Home >> Signaling Pathways >> Immunology/Inflammation >> NO Synthase

NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

Targets for  NO Synthase

Products for  NO Synthase

  1. Cat.No. Product Name Information
  2. GC40262 α-Humulene α-Humulene is a sesquiterpene that has been found in C. α-Humulene  Chemical Structure
  3. GC69799 (Rac)-ZLc-002

    (Rac)-ZLc-002 is an inhibitor that interacts with the binding protein between nNOS and nitric oxide synthase 1 (NOS1AP). It inhibits inflammatory pain and chemotherapy-induced neuropathic pain, and synergistically reduces tumor cell viability with Paclitaxel.

    (Rac)-ZLc-002  Chemical Structure
  4. GC13563 1400W dihydrochloride INOS inhibitor,potent and highly selective 1400W dihydrochloride  Chemical Structure
  5. GC64739 2-Aminoquinoline 2-Aminoquinoline (2-Quinolinamine) is a promising compound as bioavailable nNOS inhibitor but suffers from low human nNOS inhibition, low selectivity versus human eNOS, and significant binding to other CNS targets. 2-Aminoquinoline  Chemical Structure
  6. GC16664 2-Iminobiotin iNOS and nNOS inhibitor 2-Iminobiotin  Chemical Structure
  7. GC39326 2-Iminobiotin hydrobromide 2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide  Chemical Structure
  8. GC34451 3',4'-Dihydroxyflavonol 3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant, which reduces superoxide and improves nitric oxide (NO) function in diabetic rat mesenteric arteries. 3',4'-Dihydroxyflavonol  Chemical Structure
  9. GC68081 3-Amino-1,2,4-triazine 3-Amino-1,2,4-triazine  Chemical Structure
  10. GC38208 3-Bromo-7-nitroindazole A potent inhibitor of nNOS 3-Bromo-7-nitroindazole  Chemical Structure
  11. GC45673 7,8-Dihydroneopterin An antioxidant 7,8-Dihydroneopterin  Chemical Structure
  12. GC16831 Agmatine sulfate α2-adrenergic receptor ligand Agmatine sulfate  Chemical Structure
  13. GC65226 Aminopicoline Aminopicoline (Ascensil) is a potent and nonselective inhibitor of NO synthase (NOS) isoenzymes (iNOS, nNOS, eNOS). Aminopicoline  Chemical Structure
  14. GN10685 Anemarsaponin B Anemarsaponin B  Chemical Structure
  15. GC38735 AR-C102222 hydrochloride AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM. AR-C102222 hydrochloride  Chemical Structure
  16. GC35411 Asperuloside An iridoid glycoside with diverse biological activities Asperuloside  Chemical Structure
  17. GC32457 Asymmetric dimethylarginine An endogenous NOS inhibitor Asymmetric dimethylarginine  Chemical Structure
  18. GC32486 AVE-3085 AVE-3085 is a potent endothelial nitric oxide synthase enhancer, used for cardiovascular disease treatment. AVE-3085  Chemical Structure
  19. GC34046 Bendazol Bendazol is a hypotensive drug which can also enhance NO synthase activity in renal glomeruli and collecting tubules. Bendazol  Chemical Structure
  20. GC62878 Bryonolic acid Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities. Bryonolic acid  Chemical Structure
  21. GN10342 Chondroitin sulfate

    Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis.

    Chondroitin sulfate  Chemical Structure
  22. GC38900 Ciwujianoside C3 Ciwujianoside?C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax?henryi Harms. Ciwujianoside C3  Chemical Structure
  23. GN10338 Compound K Compound K  Chemical Structure
  24. GC38224 Crocin II Crocin II  Chemical Structure
  25. GC18864 Curvularin Curvularin is a natural fungal macrolactone that has cytotoxic activity against select cancer cell lines. Curvularin  Chemical Structure
  26. GC38431 Dehydroevodiamine Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine  Chemical Structure
  27. GC18259 DETA NONOate

