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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> Topoisomerase

Topoisomerase

Topoisomerase are enzymes that regulate the overwinding or underwinding of DNA.

Products for  Topoisomerase

  1. Cat.No. Product Name Information
  2. GC38194 (±)-10-Hydroxycamptothecin (±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity. (±)-10-Hydroxycamptothecin Chemical Structure
  3. GC10098 (S)-10-Hydroxycamptothecin inhibitor of topoisomerase I (S)-10-Hydroxycamptothecin Chemical Structure
  4. GC17271 4'-Demethylepipodophyllotoxin An inhibitor of tubulin polymerization 4'-Demethylepipodophyllotoxin Chemical Structure
  5. GC41643 9(Z),11(E),13(E)-Octadecatrienoic Acid 9(Z),11(E),13(E)-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. 9(Z),11(E),13(E)-Octadecatrienoic Acid Chemical Structure
  6. GC11903 9-amino Camptothecin 9-amino Camptothecin (9-amino-20(S)-camptothecin) is a topoisomerase I inhibitor with potent anticancer activity. 9-amino Camptothecin Chemical Structure
  7. GC45367 9-Hydroxyellipticine (hydrochloride)   9-Hydroxyellipticine (hydrochloride) Chemical Structure
  8. GN10035 9-Methoxycamptothecin 9-Methoxycamptothecin Chemical Structure
  9. GC35238 Aclacinomycin A hydrochloride Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors. Aclacinomycin A hydrochloride Chemical Structure
  10. GC49804 Acridine An azaarene Acridine Chemical Structure
  11. GC14858 Aldoxorubicin An albumin-binding prodrug of doxorubicin Aldoxorubicin Chemical Structure
  12. GC10779 Alternariol

    A mycotoxin with antifungal and phytotoxic activity

     Alternariol Chemical Structure
  13. GC42783 Ametantrone Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break. Ametantrone Chemical Structure
  14. GC11019 Amonafide DNA intercalator,Topo II inhibitor Amonafide Chemical Structure
  15. GC15644 Amrubicin A synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II. Antineoplastic. Amrubicin Chemical Structure
  16. GC12326 Amsacrine Topoisomerase 2 inhibitor Amsacrine Chemical Structure
  17. GC11747 Amsacrine hydrochloride Topoisomerase 2 inhibitor Amsacrine hydrochloride Chemical Structure
  18. GC62425 ARN-21934 ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etoposide (IC50=120 μM). ARN-21934 exhibits a favorable in vivo pharmacokinetic profile and is a promising lead compound for anticancer research. ARN-21934 Chemical Structure
  19. GC46880 ARN24139 A topoisomerase II poison ARN24139 Chemical Structure
  20. GC39699 Aurintricarboxylic acid Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid Chemical Structure
  21. GC33240 Banoxantrone D12 (AQ4N D12) Banoxantrone D12 (AQ4N D12) is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Banoxantrone D12 (AQ4N D12) Chemical Structure
  22. GC34169 Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride) Banoxantrone-d12 (AQ4N-d12) dihydrochloride is the deuterium labeled Banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride) Chemical Structure
  23. GC34085 Banoxantrone dihydrochloride (AQ4N dihydrochloride) Banoxantrone dihydrochloride (AQ4N dihydrochloride) is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Banoxantrone dihydrochloride (AQ4N dihydrochloride) Chemical Structure
  24. GC42912 Becatecarin Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. Becatecarin Chemical Structure
  25. GC33066 Belotecan hydrochloride (CKD-602) Belotecan hydrochloride (CKD-602) (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative. Belotecan hydrochloride (CKD-602) Chemical Structure
  26. GN10221 Berberine

    Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase.

     Berberine Chemical Structure
  27. GC35497 Berberine chloride hydrate Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties. Berberine chloride hydrate Chemical Structure
  28. GN10208 Berberine hydrochloride

    Berberine hydrochloride is an isoquinoline alkaloid derived from the Ranunculaceae medicinal plant Coptis chinensis. It has various pharmacological activities such as anti-tumor, anti-inflammatory, and hypoglycemic activities.

