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Home >> Signaling Pathways >> Endocrinology and Hormones

Endocrinology and Hormones

Endocrinology and Hormones

Endocrinology and Hormones

The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more

Targets for  Endocrinology and Hormones

Products for  Endocrinology and Hormones

  1. Cat.No. Product Name Information
  2. GC49326 5β-Dihydroprogesterone A progesterone receptor agonist and metabolite of progesterone 5β-Dihydroprogesterone Chemical Structure
  3. GC49176 5β-Tetrahydrocortisol An endogenous metabolite of cortisol 5β-Tetrahydrocortisol Chemical Structure
  4. GC46075 5,6-dimethyl-2-Thiouracil A heterocyclic building block 5,6-dimethyl-2-Thiouracil Chemical Structure
  5. GC49827 5-Androstenetriol An active metabolite of DHEA 5-Androstenetriol Chemical Structure
  6. GC15774 5α-dihydro-11-keto Testosterone 5α-dihydro-11-keto Testosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 5α-dihydro-11-keto Testosterone Chemical Structure
  7. GC49676 6β-hydroxy Budesonide A metabolite of budesonide 6β-hydroxy Budesonide Chemical Structure
  8. GC45969 6β-hydroxy Eplerenone A major metabolite of eplerenone 6β-hydroxy Eplerenone Chemical Structure
  9. GC49629 6β-hydroxy Prednisolone A metabolite of prednisolone 6β-hydroxy Prednisolone Chemical Structure
  10. GC18632 6-hydroxy Bexarotene 6-hydroxy Bexarotene is an oxidative metabolite of bexarotene , a high-affinity ligand for retinoid X receptors (RXRs). 6-hydroxy Bexarotene Chemical Structure
  11. GC18335 6β-hydroxy Dexamethasone 6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. 6β-hydroxy Dexamethasone Chemical Structure
  12. GC49206 7α-hydroxy Dehydroepiandrosterone An active metabolite of dehydroepiandrosterone 7α-hydroxy Dehydroepiandrosterone Chemical Structure
  13. GC49391 7α-Thiospironolactone An active metabolite of spironolactone 7α-Thiospironolactone Chemical Structure
  14. GC46740 7β,27-dihydroxy Cholesterol An oxysterol and agonist of RORγ and RORγt 7β,27-dihydroxy Cholesterol Chemical Structure
  15. GC63764 7-α-Methylthio Spironolactone-D3 7-α-Methylthio Spironolactone-D3 Chemical Structure
  16. GC48649 7-hydroxy Chlorpromazine (hydrochloride) An active metabolite of chlorpromazine 7-hydroxy Chlorpromazine (hydrochloride) Chemical Structure
  17. GC48880 7-Methoxyflavone A flavone with diverse biological activities 7-Methoxyflavone Chemical Structure
  18. GC17119 8-Prenylnaringenin estrogen receptor inhibitor 8-Prenylnaringenin Chemical Structure
  19. GC40464 9(R)-HETE 9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. 9(R)-HETE Chemical Structure
  20. GC40465 9(S)-HETE 9(S)-HETE is an enantiomer which makes up 50% of (±)9-HETE. 9(S)-HETE Chemical Structure
  21. GC14596 9-cis-Retinoic Acid 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic Acid Chemical Structure
  22. GP10060 a-MSH, amide

    a-MSH (α-Melanocyte-Stimulating Hormone), amide engages the melanocortin-1 receptor and activates cyclic AMP (cAMP) signaling via a G-protein transporter, can synthesize melanin.

     a-MSH, amide Chemical Structure
  23. GC46768 Abaloparatide (acetate) A synthetic derivative of PTHrP and an agonist of PTHR1 Abaloparatide (acetate) Chemical Structure
  24. GC38581 Abaloparatide TFA Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue selected to be a potent and selective activator of the PTHR1 signaling pathway. Abaloparatide TFA Chemical Structure
  25. GC45778 Abarelix (acetate) A synthetic GnRHR antagonist Abarelix (acetate) Chemical Structure
  26. GC32843 Abarelix (R3827) Abarelix (R3827) (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment. Abarelix (R3827) Chemical Structure
  27. GC35217 Abarelix Acetate Abarelix Acetate (PPI 149 Acetate; R 3827 Acetate) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research. Abarelix Acetate Chemical Structure
  28. GC50091 AC 186 Potent and selective ERβ agonist; neuroprotective AC 186 Chemical Structure
  29. GC11852 AC 261066 Potent RARβ2 agonist AC 261066 Chemical Structure
  30. GC10871 AC 55649 RARβ2 agonist, potent and selective AC 55649 Chemical Structure
  31. GC46777 AC-262536 A selective androgen receptor modulator AC-262536 Chemical Structure
  32. GP10059 Acetyl Angiotensinogen (1-14), porcine Acetyl Angiotensinogen (1-14), porcine Chemical Structure
  33. GC17059 Acetyl Podocarpic Acid Anhydride LXR agonist Acetyl Podocarpic Acid Anhydride Chemical Structure
  34. GC64147 Acetyl tetrapeptide-15 Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 Chemical Structure
  35. GC17094 Acitretin

