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Home >> Signaling Pathways >> GPCR/G protein >> Leukotriene Receptor

Leukotriene Receptor

Leukotrienes receptors are divided into two types, BLT receptors and CycLT receptors. BLT receptors mediate chemoattraction. CysLT receptors mediate pro-inflammatory effects including constriction of airways ad smooth muscle contraction.

Products for  Leukotriene Receptor

  1. Cat.No. Product Name Information
  2. GC69977 (S)-Veliflapon

    (S)-Veliflapon ((S)-BAY X 1005) is an orally active leukotriene biosynthesis and 5-lipoxygenase activating protein (FLAP) inhibitor. It inhibits the formation of leukotriene B4 (LTB4) in rat, mouse, and human white blood cells with IC50 values of 0.026 μM, 0.039 μM, and 0.22 μM respectively. (S)-Veliflapon exhibits enantioselectivity in human whole blood.

     (S)-Veliflapon Chemical Structure
  3. GC60425 (S)-Verapamil D7 hydrochloride (S)-Verapamil D7 hydrochloride ((S)-(-)-Verapamil D7 hydrochloride) is a deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells. (S)-Verapamil D7 hydrochloride Chemical Structure
  4. GC60008 (S)-Verapamil hydrochloride (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells. (S)-Verapamil hydrochloride Chemical Structure
  5. GC10821 11-keto-β-Boswellic Acid 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production. 11-keto-β-Boswellic Acid Chemical Structure
  6. GC41883 12(S)-HHTrE 12(S)-HHTrE (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12(S)-HHTrE Chemical Structure
  7. GC35168 5-O-Demethylnobiletin 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin Chemical Structure
  8. GC64356 Ablukast Ablukast (Ro 23-3544) is a specific and active leukotriene receptor antagonist. Ablukast Chemical Structure
  9. GC32058 Amelubant (BIIL 284) Amelubant (BIIL 284) (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) Chemical Structure
  10. GC11201 ARM1 LTB4 synthesis inhibitor ARM1 Chemical Structure
  11. GC31774 AS-35 AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities. AS-35 Chemical Structure
  12. GC10266 BAY-u 9773 Antagonist of CysLT1/CysLT2 receptors BAY-u 9773 Chemical Structure
  13. GC12232 BAY-X 1005 BAY-X 1005 (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor. BAY-X 1005 Chemical Structure
  14. GC35517 BIIL-260 hydrochloride BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride Chemical Structure
  15. GC13497 BML-111 BML-111, a lipoxin A4 analog, is a lipoxin A4 receptor agonist. BML-111 Chemical Structure
  16. GC32002 Bunaprolast (U66858) Bunaprolast (U66858) (U66858) is a potent inhibitor of LTB4 production in human whole blood. Bunaprolast (U66858) Chemical Structure
  17. GC31994 CI-949 CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively. CI-949 Chemical Structure
  18. GC12230 Cinalukast CysLT1 (LTD4) leukotriene receptor antagonist Cinalukast Chemical Structure
  19. GC32015 CP-105696 (Pfizer 105696) CP-105696 (Pfizer 105696) is a potent and selective Leukotriene B4 Receptor antagonist, with an IC50 of 8.42 nM. CP-105696 (Pfizer 105696) Chemical Structure
  20. GC31923 CP-96486 CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively. CP-96486 Chemical Structure
  21. GC38764 Darbufelone Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone Chemical Structure
  22. GC30604 Darbufelone mesylate (CI-1004 mesylate) Darbufelone mesylate (CI-1004 mesylate) (CI-1004 mesylate) is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone mesylate (CI-1004 mesylate) Chemical Structure
  23. GC31921 DW-1350 DW-1350 is a LTB4 receptor antagonist. DW-1350 Chemical Structure
  24. GC11283 FPL 55712 Leukotriene receptor antagonist FPL 55712 Chemical Structure
  25. GC32025 Gemilukast (ONO-6950) Gemilukast (ONO-6950) is an orally active and potent dual cysteinyl leukotriene 1 and 2 receptors (CysLT1 and CysLT2) antagonist, with IC50s of 1.7, 25 nM for human CysLT1 and CysLT2, respectively. Gemilukast (ONO-6950) Chemical Structure
  26. GC17092 HAMI3379 HAMI3379 is the racemate of HAMI 3379. HAMI3379 Chemical Structure
  27. GC31986 Iralukast (CGP 45715A) Iralukast (CGP 45715A) Chemical Structure
  28. GC31983 KP496 KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor. KP496 Chemical Structure
  29. GC17372 Leukotriene B4 BLT1/BLT2 receptor agonist Leukotriene B4 Chemical Structure
  30. GC30453 LM-1484 LM-1484 is an antagonist of CysLT1 receptor and displays a higher affinity for 3H-LTC4 sites. LM-1484 Chemical Structure
  31. GC31944 LTD4 antagonist 1 LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM. LTD4 antagonist 1 Chemical Structure
  32. GC10992 LY 255283 BLT2 receptor antagonist LY 255283 Chemical Structure
  33. GC13087 LY171883 leukotriene D4 receptor antagonist, orally active LY171883 Chemical Structure
  34. GC31963 LY210073 LY210073 is a Leukotriene B4 (LTB4) receptor antagonist with an IC50 of 6.2 nM. LY210073 Chemical Structure
  35. GC10189 LY223982 potent BLT1 receptor antagonist LY223982 Chemical Structure
  36. GC44096 LY293111 LY293111 (LY293111), an orally active leukotriene B4 receptor antagonist, inhibits the binding of [3H]LTB4, with a Ki of 25 nM. LY293111 Chemical Structure
  37. GC12197 MK 571

