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Neurotensin Receptors

Neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin. Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled. The third receptor has a single transmembrane domain and is encoded by the SORT1 gene. Neurotensin (NTS) is a 13-amino-acid peptide that functions as both a neurotransmitter and a hormone through the activation of the neurotensin receptor NTSR1, a G-protein-coupled receptor (GPCR). In the brain, NTS modulates the activity of dopaminergic systems, opioid-independent analgesia, and the inhibition of food intake; in the gut, NTS regulates a range of digestive processes.

Products for  Neurotensin Receptors

  1. Cat.No. Product Name Information
  2. GC19023 AF38469 AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM. AF38469  Chemical Structure
  3. GC38586 AF40431 AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 ?M and a Kd of 0.7 ?M . AF40431  Chemical Structure
  4. GC17784 JMV 449

    JMV 449 is a potent, long-lasting neurotensin receptor agonist

    JMV 449  Chemical Structure
  5. GC61800 JMV 449 acetate JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate  Chemical Structure
  6. GC14971 Kinetensin (human) Kinetensin (human) is a neurotensin-like peptide isolated from pepsin-treated human plasma. Kinetensin (human)  Chemical Structure
  7. GC19441 Levocabastine (hydrochloride) Levocabastine is a potent and selective histamine H1 receptor antagonist with an IC50 value of 8.32 nM (Kis = 62.5, 23,500, and 1,937 nM for H1, H2, and H3, respectively) for inhibition of phosphoinositide turnover on human conjunctival epithelial cells. Levocabastine (hydrochloride)  Chemical Structure
  8. GC18216 ML314 An NTS1 agonist ML314  Chemical Structure
  9. GC16357 Neurotensin NTR1 activator Neurotensin  Chemical Structure
  10. GC36729 Neurotensin(8-13) Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13)  Chemical Structure
  11. GC50164 NTRC 824 Potent and selective non-peptide NTS2 antagonist NTRC 824  Chemical Structure
  12. GC38847 SBI-553 SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM. SBI-553  Chemical Structure
  13. GC61739 SORT-PGRN interaction inhibitor 1 SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC50 of 2 μM. SORT-PGRN interaction inhibitor 1  Chemical Structure
  14. GC16683 SR 142948 neurotensin (NT) receptor antagonist SR 142948  Chemical Structure
  15. GC69940 SR 142948 dihydrochloride

    SR 142948 dihydrochloride is an orally active and selective non-peptide antagonist of the neurotensin receptor (NT). Its IC50 values are 1.19 nM, 0.32 nM, and 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain respectively. SR 142948 dihydrochloride inhibits NT-induced inositol phosphate formation with an IC50 value of 3.9 nM in HT-29 cells. In vivo, it blocks NT-induced hypothermia, analgesia, and turning behavior. SR 142948 dihydrochloride can penetrate the blood-brain barrier and can be used for research on psychiatric disorders.

    SR 142948 dihydrochloride  Chemical Structure
  16. GC13242 SR 48692

    nonpeptide neurotensin antagonist

    SR 48692  Chemical Structure
  17. GC50096 TC NTR1 17 Selective NTS1 partial agonist TC NTR1 17  Chemical Structure
  18. GC67786 THX-B THX-B  Chemical Structure
  19. GC11333 Xenin 8 neurotensin-like peptide that modulate pancreatic insulin and glucagon secretion/effects Xenin 8  Chemical Structure

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