Cell Cycle/Checkpoint
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Targets for Cell Cycle/Checkpoint
- ATM/ATR(26)
- Aurora Kinase(47)
- Cdc42(4)
- Cdc7(4)
- Chk(16)
- c-Myc(20)
- CRM1(8)
- Cyclin-Dependent Kinases(91)
- E1 enzyme(1)
- G-quadruplex(14)
- Haspin(7)
- HMTase(1)
- Kinesin(26)
- Ksp(6)
- Microtubule/Tubulin(243)
- Mps1(15)
- Mitotic(11)
- RAD51(18)
- ROCK(71)
- Rho(13)
- PERK(11)
- PLK(37)
- PTEN(8)
- Wee1(7)
- PAK(21)
- Arp2/3 Complex(8)
- Dynamin(12)
- ECM & Adhesion Molecules(40)
- Cholesterol Metabolism(3)
- Endomembrane System & Vesicular Trafficking(26)
- G1(38)
- G2/M(26)
- G2/S(10)
- Genotoxic Stress(18)
- Inositol Phosphates(18)
- Proteolysis(99)
- Cytoskeleton & Motor Proteins(53)
- Cellular Chaperones(8)
Products for Cell Cycle/Checkpoint
- Cat.No. Product Name Information
- GC43546 Dnp-PLALWAR (trifluoroacetate salt) Dnp-PLALWAR is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-8.
- GC43547 Dnp-PLAYWAR (trifluoroacetate salt) Dnp-PLAYWAR is a fluorogenic substrate for matrix metalloproteinase-8 (MMP-8) and MMP-26.
- GC43550 Dnp-PLGMWSR (trifluoroacetate salt) Dnp-PLGMWSR is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-9.
- GC43552 Dnp-RPLALWRS (trifluoroacetate salt) Dnp-RPLALWRS is a fluorogenic substrate for matrix metalloproteinase-7 (MMP-7).
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GC16684
Docetaxel
Docetaxel is a taxane class of anti-mitotic chemotherapeutic agents with an IC50 of 0.2 µM.
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GC48968
Docetaxel (hydrate)
An analog of taxol with antitumor properties
- GC12550 Docetaxel Trihydrate
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GC47250
Docetaxel-d9
An internal standard for the quantification of docetaxel
- GC52095 Dodecyltrimethylammonium (bromide) A cationic surfactant
- GC16273 Dolastatin 10 Antitumor agent
- GC10557 Dolastatin 10 trifluoroacetate Antitumor agent
- GA21397 Dolastatin 15 Dolastatin 15 originally isolated from the sea hare Dolabella auricularia belongs to a family of antimitotic and antineoplastic depsipeptides inducing apoptosis in various malignant cell types. It was shown to inhibit the growth of the P388 lymphocytic leukemia cell line efficiently, with an ED?? value of 2.4 ng/mL.
- GC43567 DPC-AJ1951 (trifluoroacetate salt) DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR).
- GC64927 Drp1-IN-1 Drp1-IN-1 (comp A-7) is a dynamin-1-like protein (Drp1) inhibitor, with an IC50 of 0.91 μM.
- GC50020 Dynamin inhibitory peptide, myristoylated Cell-permeable dynamin inhibitor
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GC10395
Dynasore
Dynasore, as a GTPase inhibitor, can rapidly and reversibly inhibit dynamin activity, which prevents endocytosis.
- GC17208 Dyngo-4a Hydroxy Dynasore (Dyngo-4a), a structural analog of Dynasore, is an potency improved, low cytotoxicity and non‐specific binding dynamin inhibitor with IC50values of 0.38 μM and 2.3μM for brain dynamin I and recombinant rat dynamin II, respectively.
