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STING

STING (Stimulator of Interferon Genes) is a transmembrane protein localized to the endoplasmic reticulum that undergoes a conformational change in response to direct binding of cyclic dinucleotides (CDNs), resulting in a downstream signaling cascade involving TBK1 activation, IRF-3 phosphorylation, and production of IFN-β and other cytokines.

STING is a pattern recognition receptor of cyclic dinucleotides as well as an innate immune adaptor protein that enables signaling from cytoplasmic receptors to the transcription factor interferon regulatory factor 3. Initiation of these pathways leads to the expression of type I interferons and proteins associated with antiviral and antitumor immunity. Small molecules capable of triggering STING-dependent cellular processes are effective at blocking virus replication, enhancing vaccine efficacy, and facilitating immune response to cancer cells.

Targets for  STING

Products for  STING

  1. Cat.No. Product Name Information
  2. GC49912 13C20,15N10-Cyclic di-GMP (sodium salt) An internal standard for the quantification of cyclic di-GMP 13C20,15N10-Cyclic di-GMP (sodium salt)  Chemical Structure
  3. GC42080 2'2'-cGAMP (sodium salt) 2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. 2'2'-cGAMP (sodium salt)  Chemical Structure
  4. GC42090 2'3'-cGAMP (sodium salt)

    2'3'-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA.

    2'3'-cGAMP (sodium salt)  Chemical Structure
  5. GC25014 3',3'-cGAMP 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs. 3',3'-cGAMP  Chemical Structure
  6. GC42245 3'3'-cGAMP (sodium salt) 3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases. 3'3'-cGAMP (sodium salt)  Chemical Structure
  7. GC48381 5'-pApA (sodium salt) A linearized form of cyclic di-AMP 5'-pApA (sodium salt)  Chemical Structure
  8. GC48375 5'-pGpG (sodium salt) A linearized form of cyclic di-GMP 5'-pGpG (sodium salt)  Chemical Structure
  9. GC49238 93-O17S A cationic lipidoid 93-O17S  Chemical Structure
  10. GC31649 ADU-S100 (ML RR-S2 CDA) ADU-S100 (ML RR-S2 CDA) (MIW815), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity. ADU-S100 (ML RR-S2 CDA)  Chemical Structure
  11. GC39161 ADU-S100 disodium salt ADU-S100 disodium salt (MIW815 disodium salt) is an activator of stimulator of interferon genes (STING). ADU-S100 disodium salt  Chemical Structure
  12. GC42880 Avenanthramide-C methyl ester Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). Avenanthramide-C methyl ester  Chemical Structure
  13. GC42953 BMS 345541 (trifluoroacetate salt) BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM). BMS 345541 (trifluoroacetate salt)  Chemical Structure
  14. GC46983 C-170 C-170 (C-170) is a potent and covalent STING inhibitor. C-170  Chemical Structure
  15. GC46984 C-171 C-171 is an inhibitor of stimulator of interferon genes (STING). C-171  Chemical Structure
  16. GC33823 C-176 (STING inhibitor 1) C-176 (STING inhibitor 1) is a strong and covalent mouse STING inhibitor. C-176 (STING inhibitor 1)  Chemical Structure
  17. GC38494 C-178 A STING inhibitor C-178  Chemical Structure
  18. GC13643 c-di-AMP

    C-di-AMP is a STING agonist, which binds to the transmembrane protein STING, thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF.

    c-di-AMP  Chemical Structure
  19. GC62893 c-di-AMP diammonium c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium  Chemical Structure
  20. GC64445 c-di-AMP disodium c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP disodium  Chemical Structure
  21. GC62198 c-di-AMP sodium

    C-di-AMP is a STING agonist, which binds to the transmembrane protein STING, thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF.

    c-di-AMP sodium  Chemical Structure
  22. GC50687 c-Di-AMP sodium salt c-Di-AMP sodium salt  Chemical Structure
  23. GC50292 c-Di-GMP sodium salt Endogenous STING and DDX41 agonist; activates STING-dependent signaling c-Di-GMP sodium salt  Chemical Structure
  24. GC43176 CAY10575 CAY10575 (Compound 8) is an IKK2 inhibitor with an IC50 of 0.075 μM. CAY10575  Chemical Structure
  25. GC18782 CAY10657 The NF-κB/Rel family of transcription factors induce and coordinate the expression of pro-inflammatory genes including cytokines, chemokines, interferons, MHC proteins, growth factors, and cell adhesion molecules. CAY10657  Chemical Structure
  26. GC47054 CAY10748 A STING agonist CAY10748  Chemical Structure
  27. GC14727 CCCP

    Carbonylcyanide-3-chlorophenylhydrazone (CCCP) is a protonophore, which causes uncoupling of proton gradient in the inner mitochondrial membrane, thus inhibiting the rate of ATP synthesis.

