Protein Ser/Thr Phosphatases
Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.
Products for Protein Ser/Thr Phosphatases
- Cat.No. Product Name Information
- GC17344 Alexidine dihydrochloride An alkyl bis(biguanide) antiseptic
- GC15974 bpV(HOpic) (potassium salt, technical grade) bpV(HOpic) (potassium salt, technical grade) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM.
- GC17011 C2 Ceramide A cell-permeable analog of naturally occurring ceramides
- GC12082 Cantharidic Acid (sodium salt) PP1 and PP2A inhibitor
- GC12891 CCT007093 PPM1D inhibitor
- GC15718 CID 2011756 An inhibitor of protein kinase D
- GC14024 DL-AP3 A metabotropic glutamate receptor antagonist
- GC14395 Fostriecin sodium salt A potent inhibitor of protein phosphatases 2A and 4
- GC16117 INCA-6 A cell-permeant inhibitor of NFAT signaling
- GC12189 LB-100 protein phosphatase 2A(PP2A)inhibitor
- GC17676 Nafamostat Broad spectrum serine protease inhibitor, kallikrein inhibitor
- GC16290 Nafamostat hydrochloride Synthetic serine protease inhibitor
- GC14875 NSC 663284 Cdc25 dual specificity phosphatases inhibitor
- GC11561 NSC 95397 Cdc25 dual specificity phosphatases inhibitor
- GC16958 Okadaic acid A potent inhibitor of protein phosphatases
- GC16900 PRL-3 Inhibitor PRL-3 Inhibitor is a potent PRL-3 inhibitor with an IC50 of 0.9 μM. PRL-3 Inhibitor shows a reduced invasion in cell-based assay.
- GC15120 PTP Inhibitor I PTP Inhibitor I a PTP1B inhibitor, with a Ki of 42 μM.
- GC15804 PTP Inhibitor II PTP Inhibitor II is a protein tyrosine phosphatase (PTP) inhibitor, with anti-angiogenic effect.
- GC15969 PTP Inhibitor IV PTP inhibitor
- GC13442 Sanguinarine chloride Inhibitor of PP2C and MKP-1
- GC12498 Sephin1 Sephin1 ((E/Z)-Sephin1) is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A).
- GC11381 Tautomycetin protein phosphatase (PP)1 inhibitor
- GC11806 β-Glycerophosphate (sodium salt hydrate) β-Glycerophosphate (sodium salt hydrate) is a phosphatase inhibitor.