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Dynamin

Dynamins are large superfamily GTPase proteins that are involved in various cellular processes including budding of transport vesicles, division of organelles, cytokinesis, and pathogen resistance. Dynamins are involved in scission (cleavage of the vesicle from the parent membrane) of nascent vesicles from parent membranes in eukaryotic cells. Dynamins interact directly with the lipid bilayer at the necks of clathrin-coated pits to sever and release coated vesicles. Dynamins contain five domains, including GTPase domain, middle domain, PH domain, GTPase effector domain (GED), and proline rich domain (PRD), while the dynamin-related proteins (DRPs) lack one or more of these domains or have additional domains. Dynamins and DRPs participate in a wide variety of cellular processes, including budding mitochondrial fission (mammalian Dlp1 and Saccharomyces cerevisiae Dnm1) and fusion (mammalian OPA1, S.cerevisiae Mgm1 and Schizosaccharomycespombe Msp1), vacuolar fission (S. cerevisiae Vps1), interferon-induced anti-viral protection (fish Mx proteins), plant cell cytokinesis and membrane fission (Arabidopsis thalianaDRP proteins), as well as pathogen resistance.

Targets for  Dynamin

Products for  Dynamin

  1. Cat.No. Product Name Information
  2. GC64927 Drp1-IN-1 Drp1-IN-1 (comp A-7) is a dynamin-1-like protein (Drp1) inhibitor, with an IC50 of 0.91 μM. Drp1-IN-1  Chemical Structure
  3. GC50020 Dynamin inhibitory peptide, myristoylated Cell-permeable dynamin inhibitor Dynamin inhibitory peptide, myristoylated  Chemical Structure
  4. GC10395 Dynasore

    Dynasore, as a GTPase inhibitor, can rapidly and reversibly inhibit dynamin activity, which prevents endocytosis.

    Dynasore  Chemical Structure
  5. GC17208 Dyngo-4a Hydroxy Dynasore (Dyngo-4a), a structural analog of Dynasore, is an potency improved, low cytotoxicity and non‐specific binding dynamin inhibitor with IC50values of 0.38 μM and 2.3μM for brain dynamin I and recombinant rat dynamin II, respectively. Dyngo-4a  Chemical Structure
  6. GC66056 Dynole 2-24 Dynole 2-24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2-24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2-24 also shows 4.4-fold selectivity for dynamin I. Dynole 2-24 is active in-cell inhibitor of clathrin-mediated endocytosis. CME: Clathrin mediated endocytosis Dynole 2-24  Chemical Structure
  7. GC50574 MB 0223 Dynamin-related GTPase DRP1 partial inhibitor MB 0223  Chemical Structure
  8. GC10200 Mdivi 1

    A mitochondrial division inhibitor

    Mdivi 1  Chemical Structure
  9. GC50599 P110 Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable P110  Chemical Structure
  10. GN10091 Schaftoside Schaftoside  Chemical Structure

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