STING
STING (Stimulator of Interferon Genes) is a transmembrane protein localized to the endoplasmic reticulum that undergoes a conformational change in response to direct binding of cyclic dinucleotides (CDNs), resulting in a downstream signaling cascade involving TBK1 activation, IRF-3 phosphorylation, and production of IFN-β and other cytokines.
STING is a pattern recognition receptor of cyclic dinucleotides as well as an innate immune adaptor protein that enables signaling from cytoplasmic receptors to the transcription factor interferon regulatory factor 3. Initiation of these pathways leads to the expression of type I interferons and proteins associated with antiviral and antitumor immunity. Small molecules capable of triggering STING-dependent cellular processes are effective at blocking virus replication, enhancing vaccine efficacy, and facilitating immune response to cancer cells.
Targets for STING
Products for STING
- Cat.No. Product Name Information
- GC49912 13C20,15N10-Cyclic di-GMP (sodium salt) An internal standard for the quantification of cyclic di-GMP
- GC42080 2'2'-cGAMP (sodium salt) 2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds.
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GC42090
2'3'-cGAMP (sodium salt)
2'3'-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA.
- GC25014 3',3'-cGAMP 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.
- GC42245 3'3'-cGAMP (sodium salt) 3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases.
- GC48381 5'-pApA (sodium salt) A linearized form of cyclic di-AMP
- GC48375 5'-pGpG (sodium salt) A linearized form of cyclic di-GMP
- GC49238 93-O17S A cationic lipidoid
- GC31649 ADU-S100 (ML RR-S2 CDA) ADU-S100 (ML RR-S2 CDA) (MIW815), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.
- GC39161 ADU-S100 disodium salt ADU-S100 disodium salt (MIW815 disodium salt) is an activator of stimulator of interferon genes (STING).
- GC42880 Avenanthramide-C methyl ester Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM).
- GC42953 BMS 345541 (trifluoroacetate salt) BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM).
- GC46983 C-170 C-170 (C-170) is a potent and covalent STING inhibitor.
- GC46984 C-171 C-171 is an inhibitor of stimulator of interferon genes (STING).
- GC33823 C-176 (STING inhibitor 1) C-176 (STING inhibitor 1) is a strong and covalent mouse STING inhibitor.
- GC38494 C-178 A STING inhibitor
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GC13643
c-di-AMP
C-di-AMP is a STING agonist, which binds to the transmembrane protein STING, thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF.
- GC62893 c-di-AMP diammonium c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF.
- GC64445 c-di-AMP disodium c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF.
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GC62198
c-di-AMP sodium
C-di-AMP is a STING agonist, which binds to the transmembrane protein STING, thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF.
- GC50687 c-Di-AMP sodium salt
- GC50292 c-Di-GMP sodium salt Endogenous STING and DDX41 agonist; activates STING-dependent signaling
- GC43176 CAY10575 CAY10575 (Compound 8) is an IKK2 inhibitor with an IC50 of 0.075 μM.
- GC18782 CAY10657 The NF-κB/Rel family of transcription factors induce and coordinate the expression of pro-inflammatory genes including cytokines, chemokines, interferons, MHC proteins, growth factors, and cell adhesion molecules.
- GC47054 CAY10748 A STING agonist
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GC14727
CCCP
Carbonylcyanide-3-chlorophenylhydrazone (CCCP) is a protonophore, which causes uncoupling of proton gradient in the inner mitochondrial membrane, thus inhibiting the rate of ATP synthesis.
- GC31696 cGAMP (Cyclic AMP-GMP) cGAMP (Cyclic AMP-GMP) (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA.
- GC63758 cGAMP diammonium cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA.
- GC34329 ChX710 ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
- GC31875 CL656 (c-[2'FdAMP(S)-2'FdIMP(S)]) CL656 (c-[2'FdAMP(S)-2'FdIMP(S)]) is an activator of stimulator of interferon genes (STING).
- GC45413 Cridanimod (sodium salt)
- GC47128 CU-32 A cGAS inhibitor
- GC47129 CU-76 A cGAS inhibitor
- GC43339 Cyclic di-AMP (sodium salt) Cyclic di-AMP (c-di-AMP) is a second messenger produced by bacteria but not by mammals.
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GC15048
Cyclic di-GMP
second messenger
- GC19526 Cyclic di-GMP (sodium salt) Cyclic di-GMP (sodium salt) is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic di-GMP (sodium salt) has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic di-GMP (sodium salt) can be used in cancer research.
- GC43340 Cyclic di-IMP (sodium salt) Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP.
