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Home >> Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Interleukin Related

Interleukin is a group of cytokines that mediates cell-cell communication. It plays a critical role in inflammation/immunity and regulates cell proliferation, differentiation and migration etc.

Products for  Interleukin Related

  1. Cat.No. Product Name Information
  2. GC37999 β-Anhydroicaritin β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties. β-Anhydroicaritin Chemical Structure
  3. GC65373 (R)-IL-17 modulator 4 (R)-IL-17 modulator 4 is the R-configure of IL-17 modulator 4. (R)-IL-17 modulator 4 Chemical Structure
  4. GC35184 7,3',4'-Tri-O-methylluteolin 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin Chemical Structure
  5. GC35214 A-9758 A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 Chemical Structure
  6. GC35373 Apilimod Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. Apilimod Chemical Structure
  7. GC35374 Apilimod mesylate Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. Apilimod mesylate Chemical Structure
  8. GC31661 APY0201 APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM. APY0201 Chemical Structure
  9. GC61796 Armillarisin A Armillarisin A has the potential for the ulcerative colitis (UC) study. Armillarisin A Chemical Structure
  10. GC68702 Astegolimab

    Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody that can block IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab has potential for use in research on chronic obstructive pulmonary disease (COPD).

     Astegolimab Chemical Structure
  11. GC35440 AX-024 AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 Chemical Structure
  12. GC19046 AX-024 hydrochloride AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A. AX-024 hydrochloride Chemical Structure
  13. GC18126 Balsalazide anti-inflammatory drug Balsalazide Chemical Structure
  14. GC35466 Balsalazide sodium hydrate Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. Balsalazide sodium hydrate Chemical Structure
  15. GC66331 Basiliximab Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation. Basiliximab Chemical Structure
  16. GC39346 Benralizumab Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab Chemical Structure
  17. GC68807 Briakinumab

    Briakinumab (ABT-874) is a fully human monoclonal antibody that targets and neutralizes IL-12/23p40. Briakinumab specifically targets and neutralizes both IL-12 and IL-23. It is being studied for its potential use in rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.

     Briakinumab Chemical Structure
  18. GC67748 Brodalumab Brodalumab Chemical Structure
  19. GC66328 Canakinumab Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin. Canakinumab Chemical Structure
  20. GC67859 Clerodendrin Clerodendrin Chemical Structure
  21. GN10118 Desacetyl asperulosidic acid Desacetyl asperulosidic acid Chemical Structure
  22. GC65161 Di-O-methyldemethoxycurcumin Di-O-methyldemethoxycurcumin, a curcuminoid analog, inhibits IL-6 production with an EC50 of 16.20 μg/mL. Di-O-methyldemethoxycurcumin Chemical Structure
  23. GC15320 Diacerein IL receptor inhibitor Diacerein Chemical Structure
  24. GC10801 Disulfiram An irreversible inhibitor of aldehyde dehydrogenase Disulfiram Chemical Structure
  25. GC66407 Etokimab Etokimab (Antibody ANB 020) is a humanized monoclonal antibody that targets IL-33. Etokimab can be used for the research of atopic dermatitis. Etokimab Chemical Structure
  26. GC30910 Eucalyptol (1,8-Cineole) A bicyclic monoterpene with diverse biological activities Eucalyptol (1,8-Cineole) Chemical Structure
  27. GC69104 Fezakinumab

    Fezakinumab is a monoclonal antibody against interleukin 22 (IL-22). It can be used in the research of inflammatory diseases such as psoriasis and rheumatoid arthritis.