     Berberine hydrochloride Chemical Structure
  29. GN10523 Berberine Sulfate Berberine Sulfate Chemical Structure
  30. GC10734 Beta-Lapachone Beta-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression. Beta-Lapachone Chemical Structure
  31. GC10480 Betulinic acid A plant triterpenoid similar to bile acids Betulinic acid Chemical Structure
  32. GC19073 Bisantrene Bisantrene is a highly effective antitumor drug, targets eukaryotic type II topoisomerases. Bisantrene Chemical Structure
  33. GC15439 Camptothecin

    Topoisomerase I inhibitor

     Camptothecin Chemical Structure
  34. GC60669 Camptothecin-20(S)-O-propionate Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor. Camptothecin-20(S)-O-propionate Chemical Structure
  35. GC46113 CAY10744 A topoisomerase II-α poison CAY10744 Chemical Structure
  36. GC60692 CH-0793076 TFA CH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 TFA is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 TFA Chemical Structure
  37. GC18536 Chartreusin Chartreusin is an antibiotic originally isolated from S. Chartreusin Chemical Structure
  38. GC60107 Chloroquinoxaline sulfonamide Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide Chemical Structure
  39. GC50105 CKD 602 Topoisomerase I inhibitor CKD 602 Chemical Structure
  40. GC47098 CL2-SN-38 (dichloroacetic acid salt) An antibody-drug conjugate containing SN-38 CL2-SN-38 (dichloroacetic acid salt) Chemical Structure
  41. GC60714 CL2A-SN-38 An antibody-drug conjugate containing SN-38 CL2A-SN-38 Chemical Structure
  42. GC61965 Coralyne chloride Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage. Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes. Coralyne chloride Chemical Structure
  43. GC11175 Daun02 Daun02 Chemical Structure
  44. GC12828 Daunorubicin

    DNA topoisomerase II inhibitor

     Daunorubicin Chemical Structure
  45. GC10354 Daunorubicin HCl Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin HCl Chemical Structure
  46. GC17412 Deferasirox Fe3+ chelate Deferasirox Fe3+ chelate Chemical Structure
  47. GC15250 DOXO-EMCH Prodrug of doxorubicin DOXO-EMCH Chemical Structure
  48. GC17567 Doxorubicin (Adriamycin) HCl Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin (Adriamycin) HCl Chemical Structure
  49. GC15399 Dp44mT iron chelator and anticancer agent Dp44mT Chemical Structure
  50. GC38774 DRF-1042 DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype. DRF-1042 Chemical Structure
  51. GC32926 Dxd (Exatecan derivative) Dxd (Exatecan derivative) (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Dxd (Exatecan derivative) Chemical Structure
  52. GC62212 Dxd-D5 Dxd-d5 (Exatecan-d5 derivative for ADC) is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) . Dxd-D5 Chemical Structure
  53. GC33128 Edotecarin (J 107088) Edotecarin (J 107088) is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM. Edotecarin (J 107088) Chemical Structure
  54. GC18620 EIDD-1931

    A ribonucleoside analog with antiviral activity

     EIDD-1931 Chemical Structure
  55. GC15548 Ellagic acid Casein kinase 2 (CK2) inhibitor Ellagic acid Chemical Structure
  56. GC15305 Ellipticine DNA topoisomerase II inhibitor Ellipticine Chemical Structure
  57. GC35973 Ellipticine hydrochloride Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. Ellipticine hydrochloride Chemical Structure
  58. GC35997 Epirubicin Epirubicin (4'-Epidoxorubicin), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase. Epirubicin inhibits DNA and RNA synthesis. Epirubicin is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity. Epirubicin Chemical Structure
  59. GC15617 Etoposide

    Topo II inhibitor

     Etoposide Chemical Structure
  60. GC60826 Etoposide phosphate Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor?to prevent re-ligation of DNA strands. Etoposide phosphate Chemical Structure
  61. GC33108 Exatecan (DX-8951) Exatecan (DX-8951) (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. Exatecan (DX-8951) Chemical Structure
  62. GC62184 Exatecan D5 mesylate Exatecan D5 mesylate Chemical Structure
  63. GC19148 Exatecan Mesylate Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 uM (0.975 ug/mL), and can be used in cancer research. Exatecan Mesylate Chemical Structure
  64. GC16455 Flumequine DNA topoisomerase II inhibitor，synthetic chemotherapeutic antibiotic Flumequine Chemical Structure
  65. GC49134 Flumequine-13C3 An internal standard for the quantification of flumequine Flumequine-13C3 Chemical Structure
  66. GC14376 Gatifloxacin Fluoroquinolone antibiotic,inhibits bacterial TOPO II Gatifloxacin Chemical Structure
  67. GC14102 Genistein

    Genistein is an isoflavone belonging to the flavonoid group of compounds and is found in a number of plants.

