Home >> Signaling Pathways >> DNA Damage/DNA Repair

DNA Damage/DNA Repair

Products for  DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. GC30782 ACY-775 An HDAC6 inhibitor ACY-775  Chemical Structure
  3. GC30526 ACY-957 ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957  Chemical Structure
  4. GC17186 Acyclovir Antiviral agent Acyclovir  Chemical Structure
  5. GC13432 Adenine High affinity adenine receptor agonist Adenine  Chemical Structure
  6. GC11825 Adenine HCl Adenine HCl (6-Aminopurine hydrochloride), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine HCl acts as a chemical component of DNA and RNA. Adenine HCl also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis. Adenine HCl  Chemical Structure
  7. GC17278 Adenine sulfate Adenine sulfate (6-Aminopurine hemisulfate), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine sulfate acts as a chemical component of DNA and RNA. Adenine sulfate also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis. Adenine sulfate  Chemical Structure
  8. GC67946 Adenine-d1 Adenine-d1  Chemical Structure
  9. GC14106 Adenosine nucleoside Adenosine  Chemical Structure
  10. GC49004 Adenosine 3’-monophosphate (sodium salt hydrate) A nucleotide Adenosine 3’-monophosphate (sodium salt hydrate)  Chemical Structure
  11. GC42732 Adenosine 3',5'-diphosphate (sodium salt) Adenosine 3',5'-diphosphate (sodium salt) is an hydroxysteroid sulfotransferases inhibitor. Adenosine 3',5'-diphosphate (sodium salt)  Chemical Structure
  12. GC65462 Adenosine 5′-monophosphoramidate sodium Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis. Adenosine 5′-monophosphoramidate sodium  Chemical Structure
  13. GC49285 Adenosine 5’-methylenediphosphate (hydrate) An inhibitor of ecto-5’-nucleotidase Adenosine 5’-methylenediphosphate (hydrate)  Chemical Structure
  14. GC42733 Adenosine 5'-monophosphate (sodium salt hydrate) Adenosine 5'-monophosphate (AMP) is a central nucleotide with functions in metabolism and cell signaling. Adenosine 5'-monophosphate (sodium salt hydrate)  Chemical Structure
  15. GC42734 Adenosine 5'-phosphosulfate (sodium salt) Adenosine 5'-phosphosulfate is an ATP and sulfate competitive inhibitor of ATP sulfurylase in humans, S. Adenosine 5'-phosphosulfate (sodium salt)  Chemical Structure
  16. GC49231 Adenylosuccinic Acid (ammonium salt) A purine nucleotide and an intermediate in the purine nucleotide cycle Adenylosuccinic Acid (ammonium salt)  Chemical Structure
  17. GC65330 AES-135 AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM. AES-135  Chemical Structure
  18. GC46810 Aflatoxin B1-13C17 An internal standard for the quantification of aflatoxin B1 Aflatoxin B1-13C17  Chemical Structure
  19. GC62470 AG-636 AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects. AG-636  Chemical Structure
  20. GC42765 Aldehyde Reactive Probe (trifluoroacetate salt) DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (trifluoroacetate salt)  Chemical Structure
  21. GC14858 Aldoxorubicin An albumin-binding prodrug of doxorubicin Aldoxorubicin  Chemical Structure
  22. GC15841 Alsterpaullone CDKs and GSK3β inhibitor Alsterpaullone  Chemical Structure
  23. GC67984 Alteminostat Alteminostat  Chemical Structure
  24. GC10779 Alternariol

    A mycotoxin with antifungal and phytotoxic activity

    Alternariol  Chemical Structure
  25. GC18437 Alternariol monomethyl ether Alternariol monomethyl ether, isolated from the roots of Anthocleista djalonensis (Loganiaceae), is an important taxonomic marker of the plant species. Alternariol monomethyl ether  Chemical Structure
  26. GC49039 Althiomycin A thiazole antibiotic Althiomycin  Chemical Structure
  27. GC14564 Altretamine Antineoplastic agent Altretamine  Chemical Structure
  28. GC35310 Altretamine hydrochloride Altretamine hydrochloride is an alkylating antineoplastic agent. Altretamine hydrochloride  Chemical Structure
  29. GC64638 ALV1 ALV1 is a potent Ikaros and Helios degrader. ALV1  Chemical Structure
  30. GC64818 AMA-37 AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively. AMA-37  Chemical Structure
  31. GC42783 Ametantrone Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break. Ametantrone  Chemical Structure
  32. GC50366 AMG 18 hydrochloride AMG 18 hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM. AMG 18 hydrochloride  Chemical Structure
  33. GC14899 AMG 548