    leukotriene D4 receptor antagonist, orally active

     MK 571 Chemical Structure
  38. GC14980 MK-571 sodium salt hydrate

    MK-571 sodium salt hydrate, as a potent and specific antagonist of leukotriene D4 action, used for treatment of asthma.

     MK-571 sodium salt hydrate Chemical Structure
  39. GC31832 MN-001 MN-001 (KCA 757) is a sulfidopeptide leukotriene receptor antagonist, an orally bioavailable anti-inflammatory agent and used for the treatment of asthma. MN-001 Chemical Structure
  40. GC11006 Montelukast Sodium Leukotriene receptor antagonist Montelukast Sodium Chemical Structure
  41. GC63296 Montelukast-d6 Montelukast-d6 Chemical Structure
  42. GC63566 Montelukast-d6 sodium Montelukast-d6 sodium Chemical Structure
  43. GC17000 Nedocromil anti-inflammatory agent Nedocromil Chemical Structure
  44. GC44360 Nedocromil (sodium salt) Nedocromil (sodium salt) suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2). Nedocromil (sodium salt) Chemical Structure
  45. GC32011 ONO4057 (ONO-LB457) ONO4057 (ONO-LB457) is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM. ONO4057 (ONO-LB457) Chemical Structure
  46. GC14094 Pranlukast

    selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4),

     Pranlukast Chemical Structure
  47. GC36956 Pranlukast hemihydrate Pranlukast hemihydrate is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast hemihydrate Chemical Structure
  48. GC31820 Quinotolast sodium (FR71021) Quinotolast sodium (FR71021) in the concentration range of 1-100 μg/mL inhibits histamine, LTC4 and PGD2 release in a concentration-dependent manner. Quinotolast sodium (FR71021) Chemical Structure
  49. GC14939 REV 5901 antagonist of cysteinyl-leukotriene receptors REV 5901 Chemical Structure
  50. GC33780 RG-12525 (NID 525) RG-12525 (NID 525) is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 (NID 525) is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 μM. RG-12525 (NID 525) Chemical Structure
  51. GC31837 RS-601 RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities. RS-601 Chemical Structure
  52. GC15298 SR 2640 hydrochloride leukotriene D4 and E4 receptor antagonist SR 2640 hydrochloride Chemical Structure
  53. GC31980 YM158 free base (YM-57158) YM158 free base (YM-57158) is a potent and selective LTD4 and TXA2 receptor antagonist with pA2 values of about 8.87 and 8.81, respectively. YM158 free base (YM-57158) Chemical Structure
  54. GC15839 Zafirlukast oral leukotriene receptor antagonist Zafirlukast Chemical Structure
  55. GC10283 γ-Linolenic Acid γ-Linolenic Acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. γ-Linolenic Acid Chemical Structure
  56. GC10020 γ-Linolenic Acid methyl ester weak leukotriene B4 (LTB4) receptor antagonist γ-Linolenic Acid methyl ester Chemical Structure

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