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Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> PERK

PERK

PERK (doublestranded RNA-activated protein kinase-like ER kinase) is localized on endoplasmic reticulum membrane. It is associated with insulin processing and unfolded protein response etc.

Products for  PERK

  1. Cat.No. Product Name Information
  2. GC39156 AMG PERK 44 AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively. AMG PERK 44 induces autophagy. AMG PERK 44 Chemical Structure
  3. GC33006 CCT020312 CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 Chemical Structure
  4. GC17450 GSK2606414

    A selective PERK inhibitor

     GSK2606414 Chemical Structure
  5. GC11068 GSK2656157 PERK inhibitor GSK2656157 Chemical Structure
  6. GC10581 ISRIB PERK signaling inhibitor ISRIB Chemical Structure
  7. GC61072 MK-28 MK-28 is a potent and selective PERK activator. MK-28 Chemical Structure
  8. GC69687 PERK-IN-2

    PERK-IN-2 is a highly efficient PERK inhibitor with an IC50 value of 0.2 nM.

     PERK-IN-2 Chemical Structure
  9. GC64866 PERK-IN-5 PERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC50s of 2 and 9 nM for PERK and p-eIF2α, respectively). PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model. PERK-IN-5 Chemical Structure
  10. GC69688 PERK-IN-6

    PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM.

     PERK-IN-6 Chemical Structure

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