    A NO donor

    DETA NONOate  Chemical Structure
  28. GC60152 Epibetulinic acid Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively. Epibetulinic acid  Chemical Structure
  29. GC61669 Ethyl 3,4-dihydroxybenzoate Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate  Chemical Structure
  30. GC38678 Ethyl Caffeate Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl Caffeate  Chemical Structure
  31. GN10220 Ginsenoside Rb3 Ginsenoside Rb3  Chemical Structure
  32. GC31673 GW274150 GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150  Chemical Structure
  33. GC39388 GW274150 phosphate GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 phosphate  Chemical Structure
  34. GA10738 H-Arg-OH H-Arg-OH  Chemical Structure
  35. GA11127 H-Arg-OH.HCl H-Arg-OH.HCl  Chemical Structure
  36. GN10205 Irisflorentin Irisflorentin  Chemical Structure
  37. GC41273 Isoquercetin Isoquercetin is a flavonoid that has been isolated from A. Isoquercetin  Chemical Structure
  38. GC45488 Isosorbide Dinitrate   Isosorbide Dinitrate  Chemical Structure
  39. GC31391 Kuwanon A Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L. Kuwanon A  Chemical Structure
  40. GC68379 L-Arginine-13C6,15N4 hydrochloride L-Arginine-13C6,15N4 hydrochloride  Chemical Structure
  41. GC65194 L-Arginine-15N2 hydrochloride L-Arginine-15N2 hydrochloride  Chemical Structure
  42. GC63918 L-Arginine-15N4 hydrochloride L-Arginine-15N4 hydrochloride  Chemical Structure
  43. GC16200 L-Biopterin L-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor. L-Biopterin  Chemical Structure
  44. GC16656 L-Canavanine sulfate iNOS inhibitor L-Canavanine sulfate  Chemical Structure
  45. GA11233 L-NAME hydrochloride

    NG-nitro-L-arginine methyl ester (L-NAME) have been widely used to inhibit constitutive NO synthase (NOS) in different biological systems.

    L-NAME hydrochloride  Chemical Structure
  46. GC36471 L-NIL L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS. L-NIL  Chemical Structure
  47. GC12867 L-NIO dihydrochloride inhibitor of nitric oxide (NO) synthase L-NIO dihydrochloride  Chemical Structure
  48. GC16926 L-NMMA acetate inhibitor of all three NOS isoforms L-NMMA acetate  Chemical Structure
  49. GC61015 Luteolin 5-O-glucoside Luteolin 5-O-glucoside, a major flavonoidfrom Cirsium maackii, possesses anti-inflammatory activity. Luteolin 5-O-glucoside  Chemical Structure
  50. GC30051 Methylene Blue (Basic Blue 9) Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene Blue (Basic Blue 9)  Chemical Structure
  51. GC39603 Methylene blue trihydrate Methylene blue trihydrate (C. Methylene blue trihydrate  Chemical Structure
  52. GC60267 Neocryptotanshinone Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways. Neocryptotanshinone  Chemical Structure
  53. GC50011 Nw-Propyl-L-arginine hydrochloride Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nw-Propyl-L-arginine hydrochloride  Chemical Structure
  54. GC36914 Piceatannol 3'-O-glucoside Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC50s of 11.22 ?M and 11.06 ?M against arginase I and arginase II, respectively. Piceatannol 3'-O-glucoside  Chemical Structure
  55. GN10395 Prim-O-glucosylcimifugin Prim-O-glucosylcimifugin  Chemical Structure
  56. GC61235 Regaloside B Regaloside B is a phenylpropanoid isolated from Lilium longiflorum. Regaloside B  Chemical Structure
  57. GC61238 Rehmapicrogenin Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6. Rehmapicrogenin  Chemical Structure
  58. GC31243 S-MTC

    S-MTC is a selective type I nitric oxide synthase (NOS) inhibitor.

    S-MTC  Chemical Structure
  59. GC38849 S-Nitroso-N-acetyl-DL-penicillamine An Snitrosothiol NO donor S-Nitroso-N-acetyl-DL-penicillamine  Chemical Structure
  60. GC30323 Syzalterin Syzalterin is an inhibitor of NO production with an IC50 of 1.87 μg/mL. Syzalterin  Chemical Structure
  61. GC30774 Tat-NR2B9c

    Tat-NR2B9c is designed to prevent nitric oxide (NO) production by preventing postsynaptic density protein 95 (PSD-95) binding to N-methyl-D-aspartate (NMDA) receptors and neuronal nitric oxide synthase.

    Tat-NR2B9c  Chemical Structure
  62. GC34828 Tat-NR2B9c TFA Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA  Chemical Structure
  63. GC60354 Tat-NR2Baa Tat-NR2BAA is the control peptide of Tat-NR2B9c, inactive. Tat-NR2Baa  Chemical Structure
  64. GC31672 Tetrahydrobiopterin (Sapropterin) Tetrahydrobiopterin (Sapropterin) ((Rac)-Sapropterin) is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms. Tetrahydrobiopterin (Sapropterin)  Chemical Structure
  65. GC34255 TP508 TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508  Chemical Structure
  66. GC39515 TP508 TFA TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA  Chemical Structure
  67. GC26091 ZLc002 ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc002  Chemical Structure

66 Item(s)

per page

Set Descending Direction