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Carbonic Anhydrase

Carbonic anhydrases (CAs) are a family of zinc containing metalloproteins that catalyze the reversible conversion of carbon dioxide (CO2) to bicarbonate with the releasing of a proton.  Being encoded by three distinct and evolutionarily unrelated gene families, CA enzymes are divided into three subfamilies, α-CAs (in vertebrates, eubacteria, algae and cytoplasm of green plants), β-CAs (in eubacteria, algae and chloroplasts of both mono- and di-cotyledons) and γ-CAs (in Archaea and some eubacteria). Through extensive studies, fourteen different CA isozymes have been identified in mammals, including four cytosolic isozymes (CA I-III and CA VII), four membrane-bound isozymes (CA IV, CA IX, CA XII and CA XIV), one mitochondrial isozyme (CA V) and one secreted isozyme (CA VI).

Products for  Carbonic Anhydrase

  1. Cat.No. Product Name Information
  2. GC34186 2-Aminobenzenesulfonamide (Orthanilamide) 2-Aminobenzenesulfonamide (Orthanilamide) is a carbonic anhydrase IX inhibitor. 2-Aminobenzenesulfonamide (Orthanilamide)  Chemical Structure
  3. GC49337 4-Acetamidobenzenesulfonamide A metabolite of asulam and sulfanilamide 4-Acetamidobenzenesulfonamide  Chemical Structure
  4. GC11567 Acetazolamide

    carbonic anhydrase (CA) inhibitor

    Acetazolamide  Chemical Structure
  5. GC33491 Acetazolamide D3 Acetazolamide D3 is deuterium labeled Acetazolamide, which is a potent carbonic anhydrase (CA) inhibitor. Acetazolamide D3  Chemical Structure
  6. GC65612 Acetazolamide sodium Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities. Acetazolamide sodium  Chemical Structure
  7. GC17003 Benzenesulfonamide carbonic anhydrase inhibitor Benzenesulfonamide  Chemical Structure
  8. GC64734 Benzenesulphonamide Benzenesulphonamide (compound 1) is a potent carbonic anhydrase inhibitor. Benzenesulphonamide shows CA II inhibitory activity. Benzenesulphonamide  Chemical Structure
  9. GC62864 Benzolamide Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide  Chemical Structure
  10. GC32634 Benzthiazide Benzthiazide is a long-acting diuretic and a hypertension agent. Benzthiazide  Chemical Structure
  11. GC10737 Brinzolamide A potent carbonic anhydrase inhibitor Brinzolamide  Chemical Structure
  12. GC46101 Brinzolamide-d5 An internal standard for the quantification of brinzolamide Brinzolamide-d5  Chemical Structure
  13. GC17454 Dichlorphenamide Carbonic anhydrase inhibitor Dichlorphenamide  Chemical Structure
  14. GC47210 Dichlorphenamide-13C6 An internal standard for the quantification of dichlorphenamide Dichlorphenamide-13C6  Chemical Structure
  15. GN10531 Dimethylfraxetin Dimethylfraxetin  Chemical Structure
  16. GC13932 Dorzolamide Carbonic anhydrase inhibitor Dorzolamide  Chemical Structure
  17. GC17748 Dorzolamide HCl A carbonic anhydrase inhibitor Dorzolamide HCl  Chemical Structure
  18. GC31710 Ethoxzolamide (Redupresin) Ethoxzolamide (Redupresin) is a carbonic anhydrase inhibitor with Ki of 1 nM. Ethoxzolamide (Redupresin)  Chemical Structure
  19. GC12992 Fluorometholone Acetate Glucocorticoid receptor agonist Fluorometholone Acetate  Chemical Structure
  20. GC47385 Furosemide-d5 An internal standard for the quantification of furosemide Furosemide-d5  Chemical Structure
  21. GC66360 Girentuximab Girentuximab (G250) is a chimeric monoclonal antibody that binds carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). Girentuximab  Chemical Structure
  22. GC39792 Halazone Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 ?M. Halazone  Chemical Structure
  23. GC66029 hCAI/II-IN-6 hCAI/II-IN-6 is an orally active human carbonic anhydrase (CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with Ki values of 220, 4.9, 6.5 and >50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy. hCAI/II-IN-6  Chemical Structure
  24. GC43874 Hydroflumethiazide Hydroflumethiazide is a thiazide diuretic that also inhibits carbonic anhydrase (CA). Hydroflumethiazide  Chemical Structure
  25. GC47441 Hydroflumethiazide-13C-d2 An internal standard for the quantification of hydroflumethiazide Hydroflumethiazide-13C-d2  Chemical Structure
  26. GC49195 Indapamide-13C-d3 An internal standard for the quantification of indapamide Indapamide-13C-d3  Chemical Structure
  27. GC65549 Indisulam Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15. Indisulam  Chemical Structure
  28. GC14226 Methazolamide A carbonic anhydrase inhibitor Methazolamide  Chemical Structure
  29. GC48889 Methazolamide-d6 An internal standard for the quantification of methazolamide Methazolamide-d6  Chemical Structure
  30. GC14046 Methyclothiazide thiazide diuretic Methyclothiazide  Chemical Structure
  31. GC49194 Metolazone-d7 An internal standard for the quantification of metolazone Metolazone-d7  Chemical Structure
  32. GC49210 N-desethyl Brinzolamide (oxalate) An active metabolite of brinzolamide N-desethyl Brinzolamide (oxalate)  Chemical Structure
  33. GC49211 O-desmethyl Brinzolamide (hydrochloride) An active metabolite of brinzolamide O-desmethyl Brinzolamide (hydrochloride)  Chemical Structure
  34. GC18271 Polmacoxib Polmacoxib is an inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrase subtypes I (CAI) and CAII. Polmacoxib  Chemical Structure
  35. GC48895 Rufinamide-15N-d2 An internal standard for the quantification of rufinamide Rufinamide-15N-d2  Chemical Structure
  36. GC30899 Sultiame

    Sultiame is a carbonic anhydrase inhibitor, widely used as an antiepileptic drug.

    Sultiame  Chemical Structure
  37. GC15158 Tioxolone A carbonic anhydrase I inhibitor Tioxolone  Chemical Structure
  38. GC16149 Topiramate An anticonvulsant Topiramate  Chemical Structure
  39. GC50198 Topiramate - d12 Deuterated topiramate Topiramate - d12  Chemical Structure
  40. GC17378 U-104 A carbonic anhydrase inhibitor U-104  Chemical Structure
  41. GC45802 Zonisamide-13C2,15N An internal standard for the quantification of zonisamide Zonisamide-13C2,15N  Chemical Structure

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