     Genistein Chemical Structure
  68. GC15853 Genz-644282 An inhibitor of topoisomerase I Genz-644282 Chemical Structure
  69. GC32088 Gepotidacin (GSK2140944) Gepotidacin (GSK2140944) (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor. Gepotidacin (GSK2140944) Chemical Structure
  70. GC60873 Gimatecan Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity. Gimatecan Chemical Structure
  71. GC38511 Groenlandicine Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine Chemical Structure
  72. GC14969 Idarubicin HCl Idarubicin HCl is an anthracycline antileukemic drug. Idarubicin HCl Chemical Structure
  73. GC65939 Indimitecan Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities. Indimitecan Chemical Structure
  74. GC33205 Indotecan (LMP-400) Indotecan (LMP-400) (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan (LMP-400) Chemical Structure
  75. GC33165 Intoplicine Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA. Intoplicine Chemical Structure
  76. GC63354 Intoplicine dimesylate Intoplicine (RP 60475) dimesylate, an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine dimesylate strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA. Intoplicine dimesylate Chemical Structure
  77. GC11473 Irinotecan Topoisomerase I inhibitor Irinotecan Chemical Structure
  78. GC11048 Irinotecan HCl Trihydrate Irinotecan HCl Trihydrate ((+)-Irinotecan HCl Trihydrate) is a topoisomerase I inhibitor with antitumor activity. Irinotecan HCl Trihydrate Chemical Structure
  79. GC36329 Irinotecan hydrochloride Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer. Irinotecan hydrochloride Chemical Structure
  80. GC34144 Karenitecin (Cositecan) Karenitecin (Cositecan) (Cositecan) is a topoisomerase I inhibitor, with potent anti-cancer activity. Karenitecin (Cositecan) Chemical Structure
  81. GC33389 LMP744 (MJ-III65) LMP744 (MJ-III65) (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. LMP744 (MJ-III65) Chemical Structure
  82. GC33202 LMP744 hydrochloride (MJ-III65 hydrochloride) LMP744 hydrochloride (MJ-III65 hydrochloride) (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. LMP744 hydrochloride (MJ-III65 hydrochloride) Chemical Structure
  83. GC15612 Luotonin A binds to and stabilizes the topoisomerase I-DNA binary complex Luotonin A Chemical Structure
  84. GC15336 Luotonin F stabilizing the DNA topoisomerase I-DNA complex Luotonin F Chemical Structure
  85. GC36549 Mauritianin A flavonoid glycoside and DNA topoisomerase I inhibitor Mauritianin Chemical Structure
  86. GC65079 MC-DOXHZN hydrochloride MC-DOXHZN ((E/Z)-Aldoxorubicin) hydrochloride is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties. MC-DOXHZN hydrochloride Chemical Structure
  87. GC61844 Merbarone Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent. Merbarone Chemical Structure
  88. GC32714 Mitoxantrone (mitozantrone) Mitoxantrone (mitozantrone) is a potent topoisomerase II inhibitor. Mitoxantrone (mitozantrone) Chemical Structure
  89. GC14363 Mitoxantrone HCl Mitoxantrone HCl is a potent topoisomerase II inhibitor. Mitoxantrone HCl Chemical Structure
  90. GC45998 Mitoxantrone-d8 An internal standard for the quantification of mitoxantrone Mitoxantrone-d8 Chemical Structure
  91. GC11114 Moxifloxacin HCl Moxifloxacin HCl (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia. Moxifloxacin HCl Chemical Structure
  92. GC34156 Namitecan (ST-1968) Namitecan (ST-1968) is a potent topoisomerase I inhibitor, with antitumor property. Namitecan (ST-1968) Chemical Structure
  93. GC61956 NHC-diphosphate NHC-diphosphate is an active phosphorylated?intracellular metabolite?of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form. NHC-diphosphate Chemical Structure
  94. GC61130 NHC-triphosphate

    NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form.

     NHC-triphosphate Chemical Structure
  95. GC61961 NHC-triphosphate tetrasodium NHC-triphosphate tetrasodium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form. NHC-triphosphate tetrasodium Chemical Structure
  96. GC36895 Phenoxodiol A phenol with anticancer activity Phenoxodiol Chemical Structure
  97. GC17082 Pirarubicin Topoisomerase II inhibitor;anthracycline antibiotic Pirarubicin Chemical Structure
  98. GC36928 Pirarubicin Hydrochloride Pirarubicin Hydrochloride is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors. Pirarubicin Hydrochloride Chemical Structure
  99. GC12503 Pixantrone Pixantrone (BBR 2778 (free base)), a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Pixantrone Chemical Structure
  100. GC44651 Pixantrone (maleate) Pixantrone is an aza-anthracenedione analog that intercalates in DNA, directly alkylates DNA, and forms stable DNA adducts. Pixantrone (maleate) Chemical Structure
  101. GC52455 Pixantrone-d8 (maleate) An internal standard for the quantification of pixantrone Pixantrone-d8 (maleate) Chemical Structure

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