     Fezakinumab Chemical Structure
  28. GC36106 Gamma-glutamylcysteine (TFA) Gamma-glutamylcysteine (γ-Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine (TFA) Chemical Structure
  29. GC30831 GIBH-130 GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 Chemical Structure
  30. GN10450 Ginsenoside F3 Ginsenoside F3 Chemical Structure
  31. GN10254 Ginsenoside Rc Ginsenoside Rc Chemical Structure
  32. GN10538 Ginsenoside Rh1 Ginsenoside Rh1 Chemical Structure
  33. GC62685 Guselkumab Guselkumab is a recombinant human IgG1 monoclonal antibody against the IL-23p19 subunit. Guselkumab Chemical Structure
  34. GC13074 HU 211 NMDA antagonist, novel and non-competitive HU 211 Chemical Structure
  35. GC60914 Hydrocortisone hemisuccinate Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, is an orally active steroidal anti-in?ammatory drug (SAID). Hydrocortisone hemisuccinate Chemical Structure
  36. GC65291 IL-15-IN-1 IL-15-IN-1 is a potent and selective Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM. IL-15-IN-1 Chemical Structure
  37. GC63018 IL-17 modulator 1 disodium IL-17 modulator 1 (disodium) is an orally active, highly efficacious IL-17 modulator extracted from patent WO 2020127685. IL-17 modulator 1 disodium Chemical Structure
  38. GC63019 IL-17 modulator 4 IL-17 modulator 4 is a prodrug of IL-17 modulator 1. IL-17 modulator 4 Chemical Structure
  39. GC34372 IL-17A antagonist 1 IL-17A antagonist 1 (compound 1) is an IL-17A antagonist, with a Kd of 0.66 μM and an IC50 of 1.14 μM. IL-17A antagonist 1 Chemical Structure
  40. GC34371 IL-17A antagonist 3 IL-17A antagonist 3 is an IL-17A antagonist, compound 3. IL-17A antagonist 3 Chemical Structure
  41. GC62659 IL-17A inhibitor 1 IL-17A inhibitor 1 (example 24) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells. IL-17A inhibitor 1 Chemical Structure
  42. GC64236 IL-17A modulator-1 IL-17A modulator-1 is a IL-17A modulator, extracted from patent WO2021239743+A1, example 9. IL-17A modulator-1 Chemical Structure
  43. GC64269 IL-17A modulator-2 IL-17A modulator-2 is a IL-17A modulator, extracted from patent WO2021239743+A1, example 27. IL-17A modulator-2 Chemical Structure
  44. GC31948 IX 207-887 IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1). IX 207-887 Chemical Structure
  45. GC62224 Ixekizumab Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A (KD<3 pM). Ixekizumab Chemical Structure
  46. GC12331 JC-1

    JC-1(CBIC2) is a cationic carbonyl cyanine fluorescent dye.

     JC-1 Chemical Structure
  47. GC62527 Kansuinine A Kansuinine A inhibits IL-6-induced Stat3 activation. Kansuinine A Chemical Structure
  48. GC69365 Lebrikizumab

    Lebrikizumab is a humanized monoclonal antibody of the IgG4 class that specifically binds to interleukin-13 (IL-13) and inhibits its function. Lebrikizumab can be used in research for asthma.

     Lebrikizumab Chemical Structure
  49. GC19070 LMT-28

    LMT-28 is an orally active and the first synthetic IL-6 inhibitor that functions through direct binding to gp130

     LMT-28 Chemical Structure
  50. GC66347 Mepolizumab Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma. Mepolizumab Chemical Structure
  51. GC16007 Methylthiouracil antithyroid preparation Methylthiouracil Chemical Structure
  52. GN10055 Mulberroside A Mulberroside A Chemical Structure
  53. GC69534 Nadunolimab

    Nadunolimab is a human IgG1 monoclonal antibody that targets IL1RAP. Nadunolimab blocks the signaling of IL-1α and IL-1β and triggers antibody-dependent cell cytotoxicity. Nadunolimab can be used for cancer research.

     Nadunolimab Chemical Structure
  54. GC39070 Negletein Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein Chemical Structure
  55. GC68341 Nemolizumab Nemolizumab Chemical Structure
  56. GN10429 Neochlorogenic acid Neochlorogenic acid Chemical Structure
  57. GC50243 NFAT inhibitor, Cell Permeable NFAT inhibitor, Cell Permeable is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. NFAT inhibitor, Cell Permeable Chemical Structure
  58. GC31934 NFAT Transcription Factor Regulator NFAT Transcription Factor Regulator is an IL-2 synthesis inhibitor with an IC50 of 182 nM. NFAT Transcription Factor Regulator Chemical Structure
  59. GC69561 Nidanilimab

    Nidanilimab (CAN04) is a fully humanized monoclonal antibody against IL1RAP, with a Kd value of 1.10 pM. Nidanilimab blocks the signaling pathways of IL1α and IL1β, and stimulates the immune system to destroy tumor cells. Nidanilimab can be used for research on non-small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC).

     Nidanilimab Chemical Structure
  60. GC36757 NO-prednisolone NO-prednisolone is a nitric oxide (NO)-releasing derivative of Prednisolone. NO-prednisolone Chemical Structure
  61. GC33873 Nosantine racemate (NPT-15392 racemate) Nosantine racemate (NPT-15392 racemate) is the racemate of Nosantine. Nosantine racemate (NPT-15392 racemate) Chemical Structure
  62. GC19741 NSC 247030 NSC 247030 is an inhibitor of interleukin-2 (IL-2) production. NSC 247030 Chemical Structure
  63. GC69595 NSC61610

    NSC61610 disrupts the binding between hIL-18 and ectromelia virus IL-18BP. NSC61610 inhibits the formation of hIL-18:ectvIL-18BP complex with an IC50 of approximately 6 uM.

     NSC61610 Chemical Structure
  64. GC69621 Olokizumab

    Olokizumab (CDP 6038) is a humanized monoclonal antibody that targets interleukin-6 (IL-6). Olokizumab can be used in the research of rheumatoid arthritis (RA).

     Olokizumab Chemical Structure
  65. GC69631 Ordesekimab

    Ordesekimab (AMG 714; PRV-015) is a human IgG1κ monoclonal antibody that targets IL-15 (Interleukin Related). Ordesekimab inhibits the interaction between IL-15 and the common γ chain of IL-2Rβ and IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has potential for researching non-responsive celiac disease (NRCD).

     Ordesekimab Chemical Structure
  66. GC69641 Oxelumab

    Oxelumab (R 4930) is a human monoclonal antibody that targets the OX40 ligand (OX40L). Oxelumab can be used for research on asthma.

     Oxelumab Chemical Structure
  67. GC69713 Pivekimab

    Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. It can be used for research on blastic plasmacytoid dendritic cell neoplasm (BPDCN).

     Pivekimab Chemical Structure
  68. GC31312 RCGD423

    A gp130 modulator

     RCGD423 Chemical Structure
  69. GC39430 Reslizumab Reslizumab (Sch 55700) is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma. Reslizumab Chemical Structure
  70. GC69818 Risankizumab

    Risankizumab (BI 655066) is a humanized IgG monoclonal antibody that targets the IL-23 p19 subunit (Kd <10 pM) and can inhibit human IL-23-induced IL-17 production in mouse splenocytes (IC50 = 2 pM). Risankizumab can be used to study immune and inflammatory diseases such as psoriasis, psoriatic arthritis, generalized pustular psoriasis, and erythrodermic psoriasis.

     Risankizumab Chemical Structure
  71. GC60327 RO2959 hydrochloride RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride Chemical Structure
  72. GC61248 RO2959 monohydrochloride RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 monohydrochloride Chemical Structure
  73. GC69828 Rolinsatamab

    Rolinsatamab is an effective dual inhibitor of IL-4 and IL-13, which is a fully humanized bispecific monoclonal antibody. Rolinsatamab binds to the chimeric antigen receptor sequence T cells. It can be used for research on immune diseases.

     Rolinsatamab Chemical Structure
  74. GC31804 RP-54745 RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound. RP-54745 Chemical Structure
  75. GC66414 Sarilumab Sarilumab (Anti-Human IL6Rα, Human Antibody) is a human immunoglobulin G1 monoclonal antibody. Sarilumab, a interleukin-6 (IL-6) receptor antagonist, binds to the IL-6 receptor with high affinity and inhibits cis and trans signaling by IL-6, resulting in reduced inflammation. Sarilumab can be used for the research of Rheumatoid arthritis. Sarilumab Chemical Structure
  76. GC66342 Satralizumab Satralizumab, a humanized monoclonal antibody, is a potent Interleukine-6 (IL-6) inhibitor. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research. Satralizumab Chemical Structure
  77. GC15714 SC 144 Gp130 inhibitor SC 144 Chemical Structure
  78. GC37603 SC144 hydrochloride SC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells. SC144 hydrochloride Chemical Structure
  79. GC62444 SDZ 224-015 SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 Chemical Structure
  80. GC39815 Semapimod tetrahydrochloride Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride Chemical Structure
  81. GC68336 Siltuximab Siltuximab Chemical Structure
  82. GC62370 Sodium thiocyanate Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine IL-10 levels. Sodium thiocyanate Chemical Structure
  83. GC64482 SP4206 SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 Chemical Structure
  84. GC69937 Spesolimab

    Spesolimab (BI 655130) is an anti-IL-36R antibody. IL-36 plays an important role in the immune system, and Spesolimab can be used for research on palmoplantar pustulosis (PPP). The reduction of biomarkers associated with innate, Th1/Th17, and neutrophil pathways is related to Spesolimab.