    Metabolite of etretinate

     Acitretin Chemical Structure
  36. GC17113 Acitretin sodium Second-generation, systemic retinoid Acitretin sodium Chemical Structure
  37. GC31738 ACP-105 ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. ACP-105 Chemical Structure
  38. GC31530 ACTH 4-11 (Adrenocorticotropic Hormone (4-11), human) ACTH 4-11 (Adrenocorticotropic Hormone (4-11), human), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM). ACTH 4-11 (Adrenocorticotropic Hormone (4-11), human) Chemical Structure
  39. GC10610 Adapalene RARβ and RARγ agonist Adapalene Chemical Structure
  40. GC14379 Adapalene sodium salt Retinoic acid receptor agonist Adapalene sodium salt Chemical Structure
  41. GC46798 Adapalene-d3 An internal standard for the quantification of adapalene Adapalene-d3 Chemical Structure
  42. GC13959 Adarotene An atypical retinoid Adarotene Chemical Structure
  43. GC11829 ADL5859 HCl ADL5859 HCl (compound 20) is a selective and orally active δ opioid receptor (DOR) agonist with an Ki and an EC50 value of 0.84 and 20 nM, respectively. ADL5859 HCl Chemical Structure
  44. GC67703 Adrenocorticotropic hormone TFA Adrenocorticotropic hormone TFA Chemical Structure
  45. GC42741 Adrenomedullin (22-52) (human) (trifluoroacetate salt) Adrenomedullin (22-52) is a C-terminal fragment of adrenomedullin (1-52). Adrenomedullin (22-52) (human) (trifluoroacetate salt) Chemical Structure
  46. GP10109 Adrenorphin Adrenorphin Chemical Structure
  47. GC32817 AGN 193109 AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 Chemical Structure
  48. GC33315 AGN 194078 AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively. AGN 194078 Chemical Structure
  49. GC12598 AGN 194310 pan-RAR antagonist AGN 194310 Chemical Structure
  50. GC35265 AGN 195183 AGN 195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN 195183 has no activity on RARβ/γ. AGN 195183 Chemical Structure
  51. GC35266 AGN 196996 AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). AGN 196996 Chemical Structure
  52. GC35267 AGN 205327 AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR. AGN 205327 Chemical Structure
  53. GC35268 AGN 205728 AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ. AGN 205728 Chemical Structure
  54. GC39584 AGN194204 AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 Chemical Structure
  55. GC31742 Ailanthone (δ13-Dehydrochaparrinone) Ailanthone (δ13-Dehydrochaparrinone) (δ13-Dehydrochaparrinone) is a potent inhibitor of both full-length androgen receptor (AR) (IC50=69nM) and constitutively active truncated AR splice variants (AR1-651 IC50=309nM). Ailanthone (δ13-Dehydrochaparrinone) Chemical Structure
  56. GC12374 Alarelin Acetate A peptide agonist of GnRH Alarelin Acetate Chemical Structure
  57. GC46827 Aldosterone 21-sulfate (sodium salt)

    A metabolite of aldosterone

     Aldosterone 21-sulfate (sodium salt) Chemical Structure
  58. GC14511 all-trans Retinal converted to retinoic acid in vivo all-trans Retinal Chemical Structure
  59. GC42769 all-trans Retinoyl β-D-Glucuronide all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system. all-trans Retinoyl β-D-Glucuronide Chemical Structure
  60. GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid all-trans-13,14-Dihydroretinol Chemical Structure
  61. GC18482 all-trans-5,6-epoxy Retinoic Acid all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively). all-trans-5,6-epoxy Retinoic Acid Chemical Structure
  62. GC40024 Altenusin

    Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.

     Altenusin Chemical Structure
  63. GC13297 Altrenogest Progestogen receptor agonist Altrenogest Chemical Structure
  64. GC17623 Alvimopan A μ-opioid receptor antagonist Alvimopan Chemical Structure
  65. GC12619 Alvimopan dihydrate A μ-opioid receptor antagonist Alvimopan dihydrate Chemical Structure
  66. GC35311 Alvimopan monohydrate Alvimopan monohydrate (ADL 8-2698 monohydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan monohydrate Chemical Structure
  67. GC13664 AM580 Selective RARα agonist AM580 Chemical Structure
  68. GC16433 Aminoglutethimide Aromatase inhibitor Aminoglutethimide Chemical Structure
  69. GC63932 Amsilarotene Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer. Amsilarotene Chemical Structure
  70. GC10256 Anastrozole

