Nucleoside Antimetabolite/Analogue
Nucleoside analouges belong to the fmalily of antimetablits that resemble the neleosieds for uptake and metaolism that inibitr dna sytnse and couase cain termination. It is a durg target for cacner and viral infcations.
Products for Nucleoside Antimetabolite/Analogue
- Cat.No. Product Name Information
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GC69793
(R)-5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose
(R)-5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity and target inert lymphoid malignancies. The anticancer mechanism in this process depends on inhibiting DNA synthesis, inducing apoptosis (cell death), etc.
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GC68484
1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose
1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity and target malignant tumors in the inert lymphatic system. The anticancer mechanism in this process depends on inhibiting DNA synthesis, inducing apoptosis (cell death), etc.
- GC65551 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.
- GC65038 1-Methylinosine 1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA.
- GC65489 2'-F-Bz-dC Phosphoramidite 2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotides.
- GC66651 2'-O,4'-C-Methyleneadenosine 2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog.
- GC66654 2'-O,4'-C-Methylenecytidine 2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands.
- GC66655 2'-O,4'-C-Methyleneguanosine 2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand.
- GC65170 2′,3′-Di-O-acetylguanosine 2′,3′-Di-O-acetylguanosine is a nucleoside analog.
- GC67384 2′-Deoxy-β-L-uridine 2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase.
- GC61667 2′-Deoxy-2′-fluoroadenosine 2′-Deoxy-2′-fluoroadenosine can be used for thesynthesisof 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP.
- GC62530 2’-O-Me-C(Bz) Phosphoramidite 2’-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
- GC62529 2’-OMe-A(Bz) Phosphoramidite 2’-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
- GC62531 2’-OMe-G(ibu) Phosphoramidite 2’-OMe-G(ibu) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
- GC48440 2'-Deoxycytidine-5'-triphosphate (sodium salt) 2'-Deoxycytidine-5'-triphosphate (sodium salt) (dCTP trisodium salt) is a nucleoside triphosphate that can be used for DNA synthesis.
- GC33430 2'-Deoxypseudoisocytidine 2'-Deoxypseudoisocytidine is a nucleoside analogue.
- GC35072 2'-O,4'-C-Methyleneuridine 2'-O,4'-C-Methyleneuridine (Compound 15a) is a bicyclic nucleoside.
- GC64983 2-Amino-2'-deoxyadenosine 2-Amino-2'-deoxyadenosine is a deoxyribonucleoside used for the oligonucleotide synthesis.
- GC65083 3'-Azido-3'-deoxy-5-fluorocytidine 3'-Azido-3'-deoxy-5-fluorocytidine (Compound 12) is a cytidine derivative.
- GC64985 3'-O-Methylguanosine 3'-O-Methylguanosine is a methylated nucleoside analogs and a RNA chain terminator.
- GC35105 3'-Azido-3'-deoxy-beta-L-uridine 3'-Azido-3'-deoxy-beta-L-uridine (Compound 25) is a nucleoside derivative.
- GC60023 3'-Deoxyuridine-5'-triphosphate 3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II.
- GC61862 3'-Deoxyuridine-5'-triphosphate trisodium 3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II.
- GC65084 3-Methylcytidine 3-Methylcytidine, a urinary nucleoside, can be used as a biomarker of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.
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GC68557
4-Thio-2'-deoxyuridine
4-Thio-2'-deoxyuridine is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity, targeting inert lymphatic system malignancies. The anticancer mechanism in this process depends on inhibiting DNA synthesis and inducing cell apoptosis.
- GC42474 4-Thiouridine 4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling.
- GC65520 5'-DMT-3'-TBDMS-ibu-rG 5'-DMT-3'-TBDMS-ibu-rG is is a modified nucleoside.
- GC65402 5'-O-DMT-2'-O-TBDMS-Bz-rC 5'-O-DMT-2'-O-TBDMS-Bz-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
- GC65164 5'-O-DMT-2'-O-TBDMS-rI 5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside.
- GC65396 5'-O-DMT-ibu-dC 5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.
- GC64982 5'-O-DMT-N2-DMF-dG 5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside.
- GC65482 5'-O-DMT-N6-ibu-dA 5'-O-DMT-N6-ibu-dA can be used in the synthesis of oligodeoxyribonucleotides.
- GC65562 5'-O-DMT-N6-Me-2'-dA 5'-O-DMT-N6-Me-2'-dA is a nucleoside with protective and modification effects.
- GC65401 5'-O-TBDMS-dU 5'-O-TBDMS-dU can be used in the synthesis of oligoribonucleotides.
- GC62157 5’-O-DMT-2’-O-TBDMS-Ac-rC 5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
- GC62149 5’-O-DMT-2’-TBDMS-Uridine 5’-O-DMT-2’-TBDMS-Uridine is a deoxyribonucleoside used for the oligonucleotide synthesis.
- GC62532 5’-O-DMT-3’-O-TBDMS-Ac-rC 5’-O-DMT-3’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
- GC62573 5’-O-DMT-Bz-rC 5'-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.
- GC62574 5’-O-DMT-N4-Ac-2’-F-dC 5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.
- GC62575 5’-O-DMT-N4-Bz-2’-F-dC 5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.
- GC62576 5’-O-DMT-N4-Bz-5-Me-dC 5’-O-DMT-N4-Bz-5-Me-dC is a modified nucleoside.
- GC62577 5’-O-DMT-rU 5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.
- GC62578 5’-O-TBDMS-Bz-dA 5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.
