Bromodomain
Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.
Products for Bromodomain
- Cat.No. Product Name Information
- GC13822 (-)-JQ1 A selective inhibitor of BET bromodomains
- GC46675 4-Phenyl-2-pyrrolidinone A precursor and synthetic intermediate
- GC13014 AZD 5153 orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4.
- GC15175 BAZ2-ICR Selective BAZ2 bromodomain inhibitor
- GC16299 BET bromodomain inhibitor Potent and selective inhibitor for BRD4
- GC16726 BI-7273 BRD9 bromodomain inhibitor
- GC16817 BI-9564 BRD9/7 specific inhibitor
- GC16531 Bromodomain Inhibitor, (+)-JQ1 A selective inhibitor of BET bromodomains
- GC10402 Bromosporine A non-specific bromodomain inhibitor
- GC49029 CAY17c An inhibitor of BRD4 and class I and class IIb HDACs
- GC14699 CPI-203 BET bromodomain inhibitor
- GC43320 CPI-268456 CPI-268456 (compound 141) is a potent BRD4 inhibitor with an IC50 of <0.5 μM.
- GC10382 CPI-637 CBP/EP300 bromodomain inhibitor
- GC10524 GSK 525768A
- GC12440 GSK 5959 BRPF1 bromodomain inhibitor
- GC14063 GSK1324726A BET proteins inhibitor
- GC15789 GSK2801 inhibitor of BAZ2A and BAZ2B bromodomains
- GC13025 GSK6853 BRPF1 inhibitor
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GC16611
GW841819X
BET bromodomain inhibitor
- GC50070 I-BET 151 dihydrochloride BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes
- GC13187 I-BET 151 hydrochloride BET bromodomain inhibitor
- GC17073 I-BET-762 I-BET-762 (I-BET762; GSK525762) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.
- GC15747 I-BET151 (GSK1210151A) I-BET151 (GSK1210151A) (GSK1210151A) is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively.
- GC12588 I-BRD9 BRD9 inhibitor
- GC17944 I-CBP 112 A p300 and CBP inhibitor
- GC43889 I-CBP112 (hydrochloride) cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development.
- GC48548 iBET-BD2 A BD2 bromodomain inhibitor
- GC10727 Ischemin sodium salt CBP bromodomain inhibitor
- GC13148 MS436 BRD4 inhibitor
- GC16763 NI-57 bromodomains of BRPF proteins inhibitor
- GC17482 OF-1 BRPF1B and BRPF2 bromodomain inhibitor
- GC17973 OTX-015 A BRD2, BRD3, and BRD4 inhibitor
- GC14655 OXF BD 02 Selective inhibitor of the first bromodomain of BRD4
- GC15152 PF-CBP1 CBP/p300 bromodomain inhibitor
- GC14361 PFI 3 inhibitor of polybromo 1 and SMARCA4
- GC10979 PFI 4 Potent and selective BRPF1 Bromodomain inhibitor
- GC15375 PFI-1 (PF-6405761) A BET bromodomain inhibitor
- GC14199 RVX-208 RVX-208 (RVX-208) is an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. The IC50s are 87 μM and 0.51 μM for BD1 and BD2, respectively.
- GC48408 TW9 A dual inhibitor of BRD4 and HDAC1
- GC14168 UMB-32 inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factor TAF1 and TAF1L
- GC16794 UNC1215 Potent L3MBTL3 domain inhibitor
- GC18096 UNC669 L3MBTL antagonist,potent and selective