mGluR
The mGluR (metabotropic glutamate receptor) is a group C GPCR and is active through an indirect metabotropic process.
Products for mGluR
- Cat.No. Product Name Information
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GC12394
(±)-trans-ACPD
metabotropic glutamate receptors agonist
- GC50245 (+/-)-ADX 71743 Negative allosteric modulator of mGlu7 receptors; brain penetrant
- GC61646 (-)-Camphoric acid
- GC34963 (1R,2S)-VU0155041 (1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM.
- GC34985 (R)-ADX-47273 (R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .
- GC12279 (RS)-MCPG mGluR antagonist
- GC16349 (S)-MCPG mGluR antagonist
- GC50125 ABP 688 High affinity human mGlu5 antagonist
- GC14036 ACPT-II metabotropic receptor antagonist
- GC10494 ADX-47273 mGluR5 receptor positive allosteric modulator, potent and selective
- GC30793 ADX88178 ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4.
- GC63922 AMN082 free base AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain.
- GC65389 Auglurant Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human).
- GC46092 AZ 12216052 A positive allosteric modulator of mGluR8
- GC35446 AZD 2066 AZD 2066 is a selective, orally active and brain-penetrant antagonist of mGluR5.
- GC60614 AZD 2066 hydrate AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5.
- GC31233 AZD 9272 A negative allosteric modulator of mGluR5 receptors
- GC31097 AZD-8529 AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
- GC60065 AZD-8529 mesylate AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
- GC12510 BINA BINA (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders.
- GC31081 BMT-145027 BMT-145027 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM.
- GC65081 CALP1 TFA CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 ?M) with binding to the CaM EF-hand/Ca2+-binding site.
- GC33146 CFMTI CFMTI inhibits L-glutamate-induced intracellular Ca2+ mobilization in CHO cells expressing human and rat mGluR1a, with IC50s of 2.6 and 2.3 nM, respectively.
- GC12532 CHPG mGlu5 metabotropic glutamate receptor agonist
- GC17963 CHPG Sodium salt mGlu5 agonist
- GC13426 CPPHA A positive allosteric modulator of the mGluR5
- GC16619 CTEP (RO4956371) CTEP (RO4956371) (RO 4956371) is a novel, long-acting, orally bioavailable allosteric antagonist ofmGlu5receptor withIC50of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors.
- GC33154 DFMTI (MK5435) DFMTI (MK5435) can completely block the rmGlu1 L757V glutamate response.
- GC38029 DHPG
- GC16523 Dipraglurant
- GC13192 E4CPG group I/group II metabotropic glutamate receptor antagonist
- GC11766 Fenobam mGlu5 antagonist
- GC34081 FITM An antagonist of mGluR1
- GC36064 Foliglurax Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM.
- GC31077 Foliglurax monohydrochloride (PXT002331 (monohydrochloride)) Foliglurax monohydrochloride (PXT002331 (monohydrochloride)) (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM.
- GC30224 FPTQ FPTQ is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively.
- GC50087 FTIDC Potent and selective negative allosteric modulator of mGlu1 receptors; also mGlu1 inverse agonist
- GC63008 HTL14242 HTL14242 (HTL0014242) is an advanced and orally active mGlu5 NAM with a pKi?and a pIC50 of 9.3 and 9.2, respectively.
- GC50497 JF-NP-26 Caged Raseglurant
- GC17217 JNJ 16259685 mGlu1 antagonist
- GC30819 JNJ-40411813 (ADX-71149) JNJ-40411813 (ADX-71149) (ADX-71149) is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.
- GC19207 JNJ-42153605 JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with an EC50 of 17 nM.
-
GC17932
L-AP4
group III metabotropic glutamate receptor agonist
- GC61537 L-AP4 monohydrate L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
- GC17823 L-Cysteinesulfinic acid NMDA and mGlu receptor agonist
- GC46165 L-Cysteinesulfinic Acid (hydrate) L-Cysteinesulfinic Acid (hydrate) is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
- GC17498 L-Glutamine Non-essential amino acid
- GC65068 L-Glutamine 15N
- GC68381 L-Glutamine-1-13C
- GC65971 L-Glutamine-13C5 L-Glutamine-13C5 (L-Glutamic acid 5-amide-13C5) is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.