    CCCP  Chemical Structure
  28. GC31696 cGAMP (Cyclic AMP-GMP) cGAMP (Cyclic AMP-GMP) (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP (Cyclic AMP-GMP)  Chemical Structure
  29. GC63758 cGAMP diammonium cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium  Chemical Structure
  30. GC34329 ChX710 ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3. ChX710  Chemical Structure
  31. GC31875 CL656 (c-[2'FdAMP(S)-2'FdIMP(S)]) CL656 (c-[2'FdAMP(S)-2'FdIMP(S)]) is an activator of stimulator of interferon genes (STING). CL656 (c-[2'FdAMP(S)-2'FdIMP(S)])  Chemical Structure
  32. GC45413 Cridanimod (sodium salt)   Cridanimod (sodium salt)  Chemical Structure
  33. GC47128 CU-32 A cGAS inhibitor CU-32  Chemical Structure
  34. GC47129 CU-76 A cGAS inhibitor CU-76  Chemical Structure
  35. GC43339 Cyclic di-AMP (sodium salt) Cyclic di-AMP (c-di-AMP) is a second messenger produced by bacteria but not by mammals. Cyclic di-AMP (sodium salt)  Chemical Structure
  36. GC15048 Cyclic di-GMP

    second messenger

    Cyclic di-GMP  Chemical Structure
  37. GC19526 Cyclic di-GMP (sodium salt) Cyclic di-GMP (sodium salt) is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic di-GMP (sodium salt) has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic di-GMP (sodium salt) can be used in cancer research. Cyclic di-GMP (sodium salt)  Chemical Structure
  38. GC43340 Cyclic di-IMP (sodium salt) Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP. Cyclic di-IMP (sodium salt)  Chemical Structure
  39. GC48397 Cyclic di-UMP (sodium salt) A pyrimidine-containing CDN Cyclic di-UMP (sodium salt)  Chemical Structure
  40. GC62917 Cyclic-di-GMP diammonium Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research. Cyclic-di-GMP diammonium  Chemical Structure
  41. GC62372 Cyclic-di-GMP sodium Cyclic-di-GMP sodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research. Cyclic-di-GMP sodium  Chemical Structure
  42. GC35853 diABZI STING agonist-1 diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. diABZI STING agonist-1  Chemical Structure
  43. GC35854 diABZI STING agonist-1 Tautomerism diABZI STING agonist-1 Tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. diABZI STING agonist-1 Tautomerism  Chemical Structure
  44. GC35855 diABZI STING agonist-1 trihydrochloride

    diABZI STING agonist-1 trihydrochloride, as a STING agonist, is internalized into the cytoplasm through unknown receptor and induce the activation and dimerization of STING followed by TBK1/IRF3 phosporylation leading to type I IFN response.

    diABZI STING agonist-1 trihydrochloride  Chemical Structure
  45. GC63473 diABZI-C2-NH2 diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist. diABZI-C2-NH2  Chemical Structure
  46. GC16280 DMXAA (Vadimezan) A STING activator and tumor vascular disrupting agent DMXAA (Vadimezan)  Chemical Structure
  47. GC62608 E7766 diammonium salt E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities. E7766 diammonium salt  Chemical Structure
  48. GC62609 E7766 disodium E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities. E7766 disodium  Chemical Structure
  49. GC52334 ENPP1 Inhibitor 4e An ENPP1 inhibitor ENPP1 Inhibitor 4e  Chemical Structure
  50. GC34610 H-151 H-151 is a low MW antagonist of STING, which blocks the activation-induced palmitoylation of STING, and exhibits significant inhibitory effects on STING signalling H-151 can be used in the study of autoinflammatory diseases.. H-151  Chemical Structure
  51. GC63012 IACS-8803 diammonium IACS-8803 diammonium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 diammonium has a robust systemic antitumor efficacy. IACS-8803 diammonium  Chemical Structure
  52. GC62586 IACS-8803 disodium IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy. IACS-8803 disodium  Chemical Structure
  53. GC43894 IKK2 Inhibitor VI

    Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling.