- GC66056 Dynole 2-24 Dynole 2-24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2-24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2-24 also shows 4.4-fold selectivity for dynamin I. Dynole 2-24 is active in-cell inhibitor of clathrin-mediated endocytosis. CME: Clathrin mediated endocytosis
- GC47279 Echinosporin A bacterial metabolite with antibacterial and anticancer activities
- GC35964 Eg5 Inhibitor V, trans-24 Eg5 Inhibitor V, trans-24 is a potent and specific kinesin Eg5 inhibitor with an IC50 of 0.65 μM, and can be used in the research of cancer.
- GC10681 Eg5-I potent inhibitor of Eg5
- GC43588 EGA EGA is an inhibitor of endosomal trafficking.
- GC10030 EHop-016 Rac1/Rac3 GTPase inhibitor,potent and specific
- GC25372 Elimusertib (BAY-1895344) hydrochloride Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
- GC16827 ELR510444 Novel microtubule disruptor
- GC19466 Eltanexor (KPT-8602) A second-generation exportin-1 inhibitor
- GC19213 Eltanexor Z-isomer KPT-8602 Z-isomer is the less active isomer of KPT-8602.
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GC18165
EMD534085
Inhibitor of the mitotic kinesin-5
- GC34073 Empesertib (BAY 1161909) Empesertib (BAY 1161909) (BAY 1161909) is a potent Mps1 inhibitor, with an IC50 of < 1 nM.
- GC49124 EN219 EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination.
- GC62287 EN4 EN4 is a covalent ligand that targets cysteine 171 (C171) of MYC. EN4 is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.
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GC19010
Endosidin 2
A cell-permeable inhibitor of exocytosis and endosomal recycling
- GC43605 Endosulfan II Endosulfan II is an organochlorine insecticide and a stereoisomer of endosulfan I.
- GC47291 Endothall An herbicide
- GC33125 Entasobulin Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity.
- GC43614 Enteropeptidase Fluorogenic Substrate Enteropeptidase fluorogenic substrate is a substrate for enteropeptidase that contains a 7-amino-4-trifluoromethylcoumarin (AFC) moiety.
- GC48995 Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt) A fluorogenic substrate of enteropeptidase
- GC11202 Epothilone A Microtubule stabilizing macrolide
- GC17240 Epothilone B (EPO906, Patupilone) Epothilone B (EPO906, Patupilone) is a microtubule stabilizer with a Ki of 0.71μM.
- GC17440 Epothilone D A microtubule-stabilizing agent
- GC14354 Eribulin synthetic analogue of halichondrin B
- GC12483 Eribulin mesylate synthetic analogue of halichondrin B
- GC63845 Eribulin-d3 mesylate Eribulin-d3 mesylate is a deuterium labeled Eribulin mesylate. Eribulin mesylate is a microtubule targeting agent that is used for the research of cancer.
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GC43625
Erucin
Erucin is an isothiocyanate derived from glucoerucin, a glucosinolate predominant in arugula (Eruca sativa Mill.) and other cruciferous vegetables.
- GC67333 Estramustine Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts.
- GC32816 Estramustine phosphate sodium A derivative of estradiol that destabilizes microtubules
- GC52061 Ethylene Glycol monododecyl ether A nonionic surfactant
- GC10196 ETP-46464 ATR inhibitor,potent and selective
- GC18693 Fascaplysin (chloride) Fascaplysin (chloride) is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysin (chloride)opsis sp.
- GC13869 Fasudil Calcium antagonist
- GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil (HA-1077) HCl is also a potent Ca2+ channel antagonist and vasodilator.
- GC12319 Ferulenol antimycobacterial activity and stimulates tubulin polymerization
- GC43666 Fingolimod Fingolimod is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb I.
- GC14807 Fingolimod(FTY720) Fingolimod (FTY720) HCl (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator.
