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Home >> Signaling Pathways >> GPCR/G protein >> Neuropeptide FF/AF Receptors

Neuropeptide FF/AF Receptors

Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.

Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target.

Neuropeptide Y (NPY) is widely distributed in the human body and contributes to a vast number of physiological processes. A number of other uses for modulators of NPY receptors have been implied in a range of diseases.

Products for  Neuropeptide FF/AF Receptors

  1. Cat.No. Product Name Information
  2. GA20195 (Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human) (Gly¹,Ser³.²²,Gln⁴.³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³.³¹,Aib³²)-Pancreatic Polypeptide (human) is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. (Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human) Chemical Structure
  3. GA20229 (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) is a specific neuropeptide Y Y1 receptor agonist. (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) Chemical Structure
  4. GC61530 BIBO3304 TFA

    BIBO3304 TFA has subnanomolar affinity for both the human and the rat neuropeptide Y (NPY) Y1 receptor with IC50 values of 0.38±0.06 nM and 0.72±0.42 nM, respectively.

     BIBO3304 TFA Chemical Structure
  5. GC17424 BIIE 0246 NPY Y2 receptor antagonist BIIE 0246 Chemical Structure
  6. GC14881 BMS 193885 Competitive NPY Y1 receptor antagonist BMS 193885 Chemical Structure
  7. GC10167 CGP 71683 hydrochloride

    NPY Y5 receptor antagonist

     CGP 71683 hydrochloride Chemical Structure
  8. GC17307 CYM 9484 neuropeptide Y (NPY) Y2 receptor antagonist CYM 9484 Chemical Structure
  9. GC30721 FR252384 FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC50 of 2.3 nM. FR252384 Chemical Structure
  10. GC30947 Galanin (1-16), mouse, porcine, rat Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM. Galanin (1-16), mouse, porcine, rat Chemical Structure
  11. GC34222 Galanin (1-16), mouse, porcine, rat TFA Galanin (1-16), mouse, porcine, rat (TFA) is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM. Galanin (1-16), mouse, porcine, rat TFA Chemical Structure
  12. GC10862 Galanin (1-30) (human) Endogenous peptide with multiple endocrine, metabolic and behavioral effects Galanin (1-30) (human) Chemical Structure
  13. GC36102 Galanin Receptor Ligand M35 Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). Galanin Receptor Ligand M35 Chemical Structure
  14. GC30931 Galantide Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide Chemical Structure
  15. GC36261 HT-2157 A GAL3 receptor antagonist HT-2157 Chemical Structure
  16. GC14430 JNJ 5207787 NPY Y2 antagonist JNJ 5207787 Chemical Structure
  17. GC14612 JNJ-31020028 selective brain penetrant antagonist of neuropeptide Y2 receptor JNJ-31020028 Chemical Structure
  18. GC16987 L-152,804 neuropeptide Y Y5 receptor antagonist L-152,804 Chemical Structure
  19. GC13801 M40 galanin receptor antagonist M40 Chemical Structure
  20. GC31335 MK-0557 An antagonist of NYP receptor Y5 MK-0557 Chemical Structure
  21. GC15408 Neuropeptide AF (human) Endogenous antiopioid peptide implicated in pain modulation and endocrine functions Neuropeptide AF (human) Chemical Structure
  22. GC12648 Neuropeptide FF agonist at NPFF1 and NPFF2 receptors Neuropeptide FF Chemical Structure
  23. GC15633 Neuropeptide SF (human) Endogenous antiopiate neuropeptide Neuropeptide SF (human) Chemical Structure
  24. GC13864 Neuropeptide SF (mouse, rat) neuropeptide FF receptor agonist Neuropeptide SF (mouse, rat) Chemical Structure
  25. GC31154 Neuropeptide Y (13-36), amide, human (Neuropeptide Y (13-36), human) Neuropeptide Y (13-36), amide, human (Neuropeptide Y (13-36), human) is a selectiveneuropeptide Y2 receptoragonist. Neuropeptide Y (13-36), amide, human (Neuropeptide Y (13-36), human) Chemical Structure
  26. GC31165 Neuropeptide Y (29-64), amide, human (Human neuropeptide Y (29-64)) Neuropeptide Y (29-64), amide, human (Human neuropeptide Y (29-64)) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity. Neuropeptide Y (29-64), amide, human (Human neuropeptide Y (29-64)) Chemical Structure
  27. GC34270 Neuropeptide Y (29-64), amide, human TFA Neuropeptide Y (29-64), amide, human TFA Chemical Structure
  28. GC61875 Neuropeptide Y (3-36) (human, rat) Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) Chemical Structure
  29. GC61499 Neuropeptide Y (human) (TFA) Neuropeptide Y (human) TFA is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity. Neuropeptide Y (human) (TFA) Chemical Structure
  30. GC36728 Neuropeptide Y 22-36 Neuropeptide Y 22-36, a 15 amino acid peptide, is a fragment of Neuropeptide Y. Neuropeptide Y 22-36 Chemical Structure
  31. GC31161 Neuropeptide Y(29-64) Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y. Neuropeptide Y(29-64) Chemical Structure
  32. GC13167 Pancreatic Polypeptide (human) Endogenous high affinity agonist for human NPY Y4 receptor Pancreatic Polypeptide (human) Chemical Structure
  33. GC30456 Pancreatic Polypeptide, bovine Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide, bovine Chemical Structure
  34. GC33785 Pancreatic Polypeptide, rat (Rat pancreatic polypeptide) Pancreatic Polypeptide, rat (Rat pancreatic polypeptide) is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide, rat (Rat pancreatic polypeptide) Chemical Structure
  35. GC63855 Peptide YY (PYY) (3-36), porcine TFA Peptide YY (PYY) (3-36), porcine TFA is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite. Peptide YY (PYY) (3-36), porcine TFA Chemical Structure
  36. GC30452 Peptide YY (PYY), human

    Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion.

     Peptide YY (PYY), human Chemical Structure
  37. GC15469 RF 9 neuropeptide FF receptors antagonist RF 9 Chemical Structure
  38. GC60322 RF9 hydrochloride RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively. RF9 hydrochloride Chemical Structure
  39. GC14112 RFRP 3 (human) NPFF1 receptor agonist RFRP 3 (human) Chemical Structure
  40. GA23511 Spexin Spexin (SPX, also called NPQ) is a gastro-intestinal peptide hormone. In situ hybridization localized its mRNA to the stomach and esophagus. Synthetic spexin induced dose-dependent contraction of stomach muscle, suggesting that it is involved in digestion. The results obtained by Rucinski et al. indicate that spexin may inhibit adrenocortical cell proliferation. Spexin Chemical Structure
  41. GC31338 Velneperit (S2367) Velneperit (S2367) (S-2367) is a novel neuropeptide Y (NPY) Y5 receptor antagonist. Velneperit (S2367) Chemical Structure

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