- GC48397 Cyclic di-UMP (sodium salt) A pyrimidine-containing CDN
- GC62917 Cyclic-di-GMP diammonium Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research.
- GC62372 Cyclic-di-GMP sodium Cyclic-di-GMP sodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research.
- GC35853 diABZI STING agonist-1 diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
- GC35854 diABZI STING agonist-1 Tautomerism diABZI STING agonist-1 Tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
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GC35855
diABZI STING agonist-1 trihydrochloride
diABZI STING agonist-1 trihydrochloride, as a STING agonist, is internalized into the cytoplasm through unknown receptor and induce the activation and dimerization of STING followed by TBK1/IRF3 phosporylation leading to type I IFN response.
- GC63473 diABZI-C2-NH2 diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist.
- GC16280 DMXAA (Vadimezan) A STING activator and tumor vascular disrupting agent
- GC62608 E7766 diammonium salt E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities.
- GC62609 E7766 disodium E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities.
- GC52334 ENPP1 Inhibitor 4e An ENPP1 inhibitor
- GC34610 H-151 H-151 is a low MW antagonist of STING, which blocks the activation-induced palmitoylation of STING, and exhibits significant inhibitory effects on STING signalling H-151 can be used in the study of autoinflammatory diseases..
- GC63012 IACS-8803 diammonium IACS-8803 diammonium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 diammonium has a robust systemic antitumor efficacy.
- GC62586 IACS-8803 disodium IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy.
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GC43894
IKK2 Inhibitor VI
Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling.
- GC52291 KAS 08 A STING activator
- GC49673 M04 A STING agonist
- GC18988 ML RR-S2 CDA (ammonium salt) ML RR-S2 CDA (ammonium salt) (MIW815 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.
- GC61092 MSA-2 A STING agonist
- GC63082 MSA-2 dimer MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity.
- GC44388 NF-κB Control NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.
- GC48985 NF-κB Inhibitor (trifluoroacetate salt) A cell-permeable peptide that blocks nuclear import of NF-κB
- GC13693 Omaveloxolone (RTA-408) Omaveloxolone (RTA-408) (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO).
- GC66392 PROTAC STING Degrader-1 PROTAC STING Degrader-1 (Compound SP23) is a STING PROTAC degrader with a DC50 of 3.2 μM. PROTAC STING Degrader-1 shwos anti-inflammatory activity.
- GC67719 SN-001
- GC63905 SN-008 SN-008, a less active SN-011 analog, can be used as a negative control.
- GC49400 SN-011 A STING antagonist
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GC61293
SR-717
SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic, Antitumor activity.
- GC44948 StA-IFN-1 StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1, which specifically inhibits the IKKβ component of the IFN induction pathway.
- GC48109 STING Agonist 12b A STING agonist
- GC48110 STING Agonist 1a STING Agonist 1a (1a) is a specific stimulator of interferon genes (STING) agonist.
- GC45570 STING Agonist C11
- GC12943 STING agonist-1 An indirect activator of STING signaling
- GC65282 STING agonist-12 STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM.
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GC69959
STING agonist-20
STING agonist-20 (compound 95) is an effective STING agonist used in the synthesis of XMT-2056. It can be used as a vaccine adjuvant for cancer, inflammation, and research on immune diseases.
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GC69961
STING agonist-22
STING agonist-22 (CF501) is an effective non-nucleotide STING agonist.
- GC37692 STING agonist-3 STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-moleculeSTINGagonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
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GC69962
STING agonist-3 trihydrochloride
STING agonist-3 trihydrochloride is derived from patent WO2017175147A1 (Example 10) and is a selective and non-nucleotide small molecule STING agonist with pEC50 and pIC50 values of 7.5 and 9.5, respectively. It has long-lasting anti-tumor effects and holds great potential in improving cancer research.
- GC37693 STING agonist-4 A STING agonist
- GC66008 STING agonist-7 STING agonist-7 is a non-nucleotide STING agonist. STING agonist-7 binds selectively to mouse STING but not human STING. STING agonist-7 penetrates cell membrane poorly.
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GC69963
STING agonist-8 dihydrochloride
STING agonist-8 dihydrochloride (5-AB) is an effective STING activator with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells.
- GC34322 STING ligand-1 STING ligand-1 is a lead STING ligand with an IC50 of 68 nM for HAQ STING.
- GC46227 STING18 A competitive STING ligand
- GC52084 YSK05 YSK05 is a pH-sensitive cationic lipid. YSK05 improves the intracellular trafficking of non-viral vectors. YSK05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK05 overcomes the suppression of endosomal escape by PEGylation. YSK05 effectively enhances siRNA delivery both in vitro and in vivo.