Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> Arp2/3 Complex

Arp2/3 Complex

The intact ARP2/3 complex is first purified from Acanthamoeba castellanii based on its affinity for the actin-binding protein profilin, and is shown to consist of a stable assembly of seven polypeptides. Two of the subunits are actin-related proteins of the ARP2 and ARP3 subfamilies, giving the complex its name.

The ARP2/3 complex possesses little biochemical activity on its own. However, when engaged by nucleation-promoting factor (NPF) proteins, it is activated to initiate the formation of a new (daughter) filament that emerges from an existing (mother) filament in a y-branch configuration with a regular 70° branch angle. This coupling of nucleation and branching by the ARP2/3 complex is referred to as autocatalytic branching or dendritic nucleation, and is central to its functions in vivo.

Polymerization of actin filaments directed by the Arp2/3 complex supports many types of cellular movements.

Targets for  Arp2/3 Complex

Products for  Arp2/3 Complex

  1. Cat.No. Product Name Information
  2. GC61831 Benproperine phosphate Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate  Chemical Structure
  3. GC14060 CK 666 Arp2/3 complex inhibitor that inhibits actin polymerization CK 666  Chemical Structure
  4. GC15076 CK 869 actin-related protein 2/3 (Arp2/3) complex inhibitor CK 869  Chemical Structure
  5. GC15894 CK-636 Arp2/3 complex inhibitor CK-636  Chemical Structure
  6. GC32890 Cytochalasin B (Phomin)

    Cytochalasin B is a cyto-permeable mycotoxin, and it is isolated from an ascomycete fungus belonging to the Phoma genus[1-2].

    Cytochalasin B (Phomin)  Chemical Structure
  7. GC13440 Cytochalasin D

    An inhibitor of actin polymerization, selective

    Cytochalasin D  Chemical Structure
  8. GC43461 Dihydrocytochalasin B Dihydrocytochalasin B (DCB) is a member of the cytochalasin mycotoxin family that inhibits actin assembly. Dihydrocytochalasin B  Chemical Structure
  9. GC15671 Latrunculin A

    A reversible inhibitor of actin assembly

    Latrunculin A  Chemical Structure

8 Item(s)

per page

Set Descending Direction