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Home >> Signaling Pathways >> GPCR/G protein >> CXCR

CXCR

CXCR (CXC chemokine receptor) is a group of receptors that belong to GPCRs and specifically binds and responds to cytokines of the CXC chemokine family.

Products for  CXCR

  1. Cat.No. Product Name Information
  2. GC62588 (R,R)-CXCR2-IN-2 (R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively. (R,R)-CXCR2-IN-2 Chemical Structure
  3. GC32208 ALX 40-4C ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM. ALX 40-4C Chemical Structure
  4. GC34386 ALX 40-4C Trifluoroacetate ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM. ALX 40-4C Trifluoroacetate Chemical Structure
  5. GC10473 AMD 3465 CXCR4 antagonist,potent and selective AMD 3465 Chemical Structure
  6. GC16706 AMD 3465 hexahydrobromide potent, selective CXCR4 antagonist AMD 3465 hexahydrobromide Chemical Structure
  7. GC12196 AMD-070 A CXCR4 antagonist AMD-070 Chemical Structure
  8. GC17018 AMD-070 hydrochloride CXCR4 antagonist,potent and selective AMD-070 hydrochloride Chemical Structure
  9. GC11939 AMG 487 AMG 487 is an oral, selective chemokine receptor 3 (CXCR3) antagonist that inhibits CXCL10 and CXCL11 binding to CXCR3 with IC50 values of 8.0 and 8.2 nM, respectively. AMG 487 Chemical Structure
  10. GC42817 Antileukinate Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. Antileukinate Chemical Structure
  11. GC14711 ATI-2341 CXCR4 allosteric agonist ATI-2341 Chemical Structure
  12. GC38541 ATI-2341 TFA ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 TFA Chemical Structure
  13. GC32707 AZD-5069 A CXCR2 antagonist AZD-5069 Chemical Structure
  14. GC64312 AZD4721 AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). AZD4721 Chemical Structure
  15. GC31653 AZD8797 AZD8797 (KAND567) is an allosteric non-competitive and orally active antagonist of the human CX3CR1 receptor; antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800 nM, respectively. AZD8797 Chemical Structure
  16. GC25120 Balixafortide (POL6326) Balixafortide (POL6326) Chemical Structure
  17. GN10507 Baohuoside I

    Baohuoside I, a flavonoid isolated from Epimedium koreanum Nakai, acts as an inhibitor of CXCR4, downregulates CXCR4 expression, induces apoptosis and shows anti-tumor activity.

     Baohuoside I Chemical Structure
  18. GC17526 BKT140 BKT140 (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC50 vakue of ～1 nM. BKT140 Chemical Structure
  19. GC30625 Burixafor hydrobromide (TG-0054 hydrobromide) Burixafor hydrobromide (TG-0054 hydrobromide) (TG-0054 hydrobromide) is an orally bioavailable and potent antagonist of CXCR4 and a well anti-angiogenic drug that is of potential value in treating choroid neovascularization. Burixafor hydrobromide (TG-0054 hydrobromide) Chemical Structure
  20. GC64090 Corydalmine Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine Chemical Structure
  21. GC65908 CXCR2 antagonist 2 CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC50 value of 95 nM. CXCR2 antagonist 2 Chemical Structure
  22. GC31754 CXCR2-IN-1 CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonist with a pIC50 of 9.3. CXCR2-IN-1 Chemical Structure
  23. GC62475 CXCR2-IN-2 CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 Chemical Structure
  24. GC63411 CXCR7 antagonist-1

    CXCR7 antagonist-1 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7.

     CXCR7 antagonist-1 Chemical Structure
  25. GC65476 CXCR7 antagonist-1 hydrochloride CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 hydrochloride Chemical Structure
  26. GC35763 CXCR7 modulator 1 CXCR7 modulator 1 (compound 25) is a potent and orally bioavailable peptoid hybrid CXCR7 modulator, with a Ki of 9 nM. CXCR7 modulator 1 Chemical Structure
  27. GC34339 CXCR7 modulator 2 CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM. CXCR7 modulator 2 Chemical Structure
  28. GC19116 Danirixin Danirixin is a selective, and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8. Danirixin Chemical Structure
  29. GC31763 E6130 E6130 is an orally active and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease. E6130 Chemical Structure
  30. GC66332 Eldelumab Eldelumab (BMS-936557) is a humanised anti-CXCL10 (IP-10) monoclonal antibody (IgG1 type). Eldelumab selectively binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab can be used in studies of autoimmune and auto-inflammatory diseases such as rheumatoid arthritis, ulcerative colitis and crohn's disease. Eldelumab Chemical Structure
  31. GC36033 FC131 TFA FC131 TFA is a CXCR4 antagonist, inhibits [125I]-SDF-1 binding to CXCR4, with an IC50 of 4.5 nM. FC131 TFA Chemical Structure
  32. GC36184 GPR35 agonist 1 GPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good druggability. GPR35 agonist 1 Chemical Structure
  33. GC36350 IT1t IT1t is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. IT1t Chemical Structure
  34. GC10432 IT1t dihydrochloride CXCR4 antagonist, potent IT1t dihydrochloride Chemical Structure
  35. GC36411 Kynurenic acid sodium Kynurenic acid sodium Chemical Structure
  36. GC62256 Ladarixin Ladarixin (DF 2156A free base) is an orally active, allosteric non-competitive and dual CXCR1 and CXCR2 antagonist. Ladarixin Chemical Structure
  37. GC62296 Ladarixin sodium Ladarixin sodium (DF 2156A) is an orally active, allosteric non-competitive and dual CXCR1 and CXCR2 antagonist. Ladarixin sodium Chemical Structure
  38. GC19486 LIT-927