     Spesolimab Chemical Structure
  85. GC69943 SRI-42127

    SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulatory factor that binds to ARE elements, and HuR translocation can promote the production of inflammatory cytokines in glial cells. SRI-42127 can disrupt mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial activation, reducing the recruitment/chemotaxis of neutrophils and monocytes.

     SRI-42127 Chemical Structure
  86. GC17961 Suplatast Tosylate Suplatast Tosilate (IPD 1151T) is an orally active Th2 cytokine inhibitor which can inhibit both IL-4 and IL-5 production from Th2 cells and suppress IgE synthesis. Suplatast Tosylate Chemical Structure
  87. GC37705 Suramin

    Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor.

     Suramin Chemical Structure
  88. GC16832 Suramin hexasodium salt Suramin hexasodium salt(Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin hexasodium salt Chemical Structure
  89. GC50350 TC JL 37 Potent TYK2 inhibitor TC JL 37 Chemical Structure
  90. GC70004 Tebentafusp

    Tebentafusp (IMCgp100) is a bispecific fusion protein that targets gp100, a melanoma-associated antigen. Tebentafusp guides T cells to kill tumor cells expressing gp100 through its high-affinity T cell receptor (TCR) binding domain and anti-CD3 T cell binding domain. Tebentafusp induces the production of inflammatory cytokines and cytolytic proteins, leading to direct lysis of tumor cells.

     Tebentafusp Chemical Structure
  91. GC37809 Tocilizumab

    Tocilizumab, as a humanised monoclonal antibody, can target both membrane-bound and soluble forms of the IL-6 receptor.

     Tocilizumab Chemical Structure
  92. GC70045 Tozorakimab

    Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody that targets interleukin-33. It can be used for research on chronic obstructive pulmonary disease.

     Tozorakimab Chemical Structure
  93. GC66350 Tralokinumab Tralokinumab, a fully human IgG4 monoclonal antibody, specifically binds with high affinity to IL-13 alone, preventing its interaction with the receptor and subsequent downstream signalling. Tralokinumab can be used for the research of the atopic dermatitis (AD). Tralokinumab Chemical Structure
  94. GC31659 Tyk2-IN-4 (BMS-986165) Tyk2-IN-4 (BMS-986165) (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Tyk2-IN-4 (BMS-986165) Chemical Structure
  95. GC37850 Tyrphostin A1 Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. Tyrphostin A1 Chemical Structure
  96. GC50511 UCLA GP130 2 UCLA GP130 2 is a potent, brain-penetrant and orally active GP130 receptor agonist. UCLA GP130 2 Chemical Structure
  97. GC34213 Ustekinumab (Anti-Human IL-12/IL-23, Human Antibody) Ustekinumab (Anti-Human IL-12/IL-23, Human Antibody) is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody. Ustekinumab (Anti-Human IL-12/IL-23, Human Antibody) Chemical Structure
  98. GC31791 Veledimex (INXN-1001) Veledimex (INXN-1001) (INXN-1001), a synthetic analog of the insect molting hormone ecdysone, is an orally active activator ligand for a proprietary gene therapy promoter system. Veledimex (INXN-1001) Chemical Structure
  99. GC33870 Veledimex racemate (RG-115932 racemate) Veledimex racemate (RG-115932 racemate) (INXN-1001 racemate) is the racemate of veledimex. Veledimex racemate (RG-115932 racemate) Chemical Structure
  100. GC30705 Veledimex S enantiomer (INXN-1001 S enantiome) Veledimex S enantiomer (INXN-1001 S enantiomer) is the S enantiomer of veledimex. Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5. Veledimex S enantiomer (INXN-1001 S enantiome) Chemical Structure
  101. GC10210 VGX-1027 Immunomodulator VGX-1027 Chemical Structure

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