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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Targets for  Cell Cycle/Checkpoint

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GC43546 Dnp-PLALWAR (trifluoroacetate salt) Dnp-PLALWAR is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-8. Dnp-PLALWAR (trifluoroacetate salt)  Chemical Structure
  3. GC43547 Dnp-PLAYWAR (trifluoroacetate salt) Dnp-PLAYWAR is a fluorogenic substrate for matrix metalloproteinase-8 (MMP-8) and MMP-26. Dnp-PLAYWAR (trifluoroacetate salt)  Chemical Structure
  4. GC43550 Dnp-PLGMWSR (trifluoroacetate salt) Dnp-PLGMWSR is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-9. Dnp-PLGMWSR (trifluoroacetate salt)  Chemical Structure
  5. GC43552 Dnp-RPLALWRS (trifluoroacetate salt) Dnp-RPLALWRS is a fluorogenic substrate for matrix metalloproteinase-7 (MMP-7). Dnp-RPLALWRS (trifluoroacetate salt)  Chemical Structure
  6. GC16684 Docetaxel

    Docetaxel is a taxane class of anti-mitotic chemotherapeutic agents with an IC50 of 0.2 µM.

    Docetaxel  Chemical Structure
  7. GC48968 Docetaxel (hydrate)

    An analog of taxol with antitumor properties

    Docetaxel (hydrate)  Chemical Structure
  8. GC12550 Docetaxel Trihydrate Docetaxel Trihydrate  Chemical Structure
  9. GC47250 Docetaxel-d9

    An internal standard for the quantification of docetaxel

    Docetaxel-d9  Chemical Structure
  10. GC52095 Dodecyltrimethylammonium (bromide) A cationic surfactant Dodecyltrimethylammonium (bromide)  Chemical Structure
  11. GC16273 Dolastatin 10 Antitumor agent Dolastatin 10  Chemical Structure
  12. GC10557 Dolastatin 10 trifluoroacetate Antitumor agent Dolastatin 10 trifluoroacetate  Chemical Structure
  13. GA21397 Dolastatin 15 Dolastatin 15 originally isolated from the sea hare Dolabella auricularia belongs to a family of antimitotic and antineoplastic depsipeptides inducing apoptosis in various malignant cell types. It was shown to inhibit the growth of the P388 lymphocytic leukemia cell line efficiently, with an ED?? value of 2.4 ng/mL. Dolastatin 15  Chemical Structure
  14. GC43567 DPC-AJ1951 (trifluoroacetate salt) DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). DPC-AJ1951 (trifluoroacetate salt)  Chemical Structure
  15. GC64927 Drp1-IN-1 Drp1-IN-1 (comp A-7) is a dynamin-1-like protein (Drp1) inhibitor, with an IC50 of 0.91 μM. Drp1-IN-1  Chemical Structure
  16. GC50020 Dynamin inhibitory peptide, myristoylated Cell-permeable dynamin inhibitor Dynamin inhibitory peptide, myristoylated  Chemical Structure
  17. GC10395 Dynasore

    Dynasore, as a GTPase inhibitor, can rapidly and reversibly inhibit dynamin activity, which prevents endocytosis.

