Sigma Receptor
Sigma receptors are non-opioid receptors that interacted with psychostimulants such as cocaine and methamphetamine. It is associated with central nervous systems diseases, cancer and neuropathic pain etc.
Products for Sigma Receptor
- Cat.No. Product Name Information
- GC62708 σ1 Receptor antagonist-1 σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28).
- GC15144 (±)-PPCC oxalate sigma (σ) receptor ligand
- GC18146 (+)-Igmesine hydrochloride σ1 receptor ligand
- GC17301 (+)-SK&F 10047 hydrochloride prototypical σ1 receptor agonist
- GC50048 (+/-)-PPCC oxalate Selective sigma (σ) agonist (σ1> σ2)
- GC38712 (2R,3R)-E1R (2R,3R)-E1R (Compound 2b) is an enantiomer of E1R.
- GC38713 (2R,3S)-E1R (2R,3S)-E1R (Compound 2c) is an enantiomer of E1R.
- GC38714 (2S,3S)-E1R (2S,3S)-E1R (Compound 2d) is an enantiomer of E1R.
- GC38721 (Rac)-E1R (Rac)-E1R (Compound 2) is the racemate of E1R.
- GC17723 4-IBP σ1 agonist
- GC13357 4-PPBP maleate σ ligand and NR1a/2B NMDA receptors antagonist
- GC19032 AVex-73 hydrochloride AVex-73 hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM.
- GC16595 BD 1008 dihydrobromide δ1-receptor antagonist,potent and selective
- GC15374 BD 1047 dihydrobromide σ1 receptor antagonist
- GC15838 BD 1063 dihydrochloride BD 1063 dihydrochloride is a potent and selective sigma 1 receptor antagonist.
- GC13796 BMY 14802 hydrochloride Sigma receptor antagonist
- GC63801 CM398 CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold).
- GC65450 CT1812 CT1812 (Sigma-2 receptor antagonist 1) is a sigma-2 (σ-2) receptor antagonist.
- GC33697 Cutamesine (SA4503) Cutamesine (SA4503) (SA4503; AGY-94806) is a selective sigma 1 receptor(σ1R) agonist; high affinity for the sigma 1 receptor subtype labeled by (+)-[3H]pentazocine (IC50= 17.4±1.9 nM); 100-fold less affinity for the sigma 2 receptor.
- GC30956 Dimemorfan phosphate Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.
- GC16598 DTG DTG (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).
- GC61822 DuP 734 DuP 734 is a sigma receptor antagonist.
- GC35923 E1R E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity.
- GC62959 EST64454 hydrochloride EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM.
- GC62960 EST73502 hydrochloride EST73502 hydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively.
- GC17721 IPAG Potent σ-receptor antagonist
- GC60216 KB-5492 anhydrous KB-5492 anhydrous is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM.
- GC65178 KB-5492 free base KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM.
- GC12490 L-693,403 maleate High affinity σ ligand
- GC17380 Metaphit Acylator of PCP and σ-receptors
- GC15465 N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide σ-1 selective ligand
-
GC16004
NE 100 hydrochloride
σ1 receptor antagonist
- GC32821 Noscapine ((S,R)-Noscapine)
- GC61889 OPC-14523 hydrochloride OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM).
- GC61926 Panamesine Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites.
- GC17392 PB 28 dihydrochloride σ2 receptor agonist
- GC11187 PD 144418 oxalate PD 144418 oxalate is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively).
- GC61838 Pentoxyverine Pentoxyverine (Carbetapentane) is a sigma-1 receptor agonist, with a Ki of 75 nM on guinea-pig brain membranes.
- GC14960 PRE-084 hydrochloride selective σ1 receptor agonist
-
GC10795
Rimcazole dihydrochloride
σ receptors antagonist
- GC30206 Roluperidone (CYR-101) Roluperidone (CYR-101) (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively).
- GC10407 S1RA σ1R antagonist
- GC13911 S1RA hydrochloride σ1R antagonist
- GC17088 SA 4503 dihydrochloride SA 4503 dihydrochloride (SA4503 dihydrochloride; AGY94806 dihydrochloride) is a potent Sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.
- GC38038 Sigma-1 receptor antagonist 1 Sigma?1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (Ki = 1.06 nM).
- GC38039 Sigma-1 receptor antagonist 2 Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively.
- GC38048 Sigma-1 receptor antagonist 3 Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM.
- GC31294 Sigma-LIGAND-1 Sigma-LIGAND-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.
- GC67893 Sigma-LIGAND-1 hydrochloride
- GC13083 Siramesine Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity.
-
GC15222
Siramesine hydrochloride
Sigma-2 receptor agonist
- GC16473 TC 1 σ1 receptor ligand
- GC14249 UNC 0642 G9a and GLP histone lysine methyltransferase inhibitor