PGE synthase
Prostagladin E synthase catalzyes the oxidoreduction of PGHS (prostaglandin endoperoxde h2) into PGE2(prostaglandin E2). It is implicated in physiological conditions such as fever, pain and arthritis etc.
Products for PGE synthase
- Cat.No. Product Name Information
- GC15058 Benzydamine HCl Benzydamine HCl is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties; selectively binds to prostaglandin synthetase and has notable in vitro antibacterial activity.
- GC17707 Bismuth Subsalicylate Prostaglandin G/H Synthase 1/2 inhibitor
- GC40352 Cafestol Cafestol is a natural diterpene which is abundant in unfiltered coffee.
- GC18904 CAY10678 Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product PGH2 into the biologically active PGE2.
- GC38431 Dehydroevodiamine Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes.
- GC38678 Ethyl Caffeate Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa.
- GC16880 Flurbiprofen Cyclooxygenase inhibitors
- GC14633 HPGDS inhibitor 1 HPGDS inhibitor
- GC36254 HPGDS inhibitor 2 HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC50 of 9.9 nM.
- GC10564 HQL 79 human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
- GC36463 Limaprost A stable, potent analog of PGE1
- GC16607 Mesalamine 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
- GC11743 MF63 A potent, selective, and orally active mPGES-1 inhibitor
- GC36649 mPGES1-IN-3 mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM).
- GC18700 PF-4693627 PF-4693627 is an orally bioavailable inhibitor of microsomal prostaglandin E (PGE) synthase-1 (mPGES-1; IC50 = 3 nM).
- GC32038 PGS-IN-1 (KME-4) PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.
- GC11670 Pranoprofen non-steroidal COX inhibitor
- GC12330 SAR191801 SAR191801 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay.
- GN10280 Sinensetin
- GC14438 Suprofen dual COX-1/COX-2 inhibitor
- GC50101 TFC 007 Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
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GC70119
Vipoglanstat
Vipoglanstat (BI 1029539), also known as formylamide, is an effective, selective, non-peptide small molecule inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with oral activity. Vipoglanstat also has anti-inflammatory activity.
- GC63394 Zaloglanstat Zaloglanstat (ISC-27864) is the inhibitor of the microsomal prostaglandin E synthase-1 (mPGES-1), and can be used to study asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases, etc.
- GC31687 Zomepirac sodium salt (McN-2783-21-98) Zomepirac sodium salt (McN-2783-21-98) (McN-2783-21-98) is a potent prostaglandin biosynthesis inhibitor.