    Dynasore  Chemical Structure
  18. GC17208 Dyngo-4a Hydroxy Dynasore (Dyngo-4a), a structural analog of Dynasore, is an potency improved, low cytotoxicity and non‐specific binding dynamin inhibitor with IC50values of 0.38 μM and 2.3μM for brain dynamin I and recombinant rat dynamin II, respectively. Dyngo-4a  Chemical Structure
  19. GC66056 Dynole 2-24 Dynole 2-24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2-24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2-24 also shows 4.4-fold selectivity for dynamin I. Dynole 2-24 is active in-cell inhibitor of clathrin-mediated endocytosis. CME: Clathrin mediated endocytosis Dynole 2-24  Chemical Structure
  20. GC47279 Echinosporin A bacterial metabolite with antibacterial and anticancer activities Echinosporin  Chemical Structure
  21. GC35964 Eg5 Inhibitor V, trans-24 Eg5 Inhibitor V, trans-24 is a potent and specific kinesin Eg5 inhibitor with an IC50 of 0.65 μM, and can be used in the research of cancer. Eg5 Inhibitor V, trans-24  Chemical Structure
  22. GC10681 Eg5-I potent inhibitor of Eg5 Eg5-I  Chemical Structure
  23. GC43588 EGA EGA is an inhibitor of endosomal trafficking. EGA  Chemical Structure
  24. GC10030 EHop-016 Rac1/Rac3 GTPase inhibitor,potent and specific EHop-016  Chemical Structure
  25. GC25372 Elimusertib (BAY-1895344) hydrochloride Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM. Elimusertib (BAY-1895344) hydrochloride  Chemical Structure
  26. GC16827 ELR510444 Novel microtubule disruptor ELR510444  Chemical Structure
  27. GC19466 Eltanexor (KPT-8602) A second-generation exportin-1 inhibitor Eltanexor (KPT-8602)   Chemical Structure
  28. GC19213 Eltanexor Z-isomer KPT-8602 Z-isomer is the less active isomer of KPT-8602. Eltanexor Z-isomer  Chemical Structure
  29. GC18165 EMD534085

    Inhibitor of the mitotic kinesin-5

    EMD534085  Chemical Structure
  30. GC34073 Empesertib (BAY 1161909) Empesertib (BAY 1161909) (BAY 1161909) is a potent Mps1 inhibitor, with an IC50 of < 1 nM. Empesertib (BAY 1161909)  Chemical Structure
  31. GC49124 EN219 EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination. EN219  Chemical Structure
  32. GC62287 EN4 EN4 is a covalent ligand that targets cysteine 171 (C171) of MYC. EN4 is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis. EN4  Chemical Structure
  33. GC19010 Endosidin 2

    A cell-permeable inhibitor of exocytosis and endosomal recycling

    Endosidin 2  Chemical Structure
  34. GC43605 Endosulfan II Endosulfan II is an organochlorine insecticide and a stereoisomer of endosulfan I. Endosulfan II  Chemical Structure
  35. GC47291 Endothall An herbicide Endothall  Chemical Structure
  36. GC33125 Entasobulin Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity. Entasobulin  Chemical Structure
  37. GC43614 Enteropeptidase Fluorogenic Substrate Enteropeptidase fluorogenic substrate is a substrate for enteropeptidase that contains a 7-amino-4-trifluoromethylcoumarin (AFC) moiety. Enteropeptidase Fluorogenic Substrate  Chemical Structure
  38. GC48995 Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt) A fluorogenic substrate of enteropeptidase Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt)  Chemical Structure
  39. GC11202 Epothilone A Microtubule stabilizing macrolide Epothilone A  Chemical Structure
  40. GC17240 Epothilone B (EPO906, Patupilone) Epothilone B (EPO906, Patupilone) is a microtubule stabilizer with a Ki of 0.71μM. Epothilone B (EPO906, Patupilone)  Chemical Structure
  41. GC17440 Epothilone D A microtubule-stabilizing agent Epothilone D  Chemical Structure
  42. GC14354 Eribulin synthetic analogue of halichondrin B Eribulin  Chemical Structure
  43. GC12483 Eribulin mesylate synthetic analogue of halichondrin B Eribulin mesylate  Chemical Structure
  44. GC63845 Eribulin-d3 mesylate Eribulin-d3 mesylate is a deuterium labeled Eribulin mesylate. Eribulin mesylate is a microtubule targeting agent that is used for the research of cancer. Eribulin-d3 mesylate  Chemical Structure
  45. GC43625 Erucin

    Erucin is an isothiocyanate derived from glucoerucin, a glucosinolate predominant in arugula (Eruca sativa Mill.) and other cruciferous vegetables.