    LIT-927 is a locally and orally active CXCL12 neutraligand

     LIT-927 Chemical Structure
  39. GC19230 LY2510924 LY2510924 is a potent and selective CXCR4 antagonist; blocks SDF-1 binding to CXCR4 with an IC50 of 0.079 nM. LY2510924 Chemical Structure
  40. GC36550 Mavorixafor trihydrochloride Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively. Mavorixafor trihydrochloride Chemical Structure
  41. GC17174 ML 145 GPR35 antagonist ML 145 Chemical Structure
  42. GC19255 MSX-122 MSX-122 is a partial antagonist of CXCR4, inhibiting CXCR4/CXCL12 actions, with an IC50 of ?10 nM; MSX-122 has anti-inflammatory and anti-metastatic activity. MSX-122 Chemical Structure
  43. GC68040 MSX-127 MSX-127 Chemical Structure
  44. GC36704 NBI-74330 A CXCR3 antagonist NBI-74330 Chemical Structure
  45. GC36737 Nicotinamide N-oxide Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor. Nicotinamide N-oxide Chemical Structure
  46. GC14745 Plerixafor (AMD3100) Plerixafor (AMD3100) (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor (AMD3100) Chemical Structure
  47. GC17949 Plerixafor 8HCl (AMD3100 8HCl) Plerixafor 8HCl (AMD3100 8HCl) (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor 8HCl (AMD3100 8HCl) Chemical Structure
  48. GC37022 PS372424 PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 Chemical Structure
  49. GC61219 PS372424 hydrochloride PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride Chemical Structure
  50. GC69789 Quetmolimab

    Quetmolimab is a monoclonal antibody that targets humanized fractalkine (CX3CL1), which is a chemokine that regulates chemotaxis and adhesion.

     Quetmolimab Chemical Structure
  51. GC12849 Reparixin An allosteric inhibitor of CXCR1 and CXCR2 Reparixin Chemical Structure
  52. GC13813 Reparixin L-lysine salt Perifosine is an orally active alkyl phospholipid analogue that has shown antitumor activity in a variety of cancers by interfering . Reparixin L-lysine salt Chemical Structure
  53. GC16465 SB 225002 CXCR2 antagonist, potent and selective SB 225002 Chemical Structure
  54. GC13458 SB 265610

    CXCR2 antagonist, potent

     SB 265610 Chemical Structure
  55. GC50230 SB 332235 Potent CXCR2 antagonist SB 332235 Chemical Structure
  56. GC16100 SCH 527123 An allosteric antagonist of CXCR1 and CXCR2 SCH 527123 Chemical Structure
  57. GC37605 SCH 546738 SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. SCH 546738 Chemical Structure
  58. GC15401 SCH 563705 SCH 563705 Chemical Structure
  59. GC16710 SRT3109 SRT3109 Chemical Structure
  60. GC16377 SRT3190 SRT3190 Chemical Structure
  61. GC38204 SX-682 SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 Chemical Structure
  62. GC37724 TAK-779 An antagonist of CCR5, CXCR3, and CCR2b TAK-779 Chemical Structure
  63. GC17538 UNBS 5162 A pan-antagonist of CXCL chemokines UNBS 5162 Chemical Structure
  64. GC33413 USL311 USL311 is a potent and selective CXCR4 antagonist, with anti-tumor activity. USL311 Chemical Structure
  65. GC38217 VUF11207 fumarate VUF11207 fumarate is a CXCR7 agonist that binds specifically to CXCR7. VUF11207 fumarate Chemical Structure
  66. GC15989 WZ811 Competitive CXCR4 antagonist,highly potent WZ811 Chemical Structure
  67. GC12909 Zaprinast phosphodiesterase inhibitor and GPR35 agonist Zaprinast Chemical Structure

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