    IKK2 Inhibitor VI  Chemical Structure
  54. GC52291 KAS 08 A STING activator KAS 08  Chemical Structure
  55. GC49673 M04 A STING agonist M04  Chemical Structure
  56. GC18988 ML RR-S2 CDA (ammonium salt) ML RR-S2 CDA (ammonium salt) (MIW815 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity. ML RR-S2 CDA (ammonium salt)  Chemical Structure
  57. GC61092 MSA-2 A STING agonist MSA-2  Chemical Structure
  58. GC63082 MSA-2 dimer MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer  Chemical Structure
  59. GC44388 NF-κB Control NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. NF-κB Control  Chemical Structure
  60. GC48985 NF-κB Inhibitor (trifluoroacetate salt) A cell-permeable peptide that blocks nuclear import of NF-κB NF-κB Inhibitor (trifluoroacetate salt)  Chemical Structure
  61. GC13693 Omaveloxolone (RTA-408) Omaveloxolone (RTA-408) (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone (RTA-408)  Chemical Structure
  62. GC66392 PROTAC STING Degrader-1 PROTAC STING Degrader-1 (Compound SP23) is a STING PROTAC degrader with a DC50 of 3.2 μM. PROTAC STING Degrader-1 shwos anti-inflammatory activity. PROTAC STING Degrader-1  Chemical Structure
  63. GC67719 SN-001 SN-001  Chemical Structure
  64. GC63905 SN-008 SN-008, a less active SN-011 analog, can be used as a negative control. SN-008  Chemical Structure
  65. GC49400 SN-011 A STING antagonist SN-011  Chemical Structure
  66. GC61293 SR-717

    SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic, Antitumor activity.

    SR-717  Chemical Structure
  67. GC44948 StA-IFN-1 StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1, which specifically inhibits the IKKβ component of the IFN induction pathway. StA-IFN-1  Chemical Structure
  68. GC48109 STING Agonist 12b A STING agonist STING Agonist 12b  Chemical Structure
  69. GC48110 STING Agonist 1a STING Agonist 1a (1a) is a specific stimulator of interferon genes (STING) agonist. STING Agonist 1a  Chemical Structure
  70. GC45570 STING Agonist C11   STING Agonist C11  Chemical Structure
  71. GC12943 STING agonist-1 An indirect activator of STING signaling STING agonist-1  Chemical Structure
  72. GC65282 STING agonist-12 STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM. STING agonist-12  Chemical Structure
  73. GC69959 STING agonist-20

    STING agonist-20 (compound 95) is an effective STING agonist used in the synthesis of XMT-2056. It can be used as a vaccine adjuvant for cancer, inflammation, and research on immune diseases.

    STING agonist-20  Chemical Structure
  74. GC69961 STING agonist-22

    STING agonist-22 (CF501) is an effective non-nucleotide STING agonist.

    STING agonist-22  Chemical Structure
  75. GC37692 STING agonist-3 STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-moleculeSTINGagonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer. STING agonist-3  Chemical Structure
  76. GC69962 STING agonist-3 trihydrochloride

    STING agonist-3 trihydrochloride is derived from patent WO2017175147A1 (Example 10) and is a selective and non-nucleotide small molecule STING agonist with pEC50 and pIC50 values of 7.5 and 9.5, respectively. It has long-lasting anti-tumor effects and holds great potential in improving cancer research.

    STING agonist-3 trihydrochloride  Chemical Structure
  77. GC37693 STING agonist-4 A STING agonist STING agonist-4  Chemical Structure
  78. GC66008 STING agonist-7 STING agonist-7 is a non-nucleotide STING agonist. STING agonist-7 binds selectively to mouse STING but not human STING. STING agonist-7 penetrates cell membrane poorly. STING agonist-7  Chemical Structure
  79. GC69963 STING agonist-8 dihydrochloride

    STING agonist-8 dihydrochloride (5-AB) is an effective STING activator with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells.

    STING agonist-8 dihydrochloride  Chemical Structure
  80. GC34322 STING ligand-1 STING ligand-1 is a lead STING ligand with an IC50 of 68 nM for HAQ STING. STING ligand-1  Chemical Structure
  81. GC46227 STING18 A competitive STING ligand STING18  Chemical Structure
  82. GC52084 YSK05 YSK05 is a pH-sensitive cationic lipid. YSK05 improves the intracellular trafficking of non-viral vectors. YSK05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK05 overcomes the suppression of endosomal escape by PEGylation. YSK05 effectively enhances siRNA delivery both in vitro and in vivo. YSK05  Chemical Structure

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