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Home >> Signaling Pathways >> MAPK Signaling >> MAPKAPK2 (MK2)

MAPKAPK2 (MK2)

MAP kinase-activated protein kinase 2 (MAPKAPK2) is an enzyme that in humans is encoded by the MAPKAPK2 gene. MAPKAP kinase-2 (MK2) is originally identified by its phosphorylation of glycogen synthase at serine-7 and the corresponding serine in a peptide (GS peptide-1) modelled after the N-terminus of glycogen synthase.

MAPKAP kinase-2 is a novel protein kinase activated by mitogen-activated protein kinase. This MAP kinase activated protein kinase, termed MAPKAP kinase-2, is distinguished from S6 kinase-II (MAPKAP kinase-1) by its response to inhibitors, lack of phosphorylation of S6 peptides and amino acid sequence.

Targets for  MAPKAPK2 (MK2)

Products for  MAPKAPK2 (MK2)

  1. Cat.No. Product Name Information
  2. GC63441 CC-99677 CC-99677 is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). CC-99677 Chemical Structure
  3. GC11180 CMPD-1 inhibitor of p38α-mediated MK2a phosphorylation CMPD-1 Chemical Structure
  4. GC44211 MK2 Inhibitor III MK2 Inhibitor III (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM. MK2 Inhibitor III Chemical Structure
  5. GC16723 MK2 Inhibitor IV MK2 Inhibitor IV is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode. MK2 Inhibitor IV Chemical Structure
  6. GC33142 MK2-IN-1 (MK2 Inhibitor) MK2-IN-1 (MK2 Inhibitor) is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode. MK2-IN-1 (MK2 Inhibitor) Chemical Structure
  7. GC61819 MK2-IN-3 MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC50 of 8.5 nM. MK2-IN-3 Chemical Structure
  8. GC64580 MMI-0100 MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II (MK2). MMI-0100 Chemical Structure
  9. GC14645 PF-3644022 Potent and Selective MK2 inhibitor PF-3644022 Chemical Structure
  10. GC63425 Zunsemetinib Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib Chemical Structure

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