Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> GPCR/G protein >> CCR

CCR

CCR2 (C-C chemokine receptor type 2), the receptor for monocyte chemoattractant protein-1 (CCL2), mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase.

Products for  CCR

  1. Cat.No. Product Name Information
  2. GC35185 7,4'-Dihydroxyflavone 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone Chemical Structure
  3. GC62833 ALK4290 ALK4290 (AKST4290) is a potent and orally actively CCR3 inhibitor extracted from patent US20130261153A1, compound Example 2, with a Ki of 3.2 nM for hCCR3. ALK4290 Chemical Structure
  4. GC32336 Aplaviroc (AK 602) Aplaviroc (AK 602) (AK 602), a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW. Aplaviroc (AK 602) Chemical Structure
  5. GC62610 Aplaviroc hydrochloride Aplaviroc (AK 602) hydrochloride, a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW. Aplaviroc hydrochloride Chemical Structure
  6. GC65213 AZ084 AZ084 is a potent, selective, allosteric and oral active CCR8 allosteric antagonist, with a Ki of 0.9 nM. AZ084 Chemical Structure
  7. GC63284 AZD-4818 AZD-4818 is a potent antagonist of chemokine CCR1. AZD-4818 Chemical Structure
  8. GC64274 AZD-5672 AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 Chemical Structure
  9. GC31662 AZD2098 A CCR4 receptor antagonist AZD2098 Chemical Structure
  10. GC60615 AZD2423 AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 Chemical Structure
  11. GC62412 BI-6901 BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0). BI-6901 Chemical Structure
  12. GC13335 Bindarit

    Bindarit is a small molecule that is able to prevent the chronicity of inflammation

     Bindarit Chemical Structure
  13. GC38496 BMS CCR2 22 BMS CCR2 22 Chemical Structure
  14. GC19077 BMS-813160 BMS-813160 is the first dual CCR2/CCR5 antagonist to enter clinical development for cardiovascular. BMS-813160 Chemical Structure
  15. GC14519 BX 471 CCR1 antagonist,potent and selective BX 471 Chemical Structure
  16. GC35570 BX471 hydrochloride BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. BX471 hydrochloride Chemical Structure
  17. GC11161 C 021 dihydrochloride C 021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C 021 dihydrochloride Chemical Structure
  18. GC68832 Carlumab

    Carlumab (CNTO 888) is a highly-affinity humanized antibody against CCL2 (chemokine ligand 2). Carlumab can be used for cancer research, especially in prostate cancer.

     Carlumab Chemical Structure
  19. GC31996 CCR1 antagonist 1 CCR1 antagonist 1 is an antagonist of CCR1, with anti-inflammatory activity. CCR1 antagonist 1 Chemical Structure
  20. GC31893 CCR1 antagonist 8 CCR1 antagonist 8 (compound 19n), a third azaindazole series compound, is a CCR1 antagonist, with an IC50 of 1.8 nM in Ca2+ flux assay. CCR1 antagonist 8 Chemical Structure
  21. GC30560 CCR2 antagonist 1

    CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.

     CCR2 antagonist 1 Chemical Structure
  22. GC31911 CCR2 antagonist 3

    CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist.

     CCR2 antagonist 3 Chemical Structure
  23. GC60679 CCR2 antagonist 4 CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 Chemical Structure
  24. GC31714 CCR2-RA-[R]

    CCR2-RA -[R] can inhibit CCR2 in a non-competitive binding manner, mainly by blocking activation-related conformational changes and the formation of G-protein binding interfaces.

     CCR2-RA-[R] Chemical Structure
  25. GC32017 CCR3 antagonist 1

    CCR3 antagonist 1 is a potent antagonist of CCR3, used for the research of immunologic and inflammatory diseases.

     CCR3 antagonist 1 Chemical Structure
  26. GC35626 CCR4 antagonist 2 CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 Chemical Structure
  27. GC64441 CCR4 antagonist 3 CCR4 antagonist 3 is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antagonist 3 has antitumor activity. CCR4 antagonist 3 Chemical Structure
  28. GC63857 CCR4 antagonist 3 hydrochloride CCR4 antagonist 3 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3 hydrochloride Chemical Structure
  29. GC32367 CCR5 antagonist 1 CCR5 antagonist 1 is a CCR5 antagonist which can inhibit HIV replication extracted from WO 2004054974 A2. CCR5 antagonist 1 Chemical Structure
  30. GC67788 CCR6 antagonist 1 CCR6 antagonist 1 Chemical Structure
  31. GC34521 CCR6 inhibitor 1 CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 Chemical Structure
  32. GC65141 CCR8 antagonist 1 CCR8 antagonist 1 (compound 15) is a potente human CCR8 antagonist with a Ki of 1.6 nM. CCR8 antagonist 1 Chemical Structure
  33. GC67897 CCR8 antagonist 2 CCR8 antagonist 2 Chemical Structure
  34. GC31330 CCX140 CCX140 Chemical Structure
  35. GC19101 Cenicriviroc

    Cenicriviroc (CVC) is an oral, dual CCR2/CCR5 antagonist with nanomolar potency against both receptors.

