NO Synthase
Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.
Targets for NO Synthase
Products for NO Synthase
- Cat.No. Product Name Information
- GC40262 α-Humulene α-Humulene is a sesquiterpene that has been found in C.
-
GC69799
(Rac)-ZLc-002
(Rac)-ZLc-002 is an inhibitor that interacts with the binding protein between nNOS and nitric oxide synthase 1 (NOS1AP). It inhibits inflammatory pain and chemotherapy-induced neuropathic pain, and synergistically reduces tumor cell viability with Paclitaxel.
- GC13563 1400W dihydrochloride INOS inhibitor,potent and highly selective
- GC64739 2-Aminoquinoline 2-Aminoquinoline (2-Quinolinamine) is a promising compound as bioavailable nNOS inhibitor but suffers from low human nNOS inhibition, low selectivity versus human eNOS, and significant binding to other CNS targets.
- GC16664 2-Iminobiotin iNOS and nNOS inhibitor
- GC39326 2-Iminobiotin hydrobromide 2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog.
- GC34451 3',4'-Dihydroxyflavonol 3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant, which reduces superoxide and improves nitric oxide (NO) function in diabetic rat mesenteric arteries.
- GC68081 3-Amino-1,2,4-triazine
- GC38208 3-Bromo-7-nitroindazole A potent inhibitor of nNOS
- GC45673 7,8-Dihydroneopterin An antioxidant
- GC16831 Agmatine sulfate α2-adrenergic receptor ligand
- GC65226 Aminopicoline Aminopicoline (Ascensil) is a potent and nonselective inhibitor of NO synthase (NOS) isoenzymes (iNOS, nNOS, eNOS).
- GN10685 Anemarsaponin B
- GC38735 AR-C102222 hydrochloride AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM.
- GC35411 Asperuloside An iridoid glycoside with diverse biological activities
- GC32457 Asymmetric dimethylarginine An endogenous NOS inhibitor
- GC32486 AVE-3085 AVE-3085 is a potent endothelial nitric oxide synthase enhancer, used for cardiovascular disease treatment.
- GC34046 Bendazol Bendazol is a hypotensive drug which can also enhance NO synthase activity in renal glomeruli and collecting tubules.
- GC62878 Bryonolic acid Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities.
-
GN10342
Chondroitin sulfate
Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis.
- GC38900 Ciwujianoside C3 Ciwujianoside?C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax?henryi Harms.
- GN10338 Compound K
- GC38224 Crocin II
- GC18864 Curvularin Curvularin is a natural fungal macrolactone that has cytotoxic activity against select cancer cell lines.
- GC38431 Dehydroevodiamine Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes.
-
GC18259
DETA NONOate
A NO donor
- GC60152 Epibetulinic acid Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively.
- GC61669 Ethyl 3,4-dihydroxybenzoate Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds.
- GC38678 Ethyl Caffeate Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa.
- GN10220 Ginsenoside Rb3
- GC31673 GW274150 GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM).
- GC39388 GW274150 phosphate GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM).
- GA10738 H-Arg-OH
- GA11127 H-Arg-OH.HCl
- GN10205 Irisflorentin
- GC41273 Isoquercetin Isoquercetin is a flavonoid that has been isolated from A.
- GC45488 Isosorbide Dinitrate
- GC31391 Kuwanon A Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.
- GC68379 L-Arginine-13C6,15N4 hydrochloride
- GC65194 L-Arginine-15N2 hydrochloride
- GC63918 L-Arginine-15N4 hydrochloride
- GC16200 L-Biopterin L-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.
- GC16656 L-Canavanine sulfate iNOS inhibitor
-
GA11233
L-NAME hydrochloride
NG-nitro-L-arginine methyl ester (L-NAME) have been widely used to inhibit constitutive NO synthase (NOS) in different biological systems.
- GC36471 L-NIL L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS.
- GC12867 L-NIO dihydrochloride inhibitor of nitric oxide (NO) synthase
- GC16926 L-NMMA acetate inhibitor of all three NOS isoforms
- GC61015 Luteolin 5-O-glucoside Luteolin 5-O-glucoside, a major flavonoidfrom Cirsium maackii, possesses anti-inflammatory activity.
- GC30051 Methylene Blue (Basic Blue 9) Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor.
- GC39603 Methylene blue trihydrate Methylene blue trihydrate (C.
- GC60267 Neocryptotanshinone Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways.
- GC50011 Nw-Propyl-L-arginine hydrochloride Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM.
- GC36914 Piceatannol 3'-O-glucoside Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC50s of 11.22 ?M and 11.06 ?M against arginase I and arginase II, respectively.
- GN10395 Prim-O-glucosylcimifugin
- GC61235 Regaloside B Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.
- GC61238 Rehmapicrogenin Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6.
-
GC31243
S-MTC
S-MTC is a selective type I nitric oxide synthase (NOS) inhibitor.
- GC38849 S-Nitroso-N-acetyl-DL-penicillamine An Snitrosothiol NO donor
- GC30323 Syzalterin Syzalterin is an inhibitor of NO production with an IC50 of 1.87 μg/mL.
-
GC30774
Tat-NR2B9c
Tat-NR2B9c is designed to prevent nitric oxide (NO) production by preventing postsynaptic density protein 95 (PSD-95) binding to N-methyl-D-aspartate (NMDA) receptors and neuronal nitric oxide synthase.
- GC34828 Tat-NR2B9c TFA Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively.
- GC60354 Tat-NR2Baa Tat-NR2BAA is the control peptide of Tat-NR2B9c, inactive.
- GC31672 Tetrahydrobiopterin (Sapropterin) Tetrahydrobiopterin (Sapropterin) ((Rac)-Sapropterin) is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms.
- GC34255 TP508 TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule.
- GC39515 TP508 TFA TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule.
- GC26091 ZLc002 ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain.