Home >> Signaling Pathways >> GPCR/G protein >> mGluR

mGluR

The mGluR (metabotropic glutamate receptor) is a group C GPCR and is active through an indirect metabotropic process.

Products for  mGluR

  1. Cat.No. Product Name Information
  2. GC12394 (±)-trans-ACPD

    metabotropic glutamate receptors agonist

    (±)-trans-ACPD  Chemical Structure
  3. GC50245 (+/-)-ADX 71743 Negative allosteric modulator of mGlu7 receptors; brain penetrant (+/-)-ADX 71743  Chemical Structure
  4. GC61646 (-)-Camphoric acid (-)-Camphoric acid  Chemical Structure
  5. GC34963 (1R,2S)-VU0155041 (1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM. (1R,2S)-VU0155041  Chemical Structure
  6. GC34985 (R)-ADX-47273 (R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation . (R)-ADX-47273  Chemical Structure
  7. GC12279 (RS)-MCPG mGluR antagonist (RS)-MCPG  Chemical Structure
  8. GC16349 (S)-MCPG mGluR antagonist (S)-MCPG  Chemical Structure
  9. GC50125 ABP 688 High affinity human mGlu5 antagonist ABP 688  Chemical Structure
  10. GC14036 ACPT-II metabotropic receptor antagonist ACPT-II  Chemical Structure
  11. GC10494 ADX-47273 mGluR5 receptor positive allosteric modulator, potent and selective ADX-47273  Chemical Structure
  12. GC30793 ADX88178 ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4. ADX88178  Chemical Structure
  13. GC63922 AMN082 free base AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base  Chemical Structure
  14. GC65389 Auglurant Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human). Auglurant  Chemical Structure
  15. GC46092 AZ 12216052 A positive allosteric modulator of mGluR8 AZ 12216052  Chemical Structure
  16. GC35446 AZD 2066 AZD 2066 is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066  Chemical Structure
  17. GC60614 AZD 2066 hydrate AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate  Chemical Structure
  18. GC31233 AZD 9272 A negative allosteric modulator of mGluR5 receptors AZD 9272  Chemical Structure
  19. GC31097 AZD-8529 AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. AZD-8529  Chemical Structure
  20. GC60065 AZD-8529 mesylate AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. AZD-8529 mesylate  Chemical Structure
  21. GC12510 BINA BINA (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders. BINA  Chemical Structure
  22. GC31081 BMT-145027 BMT-145027 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM. BMT-145027  Chemical Structure
  23. GC65081 CALP1 TFA CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 ?M) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 TFA  Chemical Structure
  24. GC33146 CFMTI CFMTI inhibits L-glutamate-induced intracellular Ca2+ mobilization in CHO cells expressing human and rat mGluR1a, with IC50s of 2.6 and 2.3 nM, respectively. CFMTI  Chemical Structure
  25. GC12532 CHPG mGlu5 metabotropic glutamate receptor agonist CHPG  Chemical Structure
  26. GC17963 CHPG Sodium salt mGlu5 agonist CHPG Sodium salt  Chemical Structure
  27. GC13426 CPPHA A positive allosteric modulator of the mGluR5 CPPHA  Chemical Structure
  28. GC16619 CTEP (RO4956371) CTEP (RO4956371) (RO 4956371) is a novel, long-acting, orally bioavailable allosteric antagonist ofmGlu5receptor withIC50of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors. CTEP (RO4956371)  Chemical Structure
  29. GC33154 DFMTI (MK5435) DFMTI (MK5435) can completely block the rmGlu1 L757V glutamate response. DFMTI (MK5435)  Chemical Structure
  30. GC38029 DHPG DHPG  Chemical Structure
  31. GC16523 Dipraglurant Dipraglurant  Chemical Structure
  32. GC13192 E4CPG group I/group II metabotropic glutamate receptor antagonist E4CPG  Chemical Structure
  33. GC11766 Fenobam mGlu5 antagonist Fenobam  Chemical Structure
  34. GC34081 FITM An antagonist of mGluR1 FITM  Chemical Structure
  35. GC36064 Foliglurax Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM. Foliglurax  Chemical Structure
  36. GC31077 Foliglurax monohydrochloride (PXT002331 (monohydrochloride)) Foliglurax monohydrochloride (PXT002331 (monohydrochloride)) (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM. Foliglurax monohydrochloride (PXT002331 (monohydrochloride))  Chemical Structure
  37. GC30224 FPTQ FPTQ is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. FPTQ  Chemical Structure
  38. GC50087 FTIDC Potent and selective negative allosteric modulator of mGlu1 receptors; also mGlu1 inverse agonist FTIDC  Chemical Structure
  39. GC63008 HTL14242 HTL14242 (HTL0014242) is an advanced and orally active mGlu5 NAM with a pKi?and a pIC50 of 9.3 and 9.2, respectively. HTL14242  Chemical Structure
  40. GC50497 JF-NP-26 Caged Raseglurant JF-NP-26  Chemical Structure
  41. GC17217 JNJ 16259685 mGlu1 antagonist JNJ 16259685  Chemical Structure
  42. GC30819 JNJ-40411813 (ADX-71149) JNJ-40411813 (ADX-71149) (ADX-71149) is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. JNJ-40411813 (ADX-71149)  Chemical Structure
  43. GC19207 JNJ-42153605 JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with an EC50 of 17 nM. JNJ-42153605  Chemical Structure
  44. GC17932 L-AP4

    group III metabotropic glutamate receptor agonist

    L-AP4  Chemical Structure
  45. GC61537 L-AP4 monohydrate L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively. L-AP4 monohydrate  Chemical Structure
  46. GC17823 L-Cysteinesulfinic acid NMDA and mGlu receptor agonist L-Cysteinesulfinic acid  Chemical Structure
  47. GC46165 L-Cysteinesulfinic Acid (hydrate) L-Cysteinesulfinic Acid (hydrate) is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively. L-Cysteinesulfinic Acid (hydrate)  Chemical Structure
  48. GC17498 L-Glutamine Non-essential amino acid L-Glutamine  Chemical Structure
  49. GC65068 L-Glutamine 15N L-Glutamine 15N  Chemical Structure
  50. GC68381 L-Glutamine-1-13C L-Glutamine-1-13C  Chemical Structure
  51. GC65971 L-Glutamine-13C5 L-Glutamine-13C5 (L-Glutamic acid 5-amide-13C5) is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells. L-Glutamine-13C5  Chemical Structure
  52. GC68442 L-Glutamine-15N-1 L-Glutamine-15N-1  Chemical Structure
  53. GC67974 L-Glutamine-15N2 L-Glutamine-15N2  Chemical Structure
  54. GC50025 Lamotrigine isethionate Inhibits glutamate release. Water-soluble salt of lamotrigine Lamotrigine isethionate  Chemical Structure
  55. GC15992 Lu AF21934 positive allosteric modulator of mGlu4 receptors Lu AF21934  Chemical Structure
  56. GC50053 LY 341495 disodium salt Potent and selective group II mGlu antagonist; disodium salt of LY 341495 LY 341495 disodium salt  Chemical Structure
  57. GC10605 LY 354740 LY 354740 (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. LY 354740  Chemical Structure
  58. GC12831 LY 367385 mGlu1a receptor antagonist LY 367385  Chemical Structure
  59. GC36504 LY 541850 LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells. LY 541850  Chemical Structure
  60. GC31066 LY2794193

    LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM).

