Home >> Signaling Pathways >> Chromatin/Epigenetics



Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. Product Name Information
  2. GC13822 (-)-JQ1

    BET bromodomain inhibitor

  3. GC15104 (R)-(+)-Etomoxir sodium salt carnitine palmitoyltransferase I (CPT1) inhibitor
  4. GC11340 (R)-PFI 2 hydrochloride SETD7 histone lysine methyltransferase inhibitor
  5. GC13634 (S)-PFI-2 (hydrochloride) Negative control of (R)-PFI 2 hydrochloride
  6. GC17055 1,2,3,4,5,6-Hexabromocyclohexane JAK2 tyrosine kinase inhibitor
  7. GC12775 2',3',5'-triacetyl-5-Azacytidine prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
  8. GC11873 2,4-Pyridinedicarboxylic Acid Histone LSD inhibitor
  9. GC10408 2-D08 Sumoylation inhibitor
  10. GC11249 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor
  11. GC15084 2-Methoxyestradiol (2-MeOE2)

    Apoptotic, antiproliferative and antiangiogenic agent

  12. GC17907 3-Deazaneplanocin A (DZNep) hydrochloride SAHH and ENZ2 inhibitor
  13. GC13145 3-Deazaneplanocin,DZNep S-adenosylhomocysteine and EZH2 inhibitor
  14. GC17922 4'-bromo-Resveratrol Sirt1 and Sirt3 inhibitor
  15. GC16474 4-HQN PARP inhibitor
  16. GC17005 4-iodo-SAHA class I and class II histone deacetylase (HDAC) inhibitor
  17. GC12667 4SC-202 Class I HDAC inhibitor
  18. GC10898 5-(N,N-dimethyl)-Amiloride (hydrochloride) NHE1, NHE2, and NHE3 inhibitor
  19. GC10946 5-Azacytidine DNA methyltransferase inhibitor.
  20. GC16015 A 366 G9a/GLP histone lysine methyltransferase inhibitor
  21. GC12390 A-966492 PARP-1/-2 inhibitor, highly potent

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