Endocrinology and Hormones
Endocrinology and Hormones
The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more
Targets for Endocrinology and Hormones
- 5-alpha Reductase(8)
- Smoothened Receptors(3)
- Androgen Receptor(137)
- Aromatase(13)
- CRTH2(2)
- Estrogen/progestogen Receptor(147)
- GnRH(26)
- Opioid Receptor(175)
- RAAS(8)
- Thyroid hormone Receptor(59)
- TRH(2)
- ROR/RAR/RXR(94)
- FXR & LXR(69)
- Glucocorticoids & Mineralocorticoids(49)
- GPR(1)
Products for Endocrinology and Hormones
- Cat.No. Product Name Information
- GC13971 Cyproterone Acetate Androgen receptor antagonist
- GC17677 DADLE δ-opioid receptor agonist
- GC47168 Daidzein-d4 An internal standard for the quantification of daidzein
- GC10803 DAMGO μ opioid receptor agonist
- GC35805 DAMGO (TFA) DAMGO (TFA) is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR.
- GC10785 Danazol A derivative of testosterone and ethisterone
- GC35828 Degarelix Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR/LHRHR) antagonist.
- GC18556 Degarelix (acetate) Degarelix is a synthetic gonadotropin-releasing hormone receptor (GNRHR) antagonist (IC50 = 3 nM in HEK293 cells expressing the human receptor).
- GC11070 Dehydroepiandrosterone (DHEA) Dehydroepiandrosterone (DHEA) and its sulfate ester, DHEAS, together represent the most abundant steroid hormones in the human body .
- GC34005 Dehydroisoandrosterone 3-acetate (Dehydroepiandrosterone 3-acetate) Dehydroepiandrosterone 3-acetate is a testosterone/estrogen precursor and known modulator of vertebrate aggression.
- GC61954 Deltorphin 2 TFA Deltorphin 2 TFA is a selective peptide agonist for the δ opioid receptor.
- GC12143 Deltorphin I δ-opioid receptor agonist
-
GC31168
Dermorphin
Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin.
- GC34223 Dermorphin Analog Dermorphin Analog is an analog of Dermorphin.
- GC49143 Deslorelin (acetate) A peptide agonist of GnRH
- GC49459 Desmopressin (trifluoroacetate salt) A vasopressin receptor agonist
- GC49025 Desogestrel-13C2-d2 An internal standard for the quantification of desogestrel
- GC17688 Diarylpropionitrile(DPN) Diarylpropionitrile(DPN) (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM.
- GP10126 Diazepam-Binding Inhibitor Fragment, human Diazepam-Binding Inhibitor (DBI) Fragment is encoded by the DBI gene in human.
- GC15578 Dienogest Orally active synthetic progesterone
- GC47215 Dienogest-d8 An internal standard for the quantification of dienogest
- GC40867 Diflorasone Diacetate Diflorasone is a corticosteroid with anti-inflammatory activity.
- GC10663 Dihydrodaidzein estrogen receptor agonist
- GC47231 Dimethomorph A morpholine fungicide
- GC17553 DIPPA hydrochloride κ receptor antagonist
- GC31441 DJ-V-159 DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A).
- GC50178 DPC AJ1951 Potent parathyroid hormone (PTH) receptor agonist
- GC43567 DPC-AJ1951 (trifluoroacetate salt) DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR).
- GC10333 DPDPE Prototypical selective δ-opioid receptor agonist peptide
- GC63431 DPDPE TFA DPDPE TFA, an opioid peptide, is a selective δ-opioid receptor?(DOR) agonist?with anticonvulsant effects.
- GC12379 Drospirenone Synthetic progestin
- GC52420 Drospirenone-13C3 An internal standard for the quantification of drospirenone
- GC64301 DS08210767 DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.
- GC14774 DSLET δ Opioid receptor agonist
- GC10893 Dutasteride 5-alpha-reductase inhibitor
- GC13546 Dynorphin A Endogenous kappa receptor agonist
- GC35917 Dynorphin A (1-10) TFA
- GA21407 Dynorphin A (1-8) Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts.
- GC35918 Dynorphin A 1-10 Dynorphin A 1-10 an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor.
- GC15078 Dynorphin B endogenous agonist for the kappa opioid receptor
- GC35919 Dynorphin B (1-13) (TFA) Dynorphin B (1-13) TFA acts as an agonist on opioid κ-receptor.
- GC11676 EC 23 retinoic acid receptors agonist
- GC65260 EDP-305 EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC50 values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells).
- GC19135 Elagolix Elagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM).
- GC19136 Elagolix sodium Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.
- GC67956 Endomorphin 1 acetate
- GC35986 Endomorphin 2 TFA Endomorphin 2 TFA, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM.
