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Home >> Signaling Pathways >> Immunology/Inflammation >> IFNAR

IFNAR

The interferon-α/β receptor (IFNAR) is a receptor which binds type I interferons including interferon-α and -β. It is a heteromeric cell surface receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. Upon binding of type I IFNs, IFNAR activates the JAK-STAT signaling pathway. Interferon stimulation classically results in an anti-viral immune response. Type I IFNs share a common receptor consisting of two subunits, IFNAR1 and IFNAR2, which associate upon IFN binding. IFNAR2 is the major ligand binding component of the receptor complex, exhibiting nanomolar affinity to both IFNα and IFNβ subtypes. IFNAR1 and IFNAR2 belong to the class II helical cytokine receptor (hCR) family, which includes the receptor for type II IFN, tissue factor (TF), and IL10Rβ.

Targets for  IFNAR

Products for  IFNAR

  1. Cat.No. Product Name Information
  2. GC35440 AX-024 AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 Chemical Structure
  3. GC19046 AX-024 hydrochloride AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A. AX-024 hydrochloride Chemical Structure
  4. GC14727 CCCP Carbonylcyanide-3-chlorophenylhydrazone (CCCP) is a protonophore, which causes uncoupling of proton gradient in the inner mitochondrial membrane, thus inhibiting the rate of ATP synthesis. CCCP Chemical Structure
  5. GC63591 Cirsilineol Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol Chemical Structure
  6. GC38648 Cridanimod Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod Chemical Structure
  7. GC65545 Cyclo(L-Phe-L-Pro) Cyclo(L-Phe-L-Pro) Chemical Structure
  8. GC31799 IFN alpha-IFNAR-IN-1 (IFN-alpha and IFNAR interaction inhibitor) IFN alpha-IFNAR-IN-1 (IFN-alpha and IFNAR interaction inhibitor) is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM). IFN alpha-IFNAR-IN-1 (IFN-alpha and IFNAR interaction inhibitor) Chemical Structure
  9. GC60927 IFN alpha-IFNAR-IN-1 hydrochloride An inhibitor of the IFN-α-IFNAR protein-protein interaction IFN alpha-IFNAR-IN-1 hydrochloride Chemical Structure
  10. GC34307 IFN alpha-IFNAR-IN-1 hydrochloride (IFN-alpha and IFNAR interaction inhibitor) IFN alpha-IFNAR-IN-1 hydrochloride (IFN-alpha and IFNAR interaction inhibitor) Chemical Structure
  11. GC36296 IFN-α Receptor Recognition Peptide 1 IFN-α Receptor Recognition Peptide 1 is a peptide of IFN-α associated with receptor interactions. IFN-α Receptor Recognition Peptide 1 Chemical Structure
  12. GC32019 Interferon receptor agonist Interferon receptor agonist (compound 6) is an interferon (IFN) receptor inducer. Interferon receptor agonist Chemical Structure
  13. GC65435 Monalizumab

    Monalizumab is a first-in-class immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A).

     Monalizumab Chemical Structure
  14. GC68293 ODN 1585 ODN 1585 Chemical Structure
  15. GC69613 ODN 6016

    ODN 6016 is a type of CpG-A oligonucleotide. ODN 6016 can induce the production of IFN-α and can be used to study immune disorders, including those caused by HIV-1. The sequence of ODN 6016 is T-sp-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G.

     ODN 6016 Chemical Structure
  16. GC69615 ODN D-SL03

    ODN D-SL03 is a type of Class C CpG oligonucleotide that can induce high levels of IFN-α production in PBMCs. ODN D-SL03 can activate human B cells, NK cells, and monocytes, upregulating the expression of CD80, CD86, and HLA-DR on subsets of human PBMCs. ODN D-SL03 also has the ability to inhibit tumor growth. The sequence for ODN D-SL03 is 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'.

     ODN D-SL03 Chemical Structure
  17. GC69889 Sifalimumab

    Sifalimumab (MEDI-545) is a monoclonal antibody that targets and inhibits abnormal immune activity by binding to multiple subtypes of interferon-alpha. It can be used for research on systemic lupus erythematosus (SLE).

     Sifalimumab Chemical Structure

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