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Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> Wee1

Wee1

Wee1 is a tyrosine kinase nuclear protein that catalyzes tyrosine phosphorylation of CDC2/Cyclin B kinase. It negatively regulates the entry to mitosis by protecting nucleus from cytoplasmically activated CDC2 kinase.

Products for  Wee1

  1. Cat.No. Product Name Information
  2. GC16030 MK-1775 MK-1775 (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC50 of 5.2 nM. MK-1775 Chemical Structure
  3. GC50045 PD 166285 dihydrochloride PD 166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD 166285 dihydrochloride exhibits an IC50 of 3.433 μM for Chk1. PD 166285 dihydrochloride Chemical Structure
  4. GC38216 PD 407824 PD 407824 Chemical Structure
  5. GC32853 PD0166285 PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 exhibits an IC50 of 3.433 μM for Chk1. PD0166285 Chemical Structure
  6. GC62449 WEE1-IN-3 WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. WEE1-IN-3 has anticancer activities. WEE1-IN-3 Chemical Structure
  7. GC65994 WEE1-IN-5 WEE1-IN-5 is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer. WEE1-IN-5 Chemical Structure
  8. GC62697 ZN-c3 ZN-c3 Chemical Structure

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