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Home >> Signaling Pathways >> Neuroscience >> Serotonin Transporter

Serotonin Transporter

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Targets for  Serotonin Transporter

Products for  Serotonin Transporter

  1. Cat.No. Product Name Information
  2. GC60394 (±)-Duloxetine hydrochloride (±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. (±)-Duloxetine hydrochloride Chemical Structure
  3. GC60424 (S)-Venlafaxine (S)-Venlafaxine is the (S)-configuration of Venlafaxine. Venlafaxine is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant agent. (S)-Venlafaxine Chemical Structure
  4. GC30981 Amitifadine hydrochloride (DOV-21947 hydrochloride) Amitifadine hydrochloride (DOV-21947 hydrochloride) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively. Amitifadine hydrochloride (DOV-21947 hydrochloride) Chemical Structure
  5. GC35443 Azaphen Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. Azaphen Chemical Structure
  6. GC35444 Azaphen dihydrochloride monohydrate Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. Azaphen dihydrochloride monohydrate Chemical Structure
  7. GC31283 Centanafadine (EB-1020) Centanafadine (EB-1020) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. Centanafadine (EB-1020) Chemical Structure
  8. GC31175 Centanafadine hydrochloride (EB-1020 (hydrochloride)) Centanafadine (hydrochloride) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. Centanafadine hydrochloride (EB-1020 (hydrochloride)) Chemical Structure
  9. GC11798 Cinchonidine alkaloid Cinchonidine Chemical Structure
  10. GC14035 Citalopram hydrobromide 5-HT uptake inhibitor Citalopram hydrobromide Chemical Structure
  11. GC30375 Clomipramine D3 Clomipramine D3 (Chlorimipramine-d3) is the deuterium labeled Clomipramine. Clomipramine D3 Chemical Structure
  12. GC15107 Clomipramine HCl Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine HCl Chemical Structure
  13. GC47101 Clomipramine-d3 (hydrochloride) An Analytical Reference Standard Clomipramine-d3 (hydrochloride) Chemical Structure
  14. GC17061 Dapoxetine HCl Selective serotonin reuptake inhibitor Dapoxetine HCl Chemical Structure
  15. GC18497 Dapoxetine hydrochloride Dapoxetine hydrochloride (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride Chemical Structure
  16. GC60740 Dapoxetine-D7 hydrochloride Dapoxetine-d7 (LY-210448-d7) hydrochloride is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine-D7 hydrochloride Chemical Structure
  17. GC19117 Dasotraline

    Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.

     Dasotraline Chemical Structure
  18. GC19118 Dasotraline hydrochloride Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. Dasotraline hydrochloride Chemical Structure
  19. GC10126 Desipramine hydrochloride noradrenalin transporters inhibitor Desipramine hydrochloride Chemical Structure
  20. GC11570 Desvenlafaxine serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor Desvenlafaxine Chemical Structure
  21. GC14262 Desvenlafaxine Succinate serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor Desvenlafaxine Succinate Chemical Structure
  22. GC30772 Dopamine serotonin antagonist-1 Dopamine serotonin antagonist-1 Chemical Structure
  23. GC34559 DOV-216,303 Free Base DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 Free Base Chemical Structure
  24. GC65014 DSP-1053 DSP-1053, a benzylpiperidine derivative, is a potent?Serotonin Transporter (SERT) inhibitor with a Ki of 1.02 nM. DSP-1053 Chemical Structure
  25. GC31064 Duloxetine ((S)-Duloxetine) Duloxetine ((S)-Duloxetine) is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). Duloxetine ((S)-Duloxetine) Chemical Structure
  26. GC13871 Duloxetine HCl Duloxetine HCl ((S)-Duloxetine HCl) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). Duloxetine HCl Chemical Structure
  27. GC47277 Duloxetine-d3 (hydrochloride) An internal standard for the quantification of duloxetine Duloxetine-d3 (hydrochloride) Chemical Structure
  28. GC34575 Eplivanserin mixture Eplivanserin mixture (SR-46349 mixture) is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, extracted from patent WO 2005/002578 A1. Eplivanserin mixture Chemical Structure
  29. GC13161 Escitalopram Serotonin reuptake inhibitor Escitalopram Chemical Structure
  30. GC16797 Escitalopram Oxalate Selective 5-HT reuptake inhibitor Escitalopram Oxalate Chemical Structure
  31. GC33715 Fluoxetine (LY-110140)

    Fluoxetine (LY-110140) is an orally active selective serotonin reuptake inhibitor (SSRI). Fluoxetine is a potent inhibitor of the saturated [3H]-5-HT uptake process in rat and human platelets, with IC50 values of 0.10 and 0.05 μM, respectively.