- GC68442 L-Glutamine-15N-1
- GC67974 L-Glutamine-15N2
- GC50025 Lamotrigine isethionate Inhibits glutamate release. Water-soluble salt of lamotrigine
- GC15992 Lu AF21934 positive allosteric modulator of mGlu4 receptors
- GC50053 LY 341495 disodium salt Potent and selective group II mGlu antagonist; disodium salt of LY 341495
- GC10605 LY 354740 LY 354740 (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively.
- GC12831 LY 367385 mGlu1a receptor antagonist
- GC36504 LY 541850 LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells.
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GC31066
LY2794193
LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM).
- GC36506 LY2812223 LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).
- GC36509 LY3020371 hydrochloride LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM.
- GC14555 LY341495 Selective antagonist of mGluR2 and mGluR3
- GC61816 LY367385 hydrochloride LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist.
- GC11182 LY404039 MGlu2 and mGlu3 receptors agonist
- GC64319 LY487379 LY487379 is a selective human mGluR2 positive allosteric modulator (PAM).
- GC30778 Mavoglurant (AFQ056) Mavoglurant (AFQ056) (AFQ056) is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC50 of 30 nM.
- GC30303 Mavoglurant racemate (AFQ-056 racemate) Mavoglurant racemate (AFQ-056 racemate) (AFQ-056 racemate) is the racemate of Mavoglurant.
- GC30991 Methoxy-PEPy Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.
- GC11954 mGlu2 agonist
- GC46171 ML-396 ML-396 is a positive allosteric modulator of group III mGluRs with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays.
- GC64218 MMPIP MMPIP is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (KB values 24 -30 nM).
- GC10864 MPEP MGlu5 receptor antagonist
- GC16172 MPEP Hydrochloride A potent, highly selective mGlu5a receptor antagonist
- GC17185 MSOP group III metabotropic glutamate receptor antagonist
- GC11871 MTEP hydrochloride A selective mGlu5a receptor antagonist
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GC11966
O-Phospho-D-Serine
weak agonist of the metabotropic glutamate receptor mGluR4
- GC10123 O-Phospho-L-serine group III metabotropic glutamate receptor agonist
- GC12238 Oxomemazine NULL
- GC17383 PHCCC Group I metabotropic glutamate receptor antagonist
- GC63150 Pomaglumetad methionil hydrochloride Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039.
- GC17401 RG7090 RG7090 (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
- GC12485 Ro 67-7476 positive allosteric modulator of mGlu1 receptors
- GC63173 RO0711401 RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM.
- GC50150 TASP 0433864 Selective positive allosteric modulator of mGlu2 receptors
- GC11501 TCN 238 Positive allosteric modulator of mGlu4 receptors
-
GC70108
Valiglurax
Valiglurax (VU0652957) is an orally effective selective positive allosteric modulator of mGlu4, with EC50 values of 64.6 nM and 197 nM for hmGlu4 and rmGlu4 GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant. Valiglurax can be used in research on Parkinson's disease.
- GC18087 VU 0357121 Novel positive allosteric modulator (PAM) of mGlu5
- GC13962 VU 0361737 MGlu4 receptor allosteric modulator
- GC16150 VU 0364439 Positive allosteric mGluR-4 modulator
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GC13281
VU 0364770
Positive allosteric modulator(PAM) of mGlu4
- GC50144 VU 0409106 Potent and selective negative allosteric modulator of mGlu5 receptors
- GC50598 VU 0424465 Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity
- GC50154 VU 0469650 hydrochloride VU 0469650 hydrochloride is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM.
- GC50612 VU 6001966 Potent and selective negative allosteric modulator of mGlu2 receptors
- GC64513 VU0360172 VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively.
- GC38597 VU0364770 hydrochloride VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4.
- GC18412 VU0409551 VU0409551 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM.
- GC11667 VU0483605 elective positive allosteric modulator (PAM) of mGluR1
- GC34859 VU0650786 VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM.
- GC37931 VU6001376 VU6001376 is a potent and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4 PAM) with an EC50 of 50.1 nM.