- GC62579 5’-O-TBDMS-dA 5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
- GC62580 5’-O-TBDMS-dG 5’-O-TBDMS-dG is a modified nucleoside.
- GC62581 5’-O-TBDMS-dT 5’-O-TBDMS-dT is a nucleoside with protective and modification effects.
- GC61432 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine?is an adenosine derivative and can be used as an intermediate for oligonucleotides synthesis.
- GC64952 5-Aza-7-deazaguanine 5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides.
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GC10946
5-Azacytidine
A DNA methyltransferase inhibitor
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GC11940
5-BrdU
Synthetic thymidine analog
- GC62547 5-O-TBDMS-N4-Benzoyl-2-deoxycytidine 5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside.
- GC30548 6-Amino-5-nitropyridin-2-one 6-Amino-5-nitropyridin-2-one is a pyridine base and used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine.
- GC60031 6-Azathymine 6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor.
- GC32975 6-Mercaptopurine hydrate An inhibitor of purine synthesis and interconversion
- GC65082 6-O-Methyl Guanosine 6-O-Methyl Guanosine is a modified nucleoside.
- GC35171 6-Thioinosine 6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα.
- GC66060 7-Iodo-2',3'-dideoxy-7-deaza-guanosine 7-Iodo-2',3'-dideoxy-7-deaza-guanosine is a dideoxynucleoside that can be used in DNA synthesis and sequencing reactions.
- GC30531 7-Methylguanosine A nucleotide analog
- GC65525 7-TFA-ap-7-Deaza-dG 5'-O-TBDMS-dG is a modified nucleoside.
- GC13805 Abacavir
- GC13432 Adenine High affinity adenine receptor agonist
- GC14106 Adenosine nucleoside
- GC65462 Adenosine 5′-monophosphoramidate sodium Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis.
- GC11843 Azaguanine-8 Azaguanine-8 is a purine analogue that shows antineoplastic activity. Azaguanine-8 functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth.
- GC15866 Capecitabine DNA, RNA and protein synthesis inhibitor
- GC12748 Carmofur Cytostatic derivative of fluorouracilm,antineoplatic agent
- GC64261 Censavudine Censavudine (OBP-601; BMS-986001), a nucleoside analog, is a nucleoside reverse transcriptase inhibitor.
- GC35693 CI 972 (anhydrous) CI 972 (anhydrous) is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent.
- GC15219 Clofarabine Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase
- GC33177 CNDAC CNDAC is a major metabolite of oral drug sapacitabine, and a nucleoside analog.
- GC38382 CNDAC hydrochloride CNDAC hydrochloride is a metabolite of the orally active agent sapacitabine, and a nucleoside analog.
- GC13070 Cytarabine Cytotoxic agent, blocks DNA synthesis
- GC14961 Cytarabine hydrochloride DNA synthsis inhibitor
- GC13729 Cytidine pyrimidine nucleoside
- GC14485 Dacarbazine Antineoplastic( malignant melanoma and sarcomas)
- GC34123 Deoxycytidine triphosphate (dCTP) Deoxycytidine triphosphate (dCTP) (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis.
- GC33494 Deoxypseudouridine Deoxypseudouridine is a nucleoside analog.
- GC62150 DMT-dC(ac) Phosphoramidite DMT-dC(ac) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
- GC62538 DMT-dG(dmf) Phosphoramidite DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides
- GC66711 DMTr-LNA-5MeU-3-CED-phosphoramidite DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative.
- GC11099 Doxifluridine oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU)
- GC11654 Enocitabine nucleoside analog used as chemotherapy
- GC34112 Ethynylcytidine (ECyD) Ethynylcytidine (ECyD) (ECyD), a nucleoside analog and a potent inhibitor of RNA synthesis, inhibits RNA polymerases I, II and II. Ethynylcytidine (ECyD) has robust antitumor activity in a wide range of models of cancer.
- GC18014 Floxuridine Antineoplastic antimetabolite
- GC14144 Fludarabine DNA synthsis inhibitor
- GC15134 Fludarabine Phosphate (Fludara) Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
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GC66430
Fludarabine triphosphate trisodium
Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine, is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.
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GC14466
Fluorouracil (Adrucil)
A prodrug form of FdUMP
- GC33029 Forodesine (BCX-1777 freebase) Forodesine (BCX-1777 freebase) (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine (BCX-1777 freebase) is a potent human lymphocyte proliferation inhibitor. Forodesine (BCX-1777 freebase) could induce apoptosis in leukemic cells by increasing the dGTP levels.
- GC32708 Forodesine hydrochloride (BCX-1777) Forodesine hydrochloride (BCX-1777) (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine hydrochloride (BCX-1777) is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride (BCX-1777) could induce apoptosis in leukemic cells by increasing the dGTP levels.
- GC36071 Fosteabine Fosteabine is an oral and prodrug analogue of cytarabine which is resistant to deoxycytidine deaminase.
- GC13831 FT-207 (NSC 148958) FT-207 (NSC 148958) (FT 207; NSC 148958) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil.
- GC60865 Ganciclovir sodium Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV.
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GC16805
Gemcitabine
An inhibitor of DNA synthesis
- GC36130 Gemcitabine elaidate A prodrug form of gemcitabine
- GC63777 Gemcitabine elaidate hydrochloride Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-drug of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity.
- GC14447 Gemcitabine HCl Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
- GC30554 Isocytosine Isocytosine is a non-natural nucleobase and an isomer of cytosine.
- GC33662 Isoguanine An isomer of guanine
- GC66622 L-Guanosine L-Guanosine is the L-configuration of Guanosine . Guanosine is a purine nucleoside with anti-herpesvirus activity.