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Home >> Signaling Pathways >> Immunology/Inflammation >> CD73

CD73

CD73 (Ecto-5′-nucleotidase), a component of the purinergic signaling pathway, is a 70-kD glycosylphosphatidylinositol-anchored cell surface protein encoded by the NT5E gene.

CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 catalyzes the hydrolysis of AMP into adenosine and phosphate, and CD73-generated adenosine plays an important role in tumor immunoescape. CD73 plays a crucial role in switching on adenosinergic signaling. CD73 also functions as a signal and adhesive molecule that can regulate cell interaction with extracellular matrix components, such as laminin and fibronectin, to mediate the invasive and metastatic properties of cancers. Both the enzymatic and non-enzymatic functions of CD73 are involved in cancer-associated processes and are not completely independent of each other.

Overexpression of CD73 is associated with resistance to antitumor agents. Knockdown of CD73 inhibits in vitro cell growth, cell cycle progression and cell migration in many cancers. CD73 and its associated pathways may be useful as therapeutic targets.

Targets for  CD73

Products for  CD73

  1. Cat.No. Product Name Information
  2. GC65293 AB-680 AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity. AB-680 Chemical Structure
  3. GC31914 CD73-IN-1 CD73-IN-1 is an inhibitor of CD73 which can be used in the treatment of cancer extracted from patent WO 2017153952 A1, example 80. CD73-IN-1 Chemical Structure
  4. GC62331 CD73-IN-3 CD73-IN-3 is a potent CD73 inhibitor (IC50=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research. CD73-IN-3 Chemical Structure
  5. GC62452 CD73-IN-4 CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC50 of 2.6 nM for human CD73. CD73-IN-4 Chemical Structure
  6. GC68386 CD73-IN-5 CD73-IN-5 Chemical Structure
  7. GC36587 MethADP MethADP is a specific CD73 inhibitor. MethADP Chemical Structure
  8. GC36588 MethADP sodium salt MethADP (sodium salt) is a specific CD73 inhibitor. MethADP sodium salt Chemical Structure
  9. GC68344 Mupadolimab Mupadolimab Chemical Structure
  10. GC65470 Oleclumab Oleclumab (MEDI9447) is a human IgG1λ anti-CD73 monoclonal antibody that inhibits CD73 function. Oleclumab has an anti-tumor activity. Oleclumab Chemical Structure
  11. GC62694 OP-5244 OP-5244 is a potent and orally active inhibitor of CD73, with an IC50 of 0.25 nM. OP-5244 Chemical Structure
  12. GC62695 OP-5244 sodium OP-5244 sodium is a potent and orally active inhibitor of CD73, with an IC50 of 0.25 nM. OP-5244 sodium Chemical Structure
  13. GC32795 PSB-12379 An inhibitor of CD73 PSB-12379 Chemical Structure
  14. GC68346 Uliledlimab Uliledlimab Chemical Structure

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