RSK
RSK (ribosomal s6 kinase) is a family of protein kinases involved in signal transduction.
Products for RSK
- Cat.No. Product Name Information
- GC32797 AD80 AD80, a multikinase inhibitor, inhibits RET, RAF,SRCand S6K, with greatly reduced mTOR activity.
- GC15240 APS-2-79 APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling.
- GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive
-
GC12297
AT7867
Akt1/2/3 and p70S6K/PKA inhibitor
- GC10918 AT7867 dihydrochloride A potent and orally bioavailable pan-Akt inhibitor
- GC13468 BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable
- GC12982 BIX 02565 RSK2 inhibitor
- GC16779 BRD 7389 P90 RSK inhibitor
- GN10016 Carnosol
- GC38755 CKI-7 CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases.
- GC14693 CMK
- GC61941 Eudesmin Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of S6K1 signaling pathway.
- GC14125 FMK An inhibitor of RSK2
-
GC34197
FMK-MEA
A potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor
- GC38791 GSK-25 GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM).
- GC43803 HA-1077 (hydrochloride) Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. HA-1077 (hydrochloride) is also a potent Ca2+ channel antagonist and vasodilator.
- GC16039 LJH685 RSK (p90 ribosomal S6 kinase) inhibitor
-
GC16601
LJI308
pan-RSK inhibitor
- GC36505 LY-2584702 hydrochloride LY-2584702 hydrochloride is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM.
- GC12089 LY2584702 LY2584702 is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM.
- GC44095 LY2584702 (tosylate) LY2584702 (tosylate) is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM.
- GC49440 ML-9 A PKB/Akt inhibitor
-
GC10689
PF-4708671
PF-4708671, is a novel cell-permeable inhibitor of S6K1, specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM.
- GC17407 Pluripotin dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP
- GN10814 Quercitrin
- GC50294 RMM 46 MSK/RSK family kinase inhibitor
- GC16313 SL 0101-1 ribosomal S6 kinase inhibitor
- GC62675 SM1-71 SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines.