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Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Targets for  Cell Cycle/Checkpoint

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GC11905 Cevipabulin Anti-microtubule agent Cevipabulin Chemical Structure
  3. GC35659 Cevipabulin fumarate Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line. Cevipabulin fumarate Chemical Structure
  4. GC13606 CFI-400945

    orally available, selective inhibitor of polo-like kinase 4 (PLK4)

     CFI-400945 Chemical Structure
  5. GC35660 CFI-400945 free base CFI-400945 free base Chemical Structure
  6. GC14526 CGK733 ATM/ATR inhibitor,potent and selective CGK733 Chemical Structure
  7. GC50175 CGP 74514 dihydrochloride Potent cdk1 inhibitor CGP 74514 dihydrochloride Chemical Structure
  8. GC48992 CGP 77675 (hydrate) An inhibitor of Src family kinases CGP 77675 (hydrate) Chemical Structure
  9. GC14650 CGP60474 A CDK inhibitor CGP60474 Chemical Structure
  10. GC15739 CHIR-124 Chk1 inhibitor,novel and potent CHIR-124 Chemical Structure
  11. GC43239 Chk2 Inhibitor Chk2 Inhibitor (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2 Inhibitor can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect. Chk2 Inhibitor Chemical Structure
  12. GC47079 Chloramine-T (hydrate) A common reagent Chloramine-T (hydrate) Chemical Structure
  13. GC43250 Cho-Arg (trifluoroacetate salt) Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. Cho-Arg (trifluoroacetate salt) Chemical Structure
  14. GC50145 CHR 6494 trifluoroacetate CHR 6494 trifluoroacetate is a potent inhibitor of haspin, with an IC50 of 2 nM. CHR 6494 trifluoroacetate inhibits histone H3T3 phosphorylation. CHR 6494 trifluoroacetate induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR 6494 trifluoroacetate can be used in the research of cancer. CHR 6494 trifluoroacetate Chemical Structure
  15. GC17254 CHR-6494 A selective Haspin protein kinase inhibitor CHR-6494 Chemical Structure
  16. GC16097 Chroman 1 A ROCK2 inhibitor Chroman 1 Chemical Structure
  17. GC49334 Chroman 1 (hydrochloride hydrate) A ROCK2 inhibitor Chroman 1 (hydrochloride hydrate) Chemical Structure
  18. GC43265 Chromomycin A2 Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. Chromomycin A2 Chemical Structure
  19. GC52360 Chymotrypsin Substrate I, Colorimetric (trifluoroacetate salt) A colorimetric chymotrypsin substrate Chymotrypsin Substrate I, Colorimetric (trifluoroacetate salt) Chemical Structure
  20. GC12352 cis-trismethoxy Resveratrol Cis-trismethoxy resveratrol is a potent anti-mitotic reagent.Cis-trismethoxy resveratrol inhibits tubulin polymerization with an IC50 value of 4 μM. cis-trismethoxy Resveratrol Chemical Structure
  21. GC52367 Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide A biotinylated and citrullinated mutant vimentin peptide Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide Chemical Structure
  22. GC52370 Citrullinated Vimentin (R144) (139-159)-biotin Peptide A biotinylated and citrullinated vimentin peptide Citrullinated Vimentin (R144) (139-159)-biotin Peptide Chemical Structure
  23. GC14060 CK 666 Arp2/3 complex inhibitor that inhibits actin polymerization CK 666 Chemical Structure
  24. GC15076 CK 869 actin-related protein 2/3 (Arp2/3) complex inhibitor CK 869 Chemical Structure
  25. GC15894 CK-636 Arp2/3 complex inhibitor CK-636 Chemical Structure
  26. GC43286 CMPD101 A GRK2 and GRK3 inhibitor CMPD101 Chemical Structure
  27. GC49345 Coelenterazine hcp A synthetic bioluminescent luciferin Coelenterazine hcp Chemical Structure
  28. GC40664 Colcemid

    Colcemid is a cytoskeletal inhibitor that induces mitotic arrest in the G2/M phase or meiotic arrest in the vesicle rupture (GVBD) phase in mammalian cells or oocytes, respectively.

     Colcemid Chemical Structure
  29. GC13261 Colchicine

    An inhibitor of microtubule polymerization

     Colchicine Chemical Structure
  30. GC47117 Colchicine-d6

    An internal standard for the quantification of colchicine

     Colchicine-d6 Chemical Structure
  31. GC43300 Combretastatin A1 Combretastatin A1 is a cis-stilbene originally isolated from C. Combretastatin A1 Chemical Structure
  32. GC17631 Combretastatin A4 tubulin polymerization inhibitor Combretastatin A4 Chemical Structure
  33. GC43307 Concanamycin B Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). Concanamycin B Chemical Structure
  34. GC43315 Corynecin IV Corynecin IV is a chloramphenicol-like bacterial metabolite originally isolated from Corynebacterium. Corynecin IV Chemical Structure
  35. GC40663 Corynecin V Corynecin V is a chloramphenicol-like bacterial metabolite originally isolated from Corynebacterium. Corynecin V Chemical Structure
  36. GC63333 Cotosudil Cotosudil Chemical Structure
  37. GC16489 CP-466722 ATM inhibitor,potent and reversible CP-466722 Chemical Structure
  38. GC19112 Crolibulin Crolibulin is a small molecule tubulin polymerization inhibitor. Crolibulin Chemical Structure
  39. GC45414 CRT0066854   CRT0066854 Chemical Structure
  40. GC40482 Curvulin Curvulin is a phytotoxin first isolated from several species of the mold Curvularia. Curvulin Chemical Structure
  41. GC18028 CVT-313 A Cdk2 inhibitor CVT-313 Chemical Structure
  42. GC11252 CW069 allosteric inhibitor of HSET, selective CW069 Chemical Structure
  43. GC13268 Cyclapolin 9 PLK1 inhibitor Cyclapolin 9 Chemical Structure
  44. GC49709 cyclo(RGDyC) (trifluoroacetate salt) A cyclic pentapeptide cyclo(RGDyC) (trifluoroacetate salt) Chemical Structure
  45. GC49716 Cyclo(RGDyK) (trifluoroacetate salt) A cyclic peptide ligand of αVβ3 integrin Cyclo(RGDyK) (trifluoroacetate salt) Chemical Structure
  46. GC43346 Cyclopamine-KAAD Cyclopamine-KAAD, a hedgehog signaling inhibitor, is a smoothened antagonist. Cyclopamine-KAAD Chemical Structure
  47. GC43351 Cylindrospermopsin

    Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease.

     Cylindrospermopsin Chemical Structure
  48. GC45877 CYM 5478 An S1P2 agonist CYM 5478 Chemical Structure
  49. GC35789 Cys-mcMMAD Cys-mcMMAD is a drug-linker conjugate for ADC. MMAD is a potent tubulin inhibitor. Cys-mcMMAD Chemical Structure
  50. GC43354 Cysmethynil Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. Cysmethynil Chemical Structure
  51. GC11383 CYT997 (Lexibulin) CYT997 (Lexibulin) (CYT-997) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. CYT997 (Lexibulin) induces cell apoptosis and induces mitochondrial ROS generation in GC cells. CYT997 (Lexibulin) Chemical Structure
  52. GC49863 Cytarabine 5′-monophosphate An active metabolite of cytarabine Cytarabine 5′-monophosphate Chemical Structure
  53. GC32890 Cytochalasin B (Phomin)

    Cytochalasin B is a cyto-permeable mycotoxin, and it is isolated from an ascomycete fungus belonging to the Phoma genus[1-2].

     Cytochalasin B (Phomin) Chemical Structure
  54. GC13440 Cytochalasin D

    An inhibitor of actin polymerization, selective

     Cytochalasin D Chemical Structure
  55. GC10870 Cytochalasin J alters mitotic spindle microtubule organization and kinetochore structure Cytochalasin J Chemical Structure
  56. GC43360 Cytostatin Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. Cytostatin Chemical Structure
  57. GC43361 Cytostatin (sodium salt) Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. Cytostatin (sodium salt) Chemical Structure
  58. GC12384 D-64131 An inhibitor of tubulin polymerization D-64131 Chemical Structure
  59. GC40296 D-erythro-MAPP D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). D-erythro-MAPP Chemical Structure
  60. GC43513 D-myo-Inositol-1,2-diphosphate (sodium salt) Ins(1,2)P2 (sodium salt) is one of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-1,2-diphosphate (sodium salt) Chemical Structure
  61. GC43516 D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt) D-myo-Inositol-1,3,4,5-tetraphosphate (Ins(1,3,4,5)-P4) is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase. D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt) Chemical Structure
  62. GC43517 D-myo-Inositol-1,3,4,6-tetraphosphate (ammonium salt) The inositol phosphates (IPs) are a family of molecules produced by altering the phosphorylation status of each of the six carbons on the cyclic inositol structure. D-myo-Inositol-1,3,4,6-tetraphosphate (ammonium salt) Chemical Structure
  63. GC43520 D-myo-Inositol-1,3-diphosphate (sodium salt) D-myo-Inositol-1,3-phosphate (Ins(1,3)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-1,3-diphosphate (sodium salt) Chemical Structure
  64. GC43521 D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)

    D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction.

     D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) Chemical Structure
  65. GC43522 D-myo-Inositol-1,4,5-triphosphate (potassium salt) D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C (PLC) mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. D-myo-Inositol-1,4,5-triphosphate (potassium salt) Chemical Structure
  66. GC43523 D-myo-Inositol-1,4,5-triphosphate (sodium salt) Primary intracellular IP3 receptor agonist D-myo-Inositol-1,4,5-triphosphate (sodium salt) Chemical Structure
  67. GC43524 D-myo-Inositol-1,4,6-triphosphate (sodium salt) D-myo-Inositol-1,4,6-phosphate (Ins(1,4,6)-P3) is a member of the inositol phosphate (InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-1,4,6-triphosphate (sodium salt) Chemical Structure
  68. GC43526 D-myo-Inositol-1,5,6-triphosphate (sodium salt) The inositol phosphates are a family of mono- to poly-phosphorylated compounds that act as messengers, regulating cellular functions including cell cycling, apoptosis, differentiation, andmotility. D-myo-Inositol-1,5,6-triphosphate (sodium salt) Chemical Structure
  69. GC43540 D-myo-Inositol-4-phosphate (ammonium salt) D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-4-phosphate (ammonium salt) Chemical Structure
  70. GC35797 D8-MMAD D8-MMAD Chemical Structure
  71. GC35798 D8-MMAF D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride. MMAF Hydrochloride, a potent tubulin polymerization inhibitor, is used as a antitumor agent and a cytotoxic component of antibody-drug conjugates (ADCs). D8-MMAF Chemical Structure
  72. GC35799 D8-MMAF hydrochloride D8-MMAF hydrochloride Chemical Structure
  73. GC41305 DA-3003-2 Cdc25 dual-specific protein tyrosine phosphatases are important for cell cycle progression and often overexpressed in cancers. DA-3003-2 Chemical Structure
  74. GC18421 Dabcyl-YVADAPV-EDANS Dabcyl-YVADAPV-EDANS is a fluorogenic substrate for caspase-1. Dabcyl-YVADAPV-EDANS Chemical Structure
  75. GC43371 Dabigatran Acyl-β-D-Glucuronide

    Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran.

     Dabigatran Acyl-β-D-Glucuronide Chemical Structure
  76. GC49684 Dabigatran-13C-d3 An internal standard for the quantification of dabigatran Dabigatran-13C-d3 Chemical Structure
  77. GC49682 Dabigatran-d3 An internal standard for the quantification of dabigatran Dabigatran-d3 Chemical Structure
  78. GC43379 Darinaparsin A dimethylated arsenic linked to glutathione Darinaparsin Chemical Structure
  79. GC68147 dAURK-4 hydrochloride dAURK-4 hydrochloride Chemical Structure
  80. GC49913 Davunetide (acetate) A neuroprotective ADNP-derived peptide Davunetide (acetate) Chemical Structure
  81. GC43385 DC-Chol (hydrochloride)

    DC-Chol(hydrochloric acid) can inhibit the formation of Aβ40 fibers,DC-Chol(hydrochloric acid) can inhibit the amyloid formation of oxidized hCT[1,2].

     DC-Chol (hydrochloride) Chemical Structure
  82. GC39486 DCLK1-IN-1 DCLK1-IN-1 is a selective, oral bioavailability in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1 kinase) domain. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases (IC50: DCLK1=9.5/57.2 nM and DCLK2=31/103 nM in binding and kinase assay, respectively). DCLK1-IN-1 shows low toxicity, and can investigate DCLK1 biology and establish its role in cancer, like DCLK1+ pancreatic ductal adenocarcinoma (PDAC). DCLK1-IN-1 Chemical Structure
  83. GN10426 Deacetyltaxol Deacetyltaxol Chemical Structure
  84. GC18666 Debromohymenialdisine Damaged DNA in humans is detected by sensor proteins that transmit a signal through checkpoint kinases (Chks) Chk1 and Chk2. Debromohymenialdisine Chemical Structure
  85. GC11835 Deferasirox

    Oral iron chelator

     Deferasirox Chemical Structure
  86. GC41304 Deoxybrevianamide E Deoxybrevianamide E is an alkaloid fungal metabolite that has been found in Aspergillus. Deoxybrevianamide E Chemical Structure
  87. GC38564 Deoxypodophyllotoxin Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from rhizomes of Sinopodophullumhexandrum (Berberidaceae). Deoxypodophyllotoxin Chemical Structure
  88. GC47211 Dichlorvos An organophosphate insecticide Dichlorvos Chemical Structure
  89. GC49293 Dichlorvos-d6 An internal standard for the quantification of dichlorvos Dichlorvos-d6 Chemical Structure
  90. GC43461 Dihydrocytochalasin B Dihydrocytochalasin B (DCB) is a member of the cytochalasin mycotoxin family that inhibits actin assembly. Dihydrocytochalasin B Chemical Structure
  91. GC43467 Dimethyldioctadecylammonium (bromide) Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. Dimethyldioctadecylammonium (bromide) Chemical Structure
  92. GC32969 Dimethylenastron An inhibitor of EG5 Dimethylenastron Chemical Structure
  93. GC43469 Diminutol Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. Diminutol Chemical Structure
  94. GC17648 Dinaciclib(SCH727965) Dinaciclib(SCH727965) (SCH 727965) is a potent inhibitor of CDK, with IC50s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively. Dinaciclib(SCH727965) Chemical Structure
  95. GC43472 Dios-Arg (trifluoroacetate salt) Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. Dios-Arg (trifluoroacetate salt) Chemical Structure
  96. GC60143 DM3 DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs). DM3 Chemical Structure
  97. GC38355 DM3-SMe DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM. DM3-SMe Chemical Structure
  98. GC32810 DM4 DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate. DM4 Chemical Structure
  99. GC38468 DM4-SMe DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM. DM4-SMe Chemical Structure
  100. GC38460 DM4-SPDP DM4-SPDP is a drug-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody drug conjugate. SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. DM4-SPDP Chemical Structure
  101. GC43545 Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 Chemical Structure

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