    Erucin  Chemical Structure
  46. GC67333 Estramustine Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts. Estramustine  Chemical Structure
  47. GC32816 Estramustine phosphate sodium A derivative of estradiol that destabilizes microtubules Estramustine phosphate sodium  Chemical Structure
  48. GC52061 Ethylene Glycol monododecyl ether A nonionic surfactant Ethylene Glycol monododecyl ether  Chemical Structure
  49. GC10196 ETP-46464 ATR inhibitor,potent and selective ETP-46464  Chemical Structure
  50. GC18693 Fascaplysin (chloride) Fascaplysin (chloride) is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysin (chloride)opsis sp. Fascaplysin (chloride)  Chemical Structure
  51. GC13869 Fasudil Calcium antagonist Fasudil  Chemical Structure
  52. GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil (HA-1077) HCl is also a potent Ca2+ channel antagonist and vasodilator. Fasudil (HA-1077) HCl  Chemical Structure
  53. GC12319 Ferulenol antimycobacterial activity and stimulates tubulin polymerization Ferulenol  Chemical Structure
  54. GC43666 Fingolimod Fingolimod is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb I. Fingolimod  Chemical Structure
  55. GC14807 Fingolimod(FTY720) Fingolimod (FTY720) HCl (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator. Fingolimod(FTY720)  Chemical Structure
  56. GC49344 Fisetin-d5 An internal standard for the quantification of fisetin Fisetin-d5  Chemical Structure
  57. GC49695 FKBP52 Monoclonal Antibody (Clone Hi52C) For immunochemical analysis of FKBP52 FKBP52 Monoclonal Antibody (Clone Hi52C)  Chemical Structure
  58. GC43674 FlAsH-EDT2 A fluorescent probe that tags proteins in cells FlAsH-EDT2  Chemical Structure
  59. GC16063 Flavopiridol An inhibitor of cyclin-dependent kinases Flavopiridol  Chemical Structure
  60. GC16425 Flavopiridol hydrochloride CDK inhibitor, potent and selective Flavopiridol hydrochloride  Chemical Structure
  61. GC13210 Flubendazole Autophagy activator Flubendazole  Chemical Structure
  62. GC16727 Flutax 1 A fluorescent taxol derivative used for direct imaging of the microtubule cytoskeleton Flutax 1  Chemical Structure
  63. GC50397 Flutax 2 Green fluorescent taxol derivative; binds microtubules Flutax 2  Chemical Structure
  64. GC66242 Flutax-2 (5/6-mixture) Flutax-2 (5/6-mixture) is an active fluorescent derivative of Taxol. Flutax-2 (5/6-mixture) binds to polymerized α,β-tubulin dimers. Flutax-2 (5/6-mixture) is able to stabilize microtubules of intact T. gallinae and T. foetus trophozoites. Flutax-2 (5/6-mixture)  Chemical Structure
  65. GC63596 Fmoc-MMAE Fmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Fmoc-MMAE can be used in the synthesis of ADC. Fmoc-MMAE  Chemical Structure
  66. GC12308 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium is the Combretastatin A4 prodrug that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis. Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium  Chemical Structure
  67. GC49089 FR900359 A cyclic depsipeptide and an inhibitor of Gαq, Gα11, and Gα14<•sub> FR900359  Chemical Structure
  68. GC10251 FRAX1036 p21-activated kinase I (PAK1) inhibitor FRAX1036  Chemical Structure
  69. GC16075 FRAX486 p21-activated kinase (PAK) inhibitor FRAX486  Chemical Structure
  70. GC12261 FRAX597 PAK inhibitor,potent and ATP-competitive FRAX597  Chemical Structure
  71. GC52288 Fumonisin B1-13C34 An internal standard for the quantification of fumonisin B1 Fumonisin B1-13C34  Chemical Structure
