FAAH
Fatty acid amide hydrolase (FAAH), belonging to an amidase-signature (AS) protein family, is a membrane-bound protein predominantly in microsomal and mitochondrial fractions that catalyzes the hydrolysis of several bioactive lipids, including anandamide, 2-arachidonoylglycerol (2-AG) and oleamide. The mammalian FAAHs are 63 kDa (579 amino acids in length) proteins characterized by containing several domains defined by homology and function, including, a highly conserved seine-and-glycine-rich AS domain, a predicted transmembrane domain and a proline rich domain. Results of mutation studies suggest, unlike other members of AS protein family, the catalytic activity of FAAH is not associated with the Ser-His-Asp triad but possibly with Ser217 and Lys142.
Products for FAAH
- Cat.No. Product Name Information
- GC35068 1-Monomyristin A monoacylglycerol
- GC17159 4-(n-nonyl) Benzeneboronic Acid 4-(n-nonyl) Benzeneboronic Acid (compound 13) is a potent FAAH and MAGL dual inhibitor with IC50 values of 9.1 nM and 7.9 μM, respectively.
- GC18174 BIA 10-2474 BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme).
- GN10618 Biochanin A
- GC17341 Carprofen COX inhibitor
- GC36023 FAAH inhibitor 1 FAAH inhibitor 1 (Benzothiazole analog 3) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 18±8 nM.
- GC30751 FAAH-IN-1 FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.
- GC30366 FAAH-IN-2 FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent FAAH(fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2.
- GC14581 JNJ-1661010 A selective FAAH inhibitor
- GC10133 JNJ-42165279 FAAH inhibitor
- GC12546 JP83 irreversible fatty acyl amide hydrolase (FAAH) inhibitor
- GC12693 JZL 195 Dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)
- GC15094 LY2183240 A potent, competitive inhibitor of anandamide uptake
- GC13953 Methyl α-Linolenyl Fluorophosphonate inhibitor of phospholipases, FAAH
- GC12031 Monoacylglycerol Lipase Inhibitor 21 inhibitor of monoacylglycerol lipase (MAGL) and FAAH
- GC36671 N-Benzyllinolenamide N-Benzyllinolenamide is a natural macamide isolated from Lepidium meyenii, acts as an inhibitor of fatty acid amide hydrolase (FAAH) with an IC50 of 41.8 μM.
- GC36703 N-Benzyloleamide N-Benzyloleamide is a maccamide isolated from Lepidium meyenii (Maca).
- GC13063 N-Benzylpalmitamide inhibitor of fatty acid amide hydrolase (FAAH)
- GC15231 Oleoyl Ethyl Amide FAAH inhibitor with potential analgesic and anxiolytic activity
- GC13963 Oleyl Trifluoromethyl Ketone potent inhibitor of FAAH
- GC15358 PF 750 FAAH inhibitor
- GC36879 PF-04457845 A selective FAAH inhibitor
- GC16984 PF-3845 Inhibitor of FAAH
- GC15210 PF-622 potent, time-dependent, irreversible FAAH inhibitor
- GC15077 SA 47 FAAH inhibitor
- GC17855 SA 57 FAAH inhibitor
- GC31239 SA72 SA72 is a highly selective fatty acid amide hydrolase (FAAH) inhibitor.
- GC63641 SSR411298 SSR411298 is an orally active, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor.
- GC16033 TAK 21d TAK 21d (compound 21d) is a potent, orally active and cross the blood-brain barrier fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 0.72, 0.28 nM for hFAAH, rFAAH, respectively.
- GC11290 TC-F 2 FAAH inhibitor
- GC15951 URB597 An inhibitor of FAAH