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Home >> Signaling Pathways >> MAPK Signaling >> p38

p38

p38 (p38 mitogen-activated protein kinases) are serine/threonine kinases that activated by environmental stress and proinflammatory cydtokines. They mediates cell growth, differentiation, transcrption and development.

Products for  p38

  1. Cat.No. Product Name Information
  2. GC63903 (E)-Osmundacetone (E)-Osmundacetone is the isomer of Osmundacetone. (E)-Osmundacetone Chemical Structure
  3. GC62528 (Rac)-Hesperetin (Rac)-Hesperetin is the racemate of Hesperetin. (Rac)-Hesperetin Chemical Structure
  4. GC41740 (S)-p38 MAPK Inhibitor III (S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). (S)-p38 MAPK Inhibitor III Chemical Structure
  5. GC35132 4-Hydroxylonchocarpin 4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin Chemical Structure
  6. GC63700 5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect. 5,6,7-Trimethoxyflavone Chemical Structure
  7. GA20623 Ac-muramyl-Ala-D-Glu-NH₂ Ac-muramyl-Ala-D-Glu-NH₂ (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Ac-muramyl-Ala-D-Glu-NH₂ Chemical Structure
  8. GC19019 Acumapimod Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α. Acumapimod Chemical Structure
  9. GC12646 AL 8697 p38α inhibitor,potent and selective AL 8697 Chemical Structure
  10. GC14899 AMG 548

    P38α inhibitor,potent and selective

     AMG 548 Chemical Structure
  11. GC38518 AMG-548 dihydrochloride AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride Chemical Structure
  12. GC65917 Andrograpanin Andrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties. Andrograpanin Chemical Structure
  13. GC31924 AZD7624 AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 Chemical Structure
  14. GN10590 Bakuchiol Bakuchiol Chemical Structure
  15. GC11497 BIRB 796 (Doramapimod) BIRB 796 (Doramapimod) (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. BIRB 796 (Doramapimod) Chemical Structure
  16. GC35525 Bisabolangelone Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone Chemical Structure
  17. GC16997 BMS-582949 p38 MAPK inhibitor BMS-582949 Chemical Structure
  18. GC10593 BMS-582949 hydrochloride p38 MAPK inhibitor BMS-582949 hydrochloride Chemical Structure
  19. GC35674 Chicanine Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity. Chicanine Chemical Structure
  20. GC11180 CMPD-1 inhibitor of p38α-mediated MK2a phosphorylation CMPD-1 Chemical Structure
  21. GN10409 cor-nuside cor-nuside Chemical Structure
  22. GC15477 DBM 1285 dihydrochloride p38 MAPK inhibitor DBM 1285 dihydrochloride Chemical Structure
  23. GC35832 Dehydrocorydaline chloride An alkaloid with diverse biological activities Dehydrocorydaline chloride Chemical Structure
  24. GC38319 Dihydrocaffeic acid Dihydrocaffeic acid is a phenolic acid found in Gynura bicolor, reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid Chemical Structure