    LY2794193  Chemical Structure
  61. GC36506 LY2812223 LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively). LY2812223  Chemical Structure
  62. GC36509 LY3020371 hydrochloride LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM. LY3020371 hydrochloride  Chemical Structure
  63. GC14555 LY341495 Selective antagonist of mGluR2 and mGluR3 LY341495  Chemical Structure
  64. GC61816 LY367385 hydrochloride LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride  Chemical Structure
  65. GC11182 LY404039 MGlu2 and mGlu3 receptors agonist LY404039  Chemical Structure
  66. GC64319 LY487379 LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379  Chemical Structure
  67. GC30778 Mavoglurant (AFQ056) Mavoglurant (AFQ056) (AFQ056) is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC50 of 30 nM. Mavoglurant (AFQ056)  Chemical Structure
  68. GC30303 Mavoglurant racemate (AFQ-056 racemate) Mavoglurant racemate (AFQ-056 racemate) (AFQ-056 racemate) is the racemate of Mavoglurant. Mavoglurant racemate (AFQ-056 racemate)  Chemical Structure
  69. GC30991 Methoxy-PEPy Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM. Methoxy-PEPy  Chemical Structure
  70. GC11954 mGlu2 agonist mGlu2 agonist  Chemical Structure
  71. GC46171 ML-396 ML-396 is a positive allosteric modulator of group III mGluRs with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. ML-396  Chemical Structure
  72. GC64218 MMPIP MMPIP is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (KB values 24 -30 nM). MMPIP  Chemical Structure
  73. GC10864 MPEP MGlu5 receptor antagonist MPEP  Chemical Structure
  74. GC16172 MPEP Hydrochloride A potent, highly selective mGlu5a receptor antagonist MPEP Hydrochloride  Chemical Structure
  75. GC17185 MSOP group III metabotropic glutamate receptor antagonist MSOP  Chemical Structure
  76. GC11871 MTEP hydrochloride A selective mGlu5a receptor antagonist MTEP hydrochloride  Chemical Structure
  77. GC11966 O-Phospho-D-Serine

    weak agonist of the metabotropic glutamate receptor mGluR4

    O-Phospho-D-Serine  Chemical Structure
  78. GC10123 O-Phospho-L-serine group III metabotropic glutamate receptor agonist O-Phospho-L-serine  Chemical Structure
  79. GC12238 Oxomemazine NULL Oxomemazine  Chemical Structure
  80. GC17383 PHCCC Group I metabotropic glutamate receptor antagonist PHCCC  Chemical Structure
  81. GC63150 Pomaglumetad methionil hydrochloride Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride  Chemical Structure
  82. GC17401 RG7090 RG7090 (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM. RG7090  Chemical Structure
  83. GC12485 Ro 67-7476 positive allosteric modulator of mGlu1 receptors Ro 67-7476  Chemical Structure
  84. GC63173 RO0711401 RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM. RO0711401  Chemical Structure
  85. GC50150 TASP 0433864 Selective positive allosteric modulator of mGlu2 receptors TASP 0433864  Chemical Structure
  86. GC11501 TCN 238 Positive allosteric modulator of mGlu4 receptors TCN 238  Chemical Structure
  87. GC70108 Valiglurax

    Valiglurax (VU0652957) is an orally effective selective positive allosteric modulator of mGlu4, with EC50 values of 64.6 nM and 197 nM for hmGlu4 and rmGlu4 GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant. Valiglurax can be used in research on Parkinson's disease.

    Valiglurax  Chemical Structure
  88. GC18087 VU 0357121 Novel positive allosteric modulator (PAM) of mGlu5 VU 0357121  Chemical Structure
  89. GC13962 VU 0361737 MGlu4 receptor allosteric modulator VU 0361737  Chemical Structure
  90. GC16150 VU 0364439 Positive allosteric mGluR-4 modulator VU 0364439  Chemical Structure
  91. GC13281 VU 0364770

    Positive allosteric modulator(PAM) of mGlu4

    VU 0364770  Chemical Structure
  92. GC50144 VU 0409106 Potent and selective negative allosteric modulator of mGlu5 receptors VU 0409106  Chemical Structure
  93. GC50598 VU 0424465 Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity VU 0424465  Chemical Structure
  94. GC50154 VU 0469650 hydrochloride VU 0469650 hydrochloride is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM. VU 0469650 hydrochloride  Chemical Structure
  95. GC50612 VU 6001966 Potent and selective negative allosteric modulator of mGlu2 receptors VU 6001966  Chemical Structure
  96. GC64513 VU0360172 VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172  Chemical Structure
  97. GC38597 VU0364770 hydrochloride VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0364770 hydrochloride  Chemical Structure
  98. GC18412 VU0409551 VU0409551 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM. VU0409551  Chemical Structure
  99. GC11667 VU0483605 elective positive allosteric modulator (PAM) of mGluR1 VU0483605  Chemical Structure
  100. GC34859 VU0650786 VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786  Chemical Structure
  101. GC37931 VU6001376 VU6001376 is a potent and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4 PAM) with an EC50 of 50.1 nM. VU6001376  Chemical Structure

Items 1 to 100 of 103 total

per page
  1. 1
  2. 2

Set Descending Direction