Bradykinin Receptors
Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.
Bradykinin (BK) has been reported to be involved in the progression of many types of cancer. Two bradykinin receptors, bradykinin B1 receptor (B1R) and bradykinin B2 receptor (B2R), are significantly expressed in all the tested colorectal cancer cells. Repression of B2R, but not B1R, attenuates the BK-mediated invasion and migration, and inhibits ERK1/2 activation and IL-6 production. Moreover, blocking of the ERK pathway decreases the BK-mediated IL-6 production. In addition, IL-6 repression suppresses the effects of BK on colorectal cancer cell invasion and migration.
Bradykinin, the enzymatic product of kallikrein-kinin system (KKS), is a major modulator of Ang II actions on blood volume, vascular reactivity and salt sensitivity.
Products for Bradykinin Receptors
- Cat.No. Product Name Information
- GA20221 (Hyp³)-Bradykinin (Hyp³)-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist.
- GC16761 Bombinakinin M Potent bradykinin receptor agonist
- GC14629 Bombinakinin-GAP Bioactive bradykinin-related peptide
- GC35548 Bradykinin Bradykinin is an active peptide that is generated by the kallikrein-kinin system.
- GC32576 Bradykinin 1-3 Bradykinin 1-3 is a 3-amino acid residue peptide.
- GC32592 Bradykinin 1-5 Bradykinin 1-5 is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE).
- GC32605 Bradykinin 1-6 Bradykinin 1-6 is an amino-truncated Bradykinin peptide.
- GC32601 Bradykinin 1-7(Bradykinin Fragment 1-7) Bradykinin 1-7 (Bradykinin Fragment 1-7) is an amino-truncated Bradykinin peptide.
- GC34042 Bradykinin 2-9 (Des-Arg1-bradykinin) Bradykinin 2-9 (Des-Arg1-bradykinin) is an amino-truncated Bradykinin peptide.
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GC16820
ELN441958
Potent and selective bradykinin B1 receptor antagonist
- GC31926 FR167344 free base FR167344 free base is an orally active, nonpeptide bradykinin receptor B2 antagonist.
- GC15587 HOE 140 HOE 140 (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.
- GC43888 Icatibant (acetate) Icatibant is a synthetic peptide antagonist of the bradykinin B2 receptor with IC50 and Ki values of 1.07 and 0.798 nM, respectively, in guinea pig ileal cell membranes.
- GC17164 Lys-Bradykinin Endogenous bradykinin receptor agonist
- GC10255 Lys-[Des-Arg9]Bradykinin bradykinin B1 receptor agonist
- GC61535 Lys-[Des-Arg9]Bradykinin TFA Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively.
- GC15188 MEN 11270 B2 bradykinin receptor antagonist
- GC16110 R 715 bradykinin B1 receptor antagonist
- GC13179 R 892 bradykinin B1 receptor antagonist
- GC50373 Retrobradykinin Reverse analog of Bradykinin
- GC11961 Sar-[D-Phe8]-des-Arg9-Bradykinin selective bradykinin B1 receptor agonist
- GC19339 SSR240612 SSR240612 is a potent, and orally active specific non-peptide bradykinin B1 receptor antagonist, with Kis of 0.48 nM and 0.73 nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 481 nM and 358 nM for B2 receptors of guinea pig ileum membranes and CHO cells expressing human B1 receptor, respectively.
- GC17933 WIN 64338 hydrochloride bradykinin B2 receptor antagonist, competitive
- GC35015 [Des-Arg9]-Bradykinin [Des-Arg9]-Bradykinin is a Bradykinin (B1) receptor agonist that displays selectivity for B1 over B2 receptors.
- GC33850 [Des-Arg9]-Bradykinin acetate [Des-Arg9]-Bradykinin acetate is a Bradykinin B1 receptor agonist that displays selectivity for B1 over B2 receptors.
- GC18038 [Phe8Ψ(CH-NH)-Arg9]-Bradykinin Selective bradykinin B2 receptor agonist