     Fluoxetine (LY-110140) Chemical Structure
  32. GC11709 Fluoxetine HCl Serotonin reuptake inhibitor,selective Fluoxetine HCl Chemical Structure
  33. GC13092 Fluvoxamine Selective serotonin reuptake inhibitor Fluvoxamine Chemical Structure
  34. GC15025 Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant Fluvoxamine maleate Chemical Structure
  35. GC12885 Imipramine (hydrochloride) serotonin and norepinephrine transporters inhibitor Imipramine (hydrochloride) Chemical Structure
  36. GC65209 Imipramine-d4 hydrochloride Imipramine-d4 hydrochloride Chemical Structure
  37. GC44057 Levomilnacipran (hydrochloride) Milnacipran (1S-cis) hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI), used in the clinical treatment of fibromyalgia. Levomilnacipran (hydrochloride) Chemical Structure
  38. GC14330 Milnacipran Serotonin-norepinephrine reuptake inhibitor (SNRI) Milnacipran Chemical Structure
  39. GC12055 Milnacipran HCl Milnacipran HCl is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. Milnacipran HCl Chemical Structure
  40. GC31029 Nitroxazepine (CIBA 2330Go) Nitroxazepine (CIBA 2330Go) is a tricyclic antidepressant (TCA) for the research of depression. Nitroxazepine (CIBA 2330Go) Chemical Structure
  41. GC17229 Paroxetine HCl Paroxetine HCl is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an and has GRK2 inhibitory ability with IC50 of 14μM. Paroxetine HCl Chemical Structure
  42. GC30992 Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14μM. Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) Chemical Structure
  43. GC25708 Paroxetine mesylate Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine mesylate Chemical Structure
  44. GC69880 SERT-IN-2

    SERT-IN-2 is a potent SERT inhibitor (IC50=0.58 nM) with antidepressant activity. It has good bioavailability, with an F(%) of 83.28% in rats. SERT-IN-2 can cross the blood-brain barrier.

     SERT-IN-2 Chemical Structure
  45. GC12720 Sertraline HCl Sertraline HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline HCl Chemical Structure
  46. GC31020 SPD-473 citrate SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior. SPD-473 citrate Chemical Structure
  47. GC10911 Venlafaxine hydrochloride Dual serotonin/noradrenalin re-uptake inhibitor Venlafaxine hydrochloride Chemical Structure
  48. GC15013 Vilazodone Vilazodone Chemical Structure
  49. GC37906 Vilazodone D8 Vilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist. Vilazodone D8 Chemical Structure
  50. GC10876 Vilazodone Hydrochloride An SSRI and a partial agonist of 5-HT1A Vilazodone Hydrochloride Chemical Structure
  51. GC16312 Vortioxetine A multimodal serotonergic agent Vortioxetine Chemical Structure
  52. GC14437 Vortioxetine (Lu AA21004) HBr Vortioxetine (Lu AA21004) HBr is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. Vortioxetine (Lu AA21004) HBr Chemical Structure
  53. GC48255 Vortioxetine-d8 An internal standard for the quantification of vortioxetine Vortioxetine-d8 Chemical Structure
  54. GC31041 Wf-516 Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively, and has potent antidepressant activity. Wf-516 Chemical Structure
  55. GC70178 ZZL-7

    ZZL-7 is a fast-acting antidepressant. It works by disrupting the interaction between serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can easily cross the blood-brain barrier and is used for research on major depressive disorder (MDD).

     ZZL-7 Chemical Structure

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