31104 Isocarboxazid An inhibitor of MAO Isocarboxazid Chemical Structure
  26. GC63035 Kynuramine dihydrochloride Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase. Kynuramine dihydrochloride Chemical Structure
  27. GC63038 Ladostigil Ladostigil (TV-3326) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil Chemical Structure
  28. GC63466 Ladostigil hemitartrate Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hemitartrate Chemical Structure
  29. GC30979 Lazabemide (Ro 19-6327) Lazabemide (Ro 19-6327) (Ro 19-6327) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM). Lazabemide (Ro 19-6327) Chemical Structure
  30. GC62462 LOX-IN-3 LOX-IN-3 is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 can be used for fibrosis, cancer and angiogenesis research. LOX-IN-3 Chemical Structure
  31. GC64656 LOX-IN-3 dihydrochloride LOX-IN-3 dihydrochloride is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 dihydrochloride can be used for fibrosis, cancer and angiogenesis research. LOX-IN-3 dihydrochloride Chemical Structure
  32. GC30544 LOXL2-IN-1 hydrochloride LOXL2-IN-1 hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM. LOXL2-IN-1 hydrochloride Chemical Structure
  33. GC50329 M 30 dihydrochloride M 30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM) inhibitor. M 30 dihydrochloride Chemical Structure
  34. GC30362 MAO-B-IN-1 MAO-B-IN-1 is an inhibitor of monoamine oxidase B, used for the research of neurological diseases. MAO-B-IN-1 Chemical Structure
  35. GC64009 MAO-B-IN-2 MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50 values of 0.51 and 7.00 μM, respectively. MAO-B-IN-2 Chemical Structure
  36. GC31252 MAO-IN-1 MAO-IN-1 is a monoamine oxidase B (MAO B) inhibitor with an IC50 of 20 nM. MAO-IN-1 Chemical Structure
  37. GC63556 Methyl citrate Methyl citrate is a Monoamine oxidase B (MAO-B) inhibitor (IC50=0.23 mM). Methyl citrate Chemical Structure
  38. GC30051 Methylene Blue (Basic Blue 9) Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene Blue (Basic Blue 9) Chemical Structure
  39. GC39603 Methylene blue trihydrate Methylene blue trihydrate (C. Methylene blue trihydrate Chemical Structure
  40. GC30218 Minaprine Minaprine is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression. Minaprine Chemical Structure
  41. GC30949 Minaprine dihydrochloride Minaprine dihydrochloride is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression. Minaprine dihydrochloride Chemical Structure
  42. GC11703 Moclobemide (Ro 111163) An Analytical Reference Standard Moclobemide (Ro 111163) Chemical Structure
  43. GC30976 Modaline sulfate Modaline sulfate is a MAO inhibitor, used in the treatment of depression. Modaline sulfate Chemical Structure
  44. GC36638 Mofegiline hydrochloride Mofegiline hydrochloride (MDL72974A) is an orally active and selective enzyme-activated irreversible inhibitor of MAO-B, with marked selectivity on the MAO-B over MAO-A with IC50s of 3.6 nM (MAO-B) and 680 nM (MAO-A), respectively. Mofegiline hydrochloride Chemical Structure
  45. GC30870 Nialamide

    Nialamide is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant.

     Nialamide Chemical Structure
  46. GC69591 Nrf2-ARE/hMAO-B/QR2 modulator 1

    Nrf2-ARE/hMAO-B/QR2 modulator 1 is a multi-targeted ligand based on resveratrol, with IC50 values of 8.05 μM, 9.83 μM and 0.57 μM for hMAO-B, NRF2 and QR2 respectively. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotective effects and can reduce ROS production in mouse hippocampal slices treated with okadaic acid.

     Nrf2-ARE/hMAO-B/QR2 modulator 1 Chemical Structure
  47. GC39018 Obtusin Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15 μM. Obtusin Chemical Structure
  48. GC17314 OG-L002 LSD1 inhibitor,potent and specific OG-L002 Chemical Structure
  49. GC61162 Osthenol Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 ?M). Osthenol Chemical Structure
  50. GN10498 Paeonol Paeonol Chemical Structure
  51. GC36853 Pargyline Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline Chemical Structure
  52. GC16824 Pargyline (hydrochloride) MAO inhibitor Pargyline (hydrochloride) Chemical Structure
  53. GC30112 PAT-1251 PAT-1251 is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively); PAT-1251 is used in the research of fibrotic diseases. PAT-1251 Chemical Structure
  54. GC31949 PAT-1251 Hydrochloride PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 Hydrochloride Chemical Structure
  55. GC30773 Phenelzine sulfate An inhibitor of MAO Phenelzine sulfate Chemical Structure
  56. GC69697 Pheniprazine hydrochloride

    Pheniprazine hydrochloride is an effective long-acting monoamine oxidase inhibitor. It has the potential to be used in research for treating depression.

     Pheniprazine hydrochloride Chemical Structure
  57. GC62202 PXS-4728A PXS-4728A (BI-1467335) is a selective, orally active inhibitor of semicarbazide-sensitive amine oxidase (SSAO). PXS-4728A Chemical Structure
  58. GC63158 PXS-5120A PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. PXS-5120A Chemical Structure
  59. GC31890 PXS-5153A PXS-5153A is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS-5153A Chemical Structure
  60. GC38583 PXS-5153A monohydrochloride PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS-5153A monohydrochloride Chemical Structure
  61. GC33714 Rasagiline (AGN1135) Rasagiline (AGN1135) (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43nM and 412nM for rat brain MAO B and A activity, respectively. Rasagiline (AGN1135) Chemical Structure
  62. GC33573 Rasagiline 13C3 mesylate racemic (AGN1135 13C3 racemic) Rasagiline 13C3 mesylate racemic (AGN1135 13C3 racemic) is a 13C-labeled Rasagiline mesylate racemic. Rasagiline 13C3 mesylate racemic (AGN1135 13C3 racemic) Chemical Structure
  63. GC12801 Rasagiline Mesylate An inhibitor of MAO-B Rasagiline Mesylate Chemical Structure
  64. GC19311 Ro 41-1049 hydrochloride Ro 41-1049 hydrochloride is a selective, reversible, orally-active MAO-A inhibitor. Ro 41-1049 hydrochloride Chemical Structure
  65. GN10283 Rosiridin Rosiridin Chemical Structure
  66. GN10648 Rosmarinic acid Rosmarinic acid Chemical Structure
  67. GC37558 Rosmarinic acid racemate Rosmarinic acid racemate Chemical Structure
  68. GC31024 RS 8359 RS 8359 is a selective and reversible MAO-A inhibitor, with antidepressant activity. RS 8359 Chemical Structure
  69. GC61255 Rubrofusarin triglucoside Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside Chemical Structure
  70. GC13016 Safinamide Safinamide Chemical Structure
  71. GC33749 Salsolidine Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. Salsolidine Chemical Structure
  72. GC68299 Simtuzumab Simtuzumab Chemical Structure
  73. GC30988 TB5

    A potent and selective MAO-B inhibitor

     TB5 Chemical Structure
  74. GC34842 Toloxatone

    An inhibitor of MAO-A

     Toloxatone Chemical Structure
  75. GC30766 Tranylcypromine hemisulfate (dl-Tranylcypromine hemisulfate) Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate (dl-Tranylcypromine hemisulfate) Chemical Structure
  76. GC61382 Xanthoangelol Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol Chemical Structure

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