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Oxytocin Receptors

Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which is a transmembrane receptor belonging to the rhodopsin-type class I G-protein-coupled receptor (GPCR) superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the myometrium. The main signaling pathway is the Gq/LPC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. Various peptide and nonpeptide antagonists have been developed as potential tocolytic agents or research tools for the various Oxytocin functions. Many of these oxytocin receptor antagonists are used only as pharmacological tools, while others have tocolytic action.

Products for  Oxytocin Receptors

  1. Cat.No. Product Name Information
  2. GC12194 Atosiban

    mixed antagonist of oxytocin and vasopressin receptors

    Atosiban  Chemical Structure
  3. GC39849 Atosiban acetate Atosiban acetate (RW22164 acetate;RWJ22164 acetate) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban acetate  Chemical Structure
  4. GC11419 Carbetocin oxytocin receptor agonist Carbetocin  Chemical Structure
  5. GC30594 Epelsiban (GSK 557296) Epelsiban (GSK 557296) (GSK 557296) is a potent, selective and orally bioavailable oxytocin receptor antagonist, with a pKi of 9.9 for human oxytocin receptor. Epelsiban (GSK 557296)  Chemical Structure
  6. GC16620 L-368,899 hydrochloride L-368,899 hydrochloride is an orally active and selective OT (oxytocin ) receptor antagonist, with IC50s of 8.9 and 26 nM for uterus of rat and human, respectively. L-368,899 hydrochloride  Chemical Structure
  7. GC11991 L-371,257 human oxytocin (OT) receptor antagonist L-371,257  Chemical Structure
  8. GC63036 L-372662 L-372662 is a potent and orally active non-peptide oxytocin antagonist with a Ki value of 4.8. L-372662  Chemical Structure
  9. GC38922 LIT-001 LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001  Chemical Structure
  10. GC32425 OT antagonist 1 OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM. OT antagonist 1  Chemical Structure
  11. GC34364 OT antagonist 1 demethyl derivative OT antagonist 1 demethyl derivative is the demethyl derivative of OT antagonist 1. OT antagonist 1 demethyl derivative  Chemical Structure
  12. GC32431 OT antagonist 3 OT antagonist 3 is an oxytocin (OT) antagonist extracted from patent WO2007017752A1. OT antagonist 3  Chemical Structure
  13. GC36823 OT-R antagonist 1 OT-R antagonist 1 is a new potent and selective nonpeptide low molecular weight OT-R antagonist. OT-R antagonist 1  Chemical Structure
  14. GC33540 OT-R antagonist 2 (Oxytocin receptor antagonist 2) OT-R antagonist 2 (Oxytocin receptor antagonist 2) is a nonpeptide low molecular weight OT-R antagonist. OT-R antagonist 2 (Oxytocin receptor antagonist 2)  Chemical Structure
  15. GC16222 Oxytocin mammalian neurohypophysial hormone Oxytocin  Chemical Structure
  16. GC44526 Oxytocin (acetate)

    Oxytocin is a nonapeptide hormone primarily synthesized in magnocellular neurons of the paraventricular and supraoptic nuclei of the hypothalamus.

    Oxytocin (acetate)  Chemical Structure
  17. GC17249 PF-3274167 Oral oxytocin antagonist PF-3274167  Chemical Structure
  18. GC31068 Retosiban (GSK 221149) Retosiban (GSK 221149) (GSK221149A) is a potent and selective oxytocin antagonist with a Ki of 0.65 nM. Retosiban (GSK 221149)  Chemical Structure
  19. GC37635 SHR1653 SHR1653 is a highly potent, selective and brain penetrated oxytocin receptor (OTR) antagonist, with an IC50 of 15 nM for hOTR. SHR1653  Chemical Structure
  20. GC14001 TC OT 39 oxytocin receptor partial agonist TC OT 39  Chemical Structure
  21. GC11042 WAY 267464 dihydrochloride WAY 267464 dihydrochloride is a non-peptide oxytocin receptor (OTR) agonist. WAY 267464 dihydrochloride  Chemical Structure

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