RAD51
RAD51 is a protein that contributed to homologous recombination and DSB (DNA double-strand break) repair in the DNA damage response pathway. It is associated with genome instablility and tumorgenesis.
Products for RAD51
- Cat.No. Product Name Information
- GC16391 Amuvatinib (MP-470, HPK 56) A multi-targeted RTK inhibitor
- GC33362 Amuvatinib hydrochloride (MP470 hydrochloride) Amuvatinib hydrochloride (MP470 hydrochloride) (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib hydrochloride (MP470 hydrochloride) (MP470 hydrochloride) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair. Antineoplastic activity.
- GC62128 Bractoppin Bractoppin is a inhibitor of phosphopeptide recognition by the human BRCA1 tBRCT domain with IC50 of 74 nM.
- GC65935 CAM833 CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization.
- GC32912 IBR2 IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis.
- GC19306 RAD51 Inhibitor B02 RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 uM.
- GC63165 RAD51-IN-1 RAD51-IN-1, a derivative of ?B02, is a potent inhibitor of RAD51. RAD51-IN-1 can be used for cancer research.
- GC65383 RAD51-IN-2 RAD51-IN-2 (compound example 67A) is a RAD51 inhibitor extracted from patent WO2019/051465A1.
- GC68416 RAD51-IN-3
- GC67888 RAD51-IN-5
- GC18140 RI-1 A RAD51 inhibitor
- GC12752 RI-2 Optimized reversible RAD51 inhibitor
- GC16265 RS-1 RAD51 activator