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FAAH

Fatty acid amide hydrolase (FAAH), belonging to an amidase-signature (AS) protein family, is a membrane-bound protein predominantly in microsomal and mitochondrial fractions that catalyzes the hydrolysis of several bioactive lipids, including anandamide, 2-arachidonoylglycerol (2-AG) and oleamide. The mammalian FAAHs are 63 kDa (579 amino acids in length) proteins characterized by containing several domains defined by homology and function, including, a highly conserved seine-and-glycine-rich AS domain, a predicted transmembrane domain and a proline rich domain. Results of mutation studies suggest, unlike other members of AS protein family, the catalytic activity of FAAH is not associated with the Ser-His-Asp triad but possibly with Ser217 and Lys142.

Products for  FAAH

  1. Cat.No. Product Name Information
  2. GC35068 1-Monomyristin A monoacylglycerol 1-Monomyristin  Chemical Structure
  3. GC17159 4-(n-nonyl) Benzeneboronic Acid 4-(n-nonyl) Benzeneboronic Acid (compound 13) is a potent FAAH and MAGL dual inhibitor with IC50 values of 9.1 nM and 7.9 μM, respectively. 4-(n-nonyl) Benzeneboronic Acid  Chemical Structure
  4. GC18174 BIA 10-2474 BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme). BIA 10-2474  Chemical Structure
  5. GN10618 Biochanin A Biochanin A  Chemical Structure
  6. GC17341 Carprofen COX inhibitor Carprofen  Chemical Structure
  7. GC36023 FAAH inhibitor 1 FAAH inhibitor 1 (Benzothiazole analog 3) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 18±8 nM. FAAH inhibitor 1  Chemical Structure
  8. GC30751 FAAH-IN-1 FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively. FAAH-IN-1  Chemical Structure
  9. GC30366 FAAH-IN-2 FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent FAAH(fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2. FAAH-IN-2  Chemical Structure
  10. GC14581 JNJ-1661010 A selective FAAH inhibitor JNJ-1661010  Chemical Structure
  11. GC10133 JNJ-42165279 FAAH inhibitor JNJ-42165279  Chemical Structure
  12. GC12546 JP83 irreversible fatty acyl amide hydrolase (FAAH) inhibitor JP83  Chemical Structure
  13. GC12693 JZL 195 Dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) JZL 195  Chemical Structure
  14. GC15094 LY2183240 A potent, competitive inhibitor of anandamide uptake LY2183240  Chemical Structure
  15. GC13953 Methyl α-Linolenyl Fluorophosphonate inhibitor of phospholipases, FAAH Methyl α-Linolenyl Fluorophosphonate  Chemical Structure
  16. GC12031 Monoacylglycerol Lipase Inhibitor 21 inhibitor of monoacylglycerol lipase (MAGL) and FAAH Monoacylglycerol Lipase Inhibitor 21  Chemical Structure
  17. GC36671 N-Benzyllinolenamide N-Benzyllinolenamide is a natural macamide isolated from Lepidium meyenii, acts as an inhibitor of fatty acid amide hydrolase (FAAH) with an IC50 of 41.8 μM. N-Benzyllinolenamide  Chemical Structure
  18. GC36703 N-Benzyloleamide N-Benzyloleamide is a maccamide isolated from Lepidium meyenii (Maca). N-Benzyloleamide  Chemical Structure
  19. GC13063 N-Benzylpalmitamide inhibitor of fatty acid amide hydrolase (FAAH) N-Benzylpalmitamide  Chemical Structure
  20. GC15231 Oleoyl Ethyl Amide FAAH inhibitor with potential analgesic and anxiolytic activity Oleoyl Ethyl Amide  Chemical Structure
  21. GC13963 Oleyl Trifluoromethyl Ketone potent inhibitor of FAAH Oleyl Trifluoromethyl Ketone  Chemical Structure
  22. GC15358 PF 750 FAAH inhibitor PF 750  Chemical Structure
  23. GC36879 PF-04457845 A selective FAAH inhibitor PF-04457845  Chemical Structure
  24. GC16984 PF-3845 Inhibitor of FAAH PF-3845  Chemical Structure
  25. GC15210 PF-622 potent, time-dependent, irreversible FAAH inhibitor PF-622  Chemical Structure
  26. GC15077 SA 47 FAAH inhibitor SA 47  Chemical Structure
  27. GC17855 SA 57 FAAH inhibitor SA 57  Chemical Structure
  28. GC31239 SA72 SA72 is a highly selective fatty acid amide hydrolase (FAAH) inhibitor. SA72  Chemical Structure
  29. GC63641 SSR411298 SSR411298 is an orally active, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor. SSR411298  Chemical Structure
  30. GC16033 TAK 21d TAK 21d (compound 21d) is a potent, orally active and cross the blood-brain barrier fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 0.72, 0.28 nM for hFAAH, rFAAH, respectively. TAK 21d  Chemical Structure
  31. GC11290 TC-F 2 FAAH inhibitor TC-F 2  Chemical Structure
  32. GC15951 URB597 An inhibitor of FAAH URB597  Chemical Structure

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