    P38α inhibitor,potent and selective

    AMG 548  Chemical Structure
  34. GC14974 AMG 925 FLT3/CDK4 inhibitor,potent and selective AMG 925  Chemical Structure
  35. GC35315 AMG 925 HCl AMG 925 HCl is a potent, selective, and orally available FLT3/CDK4 dual inhibitor with IC50s of 2±1 nM and 3±1 nM, respectively. AMG 925 HCl  Chemical Structure
  36. GC38518 AMG-548 dihydrochloride AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride  Chemical Structure
  37. GC42789 Aminopterin Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis. Aminopterin  Chemical Structure
  38. GC11019 Amonafide DNA intercalator,Topo II inhibitor Amonafide  Chemical Structure
  39. GC15644 Amrubicin A synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II. Antineoplastic. Amrubicin  Chemical Structure
  40. GC12326 Amsacrine Topoisomerase 2 inhibitor Amsacrine  Chemical Structure
  41. GC11747 Amsacrine hydrochloride Topoisomerase 2 inhibitor Amsacrine hydrochloride  Chemical Structure
  42. GC39284 ANI-7 ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines. ANI-7  Chemical Structure
  43. GC11559 Anisomycin

    JNK agonist, potent and specific

    Anisomycin  Chemical Structure
  44. GC68667 Anticancer agent 73

    Anticancer agent 73 (compound CIB-3b) is an anticancer drug that targets TAR RNA binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 has inhibitory effects on the proliferation and metastasis of hepatocellular carcinoma (HCC) cells both in vitro and in vivo.

    Anticancer agent 73  Chemical Structure
  45. GC40032 Antipain (hydrochloride) Antipain (hydrochloride) is a protease inhibitor isolated from Actinomycetes. Antipain (hydrochloride)  Chemical Structure
  46. GC68448 AOH1160 AOH1160  Chemical Structure
  47. GC67876 APE1-IN-1 APE1-IN-1  Chemical Structure
  48. GC17139 APY29 IRE1α inhibitor APY29  Chemical Structure
  49. GC45385 Ara-G   Ara-G  Chemical Structure
  50. GC62425 ARN-21934 ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etoposide (IC50=120 μM). ARN-21934 exhibits a favorable in vivo pharmacokinetic profile and is a promising lead compound for anticancer research. ARN-21934  Chemical Structure
  51. GC46880 ARN24139 A topoisomerase II poison ARN24139  Chemical Structure
  52. GC38736 AS2863619 A dual inhibitor of Cdk8 and Cdk19 AS2863619  Chemical Structure
  53. GC38737 AS2863619 free base AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base  Chemical Structure
  54. GC38463 ASLAN003 ASLAN003 (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. ASLAN003 inhibits protein synthesis via activation of AP-1 transcription factors. ASLAN003 induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice. ASLAN003  Chemical Structure
  55. GC61821 AT-130 AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130  Chemical Structure
  56. GC15870 AT7519 Multi-CDK inhibitor AT7519  Chemical Structure
  57. GC13998 AT7519 Hydrochloride A Cdk inhibitor AT7519 Hydrochloride  Chemical Structure
  58. GC15597 AT7519 trifluoroacetate AT7519 trifluoroacetate  Chemical Structure
  59. GC65327 ATM Inhibitor-5 ATM Inhibitor-5 [formula (1)] is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1). ATM Inhibitor-5  Chemical Structure
  60. GC65514 ATR inhibitor 1 ATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a Ki value below 1 ?Μ. ATR inhibitor 1  Chemical Structure
  61. GC68707 ATR-IN-4

    ATR-IN-4 is an effective ATR inhibitor. ATR-IN-4 inhibits the growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460, with IC50 values of 130.9 nM and 41.33 nM, respectively (excerpted from patent CN112142744A, compound 13).

    ATR-IN-4  Chemical Structure
  62. GC34422 Atuveciclib (BAY-1143572) Atuveciclib (BAY-1143572)  Chemical Structure
  63. GC34059 Atuveciclib Racemate (BAY-1143572 Racemate) Atuveciclib Racemate (BAY-1143572 Racemate) (BAY-1143572 Racemate) is the racemate mixture of Atuveciclib. Atuveciclib is a potent and highly selective, oral P-TEFb/CDK9 inhibitor which supresses CDK9/CycT1 with an IC50 of 13 nM. Atuveciclib Racemate (BAY-1143572 Racemate)  Chemical Structure
  64. GC34421 Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer)  Chemical Structure
  65. GC39699 Aurintricarboxylic acid Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid  Chemical Structure
  66. GC46895 Aurintricarboxylic Acid (ammonium salt) A protein synthesis inhibitor with diverse biological activities Aurintricarboxylic Acid (ammonium salt)  Chemical Structure
  67. GC40005 Aurodox

    Aurodox is a polyketide antibiotic originally isolated from S.