  72. GC47378 Fumonisin B2-13C34 An internal standard for the quantification of fumonisin B2 Fumonisin B2-13C34  Chemical Structure
  73. GC18720 G-5555 G-5555 is an inhibitor of p21-activated kinase 1 (PAK1; Ki = 3.7 nM), a non-receptor serine/threonine kinase involved in tumorigenesis. G-5555  Chemical Structure
  74. GC36095 G-5555 hydrochloride G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM. G-5555 hydrochloride  Chemical Structure
  75. GC40016 Ganglioside GM2 Mixture (sodium salt) Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane. Ganglioside GM2 Mixture (sodium salt)  Chemical Structure
  76. GC43732 Ganglioside GM3 Mixture (sodium salt) Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. Ganglioside GM3 Mixture (sodium salt)  Chemical Structure
  77. GC49322 GGACK (hydrochloride) A uPA and factor Xa inhibitor GGACK (hydrochloride)  Chemical Structure
  78. GC38783 Ginkgolic acid C17:1 Ginkgolic acid C17:1, extracted from Ginkgo biloba Leaves, suppresses constitutive and inducible STAT3 activation through induction of PTEN and SHP-1 tyrosine phosphatase. Ginkgolic acid C17:1 has anticancer effects. Ginkgolic acid C17:1  Chemical Structure
  79. GC49437 Gliotoxin-13C13 An internal standard for the quantification of gliotoxin Gliotoxin-13C13  Chemical Structure
  80. GC41563 Globosuxanthone A Globosuxanthone A is a fungal metabolite originally isolated from C. Globosuxanthone A  Chemical Structure
  81. GC45668 Gly-Arg-AMC (hydrochloride) A fluorogenic substrate for cathepsin C Gly-Arg-AMC (hydrochloride)  Chemical Structure
  82. GC49687 Goralatide (acetate) A tetrapeptide regulator of hematopoiesis Goralatide (acetate)  Chemical Structure
  83. GC48720 Griseofulvic Acid A metabolite of griseofulvin Griseofulvic Acid  Chemical Structure
  84. GC13484 Griseofulvin Microtubule associated inhibitor Griseofulvin  Chemical Structure
  85. GC48688 Griseofulvin-d3 An internal standard for the quantification of griseofulvin Griseofulvin-d3  Chemical Structure
  86. GC49744 GRP94 Monoclonal Antibody (Clone 9G10) For immunochemical detection of GRP94 GRP94 Monoclonal Antibody (Clone 9G10)  Chemical Structure
  87. GC38791 GSK-25 GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM). GSK-25  Chemical Structure
  88. GC15659 GSK-923295 An inhibitor of CENP-E GSK-923295  Chemical Structure
  89. GC19177 GSK180736A GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 uM. GSK180736A  Chemical Structure
  90. GC17450 GSK2606414

    A selective PERK inhibitor

    GSK2606414  Chemical Structure
  91. GC11068 GSK2656157 PERK inhibitor GSK2656157  Chemical Structure
  92. GC17936 GSK269962A ROCK inhibitor GSK269962A  Chemical Structure
  93. GC25482 GSK269962A HCl GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. GSK269962A HCl  Chemical Structure
  94. GC18119 GSK429286A Selective ROCK1/ROCK2 inhibitor GSK429286A  Chemical Structure
  95. GC12335 GSK461364 Plk1 inhibitor GSK461364  Chemical Structure
  96. GC49280 GSK579289A A Plk1 inhibitor GSK579289A  Chemical Structure
  97. GC60891 GW406108X GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK. GW406108X  Chemical Structure
  98. GC11621 GW843682X A reversible polo-like kinase inhibitor GW843682X  Chemical Structure
  99. GC16545 GX-674 Nav1.7 antagonist GX-674  Chemical Structure
  100. GC36207 H-1152 H-1152 is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2. H-1152  Chemical Structure
  101. GC36208 H-1152 dihydrochloride H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2. H-1152 dihydrochloride  Chemical Structure

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