  25. GC31697 Dilmapimod (SB-681323) Dilmapimod (SB-681323) (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease. Dilmapimod (SB-681323) Chemical Structure
  26. GC10403 EO 1428 p38α and p38β2 inhibitor EO 1428 Chemical Structure
  27. GC38708 Esculin Esculin Chemical Structure
  28. GC65329 EW-7195 EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC50 of 4.83 nM. EW-7195 has >300-fold selectivity for ALK5 over p38α. EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung. EW-7195 Chemical Structure
  29. GC40484 Ferulic Acid methyl ester Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. Ferulic Acid methyl ester Chemical Structure
  30. GC32411 FR 167653 (FR 167653 sulfate) FR 167653 (FR 167653 sulfate) (FR 167653 (FR 167653 sulfate) sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) Chemical Structure
  31. GC31058 FR 167653 free base FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base Chemical Structure
  32. GC38917 Gossypetin A flavonoid with diverse biological activities Gossypetin Chemical Structure
  33. GC63000 Gypenoside L Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L Chemical Structure
  34. GN10248 Hesperitin Hesperitin Chemical Structure
  35. GC39095 Isoliquiritin apioside Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells. Isoliquiritin apioside Chemical Structure
  36. GC32209 ITX5061 ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). ITX5061 Chemical Structure
  37. GC13116 JX 401 p38α inhibitor JX 401 Chemical Structure
  38. GC36447 Licochalcone E Licochalcone E, a flavonoid compound isolated from Glycyrrhiza inflate, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation. Licochalcone E Chemical Structure
  39. GC13717 Losmapimod p38 MAPK inhibitor, orally active Losmapimod Chemical Structure
  40. GC16835 LY2228820 LY2228820 (LY2228820 dimesylate) is a selective, ATP-competitive inhibitor of p38 MAPK α/β with IC50s of 5.3 and 3.2 nM, respectively. LY2228820 Chemical Structure
  41. GC30676 MAPK13-IN-1 MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM. MAPK13-IN-1 Chemical Structure
  42. GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram Methyl Diethyldithiocarbamate Chemical Structure
  43. GC62315 MKK7-COV-9 MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC50 of 4.98 μM. MKK7-COV-9 Chemical Structure
  44. GC65297 MW-150 MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 Chemical Structure
  45. GC34918 MW-150 dihydrochloride dihydrate MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 dihydrochloride dihydrate Chemical Structure
  46. GC60262 N-Feruloyloctopamine N-Feruloyloctopamine is an antioxidant constituent. N-Feruloyloctopamine significantly decreases thephosphorylationlevels of Akt and p38MAPK. N-Feruloyloctopamine Chemical Structure
  47. GC50316 Org 48762-0 Selective p38α/β inhibitor; orally bioavailable Org 48762-0 Chemical Structure
  48. GC69639 OVA-E1 peptide TFA

    OVA-E1 peptide TFA is an antagonist mutant of SIINFEKL [OVA (257-264)]. OVA-E1 peptide activates the p38 and JNK cascades in both mutant and wild-type thymocytes.

     OVA-E1 peptide TFA Chemical Structure
  49. GC44530 p38 MAPK Inhibitor p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). p38 MAPK Inhibitor Chemical Structure
  50. GC18602 p38 MAPK Inhibitor IV p38 MAPK Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC50s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively. p38 MAPK Inhibitor IV Chemical Structure
  51. GC33008 p38 MAPK-IN-1 p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM. p38 MAPK-IN-1 Chemical Structure
  52. GC30609 p38 MAPK-IN-2 p38 MAPK-IN-2 is an inhibitor of p38 kinase. p38 MAPK-IN-2 Chemical Structure
  53. GC62404 p38α inhibitor 2 p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 Chemical Structure
  54. GC31988 p38α inhibitor 1 p38α inhibitor 1 is a p38α inhibitor extracted from patent WO 2008076265 A1. p38α inhibitor 1 Chemical Structure
  55. GC30158 p38-α MAPK-IN-1 p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay. p38-α MAPK-IN-1 Chemical Structure
  56. GC15814 Pamapimod (R-1503, Ro4402257) Pamapimod (R-1503, Ro4402257) (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod (R-1503, Ro4402257) Chemical Structure
  57. GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia. Paris saponin VII Chemical Structure
  58. GC17737 PD 169316 P38 MAPK inhibitor PD 169316 Chemical Structure
  59. GC11857 Pexmetinib (ARRY-614) Pexmetinib (ARRY-614) is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia. Pexmetinib (ARRY-614) Chemical Structure
  60. GC14645 PF-3644022 Potent and Selective MK2 inhibitor PF-3644022 Chemical Structure
  61. GC10261 PH-797804 P38 MAP kinase inhibitor, potent and selective PH-797804 Chemical Structure
  62. GC19304 R1487 Hydrochloride R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α. R1487 Hydrochloride Chemical Structure
  63. GN10784 Rhoifolin Rhoifolin Chemical Structure
  64. GC38609 Rotundic acid Rotundic acid, a triterpenoid obtained from I. Rotundic acid Chemical Structure
  65. GC13142 RWJ 67657 orally active inhibitor of the MAP kinases p38α and p38β RWJ 67657 Chemical Structure
  66. GC18273 SB 202190 (hydrochloride) SB 202190 is a potent, selective, and cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively. SB 202190 (hydrochloride) Chemical Structure
  67. GC16019 SB 202474 a negative control in studies of p38 inhibition SB 202474 Chemical Structure
  68. GC13001 SB 203580 hydrochloride Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. SB 203580 hydrochloride Chemical Structure
  69. GC10054 SB 239063 A selective p38 MAPK inhibitor SB 239063 Chemical Structure
  70. GC37595 SB 242235 SB-242235 is a potent and selective p38 MAP kinase inhibitor, with an IC50 of 1.0　μM in primary human chondrocytes. SB 242235 Chemical Structure
  71. GC11922 SB 706504 p38 MAPK inhibitor SB 706504 Chemical Structure
  72. GC13968 SB202190 (FHPI) SB202190 (FHPI) is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB202190 (FHPI) Chemical Structure
  73. GC19325 SD 0006 SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po).IC50 value: 170 nM. SD 0006 Chemical Structure
  74. GC14982 SD 169 selective ATP competitive inhibitor of the MAP kinases p38α and p38β SD 169 Chemical Structure
  75. GC39815 Semapimod tetrahydrochloride Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride Chemical Structure
  76. GC33229 SJFα SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC50 of 7.16nM, but is far less effective at degrading p38δ (DC50=299nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5μM. SJFα Chemical Structure
  77. GC33238 SJFδ SJFδ is a 10-atom linker PROTAC based on von Hippel-Lindau ligand. SJFδ degrades p38δ with a DC50 of 46.17nM, but does not degrade p38α, p38β, or p38γ. SJFδ Chemical Structure
  78. GC30646 Skatole(3-Methylindole) Skatole(3-Methylindole) is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Skatole(3-Methylindole) Chemical Structure
  79. GC13578 Skepinone-L An inhibitor of p38 MAPK Skepinone-L Chemical Structure
  80. GC17725 SKF 86002 dihydrochloride p38 MAP kinase inhibitor SKF 86002 dihydrochloride Chemical Structure
  81. GC37646 SKF-86002 SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 Chemical Structure
  82. GC13825 TA 01

    CK1ε, CK1δ,and p38α inhibitor

     TA 01 Chemical Structure
  83. GC11635 TA 02 p38 MAPK inhibitor TA 02 Chemical Structure
  84. GC16543 TAK-715 A p38 MAPK inhibitor TAK-715 Chemical Structure
  85. GC34072 Talmapimod (SCIO-469) Talmapimod (SCIO-469) (SCIO-469) is an orally active, selective, and ATP-competitive p38α inhibitor with an IC50 of 9 nM. Talmapimod (SCIO-469) shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs. Talmapimod (SCIO-469) Chemical Structure
  86. GC19366 UM-164 UM-164 is a highly potent inhibitor of c-Src with a Kd of 2.7 nM. UM-164 Chemical Structure
  87. GC17508 VX-702 P38α MAPK inhibitor,highly selective and ATP-competitive VX-702 Chemical Structure
  88. GC12926 VX-745 VX-745 (VX-745) is a potent, blood-brain barrier penetrant, highly selective inhibitor of p38α inhibitor with an IC50 for p38α of 10 nM and for p38β of 220 nM. VX-745 Chemical Structure
  89. GC62146 XST-14 XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects. XST-14 Chemical Structure

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