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RSK

RSK (ribosomal s6 kinase) is a family of protein kinases involved in signal transduction.

Products for  RSK

  1. Cat.No. Product Name Information
  2. GC32797 AD80 AD80, a multikinase inhibitor, inhibits RET, RAF,SRCand S6K, with greatly reduced mTOR activity. AD80  Chemical Structure
  3. GC15240 APS-2-79 APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling. APS-2-79  Chemical Structure
  4. GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive AT13148  Chemical Structure
  5. GC12297 AT7867

    Akt1/2/3 and p70S6K/PKA inhibitor

    AT7867  Chemical Structure
  6. GC10918 AT7867 dihydrochloride A potent and orally bioavailable pan-Akt inhibitor AT7867 dihydrochloride  Chemical Structure
  7. GC13468 BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable BI-D1870  Chemical Structure
  8. GC12982 BIX 02565 RSK2 inhibitor BIX 02565  Chemical Structure
  9. GC16779 BRD 7389 P90 RSK inhibitor BRD 7389  Chemical Structure
  10. GN10016 Carnosol Carnosol  Chemical Structure
  11. GC38755 CKI-7 CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases. CKI-7  Chemical Structure
  12. GC14693 CMK CMK  Chemical Structure
  13. GC61941 Eudesmin Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Eudesmin  Chemical Structure
  14. GC14125 FMK An inhibitor of RSK2 FMK  Chemical Structure
  15. GC34197 FMK-MEA

    A potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor

    FMK-MEA  Chemical Structure
  16. GC38791 GSK-25 GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM). GSK-25  Chemical Structure
  17. GC43803 HA-1077 (hydrochloride) Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. HA-1077 (hydrochloride) is also a potent Ca2+ channel antagonist and vasodilator. HA-1077 (hydrochloride)  Chemical Structure
  18. GC16039 LJH685 RSK (p90 ribosomal S6 kinase) inhibitor LJH685  Chemical Structure
  19. GC16601 LJI308

    pan-RSK inhibitor

    LJI308  Chemical Structure
  20. GC36505 LY-2584702 hydrochloride LY-2584702 hydrochloride is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM. LY-2584702 hydrochloride  Chemical Structure
  21. GC12089 LY2584702 LY2584702 is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM. LY2584702  Chemical Structure
  22. GC44095 LY2584702 (tosylate) LY2584702 (tosylate) is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM. LY2584702 (tosylate)  Chemical Structure
  23. GC49440 ML-9 A PKB/Akt inhibitor ML-9  Chemical Structure
  24. GC10689 PF-4708671

    PF-4708671, is a novel cell-permeable inhibitor of S6K1, specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM.

    PF-4708671  Chemical Structure
  25. GC17407 Pluripotin dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP Pluripotin  Chemical Structure
  26. GN10814 Quercitrin Quercitrin  Chemical Structure
  27. GC50294 RMM 46 MSK/RSK family kinase inhibitor RMM 46  Chemical Structure
  28. GC16313 SL 0101-1 ribosomal S6 kinase inhibitor SL 0101-1  Chemical Structure
  29. GC62675 SM1-71 SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines. SM1-71  Chemical Structure

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