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Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. Product Name Information
  2. GC31365 γ-Oryzanol
  3. GC34958 (+)-JQ1 PA
  4. GC13822 (-)-JQ1

    BET bromodomain inhibitor

  5. GC34964 (1S,3R,5R)-PIM447 dihydrochloride
  6. GC34971 (3R,4S)-Tofacitinib
  7. GC34972 (3S,4R)-Tofacitinib
  8. GC34973 (3S,4S)-Tofacitinib
  9. GC15104 (R)-(+)-Etomoxir sodium salt carnitine palmitoyltransferase I (CPT1) inhibitor
  10. GC34443 (R)-BAY1238097
  11. GC11340 (R)-PFI 2 hydrochloride SETD7 histone lysine methyltransferase inhibitor
  12. GC34446 (rac)-BAY1238097
  13. GC33198 (S)-JQ-35 (TEN-010)
  14. GC13634 (S)-PFI-2 (hydrochloride) Negative control of (R)-PFI 2 hydrochloride
  15. GC17055 1,2,3,4,5,6-Hexabromocyclohexane JAK2 tyrosine kinase inhibitor
  16. GC12775 2',3',5'-triacetyl-5-Azacytidine prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
  17. GC11873 2,4-Pyridinedicarboxylic Acid Histone LSD inhibitor
  18. GC10408 2-D08 Sumoylation inhibitor
  19. GC11249 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor
  20. GC15084 2-Methoxyestradiol (2-MeOE2)

    Apoptotic, antiproliferative and antiangiogenic agent

  21. GC14282 3-acetyl-11-keto-β-Boswellic Acid 5-lipoxygenase inhibitor

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