- GP10065 Endomorphin-1
-
GC10059
Endomorphin-2
μ-opioid receptors agonist
- GC12140 Endoxifen Endoxifen Z-isomer is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα).
- GC49648 Enobosarm-d4 An internal standard for the quantification of enobosarm
- GC64854 Enzalutamide-d3 Enzalutamide D3 is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.
- GC16631 EPI-001 AR antagonist
- GC13072 Epiandrosterone steroid hormone with weak androgenic activity
- GC32953 Epristeride (ONO-9302) Epristeride (ONO-9302) (ONO-9302) is a selective, specific and orally active uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. Epristeride (ONO-9302) has inhibitory effects for SR isoenzymes types 2 with Ki value of 0.7-2 nM. Epristeride (ONO-9302) can be used for the research of prostatic hyperplasia and acne.
- GC33764 Eprotirome (KB2115) Eprotirome (KB2115) (KB2115) is a liver-selective thyroid hormone receptor (TR) agonist.
- GC18333 Equilenin Equilenin is an equine estrogen found in the urine of pregnant mares.
- GC16292 Equol non-steroidal estrogen
- GC12577 ER 50891 RARα receptor antagonist
- GC10389 ERB 041 ERB 041 (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. ERB 041 displays >200-fold selectivity for ERβ over ERα. ERB 041 is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. ERB 041 induces ovarian cancer apoptosis.
- GC11822 Erteberel (LY500307) Erteberel (LY500307) (LY500307) is a potent and selective estrogen receptor beta (ERβ) agonist with Ki and EC50 of 1.54 nM and 3.61 nM, respectively.
- GC47309 Estetrol (hydrate) A naturally occurring estrogen
- GC48979 Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate) A substrate of multidrug resistance protein 2
- GC43629 Estradiol 3-sulfate 17β-Glucuronide (potassium salt) Estradiol 3-sulfate is a sulfated form of the steroid hormone 17β-estradiol, and is common in fetal plasma and in the breast tissues of patients with mammary carcinoma.
- GC10139 Estradiol Cypionate Estrogen receptor inhibitor
- GC11796 Estradiol valerate Estradiol valerate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.
- GC12182 Estriol Estrogen receptor antagonist
- GC43630 Estriol 3-β-D-Glucuronide (sodium salt) Estriol 3-β-D-glucuronide is a metabolite of estriol.
- GC45450 Estriol-d2 Estriol-d2 is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.
- GC14385 Estrone Estrogenic hormone
- GC45451 Estrone 3-methyl ether
- GC43631 Estrone 3-sulfate (sodium salt) Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer.
- GC49254 Estrone-3-Glucuronide (sodium salt hydrate) A metabolite of 17β-estradiol
- GC45452 Estrone-d2
- GC16852 Estropipate Estrogen receptor agonist
- GC12148 Ethinyl Estradiol Ethinyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.
- GC11436 Ethisterone Progestogen hormone
- GC12000 Ethynodiol diacetate Progestogen receptor agonist
- GC47320 Ethynyl Estradiol 3-β-D-Glucuronide (hydrate) A metabolite of ethynyl estradiol
- GC13303 Etonogestrel steroidal progestin
- GC32451 Examorelin (Hexarelin) A peptide agonist of GHS-R
- GC11813 Exemestane Steroidal aromatase inhibitor,selective and irreversible
- GC63755 Exemestane-D2
- GC19151 Fadrozole A potent, selective and nonsteroidal inhibitor of aromatase
- GC18301 Fadrozole (hydrochloride) Fadrozole is a non-steroidal aromatase inhibitor (IC50s = 5 and 1.4 nM for human placental and rat ovarian microsomal aromatase, respectively).
- GC25410 Fasiglifam (TAK-875) Fasiglifam (TAK-875) is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line, 400-fold more potent than oleic acid.
- GC49563 Fenhexamid Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor.
- GC17143 Fenretinide A synthetic retinoic acid derivative
- GC14131 FERb 033 ERβ receptor agonist
- GC18641 Ferutinin Ferutinin is a plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for estrogen receptor (ER) α (IC50 = 33.1 nM) and an agonist/antagonist for ERβ (IC50 = 180.5 nM).
- GC10755 Fexaramine farnesoid X receptor agonist
- GC16248 Finasteride Inhibitor of Type II 5α-reductase
- GC17572 Finasteride acetate 5α-reductase inhibitor
- GC15874 FIT δ-opioid agonist, irreversible
- GC38682 Flavanone Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase).
- GC47361 Fludioxonil A fungicide
- GC49631 Fluocortolone A glucocorticoid
-
GC11694
Fluorobexarotene
RXR agonist
- GC10618 Fluoxymesterone androgen receptor agonist
- GC10064 Flurizan A COX-inactive enantiomer of flurbiprofen