    Aromatase inhibitor

     Anastrozole Chemical Structure
  71. GC46854 Anastrozole-d12 An internal standard for the quantification of anastrozole Anastrozole-d12 Chemical Structure
  72. GC13685 Andarine Andarine (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. Andarine (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity. Andarine Chemical Structure
  73. GC67698 Androgen receptor-IN-2 Androgen receptor-IN-2 Chemical Structure
  74. GC31254 Androst-4-ene-3,17-diol, dipropanoate, (3β,17β)- (Androst-4-ene-3β,17β-diol, dipropionate) Androst-4-ene-3,17-diol, dipropanoate, (3β,17β)- (Androst-4-ene-3β,17β-diol, dipropionate) Chemical Structure
  75. GC34887 Androstanolone acetate Androstanolone acetate Chemical Structure
  76. GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

    An androgenic steroid

     Androsterone (5α-Androstan-3α-ol-17-one) Chemical Structure
  77. GP10074 Angiotensin 1/2 (1-5) Angiotensin 1/2 (1-5) Chemical Structure
  78. GP10067 Angiotensin 1/2 (1-6) Angiotensin 1/2 (1-6) Chemical Structure
  79. GP10144 Angiotensin 1/2 (1-7) amide Angiotensin 1/2 (1-7) amide Chemical Structure
  80. GP10012 Angiotensin 1/2 (1-8) amide

    Vasoconstrictor

     Angiotensin 1/2 (1-8) amide Chemical Structure
  81. GP10025 Angiotensin 1/2 (1-9) Angiotensin 1/2 (1-9) Chemical Structure
  82. GP10045 Angiotensin 1/2 (2-7)

    Vasoconstrictor

     Angiotensin 1/2 (2-7) Chemical Structure
  83. GP10079 Angiotensin 1/2 (5-7) Angiotensin 1/2 (5-7) Chemical Structure
  84. GP10120 Angiotensin 1/2 + A (2 - 8) Vasoconstrictor Angiotensin 1/2 + A (2 - 8) Chemical Structure
  85. GC52415 Angiotensin A (trifluoroacetate salt) An AT1 and AT2 receptor agonist and active metabolite of angiotensin II Angiotensin A (trifluoroacetate salt) Chemical Structure
  86. GP10087 Angiotensin I (human, mouse, rat) Angiotensin I (human, mouse, rat) Chemical Structure
  87. GC46856 Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt)

    An endogenous angiotensin II fragment

     Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt) Chemical Structure
  88. GC42815 Ansatrienin A Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. Ansatrienin A Chemical Structure
  89. GC46859 Antide (acetate) A GnRHR antagonist Antide (acetate) Chemical Structure
  90. GC60589 Apalutamide D4 Apalutamide D4 (ARN-509 D4) is a deuterium labeled Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM. Apalutamide D4 Chemical Structure
  91. GC12219 AR-M 1000390 hydrochloride Delta-opioid receptor agonist,low-internalizing AR-M 1000390 hydrochloride Chemical Structure
  92. GC64540 Ar-V7-IN-1 Ar-V7-IN-1 is a potent inhibitor of Ar-V7. AR-V7 is a hormone-independent splice variant of the androgen receptor. Ar-V7-IN-1 has the potential for the research of various indications, in particular cancers such as prostate cancer (extracted from patent WO2018114781A1, compound 43). Ar-V7-IN-1 Chemical Structure
  93. GC19035 AR7 A retinoic acid receptor α (RARα) antagonist AR7 Chemical Structure
  94. GC42852 Arginine Vasotocin (trifluoroacetate salt) Arginine vasotocin is a nonapeptide hormone agonist of the AVT receptor (EC50 = 13 nM for eliciting membrane currents in X. Arginine Vasotocin (trifluoroacetate salt) Chemical Structure
  95. GC16840 ARN-509 ARN-509 (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM. ARN-509 Chemical Structure
  96. GC62118 ARV-110 ARV-110 (ARV-110) is an orally active, specific androgen receptor (AR) PROTAC degrader. ARV-110 promotes ubiquitination and degradation of AR. ARV-110 can be used for the research of prostate cancer. ARV-110 Chemical Structure
  97. GC10547 ASC-J9 A selective enhancer of AR degradation ASC-J9 Chemical Structure
  98. GC31762 Asimadoline (EMD-61753) Asimadoline (EMD-61753) (EMD-61753) is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline (EMD-61753) Chemical Structure
  99. GC61397 Asimadoline hydrochloride Asimadoline (EMD-61753) hydrochloride is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline hydrochloride Chemical Structure
  100. GC46892 ATRA-BA Hybrid A prodrug form of all-trans retinoic acid and butyric acid ATRA-BA Hybrid Chemical Structure
  101. GC66207 Atraric acid Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases. Atraric acid Chemical Structure

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