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RNA Polymerase

RNA polymerase (RNAP), also known as DNA-dependent RNA polymerase, is a large and complex enzyme of several polypeptide chain subunits that catalyzes the synthesis of all cellular RNA specifically on intact DNA templates. A complete RNAP (holoenzyme) must contain two functional parts, a sigma factor (σ) and a core enzyme consisting of one beta prime subunit (β’), one beta subunit (β) and two alpha subunits (α), where the core enzyme catalyzes RNA synthesis initiated by the sigma factor at specific sites. Moreover, a growing list of factors of RNAP, including M, CAP, psi and rho, are required for the transcription reaction.

Products for  RNA Polymerase

  1. Cat.No. Product Name Information
  2. GC50633 BMS 986094 Prodrug of HCV RNA polymerase inhibitor 2'-C-methyl guanosine triphosphate; potent HCV replication inhibitor BMS 986094  Chemical Structure
  3. GC46152 GS-441524 An antiviral nucleoside analog GS-441524  Chemical Structure
  4. GC16314 TC-E 5001 dual tankyrase (TNKS) inhibitor TC-E 5001  Chemical Structure
  5. GC17241 Thiolutin An inhibitor of Hsp27 and RNA polymerases Thiolutin  Chemical Structure

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