MAPK Signaling
Targets for MAPK Signaling
- ERK(85)
- MEK1/2(74)
- NKCC(5)
- MNK(6)
- PKA(56)
- p38(103)
- Rac(2)
- Raf(76)
- RasGAP (Ras- P21)(1)
- JNK(66)
- cAMP(33)
- Protein Kinase G(2)
- RSK(33)
- Other(759)
- MAPKAPK(1)
- MKK(2)
- KLF(3)
- MAP3K(22)
- MAP4K(21)
- MAPKAPK2 (MK2)(9)
- Mixed Lineage Kinase(9)
Products for MAPK Signaling
- Cat.No. Product Name Information
- GC48920 β-Carboline-1-carboxylic Acid An alkaloid with diverse biological activities
- GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol 2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system.
- GC60393 (-)-Zuonin A (-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively.
-
GC13944
(5Z)-7-Oxozeaenol
TAK1 mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor
- GC63903 (E)-Osmundacetone (E)-Osmundacetone is the isomer of Osmundacetone.
- GC62528 (Rac)-Hesperetin (Rac)-Hesperetin is the racemate of Hesperetin.
- GC41740 (S)-p38 MAPK Inhibitor III (S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro).
- GC12851 10Z-Hymenialdisine Pan kinase inhibitor
- GC46554 2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate 2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate is a cAMP analog that can be covalently coupled to acetylcholinesterase.
- GC39325 2,5-Dihydroxyacetophenone 2,5-Dihydroxyacetophenone, isolated from Rehmanniae Radix Preparata, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways.
- GC35132 4-Hydroxylonchocarpin 4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia.
- GC48381 5'-pApA (sodium salt) A linearized form of cyclic di-AMP
- GC63700 5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect.
- GC41423 5-trans Prostaglandin E2 5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.
- GC12834 6-Bnz-cAMP sodium salt cAMP analog,PKA activator
-
GC42616
7-oxo Staurosporine
7-oxo Staurosporine is an antibiotic originally isolated from S.
- GC16929 8-Bromo-cAMP, sodium salt Cell-permeable cAMP analog that activates PKA
- GC42622 8-bromo-Cyclic AMP 8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase.
- GC64460 8-Chloro-cAMP 8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity.
- GC15352 8-CPT-Cyclic AMP (sodium salt) 8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA).
- GC60037 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases.
- GA20623 Ac-muramyl-Ala-D-Glu-NH₂ Ac-muramyl-Ala-D-Glu-NH₂ (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln.
-
GC68597
ACA-28
ACA-28 (compound 2a) is an effective ERK MAPK signaling regulator. ACA-28 induces apoptosis through excessive activation of ERK and selectively inhibits cancer cell growth. ACA-28 inhibits the growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 and 10.1 μM, respectively.
- GC35242 Actein Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo.
- GC19019 Acumapimod Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α.
- GC32797 AD80 AD80, a multikinase inhibitor, inhibits RET, RAF,SRCand S6K, with greatly reduced mTOR activity.
- GC49285 Adenosine 5’-methylenediphosphate (hydrate) An inhibitor of ecto-5’-nucleotidase
- GC46808 ADTL-EI1712 A dual ERK1 and ERK5 inhibitor
- GC10204 AEG 3482 inhibitor of Jun kinase (JNK)-dependent apoptosis
- GC17265 AG-126 ERK1 (p44) and ERK2 (p42) inhibitor
- GC12646 AL 8697 p38α inhibitor,potent and selective
-
GC14899
AMG 548
P38α inhibitor,potent and selective
- GC38518 AMG-548 dihydrochloride AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ.
- GC65917 Andrograpanin Andrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties.
-
GC11559
Anisomycin
JNK agonist, potent and specific
- GC15240 APS-2-79 APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling.
- GC32692 APTO-253 (LOR-253) APTO-253 (LOR-253) (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells.
- GN10063 Arctigenin
- GC12882 AS 602801 A selective, orally bioavailable JNK inhibitor
- GC10010 AS601245 A c-Jun NH2-terminal protein kinase inhibitor
- GC19041 ASK1-IN-1 ASK1-IN-1 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM.
- GC62426 ASK1-IN-2 ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM.
- GC35412 Asperulosidic Acid Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd.
- GN10494 Astragaloside IV
- GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive
-
GC12297
AT7867
Akt1/2/3 and p70S6K/PKA inhibitor
- GC10918 AT7867 dihydrochloride A potent and orally bioavailable pan-Akt inhibitor
- GC31667 AX-15836 AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM.
-
GC15055
AZ 628
Raf kinases,potent and ATP-competitive
-
GC19479
AZ304
A dual inhibitor
- GC19048 AZD-0364 AZD-0364 (AZD0364) is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1, compound example 18, has an IC50 of 0.6 nM.
- GC17030 AZD6244(Selumetinib) A highly selective inhibitor of MEK1/2
- GC31924 AZD7624 AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.
- GC14643 AZD8330 MEK 1/2 inhibitor
- GC38738 Azosemide Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC50s of 0.246??M and 0.197??M for hNKCC1A and NKCC1B, respectively.
- GC10534 B-Raf IN 1 B-Raf inhibitor
- GC65978 B-Raf IN 10 B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity.
- GC67800 B-Raf IN 11
- GC64550 B-Raf IN 2 B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be used for the research of cancer.
- GC12151 B-Raf inhibitor
- GC11599 B-Raf inhibitor 1 B-Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively.
- GC14907 B-Raf inhibitor 1 dihydrochloride B-B-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively.
- GN10590 Bakuchiol
- GC33305 Balamapimod (MKI 833) Balamapimod (MKI 833) (MKI 833) is a reversible Ras/Raf/MEK inhibitor with potential anti-tumor activity.
- GC34342 BAY885 An ERK5 inhibitor
- GC32950 Belvarafenib An inhibitor of B-RAF and C-RAF
- GC35488 Belvarafenib TFA Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.
- GC19066 BGB-283 BGB-283 is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.
- GC12904 BI 78D3 Competitive JNK inhibitor
- GC17828 BI-847325 dual inhibitor of MEK and Aurora kinases
- GC18178 BI-882370 A RAF inhibitor
- GC13468 BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable
- GC35518 Bilobetin A biflavonoid with diverse biological activities
- GC11497 BIRB 796 (Doramapimod) BIRB 796 (Doramapimod) (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM.
- GC35525 Bisabolangelone Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix.
- GC15693 BIX 02188 MEK5 inhibitor,potent and selective
- GC12220 BIX 02189 Selective MEK5 inhibitor
- GC12982 BIX 02565 RSK2 inhibitor
- GC16997 BMS-582949 p38 MAPK inhibitor
- GC10593 BMS-582949 hydrochloride p38 MAPK inhibitor
- GC42968 BPIQ-II (hydrochloride) BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM).
- GC12482 BRAF inhibitor
- GC16779 BRD 7389 P90 RSK inhibitor
- GC35565 Bucladesine calcium salt Bucladesine calcium salt salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP.
- GC15524 Bumetanide NKCC cotransporter inhibitor
- GC11605 C-1 C-1 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. C-1 also used as a ROCK inhibitor.
- GC10693 c-JUN peptide JNK/c-Jun interaction inhibitor
- GC43065 C2 Phytoceramide (t18:0/2:0) C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 μM) in suspended polymorphonuclear cells.
- GC40352 Cafestol Cafestol is a natural diterpene which is abundant in unfiltered coffee.
- GC10941 cAMPS-Rp, triethylammonium salt cAMPS-Rp, triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist.
- GC12706 cAMPS-Sp, triethylammonium salt cAMPS-Sp, triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist.
- GN10016 Carnosol
- GC47045 Carvedilol-d5 An internal standard for the quantification of carvedilol
- GC43167 CAY10561 The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes.
- GC40650 CAY10706 CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells.
- GC43198 CAY10717 CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM.
- GC50400 CC 401 dihydrochloride High affinity JNK inhibitor; also inhibits HCMV replication
- GC13529 CC-401 JNK inhibitor,ATP-competitive
- GC14197 CC-401 hydrochloride A potent, specific pan-JNK inhibitor
- GC62492 CC-90001 CC-90001 is a potent, selective and orally active inhibitor of c-Jun N-terminal kinase (JNK).