    Aurodox  Chemical Structure
  68. GC60062 AV-153 free base AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity. AV-153 free base  Chemical Structure
  69. GC67960 AVG-233 AVG-233  Chemical Structure
  70. GC63449 Avotaciclib Avotaciclib (BEY1107) is a potent and orally active inhibitor of cyclin dependent kinase 1 (CDK1). Avotaciclib can be used for the research of locally advanced or metastatic pancreatic cancer. Avotaciclib  Chemical Structure
  71. GC50424 AZ 5704 Potent and selective ATM kinase inhibitor; orally bioavailable AZ 5704  Chemical Structure
  72. GC14949 AZ20 A potent, selective ATR inhibitor AZ20  Chemical Structure
  73. GC19047 AZ32 AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 uM for ATM in cell. AZ32  Chemical Structure
  74. GC65899 AZ3391 AZ3391 is a potent inhibitor of PARP. AZ3391 is a quinoxaline derivative. PARP family of enzymes play an important role in a number of cellular processes, such as replication, recombination, chromatin remodeling, and DNA damage repair. AZ3391 has the potential for the research of diseases and conditions occurring in tissues in the central nervous system, such as the brain and spinal cord (extracted from patent WO2021260092A1, compound 23). AZ3391  Chemical Structure
  75. GC16725 AZ6102 TNKS1/2 inhibitor AZ6102  Chemical Structure
  76. GC46900 AZ9482 A PARP inhibitor AZ9482  Chemical Structure
  77. GC11843 Azaguanine-8 Azaguanine-8 is a purine analogue that shows antineoplastic activity. Azaguanine-8 functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth. Azaguanine-8  Chemical Structure
  78. GC15033 Azathioprine purine synthesis and GTP-binding protein Rac1 activation inhibitor Azathioprine  Chemical Structure
  79. GC50119 AZD 7762 hydrochloride Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing AZD 7762 hydrochloride  Chemical Structure
  80. GC12438 AZD-5438 Potent CDK1/2/9 inhibitor AZD-5438  Chemical Structure
  81. GC64938 AZD-7648 AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity. AZD-7648  Chemical Structure
  82. GC11593 AZD0156 ATM kinase inhibitor AZD0156  Chemical Structure
  83. GC19468 AZD1390

    AZD1390 is a potent and selective ATM inhibitor

    AZD1390  Chemical Structure
  84. GC32717 AZD4573 AZD4573 is a potent and highly selective CDK9 inhibitor (IC50 of <4 nM) that enables transient target engagement for the treatment of hematologic malignancies. AZD4573  Chemical Structure
  85. GC16941 AZD6738 AZD6738 (AZD6738) is an orally active and bioavailable inhibitor of ATR kinase with an IC50 of 1 nM. AZD6738  Chemical Structure
  86. GC10546 AZD7762 Checkpoint kinase inhibitor,ATP competitive AZD7762  Chemical Structure
  87. GC60616 AZT triphosphate AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate  Chemical Structure
  88. GC60617 AZT triphosphate TEA AZT triphosphate TEA (3'-Azido-3'-deoxythymidine-5'-triphosphate TEA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TEA  Chemical Structure
  89. GC33406 B I09 B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM. B I09  Chemical Structure
  90. GC33240 Banoxantrone D12 (AQ4N D12) Banoxantrone D12 (AQ4N D12) is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Banoxantrone D12 (AQ4N D12)  Chemical Structure
  91. GC34169 Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride) Banoxantrone-d12 (AQ4N-d12) dihydrochloride is the deuterium labeled Banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride)  Chemical Structure
  92. GC34085 Banoxantrone dihydrochloride (AQ4N dihydrochloride) Banoxantrone dihydrochloride (AQ4N dihydrochloride) is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Banoxantrone dihydrochloride (AQ4N dihydrochloride)  Chemical Structure
  93. GC13035 Bay 11-7821

    A selective and irreversible NF-κB inhibitor

    Bay 11-7821  Chemical Structure
  94. GC50656 BAY 707 BAY 707 is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. BAY 707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy. BAY 707  Chemical Structure
  95. GC33420 BAY-1895344 BAY-1895344 (BAY-1895344) is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM. BAY-1895344 has anti-tumor activity. BAY-1895344 can be used for the research of solid tumors and lymphomas. BAY-1895344  Chemical Structure
  96. GC34374 BAY-1895344 hydrochloride An ATR inhibitor BAY-1895344 hydrochloride  Chemical Structure
  97. GC32838 BAY-2402234 A DHODH inhibitor BAY-2402234  Chemical Structure
  98. GC63763 BAY-8400 BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM). BAY-8400 can be used for the research of cancer. BAY-8400  Chemical Structure
  99. GC65259 BC-1471 BC-1471 is a STAM-binding protein (STAMBP) deubiquitinase inhibitor. BC-1471  Chemical Structure
  100. GC50572 BC-LI-0186 Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor BC-LI-0186  Chemical Structure
  101. GC62863 BCH001 BCH001, a quinoline derivative, is a specific PAPD5 inhibitor. BCH001  Chemical Structure

Items 201 to 300 of 1356 total

per page
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction