MicroRNA

MiRNAs are 21-25 nucleotide RNAs that negatively regulate gene expression through translational repression or cleavage of a target mRNA. They are transcribed as precursors that are processed by the nucleases Drosha and Dicer.

Small molecules targeting the secondary structure of precursor miRNAs can be more selective modulators of function than oligonucleotides that target RNA sequence.

MicroRNAs (miRNAs) and promoter hypermethylation are vital epigenetic mechanisms for transcriptional inactivation of tumor suppressor.

Targets for MicroRNA

Products for MicroRNA

Cat.No. Product Name Information
GC39699 Aurintricarboxylic acid Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively.
GC64115 Gypenoside LI Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration.
GC65289 Lademirsen
Lademirsen (SAR339375; RG-012) is a single stranded, chemically modified oligonucleotide that binds to and inhibits the function of miR-21.
GC14362 Lin28 1632 Lin28 1632 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction.
GC36464 LIN28 inhibitor LI71 LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM. LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28’s activity against let-7 in leukemia cells and embryonic stem cells.
GC30501 Lin28-let-7a antagonist 1 Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction.
GC32929 MIR96-IN-1 MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively.
GC64487 Miravirsen Miravirsen (SPC-3649), a β-d-oxy-locked nucleic acid-modified phosphorothioate antisense oligonucleotide, inhibit the biogenesis of miR-122.
GC38839 Pseudoprotodioscin Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
GC64499 RJW100 RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively.
GC32973 SID 3712249 (MiR-544 Inhibitor 1) SID 3712249 (MiR-544 Inhibitor 1) (MiR-544 Inhibitor 1) is a miR-544 biogenesis inhibitor. SID 3712249 (MiR-544 Inhibitor 1) binds directly to the precursor miRNA. SID 3712249 (MiR-544 Inhibitor 1) blocks production of the mature microRNA and decreases miR-544, HIF-1α, and ATM transcripts. SID 3712249 (MiR-544 Inhibitor 1) can be used in the research of cancers, such as breast cancer.
GC32435 Targapremir-210 Targapremir-210 (TGP-210) is a potent and selective miR-210 (miRNA-210, microRNA-210) inhibitor. Targapremir-210 inhibits pre-miR-210 processing with high binding affinity (Kd~200 nM).
GC70022 TGP-377/421
TGP-377/421 (Targapre-miR-377/421) is an effective inhibitor of miR-377 and miR-421, which binds to their functional sites.