     Cenicriviroc Chemical Structure
  36. GC35650 Cenicriviroc Mesylate Cenicriviroc Mesylate (TAK-652 Mesylate) is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity. Cenicriviroc Mesylate Chemical Structure
  37. GC17040 DAPTA Chemokine receptor 5 (CCR5) antagonist DAPTA Chemical Structure
  38. GC31744 GSK2239633A GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96?±?0.11. GSK2239633A Chemical Structure
  39. GC32010 GW 766994 (GW 994) GW 766994 (GW 994) (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 (GW 994) Chemical Structure
  40. GC36306 INCB 3284 INCB 3284 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 Chemical Structure
  41. GC14821 INCB 3284 dimesylate An antagonist of the MCP-1 receptor CCR2 INCB 3284 dimesylate Chemical Structure
  42. GC10207 INCB3344 An antagonist of CCR2 INCB3344 Chemical Structure
  43. GC11994 INCB8761(PF-4136309) A CCR2 antagonist INCB8761(PF-4136309) Chemical Structure
  44. GC14554 J 113863 chemokine receptor 1 (CCR1) antagonist J 113863 Chemical Structure
  45. GC60212 K777 A cysteine protease inhibitor K777 Chemical Structure
  46. GC60998 LMD-009 LMD-009 is a selective CCR8 nonpeptide agonist. LMD-009 Chemical Structure
  47. GC15090 Maraviroc

    Maraviroc, the first CCR5 antagonist, has been approved for the treatment of HIV infection, IC50 on hERG ion channel＞10μM.

     Maraviroc Chemical Structure
  48. GC11636 MK-0812 A CCR2 antagonist MK-0812 Chemical Structure
  49. GC36622 MK-0812 Succinate MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2. MK-0812 Succinate Chemical Structure
  50. GC65990 MLN3126 MLN3126 is an orally active and potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht an IC50 value of 6.3 nM for calcium influx. MLN3126 Chemical Structure
  51. GC61879 Nifeviroc Nifeviroc is an orally active CCR5 antagonist. Nifeviroc Chemical Structure
  52. GC36880 PF-04634817 PF-0463481 is a potent and orally active dual CCR2/CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC50=20.8 nM), and displays 10-20 fold less rodent CCR5 potency (rat IC50=470 nM). PF-04634817 Chemical Structure
  53. GC25728 PF-4136309 PF-4136309 (INCB8761, PF-04136309) is a potent, selective, and orally bioavailable CCR2 antagonist with an IC50 of 5.2 nM for human CCR2. PF-4136309 Chemical Structure
  54. GC12790 Pirfenidone TGF-β production inhibitor Pirfenidone Chemical Structure
  55. GC40197 Pirfenidone-d5 Pirfenidone-d5 is intended for use as an internal standard for the quantification of pirfenidone by GC- or LC-MS. Pirfenidone-d5 Chemical Structure
  56. GC69719 Plozalizumab

    Plozalizumab (MLN-1202) is a specific humanized anti-CCR2 antibody. Plozalizumab can be used in research on malignant melanoma.

     Plozalizumab Chemical Structure
  57. GC62724 R243 R243 is a potent and selective CCR8 antagonist. R243 Chemical Structure
  58. GC67869 RPT193 RPT193 Chemical Structure
  59. GC11026 RS 102895 hydrochloride

    CCR2-selective chemokine receptor antagonist

     RS 102895 hydrochloride Chemical Structure
  60. GC15489 RS 504393 A CCR2 chemokine receptor antagonist RS 504393 Chemical Structure
  61. GC37564 RS102895 RS102895 is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1. RS102895 Chemical Structure
  62. GC11946 SB 297006 CCR3 antagonist SB 297006 Chemical Structure
  63. GC32135 TAK-220 A CCR5 antagonist TAK-220 Chemical Structure
  64. GC37724 TAK-779 An antagonist of CCR5, CXCR3, and CCR2b TAK-779 Chemical Structure
  65. GC17834 Teijin compound 1 Teijin compound 1 (Teijin compound 1 hydrochloride) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. Teijin compound 1 Chemical Structure
  66. GC69120 Tivumecirnon

    Tivumecirnon (FLX475) is an effective CCR4 antagonist that can block regulatory T cells that interfere with effective anti-tumor immune responses, and has anti-tumor activity.

     Tivumecirnon Chemical Structure
  67. GC18661 Vercirnon An antagonist of CCR9 Vercirnon Chemical Structure
  68. GC17421 Vicriviroc maleate A CCR5 antagonist Vicriviroc maleate Chemical Structure
  69. GC11938 YM 022 CCK2 silent antagonist YM 022 Chemical Structure
  70. GC45714 ZK 756326 (hydrochloride) ZK 756326 (hydrochloride) is a nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8. ZK 756326 (hydrochloride) Chemical Structure

69 Item(s)

per page

Set Descending Direction