- GC49344 Fisetin-d5 An internal standard for the quantification of fisetin
- GC49695 FKBP52 Monoclonal Antibody (Clone Hi52C) For immunochemical analysis of FKBP52
- GC43674 FlAsH-EDT2 A fluorescent probe that tags proteins in cells
- GC16063 Flavopiridol An inhibitor of cyclin-dependent kinases
- GC16425 Flavopiridol hydrochloride CDK inhibitor, potent and selective
- GC13210 Flubendazole Autophagy activator
- GC16727 Flutax 1 A fluorescent taxol derivative used for direct imaging of the microtubule cytoskeleton
- GC50397 Flutax 2 Green fluorescent taxol derivative; binds microtubules
- GC66242 Flutax-2 (5/6-mixture) Flutax-2 (5/6-mixture) is an active fluorescent derivative of Taxol. Flutax-2 (5/6-mixture) binds to polymerized α,β-tubulin dimers. Flutax-2 (5/6-mixture) is able to stabilize microtubules of intact T. gallinae and T. foetus trophozoites.
- GC63596 Fmoc-MMAE Fmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Fmoc-MMAE can be used in the synthesis of ADC.
- GC12308 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium is the Combretastatin A4 prodrug that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis.
- GC49089 FR900359 A cyclic depsipeptide and an inhibitor of Gαq, Gα11, and Gα14<•sub>
- GC10251 FRAX1036 p21-activated kinase I (PAK1) inhibitor
- GC16075 FRAX486 p21-activated kinase (PAK) inhibitor
- GC12261 FRAX597 PAK inhibitor,potent and ATP-competitive
- GC52288 Fumonisin B1-13C34 An internal standard for the quantification of fumonisin B1
- GC47378 Fumonisin B2-13C34 An internal standard for the quantification of fumonisin B2
- GC18720 G-5555 G-5555 is an inhibitor of p21-activated kinase 1 (PAK1; Ki = 3.7 nM), a non-receptor serine/threonine kinase involved in tumorigenesis.
- GC36095 G-5555 hydrochloride G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.
- GC40016 Ganglioside GM2 Mixture (sodium salt) Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane.
- GC43732 Ganglioside GM3 Mixture (sodium salt) Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.
- GC49322 GGACK (hydrochloride) A uPA and factor Xa inhibitor
- GC38783 Ginkgolic acid C17:1 Ginkgolic acid C17:1, extracted from Ginkgo biloba Leaves, suppresses constitutive and inducible STAT3 activation through induction of PTEN and SHP-1 tyrosine phosphatase. Ginkgolic acid C17:1 has anticancer effects.
- GC49437 Gliotoxin-13C13 An internal standard for the quantification of gliotoxin
- GC41563 Globosuxanthone A Globosuxanthone A is a fungal metabolite originally isolated from C.
- GC45668 Gly-Arg-AMC (hydrochloride) A fluorogenic substrate for cathepsin C
- GC49687 Goralatide (acetate) A tetrapeptide regulator of hematopoiesis
- GC48720 Griseofulvic Acid A metabolite of griseofulvin
- GC13484 Griseofulvin Microtubule associated inhibitor
- GC48688 Griseofulvin-d3 An internal standard for the quantification of griseofulvin
- GC49744 GRP94 Monoclonal Antibody (Clone 9G10) For immunochemical detection of GRP94
- GC38791 GSK-25 GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM).
- GC15659 GSK-923295 An inhibitor of CENP-E
- GC19177 GSK180736A GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 uM.
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GC17450
GSK2606414
A selective PERK inhibitor
- GC11068 GSK2656157 PERK inhibitor
- GC17936 GSK269962A ROCK inhibitor
- GC25482 GSK269962A HCl GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
- GC18119 GSK429286A Selective ROCK1/ROCK2 inhibitor
- GC12335 GSK461364 Plk1 inhibitor
- GC49280 GSK579289A A Plk1 inhibitor
- GC60891 GW406108X GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK.
- GC11621 GW843682X A reversible polo-like kinase inhibitor
- GC16545 GX-674 Nav1.7 antagonist
- GC36207 H-1152 H-1152 is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
- GC36208 H-1152 dihydrochloride H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.